Glyconutrients

Our healthspan is to a great extent epigenetically determined by diets, lifestyle, and various other environmental factors. Gut microbiota has been proven to be the major player in maintaining human health. Our previous report described health benefits of long-term ingestion of aloe vera gel through the modification of the intestinal microbiota. In the present review, we broadly cover the topics of microbiota and aloe vera gel ingestion related to attenuation of reactive oxygen species, prevention of cardiovascular disorders, effects of life-prolonging calorie restriction. Additional data are summarized on prophylactic actions of fermented butyrate, and aloe-emodin related components against obesity. Prophylactic actions of aloe vera gel on healthy aging, skin photo-aging, and the viability and lifespan in Drosophila melanogaster are discussed in relation to the properties of butyrate and its potential effects involved in health and disease.

Aloe vera (AV) is popular and has been commercialized as a beauty product, laxative, herbal medicine, the antimicrobial activity of AV is proven. The antiviral activity of AV however, has not been well documented except for a handful reports. Till date extraction of AV compounds is popularized using …

Source: Enjoy the Benefits of Aloe Vera Juice by Dr. Edward Group Most people are aware that aloe vera soothes dry skin, sunburn, and other skin irritations [1], but not many know of the many healt…

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Pre-diabetes is a disturbing trend in the population, who are at risk of developing type-two diabetes. The aim of this study was to determine the effects use of Aloe vera in different doses on glucose and lipid profile in pre-diabetic subjects.This study ...

This is the highest-grade aloe product in the world: Manapol. Handcrafted exclusively for Mannatech.

The pretreatment of aqueous extract of Aloe vera leaf in rats proved to act as a potential antioxidant which could be implicated toward protection of the integrity of liver of rat against pesticide i...

The co-administration of absorption enhancing agents with macromolecular drugs (e.g., protein and peptide drugs) has been identified as a means to improve the oral bioavailability of these drugs. Absorption-enhancing agents of natural origins have received ...

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Aloe vera (Aloe barbadensis Miller) is a perennial succulent medicinal plant. It has been used as a traditional or folk medicine for thousands of year…

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. J Neurogastroenterol Motil 1970;0:. https://doi.org/

Aloe vera, a succulent perennial and drought resisting plant, is well known for its therapeutic potential. A number of beneficial effects of Aloe vera…

Introduction: Since aloe vera plant has many medical benefits, the present study aimed to investigate the protective effects of Aloe vera gel on the pancreatic islets and beta cells. Methods: This experimental study consisted of 50 mature male rats aged 2-3 months and weighed 200-250 g, who were randomly divided ...

Objective: Starvation have pro-oxidative effect as a consequence of both elevated ROS generation and defeat in neutralization of ROS. Aloe vera juice induced oxidative stress and significantly decreased antioxidant enzymes levels. The main aim of this experiment was to evaluate the effect of Aloe vera gel extract on oxidative stress status during long period starvationMethod: Twenty-four mature male albino Wistar rats were housed in standard cages. In this study starvation cycle (rats were starved for two days and then were fed for one day) was used. This study was performed during intermediate period (60 days).Animals were divided into four experimental groups (six rats in each group): 1) normal control; 2) starved rats + water/ethanol; 3) starved rats + hydro-alcoholic Aloe vera gel extract (100 mg/kg); 4) starved rats + hydro-alcoholic Aloe vera gel extract (200 mg/kg); 5) Without starvation with hydro-alcoholic Aloe Vera gel extract (100 mg/kg); 6) Without starvation with hydro-alcoholic Aloe Vera gel extract (200 mg/kg). Blood samples were obtained using cardiac puncture. In blood samples, antioxidant enzymes including SOD, GPx and catalase, antioxidant trace elements including copper, zinc and magnesium and antioxidant vitamins including vitamin A, vitamin E and vitamin C were measured Results: Plasma levels of antioxidant enzymes (SOD,GPX and catalase) significantly decreased in starved rats + water/ethanol group (P< 0.05). Plasma levels of antioxidant enzymes after treatment with hydro-alcoholic Aloe vera gel extract at doses 100 and 200 mg/kg were significantly increased (P < 0.05). Also, plasma levels of antioxidant enzymes in normal rats (without starvation) after treatment with hydro-alcoholic Aloe vera gel extract at doses 100 and 200 mg/kg were significantly increased (P < 0.05). Plasma levels of Cu, Zn and Mn in normal control group had no significant difference with starved rats + water/ethanol and starved rats + hydro-alcoholic Aloe vera gel extract in 100 and 200 mg/kg dose groups (P > 0.05). Plasma levels of vitamin A and E in normal control group had no significant difference with starved rats + water/ethanol and starved rats + hydro-alcoholic Aloe vera gel extract in the 100 and 200 mg/kg dose groups (P > 0.05). Plasma level of vitamin C significantly decreased in starved rats + water/ethanol group (P < 0.05). Plasma level of vitamin C after treatment with hydro-alcoholic Aloe vera gel extract at doses 100 and 200 mg/kg was significantly increased (P < 0.05). Also, plasma level of vitamin C in normal rats (without starvation)  after treatment with hydro-alcoholic Aloe vera gel extract at doses 100 and 200 mg/kg was significantly increased (P < 0.05)Conclusion:In concluding our results it is shown that intermediate period starvation caused  an increase in oxidative stress via impairing of antioxidant defense and Aloe vera treatment is able  to improve antioxidative defense induced by starvation

BACKGROUND: The use of herbal and synthetic compounds can be effective in improving the areas and repair of tissues that have been affected during the processes like what happens in ulcerative colitis (UC) as a common inflammatory disorder. According to the beneficial effects of aloe vera, in this study, we aimed to assess the therapeutic effects of oral aloe vera gel on acetic acid-induced colitis in rats by histopathological and molecular analysis of Bax, and BCL-2 genes expression (using RT-PCR technique) in colon tissue samples. METHODS: This experimental study comprised 32 adult male Sprague Dawley rats weighting  220±20 g that were randomly divided into four groups as follows. The control group (healthy rats), colitis group in which UC was induced by transrectal administration of 3% acetic acid with no treatment, oral form of sulfasalazine group in which UC was induced by transrectal administration of 3% acetic acid, then was treated by oral administration of sulfasalazine 500 mg/kg body weight, and the fourth group which received oral form of aloe vera gel (200 mg/kg) for 21 days, respectively after induction of UC. Then, the therapeutic effects of treatment groups were compared with the control group and the colitis group with no treatment, by the assessment of histopathological and molecular changes in the colon tissues of rats on the 7 th , 14 th , and 21 st days. Finally, the collected data were analyzed using statistical tests. RESULTS: Histologically, aloe vera gel treatment could reduce and heal colon tissue damages in induced colitis. Also, this gel reduced apoptosis in rat’s colon with acetic acid-induced colitis, which showed in significantly decreased in Bax mRNA expression and significantly increased BCL-2 mRNA expression compared with the colitis group with no treatment. CONCLUSION:  Aloe vera gel has a significant effect on the treatment of UC in rat because of the beneficial effect that was found from aloe vera such as decreasing the severity of colitis as evidenced by histopathological findings, and with respect to apoptosis and gene expression that were related to wound healing process, and suppression of the elevation of Bax mRNA with the upregulation of Bcl-2, which can be considered effective in the treatment of UC.

BACKGROUND Previous studies indicated that both Plantago major and Aloe vera have anti-inflammatory, tissue regeneration, antioxidant, and immune-stimulatory effects. It is assumed that a mixture of these two herbal medicines may provide a potent material in treatment of skin wound injuries. Therefore, in this study we investigated the effects of Plantago major ...