Diabetes Type 1

Autophagy impairment has been demonstrated in the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) and could be a new target of treatment. Trehalose is a natural, nonreducing disaccharide that has been shown to enhance autophagy. Therefore, we investigated whether trehalose treatment reduces renal cyst formation in a Pkd1-hypomorphic mouse model. Pkd1 miRNA transgenic (Pkd1 miR Tg) mice and wild-type littermates were given drinking water supplemented with 2% trehalose from postnatal day 35 to postnatal day 91. The control groups received pure water or 2% sucrose for the control of hyperosmolarity. The effect on kidney weights, cystic indices, renal function, cell proliferation, and autophagic activities was determined. We found that Pkd1 miR Tg mice had a significantly lower renal mRNA expression of autophagy-related genes, including atg5, atg12, ulk1, beclin1, and p62, compared with wild-type control mice. Furthermore, immunohistochemical analysis showed that cystic lining cells had strong positive staining for the p62 protein, indicating impaired degradation of the protein by the autophagy-lysosome pathway. However, trehalose treatment did not improve reduced autophagy activities, nor did it reduce relative kidney weights, plasma blood urea nitrogen levels, or cystatin C levels in Pkd1 miR Tg mice. Histomorphological analysis revealed no significant differences in the renal cyst index, fibrosis score, or proliferative score among trehalose-, sucrose-, and water-treated groups. Our results demonstrate that adding trehalose to drinking water does not modulate autophagy activities and renal cystogenesis in Pkd1-deficient mice, suggesting that an oral supplement of trehalose may not affect the progression of ADPKD.

Diabetic kidney disease is the most common cause of end-stage kidney disease and poses a major global health problem. Finding new, safe, and practical strategies to halt this disease has proven to be challenging for mainstream medicine because their aversion to natural medicine prevents them from understanding the underlying causes. In this essay, we will... View Article

Diabetes is the leading cause of kidney failure, and scientists have found that infusing just a small dose of a cytokine, thought to help cause that failure, can instead prevent or reverse it.

Sodium Bicarbonate (NaHCO3) commonly called baking soda is a natural substance used in the human body within the bloodstream to regulate pH as a counterbalance to acid build up. Bicarbonate affects the pH of cells and tissues, balances cell voltage, and increases CO2 which helps with oxygenation.

Tubulointerstitial fibrosis is recognized as a key determinant of progressive chronic kidney disease (CKD). Fucoidan, a sulphated polysaccharide extracted from brown seaweed, exerts beneficial effects in some nephropathy models. The present study evaluated ...

Chronic kidney disease (CKD) is a globally common and important disease and there are evidence for a bidirectional relationship between microbiota and…

To investigate the protective effect of extracts prepared from avocado, walnut, flaxseed and Eruca sativa seeds in a rat model of kidney dysfunction induced by intraperitoneal cisplatin.Ethanol and petroleum ether extracts mixture was prepared from each ...

Listen to Dr Carrie Diulus, US board-certified orthopaedic spinal surgeon and a thriving type 1 diabetic explain how she uses the vegan ketogenic diet and insulin strategies to manage her diabetes. This episode is great for type 1 diabetics or vegan/vegetarians wondering if low carb/keto diets could work for them.

We explored whether the combination of anti-oxidant and anti-inflammatory guava (Psidium guajava) and trehalose treatment protects the kidney and pancreas against Type II diabetes (T2DM)-induced injury in rats. We measured the active component of guava juice by HPLC analysis. T2DM was induced in Wis …

Chronic kidney disease results in disruption of the intestinal epithelial barrier as well as profound changes in the gut microbial flora. These events…

Plant-based diets have been successfully shown to slow or stop the progression of kidney failure, but what about all the phosphorus and potassium in plant foods? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ This is the last of an extended six-part video series on the latest science on diet and kidney health. Check out the rest of the series here: • Preventing Kidney Failure Through Diet (http://nutritionfacts.org/video/preventing-kidney-failure-through-diet/) • Treating Kidney Failure Through Diet (http://nutritionfacts.org/video/treating-kidney-failure-through-diet/) • Can Diet Protect Against Kidney Cancer? (http://nutritionfacts.org/video/can-diet-protect-against-kidney-cancer/) • Which Type of Protein is Better for Our Kidneys? (http://nutritionfacts.org/video/which-type-of-protein-is-better-for-our-kidneys/) • Protein Source: An Acid Test for Kidney Function (http://nutritionfacts.org/video/protein-source-an-acid-test-for-kidney-function) The problem for most people (98% of American Diets Potassium Deficient http://nutritionfacts.org/video/98-of-american-diets-potassium-deficient/) is not getting enough potassium, but you have to have functioning kidneys to keep you in balance. Too much phosphorus in the blood can also be a problem. Phosphate additives are something we should try to stay away from. See my three-part video series: • Phosphate Additives in Meat Purge and Cola (http://nutritionfacts.org/video/phosphate-additives-in-meat-purge-and-cola/) • Phosphate Additives in Chicken (http://nutritionfacts.org/video/phosphate-additives-in-chicken/) • How to Avoid Phosphate Additives (http://nutritionfacts.org/video/how-to-avoid-phosphate-additives/) Have a question for Dr. Greger about this video? Leave it in the comment section at http://nutritionfacts.org/video/treating-chronic-kidney-disease-with-food and he'll try to answer it! Image Credit: Steve Davis via Flickr. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

The most overlooked aspect of the coronavirus pandemic is the fact that most viruses are pH sensitive. pH medicine offers us a key to treating viral infections that is easy, safe and inexpensive. Shifting a patients pH, combined with high dosages of vitamin C, is the appropriate foundation treatments for at home and hospital care.... View Article

Medical Disclaimer - Medical Disclaimer - *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association. He is also a Diplomate with the American Clinical Board of Nutrition.

This topic contains 221 study abstracts on Diabetes Mellitus: Type 1 indicating that the following substances may be helpful: Vitamin D, Alpha-Lipoic Acid, and Benfotiamine

Whole plant sources of sugar and fat can ameliorate some of the postprandial inflammation caused by the consumption of refined carbs and meat. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ Meat protein can cause more of an insulin spike than pure table sugar. See the comparisons in my video Paleo Diets May Negate Benefits of Exercise (http://nutritionfacts.org/video/paleo-diets-may-negate-benefits-of-exercise/). I discussed the almond butter study in my last video, How to Prevent Blood Sugar and Triglyceride Spikes after Meals (http://nutritionfacts.org/video/How-to-Prevent-Blood-Sugar-and-Triglyceride-Spikes-after-Meals). Berries have sugar of their own in them, so how can eating berries lower the blood sugar spike to a meal? Find out in If Fructose is Bad, What About Fruit? (http://nutritionfacts.org/video/if-fructose-is-bad-what-about-fruit). More videos on avocadoes coming up and here’s more on red wine: • Breast Cancer Risk: Red Wine v. White Wine (http://nutritionfacts.org/video/breast-cancer-risk-red-wine-vs-white-wine/) • Resveratrol Impairs Exercise Benefits (http://nutritionfacts.org/video/resveratrol-impairs-exercise-benefits/) • How to Treat High Blood Pressure with Diet (http://nutritionfacts.org/video/how-to-treat-high-blood-pressure-with-diet/) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/effects-of-avocados-and-red-wine-on-meal-induced-inflammation and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/effects-of-avocados-and-red-wine-on-meal-induced-inflammation. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: Kristina DeMuth. Image has been modified. Icons created by Myart, H. Alberto Gongora, Sergey Demushkin, Made in France, Anton Noskov, and Creative Stall from the Noun Project. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Dietary tips for type 1 diabetic patients center on supplying carbs to balance insulin dosage. Our guest today, Dr. Keith Runyan, challenges this approach.

Is it the casein or the cow insulin that explains the link between milk consumption and the development of type I diabetes? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ If you missed the prequel to this video, check out Does Casein in Milk Exposure Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-casein-in-milk-exposure-trigger-type-1-diabetes) More on the concerns with cow’s milk exposure in infancy and childhood in: • Childhood Constipation and Cow’s Milk (http://nutritionfacts.org/video/childhood-constipation-and-cows-milk/) • Formula for Childhood Obesity (http://nutritionfacts.org/video/Formula-for-Childhood-Obesity) • Cow’s Milk Casomorphin and Crib Death (http://nutritionfacts.org/video/cows-milk-casomorphin-and-crib-death/) • Cow’s Milk Casomorphin and Autism (http://nutritionfacts.org/video/cows-milk-casomorphin-and-autism/) So what’s The Best Baby Formula? (http://nutritionfacts.org/video/the-best-baby-formula/) Breast milk! Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/does-bovine-insulin-in-milk-trigger-type-1-diabetes and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/does-bovine-insulin-in-milk-trigger-type-1-diabetes. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credits: Bradley Johnson via flickr and Jean-Alein via pixabay. Images have been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

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Why might exposure to bovine proteins increase the risk of childhood-onset autoimmune type I diabetes? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ The vast majority of diabetes cases are type 2 diabetes, so that’s what I’ve been concentrating on. See for example: • Plant-Based Diets and Diabetes (http://nutritionfacts.org/video/Plant-Based-Diets-and-Diabetes) • Can Diabetic Retinopathy Be Reversed? (http://nutritionfacts.org/video/can-diabetic-retinopathy-be-reversed) • What Causes Insulin Resistance? (http://nutritionfacts.org/what-causes-insulin-resistance) • Diabetes as a Disease of Fat Toxicity (http://nutritionfacts.org/video/Diabetes-as-a-Disease-of-Fat-Toxicity) • What Causes Diabetes? (http://nutritionfacts.org/video/what-causes-diabetes) • Reversing Diabetes with Food (http://nutritionfacts.org/video/reversing-diabetes-with-food) • Diabetes Reversal: Is it the Calories or the Food? (http://nutritionfacts.org/video/13.diabetes-reversal-is-it-the-calories-or-the-food) I’m so glad to be getting around to type 1 diabetes, though. Stay tuned for the next video, Does Bovine Insulin Exposure Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-bovine-insulin-exposure-trigger-type-1-diabetes) Please let me know what other topics you’d like me to cover. Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/does-casein-in-milk-trigger-type-1-diabetes and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/does-casein-in-milk-trigger-type-1-diabetes. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: Ishai Parasol via flickr. Image has been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Epigenetics is defined as mitotically heritable changes in gene expression that do not directly alter the DNA sequence. By implication, such epigenetic changes are non-genetically determined, although they can be affected by inherited genetic variation. ...

Type 1 diabetes (T1DM) affects approximately 1 in 500 children. Diabetic peripheral neuropathy (DPN) is the most common form of peripheral neuropathy …

“Fear of consumer reaction” led the U.S. dairy industry to suppress the discovery in retail milk of live paraTB bacteria, a pathogen linked to type 1 diabetes. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ For an exploration of other possibilities as to why cow’s milk consumption is linked to this autoimmune destruction of insulin production see Does Casein in Milk Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-casein-in-milk-trigger-type-1-diabetes/) and Does Bovine Insulin in Milk Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-bovine-insulin-in-milk-trigger-type-1-diabetes/). If it’s in the milk, what about the meat? That’s the subject of my next two videos in this 3-part series, Meat Consumption and the Development of Type 1 Diabetes (http://nutritionfacts.org/video/meat-consumption-and-the-development-of-type-1-diabetes) and Does Paratuberculosis in Meat Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-paratuberculosis-in-meat-trigger-type-1-diabetes). But if we don’t drink milk, what about our bone health? See my video Is Milk Good for Our Bones? (http://nutritionfacts.org/video/is-milk-good-for-our-bones). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/does-paratuberculosis-in-milk-trigger-type-1-diabetes and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/does-paratuberculosis-in-milk-trigger-type-1-diabetes. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: ponce_photography via pixabay. Image has been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

What if the long sought after "cure" for diabetes was as safe, affordable, and accessible as a spice sitting in your kitchen cupboard?

Denise Faustman, MD, PhD, is the Director of the Immunobiology Lab at Massachusetts General Hospital and an Associate Professor of Medicine at Harvard Medical School. She was interviewed by Diabetes Daily about 9 years ago when she was about to begin human clinical trials based on the results from her successful mice-curing BCG vaccine. Mice are certainly cured from type 1 diabetes a lot these days, but in clinical trials, they are often given type 1 diabetes through an interventional chemical administration. It is notable that Dr. Faustman cured mice who had naturally occurring type 1 diabetes which is rooted in the autoimmune attack on the insulin-making beta cells. The BCG vaccine, or Bacillus Calmette-Guerin vaccine, is about 100 years old and used around the world, though no longer in the United States, for the prevention of tuberculosis. It is being studied in various labs around the world due to its ability to spark the […]