Colitis

Original article on Mercola.com By Dr. Mercola If given a choice, virtually everyone would choose to be healthier or, if you’re already healthy, to maintain that disease-free state. Yet when you go about it in practice it might seem overwhelming. Where do you begin to “get healthy”? An excellent starting

Ulcerative colitis (UC), an idiopathic inflammatory disorder in the colon, has become a clinical challenge, owing to the increasing incidence and poor prognosis. The conventional treatments for UC including aminosalicylates, corticosteroids, and immunosuppressants, ...

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The present study was undertaken to evaluate the protective effect of aqueous leaf extract of Aloe vera (ALEAV) in animal model (wistar albino rats) through macroscopic and histopathological study of the colon after inducing ulcerative colitis by usage of acetic acid. 30 healthy albino rats of either sex 150-200g body wt. and 2-4 months age groups were divided into five groups (six in each). Group 1 was normal control group receiving vehicle 1ml of normal saline transrectally (negative control). Group 2 was ulcerative colitis control which was treated with normal saline. Group 3 & 4 were administered aqueous leaf extract of Aloe vera suspension(test drug) 150,300mg/kg bodyweight dose orally for 10 days respectively. Ulcerative colitis was induced on 10 th day. Group 5 was administered prednisolone(1mg/kg) orally for 3 days. On the 3 rd day ulcerative colitis was induced by transrectal administration of 1 ml of 4% acetic acid solution. In all the groups, animals were observed for decrease in bodyweight, stool consistency and rectal bleeding i.e Disease Activity Index for 48 hours after inducing ulcerative colitis. After 48 hours the rats were sacrificed by high dose of ether anaesthesia and a piece of colonic segment(10cm in length) were resected out and subjected to macroscopical study(colon mucosal index) and microscopic evaluation. ALEAV at 150 mg/kg produced significant improvement in macroscopic score in comparison to disease control (group 2) which is comparable to that of normal control (group 1) in ulcerative colitis model. Histopathological studies showed significant dose dependent decrease in lymphoid hyperplasia, neutrophilic infiltration, crypt damage and submucosal inflammation in ALEAV treated group (150 and 300 mg/kg b.w) in comparison to disease control.

Ulcerative colitis is a chronic idiopathic inflammatory bowel disease with a relapsing nature. It is a very challenging disease affecting a patient during the most active period of his life i.e. 20 to 40 years of age. The main features are ano-rectal ...

Pages Introduction Dictionary Economic Alternatives Fucose Galactose Glucosamine Glucose Mannose N-Acetylneuraminic Acid Nacetylgalactosamine Sugar

Ginger Improves Symptoms of Ulcerative Colitis, Enhances Quality of Life Bowel and digestive problems like ulcerative colitis can be among the most discomforting and disruptive affronts to a person's lifestyle and overall well-being. What if adding a healthy dose of ginger to your diet could prevent indigestion, inflamed insides and even protect you from colon and rectal cancers? The evidence says, it can

GlycoscienceNEWS will provide a glimpse of the GLYCOSCIENCE of tomorrow and how the future of the human race will be enriched in ways only dreamed of before. Here, we will articulate with expectancy where GLYCOSCIENCE can take us today and tomorrow.

(2016). Immunomodulatory potential of acemannan (polysaccharide from Aloe vera) against radiation induced mortality in Swiss albino mice. Food and Agricultural Immunology: Vol. 27, No. 1, pp. 72-86.

camera & edit: http://www.levroi.nl | event information www.TEDxRoermond.nl "These sugars are the missing link in our food and maybe even the missing link in our medicine." Geiske de Ruig explains us about a new science: Glycobiology, the science of sugars. You musn't confuse these essential sugars with the sugars you put in your coffee or tea. These essential sugars are important for cells to communication with each other. Geiske even advocates the relation of our modern diet and shortage of sugars with the rapid growth of health issues. She will convince you to take control over your own health by adjusting your diet. Everyone can start today! About TEDx, x = independently organized event In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.

The processed Aloe vera gel (PAG) contains immunomodulatory polysaccharides, which consists of a mixture of polymer chains of b-(1,4)-linked acetylated galactomannan with different lengths. PAG was shown to inhibit azoxymethane(AOM)-initiated and dextran sodium sulfate(DSS)-promoted colon carcinogenesis model in mice. In the present study, we examined the molecular mechanisms for the inhibition of colitis-associated colon carcinogenesis by PAG. PAG administration significantly inhibited the production of pro-inflammatory cytokines and mediators in the colon. Western blot analysis using the colon extracts showed that PAG administration reduced the activation of NF-kB resulting in the inhibition of iNOS and COX-2 expression. PAG appeared to inhibit NF-kB activation through the PPARγ activation. PAG administration also inhibited the expression and phosphorylation of STAT3, which was known to connect inflammation and cancer. PAG administration also inhibited cell cycle progression-related transcription factors such as the proliferating cell nuclear antigen (PCNA), ERK, cyclin-dependent kinase (CDK) 4 and cyclin D1. In contrast, PAG administration increased the expression of CDX2, which was known to be a tumor suppressor in colorectal cancers. These findings show that PAG suppresses colitis-related colon carcinogenesis by inhibiting both chronic inflammation and cell cycle progression in the colon.

After 8 weeks of fecal transplants, some people with tough-to-treat ulcerative colitis had no rectal bleeding or diarrhea, according to a new study. WebMD has the details.

In her talk about sugar and cancer, Stanford Chemistry Professor Carolyn Bertozzi tells us why the sugar coating on our cells is crucial to our health and well-being. Unlike the sugar coating on a peanut M&M, she explains, human cells are covered with complex sugars Bertozzi shows us are, “like foliage swaying in the breeze.” The language these sugars are speaking can tell us everything from what blood type we are to whether we have cancer. Carolyn Bertozzi is the Anne T. and Robert M. Bass Professor of Chemistry and Professor of Chemical & Systems Biology and Radiology (by courtesy) at Stanford, and an investigator of the Howard Hughes Medical Institute. She completed her undergraduate degree at Harvard and her doctorate at UC Berkeley. After postdoctoral work at UCSF and a professorship at UC Berkeley, she joined the faculty at Stanford coincident with the launch of Stanford ChEM-H. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at http://ted.com/tedx

On Nov. 1, 2018, GlycoNet held a panel discussion, Why Sugars Matter in Fighting Disease, at the Li Ka Shing Centre for Health Research Innovation in Edmonton, Alberta. The panel discussion was MC'd by author and former Daily Planet host Jay Ingram. Panel members included: Dr. Mona Nemer, Canada’s Chief Science Advisor; Dr. Todd Lowary, Scientific Director, GlycoNet; Dr. Lori West, Professor, University of Alberta and Director, Canadian Donation and Transplant Research Program (CNTRP); Dr. David Vocadlo, Professor, Simon Fraser University; Dr. Karla Williams, Assistant Professor, University of British Columbia and Co-founder of GlyCa BioSciences and; Ms. Erum Razvi, PhD candidate, The Hospital for Sick Children.