Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms. - PubMed - NCBI
Fucoidan is a natural derived compound found in different species of brown algae and in some animals, that has gained attention for its anticancer properties. However, the exact mechanism of action is currently unknown. Therefore, this review will address fucoidans structure, the bioavailability, an …
Fucoidan Structure and Its Impact on Glucose Metabolism Implications for Diabetes and Cancer Therapy - PubMed
Fucoidans are complex polysaccharides derived from brown seaweeds which consist of considerable proportions of L-fucose and other monosaccharides, and sulphated ester residues. The search for novel and natural bioproduct drugs (due to toxicity issues associated with chemotherapeutics) has led to the …
Fucoidan suppresses excessive phagocytic capacity of porcine peripheral blood polymorphonuclear cells by modulating production of tumor necrosis factor-alpha
We examined the effect of fucoidan, an immune modulator, on the phagocytic capacity of porcine peripheral blood polymorphonuclear cells (PMNs) exposed…
Fucoidan Suppresses Mitochondrial Dysfunction and Cell Death against 1-Methyl-4-Phenylpyridinum-Induced Neuronal Cytotoxicity via Regulation of PGC... - PubMed - NCBI
Mitochondria are considered to be the powerhouses of cells. They are the most commonly damaged organelles within dopaminergic neurons in patients with Parkinson's disease (PD). Despite the importance of protecting neuronal mitochondria in PD patients, the detailed mechanisms underlying mitochondrial …
Stimulatory effect of an algal fucoidan on the release of va... Blood (...)
Blood Coagulation & Fibrinolysis is an international fully refereed journal that features review and original research articles on all clinical, laboratory and experimental aspects of haemostasis and thrombosis. The journal is devoted to publishing significant developments worldwide in the field of blood coagulation, fibrinolysis, thrombosis, platelets and the kininogen-kinin system, as well as dealing with those aspects of blood rheology relevant to haemostasis and the effects of drugs on haemostatic components.
The Acacia Gum Arabinogalactan Fraction Is a Thin Oblate Ellipsoid A New Model Based on Small-Angle Neutron Scattering and Ab Initio Calculation
Acacia gum is a branched complex polysaccharide whose main chain consists of 1,3-linked β-D-galactopyranosyl units. Acacia gum is defined as a heteropolysaccharide since it contains ∼2% of a polypeptide. The major molecular fraction (F1) ...
Fucoidan suppresses the gastric cancer cell malignant phenotype and production of TGF-ß1 via CLEC-2 Glycobiology Oxford Academic
Abstract. The sulfated polysaccharide fucoidan displays excellent anticancer properties with low toxicity in many kinds of cancers. However, its detailed pharma
Fucoidan Upregulates TLR4CHOP-Mediated Caspase-3 and PARP Activation to Enhance Cisplatin-Induced Cytotoxicity in Human Lung Cancer Cells
Cisplatin-based therapy is a traditional, clinical treatment for cancers, including lung cancer. In this study, we found that sequential therapy, i.e.…
Fucoidan, A Sulfated Polysaccharides from Brown Algae as Therapeutic T (...)
Cancer is most common in worldwide and badly threaten to human’s life. Unfortunately drugs, which are used for cancer therapy, are toxic and affect not only cancer cells but also normal cells and...
The Ameliorative Role of Acacia senegal Gum against the Oxidative Stress and Genotoxicity Induced by the Radiographic Contrast Medium (Ioxitalamate) in Albino Rats - PubMed
Arabic gum (Acacia senegal, AG) is proven effective antioxidant and cytoprotective agent. The present study was designed to test this notion by investigating the possible role of AG against the radiographic contrast medium (Ioxitalamate, Telebrix-35®, TBX)-induced oxidative stress …
Fucoidan-induced ID-1 suppression inhibits the in vitro and in vivo in (...)
Hepatocellular carcinoma (HCC) is a fast growing tumor associated with a high tendency for vascular invasion and distant metastasis. Recently, we repo…
Effect of Aloe Vera Compress for Decreasing the Degree of Phlebitis among Hospitalized Children in Indonesia
Background: Aloe vera is more effective than routine treatment alone to improve symptoms of phlebitis. However, few studies have been conducted in Indonesia to explore the effectiveness of aloe vera on phlebitis among hospitalized children with wide-ranged of age. The purpose of this study was to evaluate the effectiveness of aloe vera in reducing the degree of phlebitis among hospitalized children in Indonesia.Methods: This study was conducted using a quasi-experimental design, a pretest-posttest design with a control group. The sample of this study was 42 children (21 respondents in both groups) with phlebitis that hospitalized in one general public health in West Java, Indonesia from May to July 2019. The intervention group was provided a compress of extract aloe vera (5 ml) and the control group was provided a compress of 70% Alcohol. The instrument used in this study was Visual Infusion Phlebitis (VIP) score. The Mann Whitney test was used to evaluate the difference of degree of phlebitis between intervention and control group and Wilcoxon test used to evaluate the difference before and after the intervention.Results: The majority of respondents were in the infant stage (45.23%), having normal nutrition status (54.76%). On average, the length of stay in the hospital was seven days and receive intravenous therapy solution non-electrolyte and antibiotics. The average score for the post-test score was decreased in both classes. There is a statistically significant difference between the phlebitis score both in the Aloe Vera and 70% baseline-specific experimental classes, during 8, 16, 32, 40, 48 hours of treatment implementation (p
Fucoidan-induced osteogenic differentiation promotes angiogenesis by i (...)
Osteogenesis and angiogenesis, including cell–cell communication between blood vessel cells and bone cells, are essential for bone repair. Fucoidan is a chemical compound that has a variety of biolog...
Fucoidans Downstream Processes and Recent Applications
Fucoidans are multifunctional marine macromolecules that are subjected to numerous and various downstream processes during their production. These processes were considered the most important abiotic factors affecting fucoidan chemical skeletons, quality, ...
Structural Characteristics and Antioxidant Activities of Fucoidans fro (...)
Five kinds of fucoidans from the brown seaweeds Cladosiphon okamuranus, Sargassum hornery, Kjellmaniella crassifolia (Saccharine sculpera), Nemacystus …
Stability-keeping effects of proteins and anti-oxidation-rancidity of (...)
CAB Direct platform is the most thorough and extensive source of reference in the applied life sciences, incorporating the leading bibliographic databases CAB Abstracts and Global Health
Effect of Aloe Vera gel on relief of hemodialysis patients' pruritus - Complementary Medicine Journal of faculty of Nursing & Midwifery
Introduction: Pruritus is one of the most common problems in patients with kidney failure. 60-80% of dialysis patients complain of itchy skin for which different therapies have been recommended. Medicinal plants compose a group of these therapies. This study aimed to evaluate the effect of aloe Vera gel on pruritus in ...
Fucoxanthin, the constituent of Laminaria japonica, triggers AMPK-medi (...)
Background Laminaria japonica has frequently been used as a food supplement and drug in traditional oriental medicine. Among the major active constituents responsible for the bioactivities of L. japonica, fucoxanthin (FX) has been considered as a potential antioxidant. This study was conducted to examine the effects of L. japonica extract (LJE) or FX against oxidative stress on hepatocytes and to elucidate the overall their cellular mechanisms of the effects. Methods We constructed an in vitro model with the treatment of arachidonic acid (AA) + iron in HepG2 cells to stimulate the oxidative damage. The cells were pre-treated with LJE or FX for 1 h, and incubated with AA + iron. The effect on oxidative damage and cellular mechanisms of LJE or FX were assessed by cytological examination and several biochemical assays under conditions with or without kinase inhibitiors. Results LJE or FX pretreatment effectively blocked the pathological changes caused by AA + iron treatment, such as cell death, altered expression of apoptosis-related proteins such as procaspase-3 and poly (ADP-ribose) polymerase, and mitochondria dysfunction. Moreover, FX induced AMPK activation and AMPK inhibitor, compound C, partially reduced the protective effect of FX on mitochondria dysfunction. Consistent with AMPK activation, FX increased the protein levels of autophagic markers (LC3II and beclin-1) and the number of acridine orange stained cells, and decreased the phosphorylation of mTOR and simultaneously increased the phosphorylation of ULK1. And the inhibition of autophagy by 3-methylanine or bafilomycin A1 partially inhibited the protective effect of FX on mitochondria dysfunction. Conclusion These findings suggest that FX have the function of being a hepatic protectant against oxidative damages through the AMPK pathway for the control of autophagy.
Gastric protective activities of fucoidan from brown alga Kjellmaniella crassifolia through the NF-B signaling pathway - ScienceDirect
Fucoidan has been reported to have abundant biological activities. The objective of the present study was to detect the protective effects of fucoidan…
The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease - ScienceDirect
Chronic kidney disease (CKD) is a globally common and important disease and there are evidence for a bidirectional relationship between microbiota and…
