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11 ways STOP Overactive Bladder | Overactive Bladder Symptoms & treatment

·youtube.com·Apr 1, 2025

11 ways STOP Overactive Bladder | Overactive Bladder Symptoms & treatment

Daily aspirin reduces cancer risk and slows its spread, study confirms. Taking a low dose of aspirin every day may reduce the risk of cancer and slow the spread of the disease, according to a study that followed the health of more than 100,000 patients. : r/science

platelets release pro-angiogenic proteins- proteins that promote the growth of new blood vessels

Tumors hijack these platelets to be able to grow new blood vessels to support their rapid growth

Without new blood vessels, a tumor cannot grow.

ASPIRIN's mechanism of action is to inhibit platelets

Therefore, no platelets = no new blood vessels = less tumor growth

Your body does not need to grow new blood vessels (angiogenesis) unless you have been injured.

Cancer, on the other hand, grows new blood vessels to supply the tumor as it grows.

That's why anti-angiogenics are used to fight cancer.

yes, increased vascularity inside of your muscles will make them perform better.

Cancer is closely associated with inflammation. Aspirin inhibits inflammation.

Inflammation is strongly related to poor blood circulation.

No wonder exercise and a healthy diet helps then.

A recent article on estrogen-induced apoptosis after long-term estrogen deprivation in breast cancer demonstrated that such an inflammatory pathway can actually be used to kill cancer cells, and recommended a review of NSAID use during some treatments to avoid dampening the effects of therapy.

Since aspirin permanently inhibits COX I, that receptor must be recycled and a new one made to replace it. With ibuprofen, the receptor eventually regains activity after ibuprofen wears off because it is a reversible COX inhibitor.

aspirin can cause gastrointestinal bleeding, ulcers and kidney problems over long periods of time. It really depends on the dosage

Giving aspirin or other salicylates (like those found in pepto bismol) to children under 12 can cause Reye's syndrome

Low-dose aspirin has two benefits: lowering heart attack risk and stroke risk (mostly in women), and possibly this new cancer risk reduction.

I was on full (325 mg) dose every day for a year and then on a half dose for a year and it caused my stomach lining to break down and start bleeding.

At least in women all cause mortality decreases with asprin use. The effect with heart attacks was related to more short term asprin use whereas effect on cancer was associated with longer term asprin use.

GI bleeding is the biggest risk. There is also a risk of worsening bleed from trauma (for example: you hit your head really hard! how much will you bleed inside your skull?) but this risk minimal in a younger person and in the elderly is much safer than the blood thinner warfarin

acid reflux, for this reason I don't take one

If you have an asymptomatic infection w/ H pylori, the bacteria most likely to be associated with an ulceration, prolonged use of daily aspirin can uncover that

prolonged use of higher doses of NSAIDs-non steroidal anti inflammatories, like ibuprofen-can give you kidney problems, tho usually it's in conjunction with some other cause of renal disease like hypertension or diabetes.

Still possible to have embolic stroke on warfarin but it's much more rare. Hemorrhagic stroke would be a risk, tho.

increased risk of hemorrhagic stoke, which is the single biggest side effect by mortality.

Medications

·reddit.com·Mar 19, 2025

What is Shadow Work? 8 Benefits and 27 Prompts to Start Practicing

Shadow work helps you explore your unconscious mind and develop greater self-awareness. Start your journey with practical tips and 27 prompts.

Mental Health

·betterup.com·Mar 19, 2025

What is Shadow Work? 8 Benefits and 27 Prompts to Start Practicing

Therapeutic dimethyl sulfoxide (aka DMSO) compositions and methods of use - Google Patents

****!!!****!!! The use of honey, and other sugar compositions, with pharmaceutical compositions containing DMSO is disclosed. The result is a reduction in the undesirable side effects normally associated with the application of DMSO compositions, enhancement of the desired physiological effects produced by DMSO compositions, and other benefits not present with the use of DMSO alone, and/or in conjunction with other additives.

when DMSO and honey are both administered to epithelial regions of a human or other animal subject, expected adverse skin reactions, malodorous breath and foul taste are substantially reduced

honey is discovered to potentiate DMSO in certain instances

certain DMSO formulations, which contain honey

treating diseased finger and toe nails, for softening cuticle to be removed from finger and toe nails, and for softening epidermal thickenings

DMSO, administered with honey, will repair or remove abnormal, dead, or diseased tissue more readily than with just DMSO, or honey alone

used to treat interstitial cystitis or connective tissue diseases such as progressive systemic sclerosis.

Warm applications are especially beneficial when treating musculoskeletal disorders,

DMSO-honey compositions are also well suited for use with physical therapy techniques, particularly the use of energy such as ultra sound

Honey is known to have some beneficial effect on skin, but in most standard cosmetic compositions it may wash off. When DMSO and honey are used together, skin permeation of each is enhanced so the skin softening, and moisturizing benefits of honey are increased and sustained even after washing.

excellent, general, formulation being 1 part honey, 7 parts DMSO, and 3 parts water

sugar formulations, while somewhat effective, are not nearly as effective as is honey

Honey, alone, proved to be anti-fungal,

honey is the perfect, symbiotic additive for DMSO therapy, including orally ingested DMSO therapy

the suggested storage temperature for DMSO

Aloe, spoils

at room temperature

Urea, another additive

honey should be present in a weight or volume ratio to DMSO of greater than 1:99

contain no more than about 60 weight percent honey

used with a dressing,

ratio of honey to DMSO can be increased.

DMSO

·patents.google.com·Mar 17, 2025

Therapeutic dimethyl sulfoxide (aka DMSO) compositions and methods of use - Google Patents

In Vitro Evaluation of the Combination of Melaleuca alternifolia (Tea Tree) Oil and Dimethyl Sulfoxide (DMSO) against Trophozoites and Cysts of Acanthamoeba Strains. Oxygen Consumption Rate (OCR) Assay as a Method for Drug Screening

!!!!***!! DMSO alone seems to be a non-amoebicide, triggering encystment. Regarding cytotoxicity, these compounds showed toxicity in human corneal epithelial cells (HCEpiC), even at low concentrations when tested in combination.

DMSO alone seems to be a non-amoebicide, triggering encystment.

these compounds showed toxicity in human corneal epithelial cells (HCEpiC), even at low concentrations when tested in combination.

Acanthamoeba keratitis (AK) and granulomatous amoebic encephalitis (GAE).

DMSO

·mdpi.com·Mar 17, 2025

Antibacterial synergy of curcumin with antibiotics against biofilm producing clinical bacterial isolates

The role of natural bioactive substances in treating infections has been rediscovered as bacterial resistance become common to most of the antibiotics. Curcumin is a bioactive substance from turmeric. Owing to antimicrobial properties, its prospect ...

Maximum synergy was observed with ciprofloxacin among Gram-positive and amikacin, gentamicin, and cefepime among Gram-negative isolates.

Curcumin per se as well as in combination with other antibiotics has a demonstrable antibacterial action against biofilm producing bacterial isolates

beneficial role in supplementing antibiotic therapy.

antibacterial synergy of curcumin with aminoglycosides, cephalosporins, and quinolones

of improved susceptibility was highest with amikacin (18 isolates), followed by gentamicin (16 isolates), cefepime, ceftriaxone, and imipenem

Meropenem and ampicillin AST were least affected

presence of curcumin rendered 4, 2, and 8 S. aureus strains sensitive to penicillin, erythromycin, and ciprofloxacin

change was noted in Gram-negative organisms

curcumin associated membrane damage may facilitate antibiotic influx

MIC of oxacillin, ampicillin, ciprofloxacin, and norfloxacin against 10 MRSA

against 10 strains of S. aureus and amikacin, gentamicin, and ciprofloxacin was found to have good antibacterial synergy with curcumin

Nutrition, Supplements

·pmc.ncbi.nlm.nih.gov·Mar 16, 2025

Antibacterial synergy of curcumin with antibiotics against biofilm producing clinical bacterial isolates

Antibacterial Action of Curcumin against Staphylococcus aureus: A Brief Review

***!!!*** Curcumin's antibacterial activity is increased when combined with some antibiotics

curcumin is an active iron chelator,

may potentially affect systemic iron metabolism especially those who have suboptimal iron status

block the enzymes that metabolize drugs such as cytochrome

accumulation of nonmetabolized drugs in blood and result in undesired toxicity

side effects of curcumin have been relatively mild

ranging from 0.9 to 3.6 g per day up to 4 months only caused some adverse effects that included nausea, diarrhea, and increased serum alkaline phosphatase and lactate dehydrogenase

This method can be adopted to select the effective but nontoxic curcumin or its derivatives

cost-effective cheminformatics approach

potential toxicity, poor solubility, and low bioavailability

through oral or intravenous route

large amount of curcumin may get degraded in the presence of detoxifying and metabolic enzymes

may bind to the circulatory proteins such as albumin which may potentially reduce its activity.

Contradictorily, there have been evidences showing that degraded products from curcumin are responsible of its pharmacological activities

albumin-bound curcumin exerted similar level of activity compared to the DMSO-dissolved curcumin in serum

Curcumin protects mice from Staphylococcus aureus pneumonia

synergistic effect of curcumin in combination with third generation cephalosporins against bacteria associated with infectious diarrhea

DMSO

·pmc.ncbi.nlm.nih.gov·Mar 16, 2025

Antibacterial Action of Curcumin against Staphylococcus aureus: A Brief Review

The osmotic and intrinsic mechanisms of the pharmacological laxative action of oral high doses of magnesium sulphate. Importance of the release of digestive polypeptides and nitric oxide - PubMed

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