Diabetes Type 1

Nephrotic syndrome (NS) is a clinical syndrome with a variety of causes, mainly characterized by heavy proteinuria, hypoalbuminemia, and edema. At present, identification of effective and less toxic therapeutic interventions for nephrotic syndrome remains to be an important issue. In this study, we isolated fucoidan from Saccharina japonica and prepared its depolymerized fragment by oxidant degradation. Fucoidan and its depolymerized fragment had similar chemical constituents. Their average molecular weights were 136 and 9.5 kDa respectively. The effect of fucoidan and its depolymerized fragment on adriamycin-induced nephrotic syndrome were investigated in a rat model. The results showed that adriamycin-treated rats had heavy proteinuria and increased blood urea nitrogen (BUN), serum creatinine (SCr), total cholesterol (TC), and total triglyceride (TG) levels. Oral administration of fucoidan or low-molecular-weight fucoidan for 30 days could significantly inhibit proteinuria and decrease the elevated BUN, SCr, TG, and TC level in a dose-dependent manner. At the same dose (100 mg/kg), low-molecular-weight fucoidan had higher renoprotective activity than fucoidan. Their protective effect on nephrotic syndrome was partly related to their antioxidant activity. The results suggested that both fucoidan and its depolymerized fragment had excellent protective effect on adriamycin-induced nephrotic syndrome, and might have potential for the treatment of nephrotic syndrome.

Cellular metabolic changes during chronic kidney disease (CKD) may induce higher production of oxygen radicals that play a significant role in the progression of renal damage and in the onset of important comorbidities. This condition seems to be in part related to dysfunctional mitochondria that cause an increased electron “leakage” from the respiratory chain during oxidative phosphorylation with a consequent generation of reactive oxygen species (ROS).ROS are highly active molecules that may oxidize proteins, lipids and nucleic acids with a consequent damage of cells and tissues.To mitigate this mitochondria-related functional impairment, a variety of agents (including endogenous and food derived antioxidants, natural plants extracts, mitochondria-targeted molecules) combined with conventional therapies could be employed.However, although the anti-oxidant properties of these substances are well known, their use in clinical practice has been only partially investigated. Additionally, for their correct utilization is extremely important to understand their effects, to identify the correct target of intervention and to minimize adverse effects.Therefore, in this manuscript, we reviewed the characteristics of the available mitochondria-targeted anti-oxidant compounds that could be employed routinely in our nephrology, internal medicine and renal transplant centers. Nevertheless, large clinical trials are needed to provide more definitive information about their use and to assess their overall efficacy or toxicity.

Exploring history and development of diabetes applications for the BCG vaccine which has 100 Years of safe, worldwide use

The bacillus Calmette-Guérin (BCG) vaccine is one of the oldest vaccines in history and has been investigated as a potential treatment for type 1 diabetes by Dr. Denise Faustman and her team at the Massachusetts General Hospital (MGH) for over a decade. A new study published today in npj Vaccines describes the long-term outcomes of BCG administration to patients with type 1 diabetes. The study enrolled 282 individuals, 52 of whom received the vaccine. The average age of type 1 diabetes duration among the cohort was 19 years. The patients were followed for over eight years, and their A1c levels were evaluated. The study reports that patients with type 1 diabetes who received just two doses of the BCG vaccine, spaced four weeks apart, achieved markedly lower A1c levels compared to the control group. This result was observed three years after the vaccine administration and continued for the next five years […]

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Denise Faustman, MD, PhD, is the Director of the Immunobiology Lab at Massachusetts General Hospital and an Associate Professor of Medicine at Harvard Medical School. She was interviewed by Diabetes Daily about 9 years ago when she was about to begin human clinical trials based on the results from her successful mice-curing BCG vaccine. Mice are certainly cured from type 1 diabetes a lot these days, but in clinical trials, they are often given type 1 diabetes through an interventional chemical administration. It is notable that Dr. Faustman cured mice who had naturally occurring type 1 diabetes which is rooted in the autoimmune attack on the insulin-making beta cells. The BCG vaccine, or Bacillus Calmette-Guerin vaccine, is about 100 years old and used around the world, though no longer in the United States, for the prevention of tuberculosis. It is being studied in various labs around the world due to its ability to spark the […]

Click here to subscribe - https://www.glutenfreesociety.org/wxrn Research has shown an increased risk of developing cancer for those with gluten sensitivity who fail to follow a strict gluten free diet. For cancers of the mouth, esophagus and pharynx, there was a 22.7% increased relative risk. For lymphoma, there was a 77.8% increased relative risk. Other research studies have shown that those with celiac disease who fail to comply to gluten free dietary restrictions have an increased risk for cancers of the intestine, colon, rectum, esophagus, thyroid, pancreas, skin, liver, and stomach. Aside from the studies that show a direct increase in cancer development, eating gluten (and grains) can also contribute to many cancer risk factors. So let’s take a closer look at all the possible connections. To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.

Click here to subscribe - https://www.glutenfreesociety.org/wxrn Let's talk about some of the basic kidney functions: 00:00 - Filtering The Blood 01:53 - Regular Acid/Base Balance 02:50 - Produce Renin (Regulates Blood Pressure) 03:30 - Produce Erythropoietin (Stimulates RBC Production) 03:45 - Help to Activate Vitamin D 05:40 - Lab testing to evaluate kidney function It's important to know more about these things, as we talk about what you can do to better nutritionally support your kidney. To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association. To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.

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GA has revealed potent antioxidative and anti-inflammatory properties in haemodialysis patients. Oral digestion of GA (30 g/day) decreased oxidative stress and inflammatory markers among haemodialysis patients. Trial registration. ClinicalTrials.gov Identifier: NCT03214692, registered 11 July 2017 ( …

In patients with long-term type 1 diabetes, the tuberculosis vaccine BCG lowers blood sugar levels to near-normal after three years. Denise Faustman and her team from Massachusetts General Hospital and Harvard Medical School investigated a cohort of type 1 diabetics that received two doses of BCG before being monitored over eight years. After three years, vaccine-treated patients lowered their HbA1c levels—a diabetes biomarker reflecting average blood sugar over 8–12 weeks—by over 10%. This reduction increased to 18% in the fourth year, after which HbA1c levels remained low up to the final year of monitoring. The researchers report that the BCG vaccine appeared to reset diabetes-implicated parts of the immune system and, through a novel mechanism, shift glucose metabolism to lower blood sugar to healthy levels. Future studies will further classify BCG’s benefits in diabetes.

Sodium bicarbonate is a natural compound found throughout nature—in the ocean, in the soil, in our foods, and in our bodies. Baking soda is a neutralizer of many other compounds, which makes it extremely helpful as a medicine in this age of toxicity that we are all presently passing through. Its backbone characteristic is to... View Article

Healing kidneys naturally with Sodium Bicarbonate.Sodium Bicarbonate for kidney treatment can dramatically slow the progress of chronic kidney disease.

Click here to subscribe - https://www.glutenfreesociety.org/wxrn Because gluten causes gut damage, digestion and nutrient absorption are commonly hindered in those with gluten sensitivity and celiac disease. Which is why nutrient deficiencies are common. And not getting an adequate supply of certain nutrients can contribute to poor joint health, weak muscles, and pain. For starters, amino acids are the building blocks of protein. They are used to build muscles as well as collagen, which is the most abundant protein in your body. It’s found in your tendons, ligaments, cartilage, bones, skin, and blood vessels among other places. So if your body isn’t efficiently digesting and absorbing protein, joint and muscle-related problems are possible. Vitamin C is also necessary to build and repair collagen, and a deficit is common among those with gluten sensitivity. Plus, scurvy is a muscle and joint pain disease caused by a vitamin C deficiency. A study found that those with muscle pain are often deficient in selenium and zinc. And it’s suggested that selenium and zinc play a role in both reducing inflammation and preventing tissue damage. Animal studies have found that vitamin B12 may help regenerate nerves as well as prevent pain signaling in the brain. Clinical human trials have also found vitamin B12 to be an effective treatment for lower back pain and neuralgia (nerve-related pain). Omega-3 fatty acids are known to block inflammation. However, they’re not found in grains or processed foods made with them. So deficiencies are common. Calcium is a mineral responsible for muscle contractions, while magnesium is a mineral necessary for relaxing your muscles. Thus, magnesium deficiency may cause muscle cramps. In animal studies, magnesium has been shown to block pain signals. And in humans, it’s been shown to help relieve both acute and chronic pain. Finally, vitamin D plays a role in bone, muscle, and joint health. Deficiencies have been associated with inflammatory pain. And treatment with vitamin D shows promise for those with muscular pain when deficiencies are present. To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.

The bacillus Calmette-Guérin (BCG) vaccine is the only licensed vaccine for human use against tuberculosis (TB). Although controversy exists about its efficacy, the BCG vaccine is able to protect newborns and children against disseminated forms ...

Plant-based diets have been successfully shown to slow or stop the progression of kidney failure, but what about all the phosphorus and potassium in plant foods? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ This is the last of an extended six-part video series on the latest science on diet and kidney health. Check out the rest of the series here: • Preventing Kidney Failure Through Diet (http://nutritionfacts.org/video/preventing-kidney-failure-through-diet/) • Treating Kidney Failure Through Diet (http://nutritionfacts.org/video/treating-kidney-failure-through-diet/) • Can Diet Protect Against Kidney Cancer? (http://nutritionfacts.org/video/can-diet-protect-against-kidney-cancer/) • Which Type of Protein is Better for Our Kidneys? (http://nutritionfacts.org/video/which-type-of-protein-is-better-for-our-kidneys/) • Protein Source: An Acid Test for Kidney Function (http://nutritionfacts.org/video/protein-source-an-acid-test-for-kidney-function) The problem for most people (98% of American Diets Potassium Deficient http://nutritionfacts.org/video/98-of-american-diets-potassium-deficient/) is not getting enough potassium, but you have to have functioning kidneys to keep you in balance. Too much phosphorus in the blood can also be a problem. Phosphate additives are something we should try to stay away from. See my three-part video series: • Phosphate Additives in Meat Purge and Cola (http://nutritionfacts.org/video/phosphate-additives-in-meat-purge-and-cola/) • Phosphate Additives in Chicken (http://nutritionfacts.org/video/phosphate-additives-in-chicken/) • How to Avoid Phosphate Additives (http://nutritionfacts.org/video/how-to-avoid-phosphate-additives/) Have a question for Dr. Greger about this video? Leave it in the comment section at http://nutritionfacts.org/video/treating-chronic-kidney-disease-with-food and he'll try to answer it! Image Credit: Steve Davis via Flickr. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

What are the three significant dietary risk factors for declining kidney function?

The delivery route and dose of the BCG vaccine profoundly alters the protective outcome after Mycobacterium tuberculosis challenge in non-human primates.

Repeat BCG Vaccinations for the Treatment of Established Type 1 Diabetes - Full Text View.