Trehalose

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Nutrients | Free Full-Text | Dietary Trehalose as a Bioactive Nutrient
Nutrients | Free Full-Text | Dietary Trehalose as a Bioactive Nutrient
Trehalose is a naturally occurring, non-reducing disaccharide comprising two covalently-linked glucose molecules. It possesses unique physiochemical properties, which account for multiple biological roles in a variety of prokaryotic and eukaryotic organisms. In the past few decades, intensive research on trehalose has uncovered its functions, and extended its uses as a sweetener and stabilizer in the food, medical, pharmaceutical, and cosmetic industries. Further, increased dietary trehalose consumption has sparked research on how trehalose affects the gut microbiome. In addition to its role as a dietary sugar, trehalose has gained attention for its ability to modulate glucose homeostasis, and potentially as a therapeutic agent for diabetes. This review discusses the bioactive effects of dietary trehalose, highlighting its promise in future industrial and scientific contributions.
·mdpi.com·
Nutrients | Free Full-Text | Dietary Trehalose as a Bioactive Nutrient
The potential therapeutic impacts of trehalose on cardiovascular diseases as the environmental-influenced disorders: An overview of contemporary findings - ScienceDirect
The potential therapeutic impacts of trehalose on cardiovascular diseases as the environmental-influenced disorders: An overview of contemporary findings - ScienceDirect
Cardiovascular diseases (CVDs) as environmental-influenced disorders, are a major concern and the leading cause of death worldwide. A range of therape…
·sciencedirect.com·
The potential therapeutic impacts of trehalose on cardiovascular diseases as the environmental-influenced disorders: An overview of contemporary findings - ScienceDirect
Dietary Trehalose as a Bioactive Nutrient - PubMed
Dietary Trehalose as a Bioactive Nutrient - PubMed
Trehalose is a naturally occurring, non-reducing disaccharide comprising two covalently-linked glucose molecules. It possesses unique physiochemical properties, which account for multiple biological roles in a variety of prokaryotic and eukaryotic organisms. In the past few decades, intensive resear …
·pubmed.ncbi.nlm.nih.gov·
Dietary Trehalose as a Bioactive Nutrient - PubMed
Natural Activators of Autophagy Reduce Oxidative Stress and Muscle Injury Biomarkers in Endurance Athletes A Pilot Study - PubMed
Natural Activators of Autophagy Reduce Oxidative Stress and Muscle Injury Biomarkers in Endurance Athletes A Pilot Study - PubMed
Supplementation with this mixture positively affected redox state and autophagy and improved muscle injury biomarkers in athletes, allowing for better muscle recovery. Moreover, it is speculated that this mixture could also benefit patients suffering from muscle injuries, such as cancer or cardiovas …
·pubmed.ncbi.nlm.nih.gov·
Natural Activators of Autophagy Reduce Oxidative Stress and Muscle Injury Biomarkers in Endurance Athletes A Pilot Study - PubMed
The effects of oral trehalose in patients with diabetes a pilot randomized controlled trial
The effects of oral trehalose in patients with diabetes a pilot randomized controlled trial
Introduction: Trehalose is a naturally occurring disaccharide of two glucose molecules that has been suggested as a potential therapeutic agent to reduce blood glucose and ameliorate diabetes-related complications in type 2 diabetes (T2D). This study aimed to determine the efficacy of...
·archivesofmedicalscience.com·
The effects of oral trehalose in patients with diabetes a pilot randomized controlled trial
Profiling neuroprotective potential of trehalose in animal m... Neural Regeneration Research
Profiling neuroprotective potential of trehalose in animal m... Neural Regeneration Research
ehalose on its underlying mechanisms in animal models of selected neurodegenerative disorders (tau pathology, synucleinopathy, polyglutamine tract, and motor neuron diseases). All animal studies on neurodegenerative diseases treated with trehalose published in Medline (accessed via EBSCOhost) and Scopus were considered. Of the 2259 studies screened, 29 met the eligibility criteria. According to the SYstematic Review Center for Laboratory Animal Experiment (SYRCLE) risk of bias tool, we reported 22 out of 29 studies with a high risk of bias. The present findings support the purported role of trehalose in autophagic flux and protein refolding. This review identified several other lesser-known pathways, including modifying amyloid precursor protein processing, inhibition of reactive gliosis, the integrity of the blood-brain barrier, activation of growth factors, upregulation of the downstream antioxidant signaling pathway, and protection against mitochondrial defects. The absence of adverse events and improvements in the outcome parameters were observed in some studies, which supports the transition to human clinical trials. It is possible to conclude that trehalose exerts its neuroprotective effects through both direct and indirect pathways. However, heterogeneous methodologies and outcome measures across the studies rendered it impossible to derive a definitive conclusion. Translational studies on trehalose would need to clarify three important questions: 1) bioavailability with oral administration, 2) optimal time window to confer neuroprotective benefits, and 3) optimal dosage to confer neuroprotection....
·journals.lww.com·
Profiling neuroprotective potential of trehalose in animal m... Neural Regeneration Research
effect of trehalose administration on miRNA-10a expression in patients with history of myocardial infarction (MI) and systemic inflammation European Heart Journal Oxford Academic
effect of trehalose administration on miRNA-10a expression in patients with history of myocardial infarction (MI) and systemic inflammation European Heart Journal Oxford Academic
AbstractBackground. MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of endothelial function, inflammatory cells, and cholesterol homeost
·academic.oup.com·
effect of trehalose administration on miRNA-10a expression in patients with history of myocardial infarction (MI) and systemic inflammation European Heart Journal Oxford Academic
Trehalose prevents glyphosate-induced hepatic steatosis in roosters by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation SpringerLink
Trehalose prevents glyphosate-induced hepatic steatosis in roosters by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation SpringerLink
Veterinary Research Communications - Glyphosate (Gly) is a globally spread herbicide that can cause toxic injuries to hepatocytes. Dietary trehalose (Tre) exerts cytoprotective effect in numerous...
·link.springer.com·
Trehalose prevents glyphosate-induced hepatic steatosis in roosters by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation SpringerLink
Trehalose Attenuates Learning and Memory Impairments in Aged Rats via Overexpression of miR-181c - PubMed
Trehalose Attenuates Learning and Memory Impairments in Aged Rats via Overexpression of miR-181c - PubMed
MicroRNAs have been recognized as important regulators of the aging process. Trehalose, a natural disaccharide, displays protective effects against neuronal impairment through several mechanisms. However, little is known about the interactive effects of aging and trehalose on behavioral function and …
·pubmed.ncbi.nlm.nih.gov·
Trehalose Attenuates Learning and Memory Impairments in Aged Rats via Overexpression of miR-181c - PubMed
Disaccharide trehalose in experimental therapies for neurodegenerative disorders Molecular targets and translational potential - PubMed
Disaccharide trehalose in experimental therapies for neurodegenerative disorders Molecular targets and translational potential - PubMed
Induction of autophagy is a prospective approach to the treatment of neurodegeneration. In the recent decade, trehalose attracted special attention. It is an autophagy inducer with negligible adverse effects and is approved for use in humans according to FDA requirements. Trehalose has a therapeutic …
·pubmed.ncbi.nlm.nih.gov·
Disaccharide trehalose in experimental therapies for neurodegenerative disorders Molecular targets and translational potential - PubMed
Study protocol for a pilot randomised controlled trial evaluating the effectiveness of oral trehalose on inflammatory factors, oxidative stress, nutritional and clinical status in traumatic
Study protocol for a pilot randomised controlled trial evaluating the effectiveness of oral trehalose on inflammatory factors, oxidative stress, nutritional and clinical status in traumatic
Iranian Registry of Clinical Trials (IRCT) Id: IRCT20210508051223N1, Registration date: 26 July 2021.
·pubmed.ncbi.nlm.nih.gov·
Study protocol for a pilot randomised controlled trial evaluating the effectiveness of oral trehalose on inflammatory factors, oxidative stress, nutritional and clinical status in traumatic
Trehalose–Carnosine Prevents the Effects of Spinal Cord Injury Through Regulating Acute Inflammation and Zinc(II) Ion Homeostasis SpringerLink
Trehalose–Carnosine Prevents the Effects of Spinal Cord Injury Through Regulating Acute Inflammation and Zinc(II) Ion Homeostasis SpringerLink
Cellular and Molecular Neurobiology - Spinal cord injury (SCI) leads to long-term and permanent motor dysfunctions, and nervous system abnormalities. Injury to the spinal cord triggers a signaling...
·link.springer.com·
Trehalose–Carnosine Prevents the Effects of Spinal Cord Injury Through Regulating Acute Inflammation and Zinc(II) Ion Homeostasis SpringerLink
A head-to-head comparison review of biological and toxicological studies of isomaltulose, d-tagatose, and trehalose on glycemic control - PubMed
A head-to-head comparison review of biological and toxicological studies of isomaltulose, d-tagatose, and trehalose on glycemic control - PubMed
Diabetes mellitus is the most common metabolic disorder contributing to significant morbidity and mortality in humans. Different preventive and therapeutic agents, as well as various pharmacological strategies or non-pharmacological tools, improve the glycemic profile of diabetic patients. Isomaltul …
·pubmed.ncbi.nlm.nih.gov·
A head-to-head comparison review of biological and toxicological studies of isomaltulose, d-tagatose, and trehalose on glycemic control - PubMed
Trehalose – a natural sugar that could possibly be consumed for health and longevity - AGINGSCIENCES™ - Anti-Aging Firewalls™AG
Trehalose – a natural sugar that could possibly be consumed for health and longevity - AGINGSCIENCES™ - Anti-Aging Firewalls™AG
By Vince Giuliano and James P Watson. Trehalose is a natural disaccharide sugar contained in mushrooms and many other organisms.  It has remarkable health-producing and life-extending properties that work in mice and lower organisms.  That is why we choose to … Continue reading →
·anti-agingfirewalls.com·
Trehalose – a natural sugar that could possibly be consumed for health and longevity - AGINGSCIENCES™ - Anti-Aging Firewalls™AG
New insights on trehalose a multifunctional molecule - PubMed
New insights on trehalose a multifunctional molecule - PubMed
Trehalose is a nonreducing disaccharide in which the two glucose units are linked in an alpha,alpha-1,1-glycosidic linkage. This sugar is present in a wide variety of organisms, including bacteria, yeast, fungi, insects, invertebrates, and lower and higher plants, where it may serve as a source of e …
·pubmed.ncbi.nlm.nih.gov·
New insights on trehalose a multifunctional molecule - PubMed