Three novel prevention, diagnostic, and treatment options for COVID-19 urgently necessitating controlled randomized trials
Asymptomatic or minimally symptomatic infection with COVID-19 can result in silent transmission to large numbers of individuals, resulting in expansion of the pandemic with a global increase in morbidity and mortality. New ways of screening the general ...
Two known therapies could be useful as adjuvant therapy in critical patients infected by COVID-19 Vitamin C
La neumonía causada por coronavirus, que se originó en Wuhan, China, a finales de 2019, se ha extendido por todo el mundo convirtiéndose en una pandemia. Desafortunadamente, a día de hoy no existe ninguna vacuna específica ...
Astonishing COVID-19 Testing Fraud Revealed GreenMedInfo Blog Entry
The COVID-19 pandemic has brought us many harsh lessons. Importantly, it has shown us how easy it is to manufacture panic and control entire populations through deceptive means
Busted 11 COVID Assumptions Based on Fear Not Fact GreenMedInfo
COVID assumptions - the assumptions people make about COVID, how dangerous it is, how it spreads and what we need to do to stop it - are running rampant and far more wildly than the supposed virus
If COVID Fatalities Were 90.2% Lower, How Would You Feel About
In medicine, we are taught not to guess when we can know, but that basic ethos for safe practice and the sharing of accurate information has not been applied to COVID-19
Investigation C0VlD Positive Results for People Who Were Never Given Tests - YouTube
Hundreds of people across the United States have been complaining that they are receiving calls from clinics and medical offices claiming that they have confirmed positive for C0VlD but those people say they were never tested. Is this just an internet rumor or is it really happening? We're investigating.
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Microvascular dysfunction in COVID-19 the MYSTIC study SpringerLink
Rationale Pre-clinical and autopsy studies have fueled the hypothesis that a dysregulated vascular endothelium might play a central role in the pathogenesis of ARDS and multi-organ failure in COVID-19. Objectives To comprehensively characterize and quantify microvascular alterations in patients with COVID-19. Methods Hospitalized adult patients with moderate-to-severe or critical COVID-19 (n = 23) were enrolled non-consecutively in this prospective, observational, cross-sectional, multi-center study. Fifteen healthy volunteers served as controls. All participants underwent intravital microscopy by sidestream dark field imaging to quantify vascular density, red blood cell velocity (VRBC), and glycocalyx dimensions (perfused boundary region, PBR) in sublingual microvessels. Circulating levels of endothelial and glycocalyx-associated markers were measured by multiplex proximity extension assay and enzyme-linked immunosorbent assay. Measurements and main results COVID-19 patients showed an up to 90% reduction in vascular density, almost exclusively limited to small capillaries (diameter 4–6 µm), and also significant reductions of VRBC. Especially, patients on mechanical ventilation showed severe glycocalyx damage as indicated by higher PBR values (i.e., thinner glycocalyx) and increased blood levels of shed glycocalyx constituents. Several markers of endothelial dysfunction were increased and correlated with disease severity in COVID-19. PBR (AUC 0.75, p = 0.01), ADAMTS13 (von Willebrand factor-cleaving protease; AUC 0.74, p = 0.02), and vascular endothelial growth factor A (VEGF-A; AUC 0.73, p = 0.04) showed the best discriminatory ability to predict 60-day in-hospital mortality. Conclusions Our data clearly show severe alterations of the microcirculation and the endothelial glycocalyx in patients with COVID-19. Future therapeutic approaches should consider the importance of systemic vascular involvement in COVID-19.
Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China Nature Communications
Large-scale population screening can provide insights to levels of ongoing SARS-CoV-2 transmission. Here, the authors report a citywide screening of ~10,000,000 residents of Wuhan and show that SARS-CoV-2 infection prevalence was very low five to eight weeks after the end of lockdown.
