Diabetes Type 1

I am a retired physician living with Type 1 diabetes since 1998. I follow a ketogenic diet for diabetes management, and maintain nutritional ketosis. I participate in endurance sports.

Diabetic kidney disease, diagnosed by urinary albumin excretion rate (AER), is a critical symptom of chronic vascular injury in diabetes, and is associated with dyslipidemia and increased mortality. We investigated serum lipids in 326 subjects with type 1 diabetes: 56% of patients had normal AER, 17% had microalbuminuria (20 ≤ AER < 200 μg/min or 30 ≤ AER < 300 mg/24 h) and 26% had overt kidney disease (macroalbuminuria AER ≥ 200 μg/min or AER ≥ 300 mg/24 h). Lipoprotein subclass lipids and low-molecular-weight metabolites were quantified from native serum, and individual lipid species from the lipid extract of the native sample, using a proton NMR metabonomics platform. Sphingomyelin (odds ratio 2.53, P < 10−7), large VLDL cholesterol (odds ratio 2.36, P < 10−10), total triglycerides (odds ratio 1.88, P < 10−6), omega-9 and saturated fatty acids (odds ratio 1.82, P < 10−5), glucose disposal rate (odds ratio 0.44, P < 10−9), large HDL cholesterol (odds ratio 0.39, P < 10−9) and glomerular filtration rate (odds ratio 0.19, P < 10−10) were associated with kidney disease. No associations were found for polyunsaturated fatty acids or phospholipids. Sphingomyelin was a significant regressor of urinary albumin (P < 0.0001) in multivariate analysis with kidney function, glycemic control, body mass, blood pressure, triglycerides and HDL cholesterol. Kidney injury, sphingolipids and excess fatty acids have been linked in animal models—our exploratory approach provides independent support for this relationship in human patients with diabetes.

ReferenceLazarus B, Chen Y, Wilson F, et al. Proton pump inhibitor use and the risk of chronic kidney disease. JAMA Intern Med. 2016;176(2):238-246.Study ObjectiveTo assess a potential correlation between proton pump inhibitor (PPI) use and incidence of chronic kidney disease (CKD). DesignObservational study tracking glomerular filtration rate (GFR) of PPI users compared to nonusers. ParticipantsThe study included 10,482 subjects participating in the Atherosclerosis Risk in Communities (ARIC) study. All subjects had a baseline GFR greater than 60 mL/min/1.73 m2.

Chronic kidney disease results in disruption of the intestinal epithelial barrier as well as profound changes in the gut microbial flora. These events…

Plant-based diets have been successfully shown to slow or stop the progression of kidney failure, but what about all the phosphorus and potassium in plant foods? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ This is the last of an extended six-part video series on the latest science on diet and kidney health. Check out the rest of the series here: • Preventing Kidney Failure Through Diet (http://nutritionfacts.org/video/preventing-kidney-failure-through-diet/) • Treating Kidney Failure Through Diet (http://nutritionfacts.org/video/treating-kidney-failure-through-diet/) • Can Diet Protect Against Kidney Cancer? (http://nutritionfacts.org/video/can-diet-protect-against-kidney-cancer/) • Which Type of Protein is Better for Our Kidneys? (http://nutritionfacts.org/video/which-type-of-protein-is-better-for-our-kidneys/) • Protein Source: An Acid Test for Kidney Function (http://nutritionfacts.org/video/protein-source-an-acid-test-for-kidney-function) The problem for most people (98% of American Diets Potassium Deficient http://nutritionfacts.org/video/98-of-american-diets-potassium-deficient/) is not getting enough potassium, but you have to have functioning kidneys to keep you in balance. Too much phosphorus in the blood can also be a problem. Phosphate additives are something we should try to stay away from. See my three-part video series: • Phosphate Additives in Meat Purge and Cola (http://nutritionfacts.org/video/phosphate-additives-in-meat-purge-and-cola/) • Phosphate Additives in Chicken (http://nutritionfacts.org/video/phosphate-additives-in-chicken/) • How to Avoid Phosphate Additives (http://nutritionfacts.org/video/how-to-avoid-phosphate-additives/) Have a question for Dr. Greger about this video? Leave it in the comment section at http://nutritionfacts.org/video/treating-chronic-kidney-disease-with-food and he'll try to answer it! Image Credit: Steve Davis via Flickr. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

The most overlooked aspect of the coronavirus pandemic is the fact that most viruses are pH sensitive. pH medicine offers us a key to treating viral infections that is easy, safe and inexpensive. Shifting a patients pH, combined with high dosages of vitamin C, is the appropriate foundation treatments for at home and hospital care.... View Article

Whole plant sources of sugar and fat can ameliorate some of the postprandial inflammation caused by the consumption of refined carbs and meat. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ Meat protein can cause more of an insulin spike than pure table sugar. See the comparisons in my video Paleo Diets May Negate Benefits of Exercise (http://nutritionfacts.org/video/paleo-diets-may-negate-benefits-of-exercise/). I discussed the almond butter study in my last video, How to Prevent Blood Sugar and Triglyceride Spikes after Meals (http://nutritionfacts.org/video/How-to-Prevent-Blood-Sugar-and-Triglyceride-Spikes-after-Meals). Berries have sugar of their own in them, so how can eating berries lower the blood sugar spike to a meal? Find out in If Fructose is Bad, What About Fruit? (http://nutritionfacts.org/video/if-fructose-is-bad-what-about-fruit). More videos on avocadoes coming up and here’s more on red wine: • Breast Cancer Risk: Red Wine v. White Wine (http://nutritionfacts.org/video/breast-cancer-risk-red-wine-vs-white-wine/) • Resveratrol Impairs Exercise Benefits (http://nutritionfacts.org/video/resveratrol-impairs-exercise-benefits/) • How to Treat High Blood Pressure with Diet (http://nutritionfacts.org/video/how-to-treat-high-blood-pressure-with-diet/) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/effects-of-avocados-and-red-wine-on-meal-induced-inflammation and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/effects-of-avocados-and-red-wine-on-meal-induced-inflammation. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: Kristina DeMuth. Image has been modified. Icons created by Myart, H. Alberto Gongora, Sergey Demushkin, Made in France, Anton Noskov, and Creative Stall from the Noun Project. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Is it the casein or the cow insulin that explains the link between milk consumption and the development of type I diabetes? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ If you missed the prequel to this video, check out Does Casein in Milk Exposure Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-casein-in-milk-exposure-trigger-type-1-diabetes) More on the concerns with cow’s milk exposure in infancy and childhood in: • Childhood Constipation and Cow’s Milk (http://nutritionfacts.org/video/childhood-constipation-and-cows-milk/) • Formula for Childhood Obesity (http://nutritionfacts.org/video/Formula-for-Childhood-Obesity) • Cow’s Milk Casomorphin and Crib Death (http://nutritionfacts.org/video/cows-milk-casomorphin-and-crib-death/) • Cow’s Milk Casomorphin and Autism (http://nutritionfacts.org/video/cows-milk-casomorphin-and-autism/) So what’s The Best Baby Formula? (http://nutritionfacts.org/video/the-best-baby-formula/) Breast milk! Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/does-bovine-insulin-in-milk-trigger-type-1-diabetes and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/does-bovine-insulin-in-milk-trigger-type-1-diabetes. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credits: Bradley Johnson via flickr and Jean-Alein via pixabay. Images have been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Dietary tips for type 1 diabetic patients center on supplying carbs to balance insulin dosage. Our guest today, Dr. Keith Runyan, challenges this approach.

Why might exposure to bovine proteins increase the risk of childhood-onset autoimmune type I diabetes? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ The vast majority of diabetes cases are type 2 diabetes, so that’s what I’ve been concentrating on. See for example: • Plant-Based Diets and Diabetes (http://nutritionfacts.org/video/Plant-Based-Diets-and-Diabetes) • Can Diabetic Retinopathy Be Reversed? (http://nutritionfacts.org/video/can-diabetic-retinopathy-be-reversed) • What Causes Insulin Resistance? (http://nutritionfacts.org/what-causes-insulin-resistance) • Diabetes as a Disease of Fat Toxicity (http://nutritionfacts.org/video/Diabetes-as-a-Disease-of-Fat-Toxicity) • What Causes Diabetes? (http://nutritionfacts.org/video/what-causes-diabetes) • Reversing Diabetes with Food (http://nutritionfacts.org/video/reversing-diabetes-with-food) • Diabetes Reversal: Is it the Calories or the Food? (http://nutritionfacts.org/video/13.diabetes-reversal-is-it-the-calories-or-the-food) I’m so glad to be getting around to type 1 diabetes, though. Stay tuned for the next video, Does Bovine Insulin Exposure Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-bovine-insulin-exposure-trigger-type-1-diabetes) Please let me know what other topics you’d like me to cover. Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/does-casein-in-milk-trigger-type-1-diabetes and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/does-casein-in-milk-trigger-type-1-diabetes. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: Ishai Parasol via flickr. Image has been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

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Epigenetics is defined as mitotically heritable changes in gene expression that do not directly alter the DNA sequence. By implication, such epigenetic changes are non-genetically determined, although they can be affected by inherited genetic variation. ...

“Fear of consumer reaction” led the U.S. dairy industry to suppress the discovery in retail milk of live paraTB bacteria, a pathogen linked to type 1 diabetes. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ For an exploration of other possibilities as to why cow’s milk consumption is linked to this autoimmune destruction of insulin production see Does Casein in Milk Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-casein-in-milk-trigger-type-1-diabetes/) and Does Bovine Insulin in Milk Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-bovine-insulin-in-milk-trigger-type-1-diabetes/). If it’s in the milk, what about the meat? That’s the subject of my next two videos in this 3-part series, Meat Consumption and the Development of Type 1 Diabetes (http://nutritionfacts.org/video/meat-consumption-and-the-development-of-type-1-diabetes) and Does Paratuberculosis in Meat Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-paratuberculosis-in-meat-trigger-type-1-diabetes). But if we don’t drink milk, what about our bone health? See my video Is Milk Good for Our Bones? (http://nutritionfacts.org/video/is-milk-good-for-our-bones). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/does-paratuberculosis-in-milk-trigger-type-1-diabetes and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/does-paratuberculosis-in-milk-trigger-type-1-diabetes. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: ponce_photography via pixabay. Image has been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Type 1 diabetes (T1DM) affects approximately 1 in 500 children. Diabetic peripheral neuropathy (DPN) is the most common form of peripheral neuropathy …

What if the long sought after "cure" for diabetes was as safe, affordable, and accessible as a spice sitting in your kitchen cupboard?

Denise Faustman, MD, PhD, is the Director of the Immunobiology Lab at Massachusetts General Hospital and an Associate Professor of Medicine at Harvard Medical School. She was interviewed by Diabetes Daily about 9 years ago when she was about to begin human clinical trials based on the results from her successful mice-curing BCG vaccine. Mice are certainly cured from type 1 diabetes a lot these days, but in clinical trials, they are often given type 1 diabetes through an interventional chemical administration. It is notable that Dr. Faustman cured mice who had naturally occurring type 1 diabetes which is rooted in the autoimmune attack on the insulin-making beta cells. The BCG vaccine, or Bacillus Calmette-Guerin vaccine, is about 100 years old and used around the world, though no longer in the United States, for the prevention of tuberculosis. It is being studied in various labs around the world due to its ability to spark the […]

Chronic hyperglycemia underlies microvascular complications in patients with type 1 diabetes. The mechanisms leading to these vascular complications are not fully understood. Recently, we observed that acute hyperglycemia results in endothelial glycocalyx damage. To establish whether glycocalyx is associated with microvascular damage, we performed glycocalyx perturbation volume measurements in type 1 diabetic patients with microalbuminuria (DM1-MA group; n = 7), without microalbuminuria (DM1-NA group; n = 7), and in age-matched control subjects (CON; n = 7). Systemic glycocalyx volume was determined comparing intravascular distribution volume of a glycocalyx-permeable tracer (dextran 40) to that of a glycocalyx-impermeable tracer (labeled erythrocytes). Sublingual capillaries were visualized using orthogonal polarization spectral microscopy to estimate microvascular glycocalyx. Patients and control subjects were matched according to age and BMI. Glycocalyx volume decreased in a stepwise fashion from CON, DM1-NA, and finally DM1-MA subjects (1.5 ± 0.1, 0.8 ± 0.4, and 0.2 ± 0.1 l, respectively, P < 0.05). Microvascular glycocalyx in sublingual capillaries was also decreased in type 1 diabetes versus the control group (0.5 ± 0.1 vs. 0.9 ± 0.1 μm, P < 0.05). Plasma hyaluronan, a principal glycocalyx constituent, and hyaluronidase were increased in type 1 diabetes. In conclusion, type 1 diabetic patients are characterized by endothelial glycocalyx damage, the severity of which is increased in presence of microalbuminuria.

I am a retired physician living with Type 1 diabetes since 1998. I follow a ketogenic diet for diabetes management, and maintain nutritional ketosis. I participate in endurance sports.

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Fenugreek is one of the oldest recorded medicinal plants. The recorded use of fenugreek goes back to Egypt in 1500 BCE. It was also used in Greek, Arabian, Indian and Chinese medicine.

Background This study was to investigate the effect and its possible mechanism of fucoidan on the development of spontaneous autoimmune diabetes in non-obese diabetic (NOD) mice. Methods 7-week-old NOD mice were randomly divided into three groups: control group, low-dose (300 mg/kg) and high-dose (600 mg/kg) fucoidan-treatment groups. After 5 weeks of treatment, 10 mice per group were randomly selected to be sacrificed after feces collection. The remaining 12 mice per group were fed until 26 weeks of age to assess the incidence of diabetes. Results Treatment with fucoidan increased serum insulin level, delayed the onset and decreased the development of diabetes in NOD mice. Fucoidan reduced the levels of strong Th1 proinflammatory cytokines, but induced Th2-bias ed. cytokine response. And dentridic cells (DCs) in fucoidan treatment group were characterized as low expression of MHC class II and CD86 molecules. TLR4 expressions and the downstream molecules in pancreas were down-regulated in fucoidan-treated groups. There were significant differences in the composition of gut flora between NOD control group and fucoidan group. Lactobacillus and Akkermansia were significantly enriched in fucoidan group. Conclusions Fucoidan could prevent the development of autoimmune diabetes in NOD mice via regulating DC/Treg induced immune tolerance, improving gut microecology, down-regulating TLR4 signaling pathway, and maintaining pancreatic internal environment.

Ray Peat