Characterization of novel alginate-Aloe Vera raft systems for treatment of gastroesophageal reflux disease - ScienceDirect
Raft-forming systems are designed to relieve reflux symptoms by forming a physical barrier on top of the stomach. The present study aimed to evaluate …
Molecules | Free Full-Text | Natural Drugs: A New Direction for the Prevention and Treatment of Diabetes
Insulin resistance, as a common pathological process of many metabolic diseases, including diabetes and obesity, has attracted much attention due to its relevant influencing factors. To date, studies have mainly focused on the shared mechanisms between mitochondrial stress and insulin resistance, and they are now being pursued as a very attractive therapeutic target due to their extensive involvement in many human clinical settings. In view of the complex pathogenesis of diabetes, natural drugs have become new players in diabetes prevention and treatment because of their wide targets and few side effects. In particular, plant phenolics have received attention because of their close relationship with oxidative stress. In this review, we briefly review the mechanisms by which mitochondrial stress leads to insulin resistance. Moreover, we list some cytokines and genes that have recently been found to play roles in mitochondrial stress and insulin resistance. Furthermore, we describe several natural drugs that are currently widely used and give a brief overview of their therapeutic mechanisms. Finally, we suggest possible ideas for future research related to the unique role that natural drugs play in the treatment of insulin resistance through the above targets.
A translational study of Galectin-3 as an early biomarker and potential therapeutic target for ischemic-reperfusion induced acute kidney injury - ScienceDirect
We evaluated Galectin-3 (Gal-3) as a potential early biomarker of acute kidney disease (AKI), and the effect of Gal-3 inhibition by modified citrus pe…
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease - PubMed
"Hit-and-run" treatment with senolytics, which in the case of D + Q have elimination half-lives
Insulin Units and Conversion Factors: A Story of Truth, Boots, and Faster Half-Truths - PMC
Conventional insulin concentration units (IU/mL or just U/mL) are bioefficacy based, whereas the Système International (SI) units (pmol/L) are mass based. In converting between these two different approaches, there are at least 2 well-accepted ...
After 20 years of treating patients and dealing with his own vein condition, Dr. Michael Ryan demonstrates his proven method of stopping a leg cramp in 15 se...
EP01 non-invasive Blood Glucose Monitoring Smartwatch | HRV ECG/EKG HR BP SPO2 temp Health Tracker - YouTube
Check it out on AliExpress:
https://s.click.aliexpress.com/e/_Ddxdwyr
and be sure to come visit me at:
https://www.DaveTheKayaker.com
Also check out this blood glucose watch. So far I like it the most:
https://youtu.be/4PzzQwqsWQw
Subscribe and check out my "Fitness Tracker and Smartwatch Reviews" Playlist on YT.
I like to bring you smartwatches that are new or different in some way, and this is the first one I've found with non-invasive blood glucose monitoring.
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Preventing Obesity The Myth of Calorie Counting - with Dr. Fung The Empowering Neurologist EP.156 - YouTube
What should we eat? I ask this question in the context of the incredible rates of obesity that we are now seeing, virtually worldwide. Today we will spend time with Dr. Jason Fung author of the book The Obesity Code. This is a landmark book that powerfully lays out why we are continuing to gain weight. It dispels the notion that dietary fat threatens to make us gain weight as well as the unfounded idea of calories in versus calories out as an explanation for why we gain weight.
Dr. Fung clearly focuses on the importance of the hormone, insulin, in terms of obesity, and certainly in terms of diabetes as well. He outlines a very straightforward plan that is in perfect alignment with current science. This interview is one of the most fundamental as a relates to the science of weight loss and regaining control over our blood sugar.
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0:00 Intro
2:36 Why Dr. Fung Pursued Weight Loss Research
8:08 Problem with Insulin
15:15 Mechanisms of Insulin
23:09 Reconsidering Low Fat Diets & Calorie Counting
37:34 Satiety Hormones
40:10 Leptin & Weight Loss
43:59 Threat of Fructose
51:23 Conclusion
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Dr. Jason Fung is a Canadian nephrologist and a world-leading expert on intermittent fasting and low carb, especially for treating people with type 2 diabetes.
Dr. Fung graduated from the University of Toronto and completed his residency at the University of California, Los Angeles. He lives and works in Toronto, Canada.
Here is Dr. Fung’s website:
https://thefastingmethod.com/
https://www.dietdoctor.com/intermittent-fasting
https://www.dietdoctor.com/low-carb
https://www.dietdoctor.com/diabetes
___________________________
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1 Know Labs Introduces KnowU, A Portable Medical-Grade Glucose Monitoring Device That Utilizes Bio-RFID Know Labs introduces KnowU, A Portable Glucose Monitoring Device
Know Labs, an emerging leader in non-invasive medical diagnostics, introduced the KnowU™, a new portable medical-grade glucose monitoring device that utilizes Bio-RFID™, Know Labs’ non-invasive diagnostic technology. Related Supersapiens Glucose Display Wearable Is Designed Specifically For Athletes The KnowU is a convenient, non-wearable, on-the-go alternative to fingersticks, which are used to check blood glucose levels, Know Labs introduced KnowU, a new portable medical-grade glucose monitoring device that utilizes Bio-RFID.
Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway JACC Basic to Translational Science
Highlights • In 2 different mouse models, AKI increased Gal-3 expression and induced cardiac dysfunction, cardiac and systemic inflammation, cardiac macrophage infiltration, and fibrosis. • Cardiac...
Galectin-3 in septic acute kidney injury a translational study Critical Care Full Text
Background Galectin-3 (Gal-3) is a pleiotropic glycan-binding protein shown to be involved in sepsis and acute kidney injury (AKI). However, its role has never been elucidated in sepsis-associated AKI (S-AKI). We aimed to explore Gal-3’s role and its potential utility as a therapeutic target in S-AKI. Methods In 57 patients admitted to the intensive care unit (ICU) with sepsis, serum Gal-3 was examined as a predictor of ICU mortality and development of AKI. In a rat model of S-AKI induced by cecal ligation and puncture (CLP), 7-day mortality and serum Gal-3, Interleukin-6 (IL-6), and creatinine were examined at 2, 8, and 24 hours (h) post-CLP. Two experimental groups received the Gal-3 inhibitor modified citrus pectin (P-MCP) at 400 mg/kg/day and 1200 mg/kg/day, while the control group received water only (n = 18 in each group). Results Among 57 patients, 27 developed AKI and 8 died in the ICU. Serum Gal-3 was an independent predictor of AKI (OR = 1.2 [95% CI 1.1–1.4], p = 0.01) and ICU mortality (OR = 1.4 [95% CI 1.1–2.2], p = 0.04) before and after controlling for age, AKI, and acute physiology and chronic health evaluation (APACHE II) score. In the CLP rat experiment, serum Gal-3 peaked earlier than IL-6. Serum Gal-3 was significantly lower in both P-MCP groups compared to control at 2 h post-CLP (400 mg: p = 0.003; 1200 mg: p = 0.002), and IL-6 was significantly lower in both P-MCP groups at all time points with a maximum difference at 24 h post-CLP (400 mg: p = 0.015; 1200 mg: p = 0.02). In the Gal-3 inhibitor groups, 7-day mortality was significantly reduced from 61% in the control group to 28% (400 mg P-MCP: p = 0.03) and 22% (1200 mg P-MCP: p = 0.001). Rates of AKI per RIFLE criteria were significantly reduced from 89% in the control group to 44% in both P-MCP groups (400 mg: p = 0.007; 1200 mg: p = 0.007). Conclusions This translational study demonstrates the importance of Gal-3 in the pathogenesis of S-AKI, and its potential utility as a therapeutic target. Graphic abstract
A translational study of Galectin-3 as an early biomarker and potential therapeutic target for ischemic-reperfusion induced acute kidney injury - ScienceDirect
We evaluated Galectin-3 (Gal-3) as a potential early biomarker of acute kidney disease (AKI), and the effect of Gal-3 inhibition by modified citrus pe…
Plant Based Kidneys; Michele is a registered dietitian / certified specialist in renal nutrition. Self-study program, friendly plant based kidney recipes, blog.
Episode 19: Role of Vitamin K2 in Kidney Disease
⏰ Timestamps ⏰
0:00 Introduction
0:45 What is Vitamin K and what is its role in kidney disease?
10:24 How do you get Vitamin K2 from your diet?
14:03 Why should you combine D3 with K2?
15:05 What dosage of K2 should you take?
16:30 Should you check your Vitamin K levels checked?
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⚡️Connect with us on Social Media:
Sean Hashmi, MD, MS, FASN
https://www.SELFPrinciple.org
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Michele Crosmer, RD CSR
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Disclaimer
The information provided on this channel is for educational purposes only, and does not substitute for professional medical advice. Please consult a medical professional or healthcare provider for medical advice, diagnoses, or treatment.
Ways and Means of Cellular Reconditioning for Kidney Regeneration - FullText - American Journal of Nephrology 2022, Vol. 53, No. 2-3 - Karger Publishers
Background: Mitochondrial, lysosomal, and peroxisomal dysfunction; defective autophagy; mitophagy; and pexophagy, as well as the loss of glycocalyx integrity are known contributors to initiation and progression of diverse kidney diseases. Those cellular organelles are tightly interactive in health, and during development of a disease, damage in one
Acute Renal Failure Acute Kidney Injury Made Easy Videos
Understand acute renal failure (acute kidney injury) causes, diagnosis, and treatment with this clear medical course. Medical illustrations by Dr. Seheult.
GAD65 autoantibodies and its role as biomarker of Type 1 diabetes and Latent Autoimmune Diabetes in Adults (LADA) - PMC
One of the hallmarks of autoimmune diabetes is the presence of adaptive responses directed to neuroendocrine proteins. One of these proteins is glutamic acid decarboxylase (GAD). While GAD is widely distributed in neuroendocrine tissues, its specific ...
Own Kidney Health and Metabolic Syndrome – NaturalHealth365 Programs
Presented byTHE BEST OFThe Kidney Health Docu-Class and The Metabolic Syndrome Docu-ClassA compilation of some of the most powerful moments from each docu-class — condensed into two amazing presentations for you to enjoy.Love what you're seeing?Click below to get the recordings of all 30 presentations plus access to transcripts and all the other great bonuses you see here...GET ACCESS TODAY!Own…