Trehalose

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Superbug impact on the gut -- ScienceDaily
Superbug impact on the gut -- ScienceDaily
Researchers have discovered that the devastating bacterial superbug Clostridioides difficile hijacks the human wound healing system in order to cause serious and persistent disease, opening up the development of new therapies to treat the disease.
·sciencedaily.com·
Superbug impact on the gut -- ScienceDaily
Is there a causal relationship between trehalose consumption... Current Opinion in Gastroenterology
Is there a causal relationship between trehalose consumption... Current Opinion in Gastroenterology
c ribotypes of C. difficile harbour mutations or have acquired extra genes that mean these strains can utilize lower concentrations of bioavailable trehalose, providing a competitive metabolic advantage in some CDI animal models. By contrast, evidence has emerged to show that trehalose-induced microbiota changes can help protect/reduce CDI in other models. In addition, C. difficile trehalose metabolic variants are widespread among epidemic and nonepidemic ribotypes alike, and the occurrence of these trehalose variants was not associated with increase disease severity or mortality. Summary Currently, there is no proven causal association between the incidence or severity of human CDI and the presence of trehalose metabolism variants. Furthermore, microbial metabolism reduces trehalose bioavailability, potentially removing this competitive advantage for C. difficile trehalose metabolism variants. Taken together, trehalose consumed as part of a normal diet has no increased risk of CDI....
·journals.lww.com·
Is there a causal relationship between trehalose consumption... Current Opinion in Gastroenterology
Microorganisms Free Full-Text Insights into the Role of Human Gut Microbiota in Clostridioides difficile Infection
Microorganisms Free Full-Text Insights into the Role of Human Gut Microbiota in Clostridioides difficile Infection
Clostridioides difficile infection (CDI) has emerged as a major health problem worldwide. A major risk factor for disease development is prior antibiotic use, which disrupts the normal gut microbiota by altering its composition and the gut’s metabolic functions, leading to the loss of colonization resistance and subsequent CDI. Data from human studies have shown that the presence of C. difficile, either as a colonizer or as a pathogen, is associated with a decreased level of gut microbiota diversity. The investigation of the gut’s microbial communities, in both healthy subjects and patients with CDI, elucidate the role of microbiota and improve the current biotherapeutics for patients with CDI. Fecal microbiota transplantation has a major role in managing CDI, aiming at re-establishing colonization resistance in the host gastrointestinal tract by replenishing the gut microbiota. New techniques, such as post-genomics, proteomics and metabolomics analyses, can possibly determine in the future the way in which C. difficile eradicates colonization resistance, paving the way for the development of new, more successful treatments and prevention. The aim of the present review is to present recent data concerning the human gut microbiota with a focus on its important role in health and disease.
·mdpi.com·
Microorganisms Free Full-Text Insights into the Role of Human Gut Microbiota in Clostridioides difficile Infection
Probiotic Supplementation in a Clostridium difficile-Infected Gastrointestinal Model Is Associated with Restoring Metabolic Function of Microbiota
Probiotic Supplementation in a Clostridium difficile-Infected Gastrointestinal Model Is Associated with Restoring Metabolic Function of Microbiota
Clostridium (C.) difficile-infection (CDI), a nosocomial gastrointestinal disorder, is of growing concern due to its rapid rise in recent years. Antibiotic therapy of CDI is associated with disrupted metabolic function and altered gut microbiota. The use of probiotics as an adjunct is being studied extensively due to their potential to modulate metabolic functions and the gut microbiota. In the present study, we assessed the ability of several single strain probiotics and a probiotic mixture to change the metabolic functions of normal and C. difficile-infected fecal samples. The production of short-chain fatty acids (SCFAs), hydrogen sulfide (H2S), and ammonia was measured, and changes in microbial composition were assessed by 16S rRNA gene amplicon sequencing. The C. difficile-infection in fecal samples resulted in a significant decrease (p < 0.05) in SCFA and H2S production, with a lower microbial alpha diversity. All probiotic treatments were associated with significantly increased (p < 0.05) levels of SCFAs and restored H2S levels. Probiotics showed no effect on microbial composition of either normal or C. difficile-infected fecal samples. These findings indicate that probiotics may be useful to improve the metabolic dysregulation associated with C. difficile infection.
·mdpi.com·
Probiotic Supplementation in a Clostridium difficile-Infected Gastrointestinal Model Is Associated with Restoring Metabolic Function of Microbiota
Hype or hypervirulence a reflection on problematic C. difficile strains. - PubMed - NCBI
Hype or hypervirulence a reflection on problematic C. difficile strains. - PubMed - NCBI
Clostridium difficile infections (CDI) have emerged as a major cause of healthcare associated disease, and recent epidemiological evidence also suggests an important role in community-acquired diarrhea. This increase is associated with specific types, especially PCR ribotypes 027 and 078, which are …
·ncbi.nlm.nih.gov·
Hype or hypervirulence a reflection on problematic C. difficile strains. - PubMed - NCBI
Dietary trehalose enhances virulence of epidemic Clostridium difficile. - PubMed - NCBI
Dietary trehalose enhances virulence of epidemic Clostridium difficile. - PubMed - NCBI
Clostridium difficile disease has recently increased to become a dominant nosocomial pathogen in North America and Europe, although little is known about what has driven this emergence. Here we show that two epidemic ribotypes (RT027 and RT078) have acquired unique mechanisms to metabolize low conce …
·ncbi.nlm.nih.gov·
Dietary trehalose enhances virulence of epidemic Clostridium difficile. - PubMed - NCBI
Dietary trehalose enhances virulence of epidemic Clostridium difficile (...)
Dietary trehalose enhances virulence of epidemic Clostridium difficile (...)
Two hypervirulent ribotypes of the enteric pathogen Clostridium difficile, RT027 and RT078, have independently acquired unique mechanisms to metabolize low concentrations of the disaccharide trehalose, suggesting a correlation between the emergence of these ribotypes and the widespread adoption of trehalose in the human diet.
·nature.com·
Dietary trehalose enhances virulence of epidemic Clostridium difficile (...)
Antibiotics pave way for C. diff infections by killing bile acid-alter (...)
Antibiotics pave way for C. diff infections by killing bile acid-alter (...)
Bile acids, which are altered by bacteria normally living in the large intestine, inhibit the growth of Clostridium difficile, new research indicates. The work sheds light on the ways in which some commonly used antibiotics can promote C. diff infections by killing off the bile acid-altering microbes.
·sciencedaily.com·
Antibiotics pave way for C. diff infections by killing bile acid-alter (...)
A randomized crossover study comparing trehalosehyaluronate eyedrops and standard treatment patient satisfaction in the treatment of dry eye synd... - PubMed - NCBI
A randomized crossover study comparing trehalosehyaluronate eyedrops and standard treatment patient satisfaction in the treatment of dry eye synd... - PubMed - NCBI
Dry eye is a common disorder in routine ophthalmological practice, and a better understanding of the complex pathophysiology is leading to improved treatment. Thealoz Duo(®) is a novel artificial tear preparation containing two active ingredients: Trehalose, a naturally occurring disaccharide with a …
·ncbi.nlm.nih.gov·
A randomized crossover study comparing trehalosehyaluronate eyedrops and standard treatment patient satisfaction in the treatment of dry eye synd... - PubMed - NCBI