Alzheimers Parkinsons ALS

We now can convincingly demonstrate that a ketogenic diet is helpful in Parkinson’s, and we now have a better understanding of the underlying mechanisms.

Sarah King, PT, DPT shows people diagnosed with Parkinson's Disease how to create a personalized Parkinson’s action plan that improves their symptoms, so they can spend less time worrying and more time doing the things they love, with the people they love, for as long as possible.

We have already reported that glucosamine (GlcN) distinctly abrogates the pigmentation of human epidermal equivalents stimulated by stem cell factor + endothelin-1 (SE). In this study, we characterized the molecular mechanism involved in the anti-melanogenic effects of GlcN using normal human melanocytes (NHMs) in culture. The SE-stimulated gene (12 h) and protein (24 h) expression levels of melanocyte-specific proteins (at the indicated times post-stimulation) were significantly abrogated by pretreatment with GlcN for 72 h. Western blotting analysis of the phosphorylation of intracellular signaling molecules in the MAPK pathway revealed that despite the significantly decreased level of total CREB protein at all times post-stimulation, the SE-stimulated phosphorylation of ERK, CREB and MITF is not attenuated at 15 min post-stimulation in GlcN-treated NHMs. However, the SE-stimulated protein expression level of total MITF at 2 and 6 h post-stimulation was significantly abrogated by 72 h pretreatment with GlcN. Consistently, pretreatment with GlcN for 72 h abrogated the stimulated gene and protein expression levels of MITF at 1 h and 2 h post-stimulation, respectively. Analysis of gene and protein expression levels also demonstrated that pretreatment with GlcN for 72 h significantly reduced the protein levels of CREB and MITF without affecting their gene expression levels prior to the SE stimulation. Silencing with a CREB siRNA distinctly abrogated the SE-stimulated expression of MITF (at 2 h post-stimulation) and melanocyte-specific proteins (at 24 h post-stimulation). Similarly, transfection of MITF siRNA markedly abrogated the SE-stimulated expression of MITF protein and melanocyte-specific proteins at 2 and 24 h post-stimulation, respectively. Finally, the decreased levels of CREB and MITF proteins induced by 72 h pretreatment with GlcN were abrogated by the co-addition of the proteosomal degradation inhibitor MG132. These findings suggest that the anti-melanogenic effect elicited by GlcN is mediated via the decreased expression of MITF which results from the attenuated transcriptional activity of CREB due to proteolytic degradation.

Could gluten's toxicity extend to the nervous system, producing symptoms identical to classical Parkinson's disease? A compelling case study adds to a growing body of research indicating that wheat's neurotoxicity is greatly underestimated.

Parkinson’s disease (PD) is the second most common neurodegenerative disease in the elderly, which is clinically characterized by bradykinesia, resting tremor, abnormal posture balance, and hypermyotonia. Currently, the pathogenic mechanism of PD remains unclear. Numerous clinical studies as well as animal and cell experiments have found a certain relationship between the vitamin family and PD. The antioxidant properties of vitamins and their biological functions of regulating gene expression may be beneficial for the treatment of PD. Current clinical evidence indicates that proper supplementation of various vitamins can reduce the incidence of PD in the general population and improve the clinical symptoms of patients with PD; nevertheless, the safety of regular vitamin supplements still needs to be highlighted. Vitamin supplementation may be an effective adjuvant treatment for PD. In this review, we summarized the biological correlations between vitamins and PD as well as the underlying pathophysiological mechanisms. Additionally, we elaborated the therapeutic potentials of vitamins for PD.

Parkinson's disease (PD) is a progressive movement disorder resulting primarily from loss of nigrostriatal dopaminergic neurons. PD is characterized by the accumulation of protein aggregates, and evidence suggests that aberrant protein deposition in dopaminergic neurons could be related to the dysre …

Science says eating just one meal per day can improve your health. Learn more at https://highintensityhealth.com/OMAD ----- Connect with Bill Curtis: https://www.thefourthfoodgroup.com/ Related Video testing the KetoAid Ketone Ester: https://youtu.be/V-ILObXYsaQ This episode is brought to you by: ➢ Health IQ, an insurance company that helps health conscious people like weightlifters, cyclist, keto dieters and vegetarians get lower rates on their life insurance. ➢ Get a Free Quote: http://healthiq.com/HIH Somnifix.com, the world’s only hypoallergenic mouth tape, developed by Harvard Scientists. https://www.somnifix.com Key Timestamps: 01:55 Journalist Bill Curtis has had Parkinson's since 2000. As predicted, he was dramatically affected 10 years later with advanced Parkinson's. Now the only symptom he has is a slight tremor. 04:48 Within about 2 hours of eating carbs, Bill will begin to shake and feel rigid. He doesn't get the full on symptoms he had before. 07:38 Bill was in an exercise program. In an attempt to enhance the effects of the program, he fasted overnight and had nothing for breakfast before the workout. He found it alleviated his profound fatigue. 11:27 Fasting helped with the fatigue, but there were many more symptoms that were not reversed. Bill continued researching. 13:02 Bill exercised fasted every day for a year. He lost weight, but eventually, it stopped working. As you become fit, you make fewer ketones. 15:04 Dr. Veech suggested that Bill try Bulletproof Coffee after the night fast. Nearly all of his symptoms abated at the end of the first hour. 19:36 The military has been experimenting with Dr. Veech's ketone ester for radiation exposure. 22:26 A therapeutic ketogenic diet is one with 80 to 90% of your food as fat. Bill has devised 4 levels of ketosis. 30:33 Within the first 10 days of taking ketone ester, Bill no longer had urinary incontinence. 32:07 There is data that an elevation of uric acid it will delay the onset of Parkinson's. If you have Parkinson's, and your uric acid levels are higher, you decline more slowly. 36:14 BHB allows you to make more dopamine, serotonin, adrenaline, noradrenaline and nitric oxide. 38:00 In advanced Parkinson's neurotransmitters are negatively impacted. With ketosis, you are making serotonin, noradrenaline, adrenaline, dopamine and nitric oxide synthase. 38:52 Every antioxidant has to be recharged with an electron from NADPH, directly or indirectly. 39:50 Beta hydroxybutyrate raises NADPH levels using isocitrate dehydrogenase in the cytoplasm, outside of the mitochondria. 42:24 NADPH levels in the mitochondria does not correlate with NADPH levels in the cytosol. We should measure the cytosolic NADPH. 44:09 NADPH voltage is dependent upon the relative concentrations. More equals more resilience. 48:52 Dismutase does not get its electrons from the battery. It does this by taking 2 molecules of superoxide, oxidizing one and reducing the other. 52:59 You have the ability to use ketones to restore ischemia-reperfusion and turn off inflammation. 54:08 NADPH controls inflammation. 55:04 Dr. Veech found that treating Alzheimer's mouse models with beta hydroxybutyrate kept them from accumulating beta amyloid deposits. 58:03 Bill believes that TBI will respond very well to BHB, as evidenced by people close to him with head injuries. 01:02:41 Bill has created an online course to help people help each other. You need a cook, a coach, a nutritionist and a doctor. 01:04:36 Bill must still take his Parkinson's medications.

Dr. Sarah King, PT, DPT interviews Colin Potter about his experience being diagnosed with Parkinson's Disease and his hard-fought battle to dramatically improve his Parkinson's symptoms. Start building your own Parkinson's Plan of Attack with similar strategies to Colin's: http://www.InvigoratePT.com/start-here LEARN MORE ABOUT SARAH'S PARKINSON'S SPECIFIC EXERCISE PROGRAM: http://www.InvigoratePT.com/Booster FOR ADDITIONAL INTERVIEWS WITH COLIN: http://www.invigoratept.com/blog/colin-potter-fight-parkinsons-special-interview-2017

Disease modification in Parkinson's disease (PD) is an unmet medical need. In the current study, we evaluated trehalose, a safe and well-tolerated disaccharide that has previously demonstrated efficacy in rodent models of neurodegenerative diseases, including PD. In a rat model of PD, based on deliv …

My current research is on Alzheimer's disease (AD) and Parkinson's disease (PD). I believe that these two diseases are related.

New research connects some very important dots and gives further substantiation to the idea that coffee is good for the brain.

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. As the aging population is increasing, AD is becoming one of the leading causes of disability and death among the elderly. However, currently there is no cure for this disease. Fucoidan is a complex sulfated polysaccharide ma

Europe PMC is an archive of life sciences journal literature.

This is a journal and virtual library useful to scientists, physicians and patients. The site contains medical and biology information as articles, databases, books, lectures and more. The site also contains the forms to search the most useful sites on the Web.

Alzheimer's disease is a neurodegenerative disorder involving extracellular plaques (amyloid-β) and intracellular tangles of tau protein. Recently, tangle formation has been identified as a major event involved in the neurodegenerative process, due to the conversion of either soluble peptides or oli …

Omega-3 fatty acids are known to be good for heart health, but did you know that in high doses they may also slow cognitive decline?

Transgenic APPswe/PS1dE9 mice modeling Alzheimer’s disease demonstrate ongoing accumulation of β-amyloid fragments resulting in formation of amy...

Muses Labs, partnering with leading Alzheimer's researchers, pioneered the MEND™ Protocol to treat underlying drivers of Alzheimer’s disease with big-data.

Dementia and Alzheimer's a big problem in industrialized countries. With the aging population at greater and greater risk for these conditions, it is imperative to understand that there are a variety of natural ways to stop dementia in its tracks. In this video, Dr. Osborne breaks down 6 natural ways you can overcome brain inflammation (brainflammation) including: 1. Avoid gluten 2. Eat lots of healthy fats 3. Avoid eating excessive carbohydrates 4. Take exercise more seriously 5. Maintain a healthy blood sugar 6. Do a medication review with your doctor. Remember, natural help is all about your diet and your lifestyle. There are no magic cures. You have to put in the work. To connect with Dr. Osborne visit: Facebook: https://www.facebook.com/DoctorPeterO... Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.

A new study provides additional evidence that amyloid-beta protein -- which is deposited in the form of beta-amyloid plaques in the brains of patients with Alzheimer's disease -- is a normal part of the innate immune system, the body's first-line defense against infection.

In a new study, compared with the standard diet, patients on the ketogenic diet showed a small trend towards improved cognition.