Trehalose

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Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cy (...)
Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cy (...)
HCMV infects multiple cell types in vivo, establishes lifelong persistence in the host, and can cause serious health problems for fetuses and immunocompromised individuals. HCMV, like all other persistent pathogens, has to finely tune its interplay with the host cellular machinery to replicate effic …
·ncbi.nlm.nih.gov·
Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cy (...)
Trehalose, sucrose and raffinose are novel activators of autophagy in (...)
Trehalose, sucrose and raffinose are novel activators of autophagy in (...)
Trehalose is a natural disaccharide that is found in a diverse range of organisms but not in mammals. Autophagy is a process which mediates the sequestration, lysosomal delivery and degradation of proteins and organelles. Studies have shown that trehalose exerts beneficial effects through inducing autophagy in mammalian cells. However, whether trehalose or other saccharides can activate autophagy in keratinocytes is unknown. Here, we found that trehalose treatment increased the LC3-I to LC3-II conversion, acridine orange-stained vacuoles and GFP-LC3B (LC3B protein tagged with green fluorescent protein) puncta in the HaCaT human keratinocyte cell line, indicating autophagy induction. Trehalose-induced autophagy was also observed in primary keratinocytes and the A431 epidermal cancer cell line. mTOR signalling was not affected by trehalose treatment, suggesting that trehalose induced autophagy through an mTOR-independent pathway. mTOR-independent autophagy induction was also observed in HaCaT and HeLa cells treated with sucrose or raffinose but not in glucose, maltose or sorbitol treated HaCaT cells, indicating that autophagy induction was not a general property of saccharides. Finally, although trehalose treatment had an inhibitory effect on cell proliferation, it had a cytoprotective effect on cells exposed to UVB radiation. Our study provides new insight into the saccharide-mediated regulation of autophagy in keratinocytes.
·nature.com·
Trehalose, sucrose and raffinose are novel activators of autophagy in (...)
Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway. - PubMed - NCBI
Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway. - PubMed - NCBI
Trehalose is a natural disaccharide that is found in a diverse range of organisms but not in mammals. Autophagy is a process which mediates the sequestration, lysosomal delivery and degradation of proteins and organelles. Studies have shown that trehalose exerts beneficial effects through inducing a …
·ncbi.nlm.nih.gov·
Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway. - PubMed - NCBI
Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of A (...)
Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of A (...)
Trehalose has been proven to provide protection to different proteins to various extents, inhibiting at elevated concentrations the aggregation of proteins involved in neurodegenerative disorders such Alzheimer's, Parkinson's and Huntington's diseases. Moreover, 8-hydroxyquinolines have also been found to protect a
·pubs.rsc.org·
Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of A (...)
Trehalose-Induced Structural Transition Accelerates Aggregation of a-S (...)
Trehalose-Induced Structural Transition Accelerates Aggregation of a-S (...)
Fibrillation of α-synuclein proceeds through distinct stages, with oligomers combining to form the seed or the nucleus, followed by exponential and saturation phases. Osmolytes are considered to act as protein stabilizers by virtue of their ability to inhibit protein aggregation. Trehalose, a non-re …
·ncbi.nlm.nih.gov·
Trehalose-Induced Structural Transition Accelerates Aggregation of a-S (...)
Trehalose-Induced Structural Transition Accelerates Aggregation of a-Synuclein. - PubMed - NCBI
Trehalose-Induced Structural Transition Accelerates Aggregation of a-Synuclein. - PubMed - NCBI
Fibrillation of α-synuclein proceeds through distinct stages, with oligomers combining to form the seed or the nucleus, followed by exponential and saturation phases. Osmolytes are considered to act as protein stabilizers by virtue of their ability to inhibit protein aggregation. Trehalose, a non-re …
·ncbi.nlm.nih.gov·
Trehalose-Induced Structural Transition Accelerates Aggregation of a-Synuclein. - PubMed - NCBI
Trehalose-mediated autophagy impairs the anti-viral function of human (...)
Trehalose-mediated autophagy impairs the anti-viral function of human (...)
Human rhinovirus (HRV) is the most common cause of acute exacerbations of chronic lung diseases including asthma. Impaired anti-viral IFN-λ1 production and increased HRV replication in human asthmatic airway epithelial cells may be one of the underlying mechanisms leading to asthma exacerbations. In …
·ncbi.nlm.nih.gov·
Trehalose-mediated autophagy impairs the anti-viral function of human (...)
Variable Effects of Autophagy Induction by Trehalose on Herpesviruses (...)
Variable Effects of Autophagy Induction by Trehalose on Herpesviruses (...)
Trehalose is a non-reducing sugar formed from two glucose units. Trehalose induces abundant autophagy in cultured cells and also reduces the rate of aggregation of the huntingtin protein in the animal model of Huntington disease, a chronic neurological disease in humans. The mechanism of this effect …
·ncbi.nlm.nih.gov·
Variable Effects of Autophagy Induction by Trehalose on Herpesviruses (...)