Alzheimers Parkinsons ALS

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Glucosamine and Its Analogues as Modulators of Amyloid-ß Toxicity ACS Medicinal Chemistry Letters
Glucosamine and Its Analogues as Modulators of Amyloid-ß Toxicity ACS Medicinal Chemistry Letters
In Alzheimer’s disease (AD), amyloid-β (Aβ) oligomers are considered key mediators of synaptic dysfunction and cognitive impairment. These unstable intermediate Aβ species can interfere with different cellular organelles, leading to neuronal cell death, through the formation of Ca2+-permeable membrane pores, impairment in the levels of acetylcholine neurotransmitters, increased insulin resistance, promotion of pro-inflammatory cascades, among others. Based on a series of evidences that indicate the key role of glycosaminoglycans (GAGs) in amyloid plaque formation, we evaluated the capacity of four monosaccharides, i.e., glucosamine (GlcN), N-acetyl glucosamine (GlcNAc), glucosamine-6-sulfate (GlcN6S), and glucosamine-6-phosphate (GlcN6P), to reduce the Aβ-mediated pathological hallmarks. The tested monosaccharides, in particular, GlcN6S and GlcN6P, were able to interact with Aβ aggregates, reducing neuronal cell death, Aβ-mediated damage to the cellular membrane, acetylcholinesterase activity, insulin resistance, and pro-inflammation levels.
·pubs.acs.org·
Glucosamine and Its Analogues as Modulators of Amyloid-ß Toxicity ACS Medicinal Chemistry Letters
Benefits of Vitamins in the Treatment of Parkinson’s Disease
Benefits of Vitamins in the Treatment of Parkinson’s Disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease in the elderly, which is clinically characterized by bradykinesia, resting tremor, abnormal posture balance, and hypermyotonia. Currently, the pathogenic mechanism of PD remains unclear. Numerous clinical studies as well as animal and cell experiments have found a certain relationship between the vitamin family and PD. The antioxidant properties of vitamins and their biological functions of regulating gene expression may be beneficial for the treatment of PD. Current clinical evidence indicates that proper supplementation of various vitamins can reduce the incidence of PD in the general population and improve the clinical symptoms of patients with PD; nevertheless, the safety of regular vitamin supplements still needs to be highlighted. Vitamin supplementation may be an effective adjuvant treatment for PD. In this review, we summarized the biological correlations between vitamins and PD as well as the underlying pathophysiological mechanisms. Additionally, we elaborated the therapeutic potentials of vitamins for PD.
·hindawi.com·
Benefits of Vitamins in the Treatment of Parkinson’s Disease
Colin Potter - How He Reversed His Parkinson's Symptom's (FULL Interview by Sarah King, PT, DPT) - YouTube
Colin Potter - How He Reversed His Parkinson's Symptom's (FULL Interview by Sarah King, PT, DPT) - YouTube
Dr. Sarah King, PT, DPT interviews Colin Potter about his experience being diagnosed with Parkinson's Disease and his hard-fought battle to dramatically improve his Parkinson's symptoms. Start building your own Parkinson's Plan of Attack with similar strategies to Colin's: http://www.InvigoratePT.com/start-here LEARN MORE ABOUT SARAH'S PARKINSON'S SPECIFIC EXERCISE PROGRAM: http://www.InvigoratePT.com/Booster FOR ADDITIONAL INTERVIEWS WITH COLIN: http://www.invigoratept.com/blog/colin-potter-fight-parkinsons-special-interview-2017
·youtube.com·
Colin Potter - How He Reversed His Parkinson's Symptom's (FULL Interview by Sarah King, PT, DPT) - YouTube
Beneficial effects of trehalose on striatal dopaminergic deficits in rodent and primate models of synucleinopathy in Parkinson's disease. - PubMed - NCBI
Beneficial effects of trehalose on striatal dopaminergic deficits in rodent and primate models of synucleinopathy in Parkinson's disease. - PubMed - NCBI
Disease modification in Parkinson's disease (PD) is an unmet medical need. In the current study, we evaluated trehalose, a safe and well-tolerated disaccharide that has previously demonstrated efficacy in rodent models of neurodegenerative diseases, including PD. In a rat model of PD, based on deliv …
·ncbi.nlm.nih.gov·
Beneficial effects of trehalose on striatal dopaminergic deficits in rodent and primate models of synucleinopathy in Parkinson's disease. - PubMed - NCBI
Dramatic Recovery In Parkinson’s Patient with Gluten Free Diet
Dramatic Recovery In Parkinson’s Patient with Gluten Free Diet
Could gluten's toxicity extend to the nervous system, producing symptoms identical to classical Parkinson's disease? A compelling case study adds to a growing body of research indicating that wheat's neurotoxicity is greatly underestimated.
·greenmedinfo.com·
Dramatic Recovery In Parkinson’s Patient with Gluten Free Diet
Fucoidan serves a neuroprotective effect in an Alzheimer’s disease model
Fucoidan serves a neuroprotective effect in an Alzheimer’s disease model
This is a journal and virtual library useful to scientists, physicians and patients. The site contains medical and biology information as articles, databases, books, lectures and more. The site also contains the forms to search the most useful sites on the Web.
·bioscience.org·
Fucoidan serves a neuroprotective effect in an Alzheimer’s disease model
Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease. - PubMed - NCBI
Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease. - PubMed - NCBI
Alzheimer's disease is a neurodegenerative disorder involving extracellular plaques (amyloid-β) and intracellular tangles of tau protein. Recently, tangle formation has been identified as a major event involved in the neurodegenerative process, due to the conversion of either soluble peptides or oli …
·ncbi.nlm.nih.gov·
Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease. - PubMed - NCBI
How to Stop Dementia and Alzheimer's Naturally - YouTube
How to Stop Dementia and Alzheimer's Naturally - YouTube
Dementia and Alzheimer's a big problem in industrialized countries. With the aging population at greater and greater risk for these conditions, it is imperative to understand that there are a variety of natural ways to stop dementia in its tracks. In this video, Dr. Osborne breaks down 6 natural ways you can overcome brain inflammation (brainflammation) including: 1. Avoid gluten 2. Eat lots of healthy fats 3. Avoid eating excessive carbohydrates 4. Take exercise more seriously 5. Maintain a healthy blood sugar 6. Do a medication review with your doctor. Remember, natural help is all about your diet and your lifestyle. There are no magic cures. You have to put in the work. To connect with Dr. Osborne visit: Facebook: https://www.facebook.com/DoctorPeterO... Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
·youtube.com·
How to Stop Dementia and Alzheimer's Naturally - YouTube
Human amyloid-beta acts as natural antibiotic in the brain Alzheimer's (...)
Human amyloid-beta acts as natural antibiotic in the brain Alzheimer's (...)
A new study provides additional evidence that amyloid-beta protein -- which is deposited in the form of beta-amyloid plaques in the brains of patients with Alzheimer's disease -- is a normal part of the innate immune system, the body's first-line defense against infection.
·sciencedaily.com·
Human amyloid-beta acts as natural antibiotic in the brain Alzheimer's (...)
Leaky blood-brain barrier linked to Alzheimer's disease -- ScienceDail (...)
Leaky blood-brain barrier linked to Alzheimer's disease -- ScienceDail (...)
Researchers using contrast-enhanced MRI have identified leakages in the blood-brain barrier of people with early Alzheimer's disease, according to a new study. The results suggest that increased BBB permeability may represent a key mechanism in the early stages of the disease.
·sciencedaily.com·
Leaky blood-brain barrier linked to Alzheimer's disease -- ScienceDail (...)
Link between gum disease and cognitive decline in Alzheimer’s -- Scien (...)
Link between gum disease and cognitive decline in Alzheimer’s -- Scien (...)
A new study has found a link between gum disease and greater rates of cognitive decline in people with early stages of Alzheimer's Disease.Periodontitis or gum disease is common in older people and may become more common in Alzheimer's disease because of a reduced ability to take care of oral hygiene as the disease progresses. Higher levels of antibodies to periodontal bacteria are associated with an increase in levels of inflammatory molecules elsewhere in the body, which in turn has been linked to greater rates of cognitive decline in Alzheimer's disease in previous studies. The latest study set out to determine whether periodontitis or gum disease is associated with increased dementia severity and subsequent greater progression of cognitive decline in people with Alzheimer's disease.
·sciencedaily.com·
Link between gum disease and cognitive decline in Alzheimer’s -- Scien (...)
Lipid-based diets effectively combat Alzheimer's disease in mouse mode (...)
Lipid-based diets effectively combat Alzheimer's disease in mouse mode (...)
Researchers have devised several lipid-based diets aimed at slowing down progression and relieving symptoms of Alzheimer's disease (AD). It is generally accepted that lifestyle and particularly dietary habits influence mental health, and prevalence and progression of AD. Numerous epidemiological studies have revealed profitable effects of dietary intake of especially fish oil on cognitive decline during aging and dementia.
·sciencedaily.com·
Lipid-based diets effectively combat Alzheimer's disease in mouse mode (...)
Marijuana Compound Found Superior To Drugs For Alzheimer's
Marijuana Compound Found Superior To Drugs For Alzheimer's
Could the active ingredient in marijuana, responsible for its characteristic "high," help turn the tide against the accelerating Alzheimer's epidemic? A remarkable study published in the journal Molecular Pharmacology in 2006, found that this long vilified plant may contain a compound with not one, but two therapeutic properties ideal for addressing both the surface symptom (memory problems) and root cause (brain plaque) of Alzheimer’s disease
·greenmedinfo.com·
Marijuana Compound Found Superior To Drugs For Alzheimer's