PDF | On Sep 11, 2020, Christopher Kagan and others published Lysine Therapy for SARS-CoV-2 | Find, read and cite all the research you need on ResearchGate
Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab707/6353927
Background
Post-vaccination myocarditis and pericarditis reported after coronavirus mRNA vaccines.
The effect of accidental intravenous injection of this vaccine on the heart is unknown
Methods in mice
Compared difference between i.m. and i.v. injection of vaccine
Clinical manifestations
Histopathological changes
Tissue mRNA expression
Serum levels of cytokines and troponins
With normal saline (NS) control
Results
Intravenous SARS-CoV-2 mRNA Vaccine Administration Induced Grossly Visible Pathology in Heart
Only IV group developed histopathological changes of myopericarditis
Evidenced by cardiomyocyte degeneration
Apoptosis
Necrosis with adjacent inflammatory cell infiltration
Calcific deposits on visceral pericardium
But
Evidence of coronary artery or other cardiac pathologies was absent
Spike antigen (immunostaining) occasionally found in infiltrating immune cells of the heart
And in cardiomyocytes and intracardiac vascular endothelial cells
The histological changes of myopericarditis after the first IV-priming dose persisted for 2 weeks
and were markedly aggravated by a second IM- or IV-booster dose
Numerous inflammatory cytokines found in cardiac tissue
(interleukin (IL)-1β, interferon (IFN)-β, IL-6, and tumor necrosis factor (TNF)-α)
in the IV group but not the IM group
compatible with presence of myopericarditis in the IV group
Ballooning degeneration of hepatocytes was consistently found in the IV group.
All other organs appeared normal.
Conclusions
In vivo evidence that inadvertent intravenous injection of COVID-19 mRNA vaccines may induce myopericarditis.
Brief withdrawal of syringe plunger to exclude blood aspiration may be one possible way to reduce such risk.
Both Pfizer/BioNTech and Moderna have clearly stated that their vaccines should only be given via IM route
Current CDC and WHO guidelines no longer recommend precautionary measures during IM vaccine administration
The CDC Pink Book 2020 and WHO
2015 position paper have recommended against aspiration prior to vaccine injection so as to minimize pain
Deltoid to the vastus lateralis?
Our study indicates that IV injection of vaccines might partially contribute to this clinical phenotype,
thus warranting a reconsideration of the practice of IM injection without aspiration,
which carries the risk of inadvertent IV injection.
Thrombocytopenia in mice reported in 2006
Blood, (2006)
https://ashpublications.org/blood/article/109/7/2832/125650/Adenovirus-induced-thrombocytopenia-the-role-of
All mice received virus through a single tail vein injection
Thrombocytopenia has been consistently reported following the administration of adenoviral gene transfer vectors.
Use the tag #Vaccine to bring up important documents related to Vaccine Exemptions, Prevention and Treatment. I am really impressed with the ! 1 Free Rapid Virus Recovery Book.
The sequel to the historic Judy Mikovitz interview lays bare the corrupt and dangerous machinations behind Covid and the mandatory vaccine through the expert eyes of Dr. David Martin.
Link to featured video
https://www.youtube.com/watch?v=ctwX1cz_-dw&t=323s
Link to Wefwafwa’s channel
https://www.youtube.com/channel/UCzsLklGgOttU3Se-WGLp7ow
(he needs more subscribers)
Link to support Wefwafwa’s work in Africa
patreon:https://www.patreon.com/awmedicalvideos
Drugs Shown to Inhibit SARS-CoV-2 in COVID-19 Disease: Comparative Basic and Clinical Pharmacology of Molnupiravir and Ivermectin
https://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v9-id1149.pdf
https://www.linkedin.com/in/leslie-adesuyi-ajayi-md-phd-fbpharmacols-fwacp-69154a38/
There are still many nations where vaccines are not yet widely available,
There is a gradual shift in focus, to antiviral drugs,
Adjunctive chemoprophylaxis
Active treatment of new SARS-CoV-2 infections
Post -vaccination breakthrough COVID-19 cases
The two ways to get new drugs
Develop novel antiviral drugs for SARS-CoV-2
Repurpose existing FDA -approved drugs to treat COVID-19
Ivermectin is the most studied “repurposed” medication globally,
in randomized clinical trials, retrospective studies and meta- analyses.
Molnupiravir and Ivermectin Anti-SARS- CoV-2 Mechanisms, Pharmacokinetics and Pharmacodynamics
Molnupiravir is a broad spectrum antiviral agent against SARS- CoV-2, SARS-CoV,
seasonal or pandemic influenza and MERS corona virus
Ivermectin is an FDA-approved, WHO essential drug used as broad spectrum antiparasitic, antibiotic
and which has demonstrated broad spectrum antiviral activity against RNA viruses, including HIV, Zika, MERS corona virus
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
https://www.sciencedirect.com/science/article/pii/S0166354220302011
5000-fold inhibition of SARS-CoV-2, (99.98% at 48 hours
The inhibitory concentration IC50 of Molnupiravir shows it to be a more potent anti-SARS-CoV-2 agent, compared to Ivermectin in vitro.
Both molnupiravir and ivermectin are well absorbed after oral dosing
Tmax of molnupiravir being 1-1.75 hours,
With a half life of 7 hours
Tmax of ivermectin is 4-6 hours
Very long half life of 81-91 hours
Ivermectin, being lipophilic has a large volume of distribution
Ivermectin has the ability to accumulate in the lungs
The anti-SARS-CoV-2 actions, both of molnupiravir and ivermectin, are dose and concentration dependent
Molnupiravir active metabolite (NHC-5’ Triphosphate), acts as a competitive alternative substrate for viral RNA
causing viral mutagenesis or mutations, which leads to viral error catastrophe and extinction of replication
There is some concern about the safety of NHC -nucleoside triphosphate, which is also mutagenic to mammalian cells
Ivermectin, multifarious actions,
Binding to SARS-CoV-2 spike protein S
Reducing cell entry via human ACE2 receptors
Reducing viral transcription
Inhibition of cytokine production and inflammation
(not yet been shown for molnupiravir)
Complimentary pharmacokinetics and pharmacodynamics of the drugs
May be additive or synergistic
This should be further investigated in anti-SARS- CoV-2 antiviral combination therapy.
A combination of molnupiravir with Ivermectin putatively, in effects on RdRP or cytokine release.
Cost
https://www.who.int/selection_medicines/committees/expert/21/reviews/Ivermectin_Review1.pdf
The cost for a package of 100 tablets of 3 mg ivermectin is $2.96.
Say, 12mg per day for 5 days = $0.53
Safety
http://www.vigiaccess.org
https://www.who-umc.org/vigibase/vigibase/
Efficacy
Ivermectin
https://pubmed.ncbi.nlm.nih.gov/34145166/
For deaths, average risk ratio 0.38, (62% benefit) (moderate-certainty evidence
https://ivmmeta.com
Early treatment
Late treatment
Prophylaxis
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015017.pub2/epdf/full
Main results, Treating people in hospital with COVID-19
We don't know whether ivermectin compared with placebo or usual care, 28 days after treatment:–
leads to more or fewer deaths
worsens or improves patients' condition assessed by need for ventilation or oxygen
increases or reduces unwanted events
Preventing COVID-19
We don't know whether ivermectin leads to more or fewer deaths compared with no drug
The FDA has been assuming that nearly all of the adverse events reported in VAERS have been due to "over-reporting" of "background events." In short, there is nothing to see here: it's all noise. This
Fully Vaccinated Are COVID 'Super-Spreaders,' Says Inventor of mRNA
On the latest episode of "The Hidden Gateway" podcast, Dr. Robert Malone, recognized for his role in inventing mRNA vaccine technology, said, "The idea that if you have a workplace where everybody's vaccinated, you're not going to have virus spread is totally false. A total lie."
It’s Mandate Mayhem! Southwest Airlines in Disarray; Is Biden’s Vaccine Order Legal?; The Pushback Against Tyranny Goes Viral!; Tech CEO’s New Mandate-Free Job Site Guests: Tammy Clark, Kristen Meghan, Andrew Crapuchettes
How Israeli Ministry of Health, deleted thousands of testimonies
I re-posted this from YouTube (where it will surely be censored) to Rumble where it will live on. Original video from Avi Barak Media. This video details on how Israel citizens weren't given a place t
Dr. Ealy's Fearless, Love-Driven Activism at It's Finest! EXPOSING Data Manipulation at the CDC : In this powerful interview, you will meet Dr. Henry Ealy, one of the most courageous, principled, and productive humanitarians of our time, who has gathered together some of the world's finest researchers to expose the CDC's COVID data manipulation and overinflation, which translated into the government's draconian COVID policies.Don't forget to check out the following links mentioned in this important interview (which we encourage you to share widely):1) Breaking News: Oregon legislators file for a Federal Grand Jury Investigation2) COVID-19 Data Collection, Comorbidity & Federal Law: A Historical Retrospective 3) The Problems With PCR Testing Why Public Officials Shouldn’t Base Restrictions On PCR Tests4) COVID-19: Restoring Public Trust During A Global Health Crisis5) Register for COVID CON 2021Don't forget to register for COVID CONFERENCE 2021, STARTING OCTOBER 14TH HERE. Get free access for the kick off day! You are invited to attend an exciting in-person and online event, the COVID CON ‘21 SOLUTION SUMMIT, kicking off October 14th, 15th & 16th from the Church of Glad Tidings in Live Oak, California!⠀✅ Claim Your Free Special Guest Pass at the LINK below for the first day of the conference & get 10% off for the rest of the weekend, using Promo Code: GMI.⠀What’s also fantastic about this community-building, solution-centered gathering is that all proceeds go directly towards funding unbiased science, public education and expert legal action coordinated to fight for and protect your freedom!⠀The good news is that the COVID CON ‘21 team has also created a growing list of FREE and amazingly useful resources to support you and your family available at the link HERE.
Effects of adding L-arginine orally to standard therapy in patients with COVID-19 A randomized, double-blind, placebo-controlled, parallel-group trial
In this interim analysis, adding oral L-arginine to standard therapy in patients with severe COVID-19 significantly decreases the length of hospitalization and reduces the respiratory support at 10 but not at 20 days after starting the treatment.
Hydrogen Peroxide as an Adjuvant Therapy for COVID-19 A Case Series of Patients and Caregivers in the Mexico City Metropolitan Area
Knowledge of the antiseptic effects of hydrogen peroxide (H2O2) dates back to the late 19th century, and its mechanisms of action has been amply described. Globally, many physicians have reported using H2O2 successfully, in different modalities, against COVID-19. Given its anti-infective and oxygenating properties, hydrogen peroxide may offer prophylactic and therapeutic applications for responding to the COVID-19 pandemic. We report a consecutive case series of twenty-three COVID-19 patients (of 36 initially enrolled) who had been diagnosed by their primary care physician (mean age: 39, range: 8 months–70 years; 74% male) and twenty-eight caregivers in the Mexico City Metropolitan Area who received a complementary and alternative medicine (CAM) telemedicine treatment with H2O2 taken by mouth (PO, at a concentration of 0.06%), oral rinse (mouthwash, 1.5%), and/or nebulization (0.2%). We describe the treatment program and report the response of the COVID-19 patients and their caregivers. The patients mainly recovered well, reporting feeling “completely better” at 9.5 days on average. Two (9%) were hospitalized prior to joining the study, and one did not fully recover. Patients frequently reported nausea and sometimes dizziness or vomiting related to the oral treatment. None of the twenty-eight caregivers in close contact with the patients reported contracting COVID-19. Given its low cost and medical potential and considering its relative safety if used properly, we suggest that randomized controlled trials should be conducted. These should include both SARS-CoV-2-positive and SARS-CoV-2-negative participants, with single or combined modes of administration of H2O2, to study the benefits of this simple molecule and offer safe guidance regarding its use by health professionals.
Senator Rand Paul, MD, laid into Xavier Becerra, the Secretary of the Department of Health and Human Services, last week for publicly insulting the intelligence of anyone who has questioned natural immunity over immunity from the #Covid vaccine. #RandPaul #XavierBecerra #FlatEarthers #HHS #NaturalImmunity #VaccineEfficacy #VaccineSafety #VaccineMandate #TheHighwire #DelBigtree #HW236 POSTED: October 8, 2021
In an interview this week on his podcast, Hugh Hewitt asked Tony Fauci tough questions concerning his part in the many controversies surrounding the handling of the pandemic. #HughHewitt #AnthonyFauci #Fauci #FireFauci #VaccineMandate #Covid19 #CovidVaccine #TheHighwire #DelBigtree #HW236 POSTED: October 8, 2021
Fauci & Becerra Get Ripped A New One; Bombshell W.H.O. Exposé Through The Lens of A Pandemic; More U.S. Health Officials Jump Ship #WhoIsLyingToYou #HindSight2020 #Fauci #HughHewitt #RandPaul #XavierBecerra #NIH #DHHS #NIAID #NaturalImmunity #NaturallyAcquiredImmunity #WHO #Timewarp #SoumyaSwaminathan #GlobalVaccineSafetySummit #VaccineSafety #VaccineSideEffects #Proof #TheHighwire #DelBigtree #HW236
Leaked Dept. of Defense Document Reveals Evidence of Widespread
A leaked Department of Defense document first reported on by attorney Tom Rentz reveals high rates of "breakthrough" infections (4% of which died) and hospitalizations within a cohort of 5.6 million Medicare beneficiaries all of whom were fully vaccinated.