Glyconutrients

Hepatocellular carcinoma (HCC) is a fast growing tumor associated with a high tendency for vascular invasion and distant metastasis. Recently, we repo…

Osteogenesis and angiogenesis, including cell–cell communication between blood vessel cells and bone cells, are essential for bone repair. Fucoidan is a chemical compound that has a variety of biolog...

Background: Aloe vera is more effective than routine treatment alone to improve symptoms of phlebitis. However, few studies have been conducted in Indonesia to explore the effectiveness of aloe vera on phlebitis among hospitalized children with wide-ranged of age. The purpose of this study was to evaluate the effectiveness of aloe vera in reducing the degree of phlebitis among hospitalized children in Indonesia.Methods: This study was conducted using a quasi-experimental design, a pretest-posttest design with a control group. The sample of this study was 42 children (21 respondents in both groups) with phlebitis that hospitalized in one general public health in West Java, Indonesia from May to July 2019. The intervention group was provided a compress of extract aloe vera (5 ml) and the control group was provided a compress of 70% Alcohol. The instrument used in this study was Visual Infusion Phlebitis (VIP) score. The Mann Whitney test was used to evaluate the difference of degree of phlebitis between intervention and control group and Wilcoxon test used to evaluate the difference before and after the intervention.Results: The majority of respondents were in the infant stage (45.23%), having normal nutrition status (54.76%). On average, the length of stay in the hospital was seven days and receive intravenous therapy solution non-electrolyte and antibiotics. The average score for the post-test score was decreased in both classes. There is a statistically significant difference between the phlebitis score both in the Aloe Vera and 70% baseline-specific experimental classes, during 8, 16, 32, 40, 48 hours of treatment implementation (p

Fucoidans are multifunctional marine macromolecules that are subjected to numerous and various downstream processes during their production. These processes were considered the most important abiotic factors affecting fucoidan chemical skeletons, quality, ...

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Introduction: Pruritus is one of the most common problems in patients with kidney failure. 60-80% of dialysis patients complain of itchy skin for which different therapies have been recommended. Medicinal plants compose a group of these therapies. This study aimed to evaluate the effect of aloe Vera gel on pruritus in ...

Background Laminaria japonica has frequently been used as a food supplement and drug in traditional oriental medicine. Among the major active constituents responsible for the bioactivities of L. japonica, fucoxanthin (FX) has been considered as a potential antioxidant. This study was conducted to examine the effects of L. japonica extract (LJE) or FX against oxidative stress on hepatocytes and to elucidate the overall their cellular mechanisms of the effects. Methods We constructed an in vitro model with the treatment of arachidonic acid (AA) + iron in HepG2 cells to stimulate the oxidative damage. The cells were pre-treated with LJE or FX for 1 h, and incubated with AA + iron. The effect on oxidative damage and cellular mechanisms of LJE or FX were assessed by cytological examination and several biochemical assays under conditions with or without kinase inhibitiors. Results LJE or FX pretreatment effectively blocked the pathological changes caused by AA + iron treatment, such as cell death, altered expression of apoptosis-related proteins such as procaspase-3 and poly (ADP-ribose) polymerase, and mitochondria dysfunction. Moreover, FX induced AMPK activation and AMPK inhibitor, compound C, partially reduced the protective effect of FX on mitochondria dysfunction. Consistent with AMPK activation, FX increased the protein levels of autophagic markers (LC3II and beclin-1) and the number of acridine orange stained cells, and decreased the phosphorylation of mTOR and simultaneously increased the phosphorylation of ULK1. And the inhibition of autophagy by 3-methylanine or bafilomycin A1 partially inhibited the protective effect of FX on mitochondria dysfunction. Conclusion These findings suggest that FX have the function of being a hepatic protectant against oxidative damages through the AMPK pathway for the control of autophagy.

Fucoidan has been reported to have abundant biological activities. The objective of the present study was to detect the protective effects of fucoidan…

Chronic kidney disease (CKD) is a globally common and important disease and there are evidence for a bidirectional relationship between microbiota and…

Eating seaweed salad may boost the efficacy of vaccinations and help treat cold sores, herpes, Epstein-Barr virus, and shingles. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ What else can seaweed salad do (other than tasting yummy)? See Wakame Seaweed Salad May Lower Blood Pressure (http://nutritionfacts.org/video/wakame-seaweed-salad-may-lower-blood-pressure). In general sea vegetables are good sources of iodine (Iodine Supplements Before, During, and After Pregnancy (http://nutritionfacts.org/video/iodine-supplements-before-during-and-after-pregnancy/)) and may be one reason Japanese women have historically had such low rates of breast cancer (Which Seaweed is Most Protective Against Breast Cancer?(http://nutritionfacts.org/video/which-seaweed-is-most-protective-against-breast-cancer/)). What else can we do to boost our immunity? Check out: • Using the Produce Aisle to Boost Immune Function (http://nutritionfacts.org/video/using-the-produce-aisle-to-boost-immune-function/) • Preserving Athlete Immunity with Chlorella (http://nutritionfacts.org/video/preserving-athlete-immunity-with-chlorella-2/) • Preserving Immune Function in Athletes With Nutritional Yeast (http://nutritionfacts.org/video/preserving-immune-function-in-athletes-with-nutritional-yeast/) • Benefits of Green Tea for Boosting Antiviral Immune Function (http://nutritionfacts.org/video/benefits-of-green-tea-for-boosting-antiviral-immune-function) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/how-to-boost-your-immune-system-with-wakame-seaweed and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/how-to-boost-your-immune-system-with-wakame-seaweed. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: mroach via flickr. Image has been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Five cents worth of seaweed a day may dramatically improve a major cause of disability and compromised quality of life among women. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ I’m so glad I finally got an endometriosis video out. I think the only other video I touch on it is What Diet Best Lowers Phthalate Exposure? (http://nutritionfacts.org/video/what-diet-best-lowers-phthalate-exposure). I’ve also been neglecting sea vegetables. I did do Which Seaweed is Most Protective Against Breast Cancer? (http://nutritionfacts.org/video/which-seaweed-is-most-protective-against-breast-cancer/) and more recently, Wakame Seaweed Salad May Lower Blood Pressure (http://nutritionfacts.org/video/wakame-seaweed-salad-may-lower-blood-pressure) with more on the way. I’d recommend staying away from kelp and hijiki, though. See Too Much Iodine Can Be as Bad as Too Little (http://nutritionfacts.org/video/too-much-iodine-can-be-as-bad-as-too-little/). Other natural remedies for menstrual problems include • Dietary Treatment for Painful Menstrual Periods (http://nutritionfacts.org/video/dietary-treatment-for-painful-menstrual-periods/) • Flax Seeds for Breast Pain (http://nutritionfacts.org/video/flax-seeds-for-breast-pain/) • Ginger for Nausea, Menstrual Cramps, and Irritable Bowel Syndrome (http://nutritionfacts.org/video/ginger-nausea-menstrual-cramps-irritable-bowel-syndrome/) • Fennel Seeds for Menstrual Cramps and PMS (http://nutritionfacts.org/video/fennel-seeds-for-menstrual-cramps-and-pms/) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/how-to-treat-endometriosis-with-seaweed and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/how-to-treat-endometriosis-with-seaweed. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: kreuzfeld via pixabay. Image has been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Background: The prevalence of diabetes is rapidly rising worldwide at an alarming rate. Over the last 30 years, the status of diabetes has changed from being considered as a mild disorder of the elderly to one of the major causes of morbidity and mortality affecting the youth and middle aged people. Aloe vera has been used in folk medicine as a remedy for various diseases. It is extensively studied in treating diabetes mellitus. Aims and Objectives: This study evaluates the hypoglycemic effect of A. vera leaf dried powder and compares it with standard Metformin in alloxan-induced diabetic rats. Materials and Methods: Diabetes mellitus was experimentally induced in rats by intraperitoneal injection of alloxan monohydrate at a dose of 150 mg/kg. A pure extract of A. vera leaf was given orally once daily for 5 weeks in three graded doses of 100, 200, 400 mg/kg and compared with control (2 ml distilled water) and standard (metformin 50 mg/kg). Results: The elevated blood glucose levels in diabetic rats were reduced by the treatment with A. vera leaf extract at doses of 200 mg/kg and 400 mg/kg which was comparable to 50 mg/kg of metformin with no statistically significant difference (P < 0.0001). Conclusion: Our study concludes that A. vera leaf extract has a favorable effect in reversing alloxan induced hyperglycemia in rats.

This manuscript revals that the aqueous extraction methods with and without citric acid could produce such hyperlipidaemic and antioxidative polysaccharides from L. japonica.

Beside biomaterials’ bulk properties, their surface properties are equally important to control interfacial biocompatibility. However, due to the inadequate interaction with tissue, they may cause foreign body reaction. Moreover, surface induced thrombosis can occur when biomaterials are used for blood containing applications. Surface modification of the biomaterials can bring enhanced surface properties in biomedical applications. Sulfated polysaccharide coatings can be used to avoid surface induced thrombosis which may cause vascular occlusion (blocking the blood flow by blood clot), which results in serious health problems. Naturally occurring heparin is one of the sulfated polysaccharides most commonly used as an anticoagulant, but its long term usage causes hemorrhage. Marine sourced sulfated polysaccharide fucoidan is an alternative anticoagulant without the hemorrhage drawback. Heparin and fucoidan immobilization onto a low density polyethylene surface after functionalization by plasma has been studied. Surface energy was demonstrated by water contact angle test and chemical characterizations were carried out by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. Surface morphology was monitored by scanning electron microscope and atomic force microscope. Finally, their anticoagulation activity was examined for prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin time (TT).

There is a tendency nowadays to encourage the use of natural substances in dentistry. Aloe vera is one of these substances, which has recently gained …

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that leads to severe hepatotoxicity at excessive doses. Fucoidan, a sulfated polysaccharide derived from brown seaweeds, possesses a wide range of pharmacological properties. However, the impacts of fucoidan on APAP-induced liver injury have not been sufficiently addressed. In the present study, male Institute of Cancer Research (ICR) mice aged 6 weeks were subjected to a single APAP (500 mg/kg) intraperitoneal injection after 7 days of fucoidan (100 or 200 mg/kg/day) or bicyclol intragastric administration. The mice continued to be administered fucoidan or bicyclol once per day, and were sacrificed at an indicated time. The indexes evaluated included liver pathological changes, levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the serum, levels of reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT) in the liver, and related proteins levels (CYP2E1, pJNK and Bax). Furthermore, human hepatocyte HL-7702 cell line was used to elucidate the potential molecular mechanism of fucoidan. The mitochondrial membrane potential (MMP) and nuclear factor-erythroid 2-related factor (Nrf2) translocation in HL-7702 cells were determined. The results showed that fucoidan pretreatment reduced the levels of ALT, AST, ROS, and MDA, while it enhanced the levels of GSH, SOD, and CAT activities. Additionally, oxidative stress-induced phosphorylated c-Jun N-terminal protein kinase (JNK) and decreased MMP were attenuated by fucoidan. Although the nuclear Nrf2 was induced after APAP incubation, fucoidan further enhanced Nrf2 in cell nuclei and total expression of Nrf2. These results indicated that fucoidan ameliorated APAP hepatotoxicity, and the mechanism might be related to Nrf2-mediated oxidative stress.

Fucoidan, a sulfated polysaccharide extracted from brown seaweeds, has been shown to possess various bioactivities. In particular, low molecular weight fucoidan (LMWF) has been shown to have better bioactivities. In this study, a LMWF (

The purpose of the study is to compare the effects of Aloe vera mouthwash on postoperative complications after impacted third molar surgery.The random…

This study comparatively evaluated the effects of different extraction methods on yield, structural features and antioxidant activities of Laminaria j…

It’s clear that boosting prebiotic fiber goes a long way to balancing important areas of human metabolism and this in turn paves for the way for health.

Aloe vera may reduce fasting plasma glucose in prediabetes and type 2 diabetes.

Introduction: The enzyme cyclooxygenase (COX) is an enzyme that catalyzes the formation of one of the mediators of inflammation, the prostaglandins. Inhibition of COX allegedly can improve inflammation-induced pathological conditions. Aim: The purpose of the present study was to evaluate the potential of Sargassum sp. components, Fucoidan and alginate, as COX inhibitors. Material and methods: The study was conducted by means of a computational (in silico) method. It was performed in two main stages, the docking between COX-1 and COX-2 with Fucoidan, alginate and aspirin (for comparison) and the analysis of the amount of interactions formed and the residues directly involved in the process of interaction. Results: Our results showed that both Fucoidan and alginate had an excellent potential as inhibitors of COX-1 and COX-2. Fucoidan had a better potential as an inhibitor of COX than alginate. COX inhibition was expected to provide a more favorable effect on inflammation-related pathological conditions. Conclusion: The active compounds Fucoidan and alginate derived from Sargassum sp. were suspected to possess a good potential as inhibitors of COX-1 and COX-2.

Seaweed and their constituents have been traditionally employed for the management of various human pathologic conditions such as edema, urinary disor…