Excitingly, new research is finding that the placenta may actually play a significant role in microbiome development of children.

Everything you eat or drink affects your intestinal bacteria, and is likely to have an impact on your health. That is the finding of a large-scale study into the effect of food and medicine on the bacterial diversity in the human gut.

There is currently a lack of long-term longitudinal studies investigating the stability of the microbiome. In this n-of-one study, we characterised th…

Gut microbes are well known to contribute to health and disease, but what has been less clear is how the host controls gut microbes. A study now reveals that mice and humans produce small molecules (microRNAs) from their GI tract, which are shed in feces, to regulate the composition of gut microbes and thereby protect against intestinal diseases such as colitis.

Science continues to find the benefits a probiotic-rich diet can have for four key areas of health: your mood, gut health, brain health, and immune system.

Scientists have identified a mechanism that might explain the link between maternal infections during pregnancy and cognitive problems in children. These findings may impact clinical care, they say.

The development of food allergies in mice can be linked to what their gut bacteria are being fed, reports a new study. Rodents that received a diet with average calories, sugar, and fiber content had more severe peanut allergies than those that received a high-fiber diet. The researchers show that gut bacteria release a specific fatty acid in response to fiber intake, which eventually impacts allergic responses via changes to the immune system.

The best prebiotics and probiotics come from these foods. Nurture your microbiome and good gut bacteria.

In certain medical conditions, probiotic supplements may actually make things worse. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ Support NutritionFacts.org with a donation at http://www.NutritionFacts.org/donate. This is a link to the video I alluded to: Preventing the Common Cold with Probiotics? (http://nutritionfacts.org/video/preventing-the-common-cold-with-probiotics). I also talk about the potential benefits in my videos Preventing and Treating Diarrhea with Probiotics (https://nutritionfacts.org/video/preventing-and-treating-diarrhea-with-probiotics/) and Gut Feelings: Probiotics and Mental Health (https://nutritionfacts.org/video/gut-feelings-probiotics-and-mental-health/). Perhaps it would be safer and more effective to instead focus on fostering the growth of the good bacteria with have by feeding them prebiotics (fiber and resistant starch): • Prebiotics: Tending Our Inner Garden (https://nutritionfacts.org/video/prebiotics-tending-our-inner-garden) • Boosting Good Bacteria in the Colon Without Probiotics (https://nutritionfacts.org/video/boosting-good-bacteria-in-the-colon-without-probiotics/) • Resistant Starch and Colon Cancer (https://nutritionfacts.org/video/resistant-starch-colon-cancer) • Gut Dysbiosis - Starving Our Microbial Self (https://nutritionfacts.org/video/is-obesity-infectious) • How to Become a Fecal Transplant Super Donor (https://nutritionfacts.org/video/How-to-Become-a-Fecal-Transplant-Super-Donor) • Microbiome: We Are What They Eat (https://nutritionfacts.org/video/Microbiome-We-Are-What-They-Eat) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/culture-shock-questioning-the-efficacy-and-safety-of-probiotics and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/culture-shock-questioning-the-efficacy-and-safety-of-probiotics. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. Icons created by Laymik, Tinashe Mugayi, Nikita Kozin, and Tomas Knopp from The Noun Project. Image credit: Kristina DeMuth https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Visit the Mercola Video Library By Dr. Mercola The US Food and Drug Administration (FDA) recently issued a warning that fluoroquinolone antibiotics, taken by mouth or injection, carry a risk for permanent peripheral neuropathy. The safety announcement states:1 “The U.S. Food and Drug Administration (FDA) has required the drug labels and Medication Guides for all fluoroquinolone antibacterial drugs be updated to better describe the serious side effect of peripheral neuropathy. This serious nerve damage potentially caused by fluoroquinolones may occur soon after these drugs are taken and may be permanent… The topical formulations of fluoroquinolones, applied to the ears or … Continue reading →

Similar to the use of GcMAF, degalactosylated/desialylated bovine colostrum can be used as a potential macrophage activator for various immunotherapies.

Once thought to be sterile, the bladder contains microbes that could influence the development and treatment of cancer.

Scientists have developed a pioneering new treatment to prevent bacterial skin infections, which could be used in the battle against 'superbugs', such as MRSA.

Can gut bugs change the world? Join Warren Peters on a journey into understanding your microbiome and the new discoveries changing the way we understand diabetes, obesity, Alzheimer's disease, autism, and our everyday health and wellness. If asked, he will tell you that the first part of his medical career was in general surgery, where “if something is wrong with you, I will cut it out." The next was dedicated to lifestyle and natural medicines, where “if something is wrong with you, just try harder." And finally, the last part is dedicated to the molecular and genetic basis of obesity, where "if something is wrong with you, it is the fault of your parents and the changing environment." Within these three perspectives, reside the virtues of common sense and wisdom. He obtained his medical degree from Loma Linda University, his surgical training at the Mason Clinic in Seattle Washington, and, his Master’s degree in biostatistics and epidemiology from Loma Linda University. He is privileged to travel and lecture nationally and internationally on topics of nutrition, wholeness, and wellness. He has practiced surgical care, wholistic care, and, primary care in Washington, Maryland, Virginia, and California. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at http://ted.com/tedx

The microbiome revolution in medicine is beginning to uncover the underappreciated role our healthy gut bacteria play in nutrition and health. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ This is the first of a long series of in-depth videos on the microbiome, though I have touched on friendly flora before: • How to Reduce Carcinogenic Bile Acid Production (http://nutritionfacts.org/video/how-to-reduce-carcinogenic-bile-acid-production/) • Putrefying Protein and “Toxifying” Enzymes (http://nutritionfacts.org/video/putrefying-protein-and-toxifying-enzymes/) • Why Do Plant-Based Diets Help Rheumatoid Arthritis? (http://nutritionfacts.org/video/why-do-plant-based-diets-help-rheumatoid-arthritis) • Bowel Wars: Hydrogen Sulfide vs. Butyrate (http://nutritionfacts.org/video/bowel-wars-hydrogen-sulfide-vs-butyrate/) • Preventing Ulcerative Colitis with Diet (http://nutritionfacts.org/video/preventing-ulcerative-colitis-with-diet/) • Treating Ulcerative Colitis with Diet (http://nutritionfacts.org/video/treating-ulcerative-colitis-with-diet) How does the body maintain the right balance of bacteria? Wait until the next video—you’ll be amazed (I know I was!): Prebiotics: Tending Our Inner Garden (http://nutritionfacts.org/video/prebiotics-tending-our-inner-garden). Have a question for Dr. Greger about this video? Leave it in the comment section at http://nutritionfacts.org/video/microbiome-the-inside-story and he'll try to answer it! https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

A connection between the bacteria living in the gut and immunological disorders such as multiple sclerosis have long been suspected, but for the first time, researchers have detected clear evidence of changes that tie the two together. Investigators have found that people with multiple sclerosis have different patterns of gut microorganisms than those of their healthy counterparts. In addition, patients receiving treatment for MS have different patterns than untreated patients.

A new literature review suggests that nutrition and diet have a profound impact on the microbial composition of the gut.

Did you know that probiotic bacteria are capable of helping you detoxify the most noxious chemicals known to humankind?

Science says eating just one meal per day can improve your health. Learn more at https://highintensityhealth.com/OMAD ----- Access the Show Notes & Download the Audio: http://highintensityhealth.com/digestion-gut-microbiome-probiotics-prebiotics-russell-jaffe-md-phd-ccn/ Key Points: 15:15 Antibiotics Lay Waste to our Microbiome. This is well explained in When Antibiotics Fail: Restoring the Ecology of the Body, a book by Mark Lappe’ and in Michael Schmidt’s work. You need to work intensively replenishing every day for 3 to 6 months after antibiotic exposure using multiple healthy organisms, fermented food and active supplements. Dr. Jaffe uses the power of billions of live CFU, colony forming units, in human implantable strains. Live bugs work and dead bugs don’t. 16:43 We Can Make Our Own: We can make our own prebiotic foods with high fiber to feed the good bugs. We can take in enough probiotic organisms to replenish those expended from stress and toxin exposure, and symbiotic foods, nutrients like recycled glutamine, which helps repair the digestive tract. Prebiotics, probiotics and symbiotics form a triad. 17:33 Renaissance of Proactive Primary Prevention: For the past 3 years, throughout the world there have been public health initiatives to get more prebiotic high fiber, probiotic organisms, and symbiotics into our diets. The lining of the intestinal tract is one of the most vulnerable places in the body. It replaces itself about every 3 days. A healthy person’s digestive tract, if laid out flat, would be as large as a tennis court. Most American adults suffer from atrophy of their digestive tract because they have not been nourishing and nurturing it. This means that they only have a few square feet. The good news is that this can nearly always be rehabilitated. 18:57 The Age Myth: It is a lie that once we begin to decline with age that it can be slowed and symptoms can be suppressed, but the decline is irreversible and inescapable. The age myth is about the proportion of unhealthy people at certain stages of life. Dr. Jaffe has tested groups of 90 to 100 year olds and healthy 20 to 30 year olds, drawing their blood, culturing their white cells, culturing muscles and other cells, and the groups are indistinguishable from each other. 20:48 A Detailed Description of Digestion: Digestion begins with your eyes. They tell your gut and your brain, what you will be consuming. As we chew, small bits of food escape through the mucosa to inform the brain and the gut as to what digestive juices will be needed for this meal. The stomach churns and produces acid. People with ulcers have low stomach acid and healthy people have lots of stomach acid. Proton pump inhibitors are prescribed all the time. Often, if you believe they will work, they will work just slightly better than placebos. When you inhibit stomach acid production, you set up a chain of events of maldigestion, often with the sensitization of the immune system. It is essential that we have an amino acid called histadine that donates the proton, the acid that keeps the stomach acidic so that pepsin, the enzyme that loves to be in that acid environment, begins to open the food particles, especially the proteins and the concentrated foods. The acid in the chyme, which is the stuff that comes out of the stomach and is delivered to the small intestine, triggers a bicarbonate and digestive enzyme release from the pancreas. . We meet the bicarbonate and digestive enzymes that pour out of the pancreas to neutralize the stomach acid and begin the next phase. At a small duct, bile comes in to emulsify fats, bringing fat soluble vitamins and nutrients into the body. For the next 20 feet, nutrients are taken up selectively. Then it is on to the large intestine, which should not have digestive remnants. By the time we get to the ileocecal valve that separates the small intestine from the large, the food should be broken down to non-immune reactive building blocks that get assimilated. There should be enough fiber to bind toxins and remove them from the body. These toxins are putrescine, cadaverine, and other polyamines, which can form when digestive transit time is longer than the healthy 12 to 18 hours. 25:17 Digestive Transit Time: Typical Americans have a 72 hour to 144 hour transit time from entrance to exit. If you are, you will want to increase the fiber in your diet, you eat foods that you can digest, assimilate and eliminate without immune burden, if you have some sense of portion control, so we do not overwhelm the body. Only about 1 in 20 Americans, or about 5% of our population, has a healthy transit time of 12 to 18 hours and a healthy digestion. Maldigestion, dysbiosis, inflammatory atrophy and enteropathy of the digestive mechanisms is at epidemic proportions and has been for many decades. These digestive disorders are most often the cause of chronic degenerative autoimmune and inflammatory conditions.

This research effort aimed at isolating and phenotypically characterizing lactic acid bacteria (LAB) isolates from a spontaneous rye sourdough manufactured following traditional protocols, as well as at evaluating their antimicrobial and antifungal properties as key features for future industrial applications. Thirteen LAB strains of potential industrial interest were isolated and identified to species-level via PCR. Most of the sourdough isolates showed versatile carbohydrate metabolisms. The Leuconostoc mesenteroides No. 242 and Lactobacillus brevis No. 173 demonstrated to be gas producers; thus, revealing their heterofermenter or facultative homofermenter features. Viable counts higher than 7.0 log10 (CFU/mL) were observed for Lactobacillus paracasei No. 244, Lactobacillus casei No. 210, L. brevis No. 173, Lactobacillus farraginis No. 206, Pediococcus pentosaceus No. 183, Lactobacillus uvarum No. 245 and Lactobacillus plantarum No. 135 strains, after exposure at pH 2.5 for 2 h. Moreover, L. plantarum No. 122, L. casei No. 210, Lactobacillus curvatus No. 51, L. paracasei No. 244, and L. coryniformins No. 71 showed growth inhibition properties against all the tested fifteen pathogenic strains. Finally, all LAB isolates showed antifungal activities against Aspergillus nidulans, Penicillium funiculosum, and Fusarium poae. These results unveiled the exceptionality of spontaneous sourdough as a source of LAB with effective potential to be considered in the design of novel commercial microbial single/mixed starter cultures, intended for application in a wide range of agri-food industries, where the antimicrobial and antifungal properties are often sought and necessary. In addition, metabolites therefrom may also be considered as important functional and bioactive compounds with high potential to be employed in food and feed, as well as cosmetic and pharmaceutical applications.

In a recent study, children with multiple sclerosis had differences in the abundance of specific gut bacteria than children without the disease. Certain types of bacteria were either more or less abundant in children with multiple sclerosis. In particular, there was an association between multiple sclerosis and an increase in gut bacteria that have been linked to inflammation and a decrease in gut bacteria that are considered anti-inflammatory.

Vaginal infections are the most prevalent women’s health problem. Incompetent diagnosis, inappropriate treatments, and antibiotic resistance are the main causes of the unsatisfactory results of conventional, antimicrobic treatment for these infections. Research has thus been conducted to identify new treatments for these genital diseases. The significant enhancement in our knowledge of vaginal microbiota has permitted the development of new, nonpharmacological strategies for the treatment of vaginal infections that seek to restore the balance of vaginal microflora, as opposed to modifying its components. Among these approaches, bioactive compounds, such as probiotics and nutraceutical proteins (such as lactoferrin), deserve particular attention. The aim of this review is to examine the role of probiotics (mainly Lactobacillus spp.) and lactoferrin as new strategies for counteracting bacterial and fungal vaginal infections.

Bacteria that live in the gut have been used to reverse obesity and Type-2 diabetes, animal studies show.

An extraordinary Facebook Live with Dr. Mike Hoaglin, MD from uBiome. You’ll understand: ✓ What the microbiome is and why it’s a huge clue into your health status. ✓ What it impacts and how you can change your microbiome and change the course of your health. ✓ The best evidenced-based way to test your microbiome. ✓ What your weight has to do with your microbiome. ✓ The number one change you can make right now to alter your microbiome, and so much more...

Background Type II diabetes is a chronic health condition which is associated with skin conditions including chronic foot ulcers and an increased incidence of skin infections. The skin microbiome is thought to play important roles in skin defence and immune functioning. Diabetes affects the skin environment, and this may perturb skin microbiome with possible implications for skin infections and wound healing. This study examines the skin and wound microbiome in type II diabetes. Methods Eight type II diabetic subjects with chronic foot ulcers were followed over a time course of 10 weeks, sampling from both foot skin (swabs) and wounds (swabs and debrided tissue) every two weeks. A control group of eight control subjects was also followed over 10 weeks, and skin swabs collected from the foot skin every two weeks. Samples were processed for DNA and subject to 16S rRNA gene PCR and sequencing of the V4 region. Results The diabetic skin microbiome was significantly less diverse than control skin. Community composition was also significantly different between diabetic and control skin, however the most abundant taxa were similar between groups, with differences driven by very low abundant members of the skin communities. Chronic wounds tended to be dominated by the most abundant skin Staphylococcus, while other abundant wound taxa differed by patient. No significant correlations were found between wound duration or healing status and the abundance of any particular taxa. Discussion The major difference observed in this study of the skin microbiome associated with diabetes was a significant reduction in diversity. The long-term effects of reduced diversity are not yet well understood, but are often associated with disease conditions.

Long-term survival of lung transplant recipients (LTRs) is limited by the occurrence of bronchiolitis obliterans syndrome (BOS). Recent evidence suggests a role for microbiome alterations in the occurrence of BOS, although the precise mechanisms are unclear. In this study we evaluated the relationship between the airway microbiome and distinct subsets of immunoregulatory myeloid-derived suppressor cells (MDSCs) in LTRs.

Do Antibiotics Cause Celiac Disease? Some researchers say yes they can. Especially in those with genetic susceptibility to gluten sensitivity. Antibiotics cause a yeast overgrowth, and emerging research shows that yeast - AKA candida, can create a protein that mimics gluten, causing an intestinal reaction leading to the development of celiac disease. To connect with Dr. Osborne visit: Facebook: https://www.facebook.com/DoctorPeterO... Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.

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Researchers have made the first direct demonstration that fecal donor microbes remained in recipients for months or years after a transplant to treat the diarrhea and colitis caused by recurrent Clostridium difficile infections -- a serious and stubborn cause of diarrhea after an antibiotic treatment for some other illness.

Healthy digestion within a resilient, repair-enabled microbiome is essential for 21st century survival. The human microbiome will be explained in functional and practical terms. Issues such as leaky gut, SIBO and IBS will be explored.Those who are proactive about their health, particularly about what they eat and drink, think and do can achieve a healthy microbiome. Eating and drinking what can be digested, assimilated and eliminated without immune burden provides a context for this presentation.