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Comparative effectiveness of combined low- and standard-dose trospium and solifenacin for moderate overactive bladder symptoms in elderly men and women - PubMed
Comparative effectiveness of combined low- and standard-dose trospium and solifenacin for moderate overactive bladder symptoms in elderly men and women - PubMed
The combination of low-dose trospium and solifenacin provides good clinical and urodynamic effects in elderly patients with moderate symptoms of OAB. Combination of these drugs in standard doses for such patients is excessive.
·pubmed.ncbi.nlm.nih.gov·
Comparative effectiveness of combined low- and standard-dose trospium and solifenacin for moderate overactive bladder symptoms in elderly men and women - PubMed
Proliferative Diabetic Retinopathy: What to Know to Avoid Vision Loss
Proliferative Diabetic Retinopathy: What to Know to Avoid Vision Loss
Proliferative diabetic retinopathy is a late-stage complication of diabetes-related eye disease. How to prevent progression to avoid vision loss.
Anti-VEGF injections block the effects of vascular endothelial growth factor, a protein that spurs the growth of new blood vessels. This may even help to shrink some of the new blood vessels that have already developed.
High blood sugar can also contribute to the formation of a cataract
Neovascular glaucoma can also develop. This can damage the optic nerve and lead to vision loss.
·verywellhealth.com·
Proliferative Diabetic Retinopathy: What to Know to Avoid Vision Loss
Overactive Bladder Syndrome: Evaluation and Management
Overactive Bladder Syndrome: Evaluation and Management
Overactive bladder (OAB) syndrome is a chronic medical condition which has a major influence on the quality of life in a significant amount of the population. OAB affects performance of daily activities and has an estimated prevalence of 16.5%. Many sufferers ...
agents
agents with reduced blood-brain barrier penetrance (such as trospium and darifenacin) may prevent the co-vagolytic influence on the cardiovascular system that may lead to alternations in heart rate and blood pressure
·ncbi.nlm.nih.gov·
Overactive Bladder Syndrome: Evaluation and Management
Alternative Choices to Oxybutynin: When, Why, and How Much?
Alternative Choices to Oxybutynin: When, Why, and How Much?
tolterodine (Detrol), and trospium (Sanctura)
tolterodine (Detrol), and trospium (Sanctura)
tolterodine and trospium are significantly less expensive, at about $2 per pill,
anticholinergic, trospium
does not readily cross the blood brain barrier
trospium
·pharmacytimes.com·
Alternative Choices to Oxybutynin: When, Why, and How Much?
These highlights do not include all the information needed to use Trospium Chloride Tablets safely and effectively. See full prescribing information for Trospium Chloride Tablets. Trospium Chloride Tablets, for oral use Initial U.S. Approval: 2004
These highlights do not include all the information needed to use Trospium Chloride Tablets safely and effectively. See full prescribing information for Trospium Chloride Tablets. Trospium Chloride Tablets, for oral use Initial U.S. Approval: 2004
·dailymed.nlm.nih.gov·
These highlights do not include all the information needed to use Trospium Chloride Tablets safely and effectively. See full prescribing information for Trospium Chloride Tablets. Trospium Chloride Tablets, for oral use Initial U.S. Approval: 2004
New once‐daily formulation for trospium in overactive bladder
New once‐daily formulation for trospium in overactive bladder
Aims: We examined the relative efficacy and safety of trospium 20 mg bid and 60 mg extended release formulations and position this drug against other antimuscarinic agents. Methods: Data were ident...
·onlinelibrary.wiley.com·
New once‐daily formulation for trospium in overactive bladder
Ocular Side Effects of Oxybutynin and Other Oral Anticholinergics Used In the Management of Overactive Bladder Syndrome: A Review ~borgman2.pdf
Ocular Side Effects of Oxybutynin and Other Oral Anticholinergics Used In the Management of Overactive Bladder Syndrome: A Review ~borgman2.pdf
proven ocular side effects from oral ingestion of these anticholinergics, the prescribing physician should be notified by the managing eye care provider.. patients with decreased hepatic and/or renal function may be at higher risk of overdose or of experiencing side effects than patients with normal hepatic and/or renal function.7 Interestingly, co-administration of medications that can inhibit the P-450 enzymes in the liver responsible for metabolizing a variety of substances and medications can lead to a build-up of toxic by-products of anticholinergic OBS medications.7 Specifically, medications like buproprion, fluoxetine, paroxetine, terbinafine, quinidine, cimetidine, ritonavir, ketoconazole, itraconazole, verapamil, cyclosporine, erythro- mycin, clarithromycin, and fluconazole, and even grapefruit juice, can lead to a faster build- up of toxic levels of OBS anticholinergics.7
·ovpjournal.org·
Ocular Side Effects of Oxybutynin and Other Oral Anticholinergics Used In the Management of Overactive Bladder Syndrome: A Review ~borgman2.pdf
Nonalcoholic Fatty Liver Disease: Common Questions and Answers on Diagnosis and Management
Nonalcoholic Fatty Liver Disease: Common Questions and Answers on Diagnosis and Management
Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease in the United States, affecting up to 30% of adults. There are two forms of NAFLD: nonalcoholic fatty liver (NAFL), defined as 5% or greater hepatic steatosis without hepatocellular injury or fibrosis, and nonalcoholic steatohepatitis (NASH), defined as 5% or greater hepatic steatosis plus hepatocellular injury and inflammation, with or without fibrosis. Individuals with obesity are at highest risk of NAFLD. Other established risk factors include metabolic syndrome and type 2 diabetes mellitus. Although NAFLD is common and typically asymptomatic, screening is not currently recommended, even in high-risk patients. NAFLD should be suspected in patients with elevated liver enzymes or hepatic steatosis on abdominal imaging that are found incidentally. Once other causes, such as excessive alcohol use and hepatotoxic medications, are excluded in these patients, risk scores or elastography tests can be used to identify those who are likely to have fibrosis that will progress to cirrhosis. Liver biopsy should be considered for patients at increased risk of fibrosis and when other liver disorders cannot be excluded with noninvasive tests. Weight loss through diet and exercise is the primary treatment for NAFLD. Other treatments, such as bariatric surgery, vitamin E supplements, and pharmacologic therapy with thiazolidinediones or glucagon-like peptide-1 analogues, have shown potential benefit; however, data are limited, and these therapies are not considered routine treatments. NAFL typically follows an indolent course, whereas patients with NASH are at higher risk of death from cardiovascular disease, cancer, and end-stage liver disease. (Am Fam Physician. 2020;102(10):603–612. Copyright © 2020 American Academy of Family Physicians.)
Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease in the United States, affecting up to 30% of adults
. There are two forms of NAFLD: nonalcoholic fatty liver (NAFL), defined as 5% or greater hepatic steatosis without hepatocellular injury or fibrosis, and
Most patients with NAFL will have a benign, nonprogressive disease course. Only 20% develop NASH, and 20% of those with NASH develop cirrhosis.
·aafp.org·
Nonalcoholic Fatty Liver Disease: Common Questions and Answers on Diagnosis and Management
***** Turmeric ~NCCIH, NIH
***** Turmeric ~NCCIH, NIH
This fact sheet provides basic information about turmeric—common names, usefulness and safety, and resources for more information. Javanese turmeric (Curcuma xanthorrhiz) is a different plant and not discussed in this fact sheet.
Turmeric may be unsafe for use during pregnancy in amounts greater than those commonly found in food. Little is known about whether it’s safe to use turmeric in amounts greater than those commonly found in food while breastfeeding.
·nccih.nih.gov·
***** Turmeric ~NCCIH, NIH
Superfoods: Nuts and Seeds
Superfoods: Nuts and Seeds
Nuts and seeds come in many varieties. Although most nuts and seeds have a high oil content, they provide “good fats” such as monounsaturated and polyunsaturated fats.
·kidney.org·
Superfoods: Nuts and Seeds
Effect of dehydration on blood tests
Effect of dehydration on blood tests
Click on the article title to read more.
Creatinine (µmol/L) 263 145 133
Albumin (g/L) 29 – 23
dehydration3
Orthostatic hypotension
Concentrated urine
Raised creatinine
(eGFR)
Reduced e
Raised serum or urine osmolality
Raised urine specific gravity
Total proteins (g/L) 60 – 48
significant difference in serum total proteins and albumin levels in a dehydrated patient
·wchh.onlinelibrary.wiley.com·
Effect of dehydration on blood tests
High Albumin (Hyperalbuminemia): Symptoms, Causes - science - 2023
High Albumin (Hyperalbuminemia): Symptoms, Causes - science - 2023
High albumin is medically known as hyperalbuminemia, and it means an excess or high concentration of albumin in the blood. The serum albumin concentration is typically 35-50 g / L (3.5-5.0 g / dl).
high concentration of albumin in the blood
albumin
proteins
One of the main reasons behind high levels of albumin in the blood is severe dehydration
inadequate water intake
the loss of water causes the blood to thicken, which in turn causes the components of the blood to become concentrated
although high protein is found in the blood of people who are dehydrated, the real problem is actually that the blood plasma is more concentrated.
Dehydration
This makes the blood thicken, causing the concentration of its elements. The test results, therefore, will show that there is a high globulin level in the blood, whereas in truth this is not the case.
·warbletoncouncil.org·
High Albumin (Hyperalbuminemia): Symptoms, Causes - science - 2023
can creatinine levels become high because of dehydration? | HealthTap Online Doctor
can creatinine levels become high because of dehydration? | HealthTap Online Doctor
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.
·healthtap.com·
can creatinine levels become high because of dehydration? | HealthTap Online Doctor
Should You Drink Pedialyte or Gatorade for a Hangover?
Should You Drink Pedialyte or Gatorade for a Hangover?
Both Pedialyte and Gatorade contain electrolytes and aim to rehydrate you when your body loses water. Find out which one you should use and when.
the combination of sugar and sodium in Gatorade not only helps replenish body fluids but also slows urination and gastric emptying
improve water retention, particularly when engaging in strenuous activity or planning to be outdoors in the heat.
electrolyte drinks may help ease
headaches by increasing water volumes
Gatorade should not be used if you have diabetes
·verywellhealth.com·
Should You Drink Pedialyte or Gatorade for a Hangover?
inTransition
inTransition
The inTransition program is a free, confidential program that offers specialized coaching and assistance for active-duty service members, National Guard members, reservists, veterans and retirees who need access to mental health care when relocating to another assignment, returning from deployment, transitioning from active duty to reserve component or reserve component to active duty, preparing to leave military service, any other time they need a new mental health provider or need a provider for the first time.
·health.mil·
inTransition
Pharmacotherapy of overactive bladder in adults: a review of efficacy, tolerability, and quality of life
Pharmacotherapy of overactive bladder in adults: a review of efficacy, tolerability, and quality of life
Overactive bladder (OAB) is a prevalent condition that has a significant impact on quality of life. The usual treatment approach is both behavioral and pharmacological. The first-line pharmacological treatment commonly utilizes anticholinergic agents, ...
Conservative measures include
Lower urinary tract conditions that may present with overactive bladder (OAB) symptoms
Tolterodine-IR is dosed at 1−2 mg twice daily
·ncbi.nlm.nih.gov·
Pharmacotherapy of overactive bladder in adults: a review of efficacy, tolerability, and quality of life
USP Verified Dietary Supplements
USP Verified Dietary Supplements
Over 100 different dietary supplement formulas have received the USP Verified Mark, representing several different brands and retailers. Here are three different ways you can find a quality supplement.
·quality-supplements.org·
USP Verified Dietary Supplements
Folate Deficiency: Symptoms, Causes & Prevention
Folate Deficiency: Symptoms, Causes & Prevention
Folate deficiency occurs when your blood lacks the amount of folate it needs to function properly. Folate deficiency can cause a wide range of complications.
·my.clevelandclinic.org·
Folate Deficiency: Symptoms, Causes & Prevention
Adverse Effects of Antipsychotic Medications
Adverse Effects of Antipsychotic Medications
The use of antipsychotic medications entails a difficult trade-off between the benefit of alleviating psychotic symptoms and the risk of troubling, sometimes life-shortening adverse effects. There is more variability among specific antipsychotic medications than there is between the first- and second-generation antipsychotic classes. The newer second-generation antipsychotics, especially clozapine and olanzapine, generally tend to cause more problems relating to metabolic syndrome, such as obesity and type 2 diabetes mellitus. Also, as a class, the older first-generation antipsychotics are more likely to be associated with movement disorders, but this is primarily true of medications that bind tightly to dopaminergic neuroreceptors, such as haloperidol, and less true of medications that bind weakly, such as chlorpromazine. Anticholinergic effects are especially prominent with weaker-binding first-generation antipsychotics, as well as with the second-generation antipsychotic clozapine. All antipsychotic medications are associated with an increased likelihood of sedation, sexual dysfunction, postural hypotension, cardiac arrhythmia, and sudden cardiac death. Primary care physicians should understand the individual adverse effect profiles of these medications. They should be vigilant for the occurrence of adverse effects, be willing to adjust or change medications as needed (or work with psychiatric colleagues to do so), and be prepared to treat any resulting medical sequelae.
·aafp.org·
Adverse Effects of Antipsychotic Medications