Central nervous system (CNS) depressants used to manage symptoms of psychosis and anxiety disorders include antipsychotics and anxiolytics, which may cause psychosis. Antipsychotics are also…
S3E117: Series III, Part V: From Burnout To Balance: How Therapy Can Transform OCPD Warriors’ Lives
Join your host, Nicole Morris, LMFT and Mental Health Correspondent, for Part V of our 3rd Annual OCRD Series to chat about Obsessive Compulsive Personality ...
Should You Consider Botox Injections for Your Bladder?
When people think of Botox®, most think of cosmetic or plastic surgery. But Botox injections can be used to treat urinary incontinence and overactive bladder symptoms, too. Are injections right for you?
Skull Base Bone Lesions II: Benign and Malignant Tumors
Abstract This chapter describes primary and secondary bone tumors affecting the skull base and provides important epidemiologic and imaging clues for the differential diagnosis. Except for bone met…
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Pray as you fall asleep and enjoy a healing, restful, deep sleep tonight. Meditate on the Peace of God, above all understanding. This soothing meditation read by James Seawood helps you relax. Abide App Meditation has been watched by millions to rest every night. Embracing peace along with millions of others using the Abide app!
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0:16 God's presence brings comfort and eliminates fear
22:07 The Apostle John's understanding of Jesus
57:55 Jesus teaches his followers not to worry and to trust in God
1:13:39 God cares for his creation and provides for our needs
1:30:45 God brings joy, healing, and peace to those who trust in Him
2:09:39 The Holy Spirit in us is proof of God's love and care
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https://www.youtube.com/watch?v=Q0IYEUDCuOQ
Meditation: I AM NOT AFRAID in the Abide App
Gentle relaxation music and bible sleep stories is a perfect to sleep. Find comforting presence of God. Christian meditation and Bible stories can help improve sleep. Rest in the deep assurance of God's love.
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First Manic Episode in a 55-Year-Old Man After Initiation of Aripiprazole
Aripiprazole is a novel antipsychotic medication that is used to treat a number of psychiatric conditions, including schizophrenia, bipolar disorder, and major depressive disorder. Although not specifically indicated for this, novel antipsychotics ...
Oral Fenbendazole for Cancer Therapy in Humans and Animals
Fenbendazole is a benzimidazole anthelmintic agent commonly used to treat animal parasitic infections. In humans, other benzimidazoles, such as mebendazole and albendazole, are used as antiparasitic agents. Since fenbendazole is not currently approved by the FDA or EMA, its pharmacokinetics and safety in humans have yet to be well-documented in medical literature. Despite this, insights can be drawn from existing in vitro and in vivo animal studies on its pharmacokinetics. Given the low cost of fenbendazole, its high safety profile, accessibility, and unique anti-proliferative activities, fenbendazole would be the preferred benzimidazole compound to treat cancer. To ensure patient safety in the repurposing use of fenbendazole, it is crucial to perform clinical trials to assess its potential anticancer effects, optimal doses, therapeutic regimen, and tolerance profiles. This review focuses on the pharmacokinetics of orally administered fenbendazole and its promising anticancer biological activities, such as inhibiting glycolysis, down-regulating glucose uptake, inducing oxidative stress, and enhancing apoptosis in published experimental studies. Additionally, we evaluated the toxicity profile of fenbendazole and discussed possibilities for improving the bioavailability of the drug, enhancing its efficacy, and reducing potential toxicity.
Cholinesterase Inhibitors: Alzheimer's Uses, Side Effects
Cholinesterase inhibitors are drugs that prevent the breakdown of acetylcholine, and blocks the action of acetylcholinesterase in the body. Researchers believe that decreased levels of acetylcholine in the brain causes Alzheimer's disease symptoms. Common side effects of cholinesterase inhibitors are insomnia, abnormal dreams, weight loss, headache, nausea, vomiting, diarrhea, confusion, and fatigue.
~Venlafaxine and ODV have no significant affinity for muscarinic,
~Aggression may occur in some patients who have received antidepressants, including venlafaxine treatment, dose reduction, or discontinuation
~aggression have been observed in patients during changes in venlafaxine dosing regimen, including during discontinuation
~Discontinuation.. symptoms include aggression, agitation,
Muscarinic acetylcholine receptor expression in memory circuits: Implications for treatment of Alzheimer disease
Cholinergic transmission at muscarinic acetylcholine receptors (mAChR) has been implicated in higher brain functions such as learning and memory, and loss of synapses may contribute to the symptoms of Alzheimer disease. A heterogeneous family of ...
The potential of muscarinic M1 and M4 receptor activators for the treatment of cognitive impairment associated with schizophrenia
Cognitive impairment is a core symptom of schizophrenia and a major determinant of poor long-term functional outcomes. Despite considerable efforts, we do not yet have any approved pharmacological treatments for cognitive impairment associated with ...
Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia | NEJM
The muscarinic receptor agonist xanomeline has antipsychotic properties and is devoid
of dopamine receptor–blocking activity but causes cholinergic adverse events. Trospium
is a peripherally restri...
Dementia with Lewy bodies (DLB) is a type of dementia characterized by changes in sleep, behavior, cognition, movement, and regulation of automatic bodily functions. Memory loss is not always an early symptom. The disease worsens over time and is usually diagnosed when cognitive impairment interferes with normal daily functioning. Together with Parkinson's disease dementia, DLB is one of the two Lewy body dementias. It is a common form of dementia, but the prevalence is not known accurately and many diagnoses are missed. The disease was first described on autopsy by Kenji Kosaka in 1976, and he named the condition several years later.