A new study is helping to explain why the long-term use of common anticholinergic drugs used to treat conditions like allergies and overactive bladder lead to an increased risk of developing dementia later in life. The study used mouse models to show that long-term suppression of the neurotransmitter acetylcholine -- a target for anticholinergic drugs -- results in dementia-like changes in the brain.

Inhibition of platelets in Alzheimer's disease patients may become important in therapy in future, say researchers whose findings could be of great importance for the treatment of Alzheimer's disease patients.

2019 RYB ALZ Risk - Main Opt-In.

This is the first time a randomized, double-blind, clinical trial has shown that a nutritional intervention can help to conserve the ability of prodromal AD patients to carry out everyday tasks, such as paying bills, or finding your way around, as measured by the Clinical Dementia Rating-Sum of Boxes (CDR-SB) -- a combined measure for the ability to think and perform everyday tasks. This is important because those with prodromal AD currently have no approved, available pharmacological options.

The disaccharide trehalose is commonly considered to stimulate autophagy. Cell treatment with trehalose could decrease cytosolic aggregates of potentially pathogenic proteins, including mutant huntingtin, α-synuclein, and phosphorylated tau that are associated with neurodegenerative diseases. Here, …