Coronavirus

Ivermectin proposes many potentials effects to treat a range of diseases, with its antimicrobial, antiviral, and anti-cancer properties as a wonder drug. It is highly effective against many microorganisms including some viruses. In this comprehensive systematic review, antiviral effects of ivermectin are summarized including in vitro and in vivo studies over the past 50 years. Several studies reported antiviral effects of ivermectin on RNA viruses such as Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, and severe acute respiratory syndrome coronavirus 2. Furthermore, there are some studies showing antiviral effects of ivermectin against DNA viruses such as Equine herpes type 1, BK polyomavirus, pseudorabies, porcine circovirus 2, and bovine herpesvirus 1. Ivermectin plays a role in several biological mechanisms, therefore it could serve as a potential candidate in the treatment of a wide range of viruses including COVID-19 as well as other types of positive-sense single-stranded RNA viruses. In vivo studies of animal models revealed a broad range of antiviral effects of ivermectin, however, clinical trials are necessary to appraise the potential efficacy of ivermectin in clinical setting.

Antiparasitic Drug Ivermectin Has Remarkable Anti-Cancer Activity.

Ivermectin has been repurposed as highly effective antiviral drug. Sadly, this is being ignored by US Medicine.

Ivermectin for COVID-19. Early treatment - 78% improvement, p < 0.0001. All studies - 71% improvement, p < 0.0001. 1 in 9 trillion probability results of the 58 studies are from an ineffective treatment (p = 1.1e-13).

Ivermectin Works For COVID-19 - LATEST STUDIES More lectures on drbeen.com Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US Start your free trial - no credit card needed: https://members.drbeen.com/freetrial Original in-vitro study about Ivermectin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129059/ A study from bangladesh found that Ivermectin + Doxyclyclin significantly reduces mortality and morbidity in COVID-19 patients. https://clinicaltrials.gov/ct2/show/study/NCT04523831 A systemic review of the antiviral activity of Ivermectin https://www.nature.com/articles/s41429-020-0336-z https://journal.chestnet.org/article/S0012-3692(20)34898-4/fulltext PDF for the above study after it was accepted https://journal.chestnet.org/article/S0012-3692(20)34898-4/pdf Pre-print of the above study https://www.medrxiv.org/content/10.1101/2020.06.06.20124461v2 A search of various Ivermectin studies for your reading pleasure https://clinicaltrials.gov/ct2/results?cond=Covid19&term=ivermectin&cntry=&state=&city=&dist= Iota carrageenan and Ivermectin oral drops https://clinicaltrials.gov/ct2/show/results/NCT04425850?term=ivermectin&cond=Covid19&draw=2

Background: Innovative approaches are needed to complement existing tools for malaria elimination. Ivermectin is a broad spectrum antiparasitic endectocide clinically used for onchocerciasis and lymphatic filariasis control at single doses of 150 to 200 mcg/kg. It also shortens the lifespan of mosquitoes that feed on individuals recently treated with ivermectin. However, the effect after a 150 to 200 mcg/kg oral dose is short-lived (6 to 11 days). Modeling suggests higher doses, which prolong the mosquitocidal effects, are needed to make a significant contribution to malaria elimination. Ivermectin has a wide therapeutic index and previous studies have shown doses up to 2000 mcg/kg (ie, 10 times the US Food and Drug Administration approved dose) are well tolerated and safe; the highest dose used for onchocerciasis is a single dose of 800 mcg/kg. Objective: The aim of this study is to determine the safety, tolerability, and efficacy of ivermectin doses of 0, 300, and 600 mcg/kg/day for 3 days, when provided with a standard 3-day course of the antimalarial dihydroartemisinin-piperaquine (DP), on mosquito survival. Methods: This is a double-blind, randomized, placebo-controlled, parallel-group, 3-arm, dose-finding trial in adults with uncomplicated malaria. Monte Carlo simulations based on pharmacokinetic modeling were performed to determine the optimum dosing regimens to be tested. Modeling showed that a 3-day regimen of 600 mcg/kg/day achieved similar median (5 to 95 percentiles) maximum drug concentrations (Cmax) of ivermectin to a single of dose of 800 mcg/kg, while increasing the median time above the lethal concentration 50% (LC50, 16 ng/mL) from 1.9 days (1.0 to 5.7) to 6.8 (3.8 to 13.4) days. The 300 mcg/kg/day dose was chosen at 50% of the higher dose to allow evaluation of the dose response. Mosquito survival will be assessed daily up to 28 days in laboratory-reared Anopheles gambiae s.s. populations fed on patients’ blood taken at days 0, 2 (Cmax), 7 (primary outcome), 10, 14, 21, and 28 after the start of treatment. Safety outcomes include QT-prolongation and mydriasis. The trial will be conducted in 6 health facilities in western Kenya and requires a sample size of 141 participants (47 per arm). Sub-studies include (1) rich pharmacokinetics and (2) direct skin versus membrane feeding assays. Results: Recruitment started July 20, 2015. Data collection was completed July 2, 2016. Unblinding and analysis will commence once the database has been completed, cleaned, and locked. Conclusions: High-dose ivermectin, if found to be safe and well tolerated, might offer a promising new tool for malaria elimination.

Caly et al.1 reported that ivermectin inhibited severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in vitro for up to 48 hours using ivermectin at 5 μM. The concentration resulting in 50% i...

People are dying, but what are they dying from? Is it an all-powerful virus that is doing hundreds of thousands of people in, or is it medical ignorance and medical malpractice? Ignorance is deadly in medicine and is usually sourced in arrogance and pharmaceutical greed and power, which is in full view with the American... View Article

Will Ivermectin Block a Vaccine? A very common question asked is, if Ivermectin will block the effect of a vaccine? We will discuss the vaccine’s lifecycle in our body and if the Ivermectin’s presence cause any issues? We will also discuss Virus’ lifecycle and see how Ivermectin works there. We will also compare and contrast the effect of the Ivermectin for a vaccine and the virus (SARS-COV-2) Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US Discuss various topics on DrBeen forum: https://members.drbeen.com/forum/ #drbeen #koolbeens #COVID

Ivermectin has been repurposed as highly effective antiviral drug. Sadly, this is being ignored by US Medicine.

Frank Lee, MD's Push Health practice in Allen, TX. Register to get online healthcare services today.

Courageous Doctors quote FDR in 1933 We have Nothing to Fear except Fear itself.

One does not have to be an anti-vaxxer to see and understand that COVID vaccines are not needed. They are not required legally or for any medical or public health reason to treat or prevent COVID-19. There is a broad range of both natural and pharmaceutical treatments widely available, many already proven to be very... View Article

Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection ...

Corona Virus how to protect ourselves, hydroxychloroquine, botanicals and supplements.

Doctors in Germany say Corona Virus is Over, We Should Return to Normal

Presentations will include highly-effective, death-preventing Covid treatments for outpatients and inpatients and Covid prevention for first-responder

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The 'I-MASK+ Prophylaxis and Early Outpatient Treatment Protocol for COVID-19' and the 'MATH+ Hospital Treatment Protocol for COVID-19' are physiologic-based combination treatment regimen created by the FLCCC Alliance, a group of leaders in critical care medicine. All component medicines in our protocols are well approved, inexpensive, readily available and have been used for decades with well-established safety profiles.

"My husband was dealing with stage 4 leukemia, and tests showed he developed multiple myeloma (M spike), yet we’re doing well due in large part to following some of Dr. Sircus’ protocols. My husband self-discharged from the hospital in Oct 2019 after a three-week stay nearly killed him. As a parting present from the hospital,... View Article

Challenge-Rechallenge Data from Switzerland reveals Efficacy of Hydroxyxhloroquine Against Corona Virus.