Having elevated uric acid indicates high blood pressure. New research demonstrates that lowering uric acid with allopurinol results in lower blood pressure.

Effectively Manage Your Uric Acid. Find the supplies you need to manage your uric acid easily and accurately with state-of-the-art UriTouch Blood Uric Acid Monitoring System.

Researchers set out to determine if there is a relationship between elevation of uric acid and erectile dysfunction in men.

We want to do everything we can to keep our uric acid levels in the optimal range, typically below 5.5 mg/dl. And by far and away, the biggest contributor to the elevation of uric acid that we are seeing around the world seems to be the global increase in consumption of fructose sugar. That said, there are other contributors to the formation of uric acid, and one of them is alcohol. As it turns out, when we look at the metabolism of alcohol and recognize that it directly contributes to the formation of uric acid, we shouldn't be surprised that alcoholic beverages do in fact increase uric acid. To a significant degree it depends on what type of alcohol is consumed, and indeed there are some gender-specific findings as well that are important. This is important information that leverages the new and exciting research coming out from around the world on the threat posed by elevation of uric acid in terms of our health. In my new book, Drop Acid (https://www.drperlmutter.com/books/drop-acid/), I do a deep dive into the science of uric acid and provide a valuable game plan for getting uric acid levels under control. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

It has been revealed that a central mechanism that reduces the activity of AMPK, paving the way for fat retention and elevated glucose is uric acid.

Let’s unpack a unique compilation of supplements and explore not just the value of each component and how they work synergistically to lower uric acid.

UAsure is an easy and quick way (just three steps with results in thirty seconds!) to measure the level of uric acid in your blood at any given time.

UAsure is an easy and quick way (just three steps with results in thirty seconds!) to measure the level of uric acid in your blood at any given time.

UAsure is an easy and quick way (just three steps with results in thirty seconds!) to measure the level of uric acid in your blood at any given time.

UAsure is an easy and quick way (just three steps with results in thirty seconds!) to measure the level of uric acid in your blood at any given time.

UAsure is an easy and quick way (just three steps with results in thirty seconds!) to measure the level of uric acid in your blood at any given time.

If you don’t have kidney stones or gout, why would you need to know your uric acid level? As it turns out, this is a key metric to understand.

UAsure is an easy and quick way (just three steps with results in thirty seconds!) to measure the level of uric acid in your blood at any given time.

UAsure is an easy and quick way (just three steps with results in thirty seconds!) to measure the level of uric acid in your blood at any given time.

UAsure is an easy and quick way (just three steps with results in thirty seconds!) to measure the level of uric acid in your blood at any given time.

Unfortunately, there is still so much old-school information out there about Uric acid, mostly derived from the science surrounding gout. We know that purines, the breakdown products of DNA and RNA, do contribute to uric acid in the human body. That said, for many years, doctors were telling people to not consume vegetables that are high in purines for fear of raising their uric acid if that was a problem for them. The great news is that we now know that these very helpful vegetables are actually associate with a lower uric acid level! ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

So many people these days are having issues with weight gain and even obesity and with good reason. The diet that many people are consuming is remarkably different in comparison to what people ate even one hundred years ago. One of the biggest changes has been the amount of sugar, specifically fructose, that has entered the human diet. Fructose consumption in humans enhances insulin resistance and the creation of body fat. Importantly, as well, fructose metabolism increases the production of uric acid, which further contributes to increasing body weight through several mechanisms. In fact, uric acid directly relates to overweight and obesity, even beyond its connection to fructose. This video explores this relationship as well as what leads to elevation of uric acid, again in the context of overweight and obesity. This study and so many more will be incorporated into my new book Drop Acid (https://www.dropacidbook.com), where you will learn the specifics of uric acid management including how to measure it and what to do to bring it under control. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

This work aimed to investigate the effect of fucoidan (FPS) on urate transporters induced by uric acid (UA). The results showed that UA stimulated the expression of glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) in HK-2 cells, and FPS could reverse the effect. Moreover, UA could activate NF-κB, JNK and PI3K/Akt pathways, but both pathway inhibitors and FPS inhibited the UA-induced activation of these three pathways. These data suggested that FPS effectively inhibited the expression induction of reabsorption transporters URAT1 and GLUT9 by UA, through repressing the activation of NF-κB, JNK and PI3K/Akt signal pathways in HK-2 cells. The in vitro research findings support the in vivo results that FPS reduces serum uric acid content in hyperuricemia mice and rats through inhibiting the expression of URAT1 and GLUT9 in renal tubular epithelial cells. This study provides a theoretical basis for the application of FPS in the treatment of hyperuricemia.

So many choices we make each and every day factor into our risk of developing dementia, basically an untreatable condition. We know that, for example, foods that raise blood sugar are associated with risk as is lack of exercise. Now we have learned that having a high uric acid also, dramatically, factors into our risk calculation. Understanding this is so empowering! ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

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Hyperuricemia is a common metabolic disease with prominent morbidity, it can lead to many adverse effects and complications, such as chronic nephrosis…

The link between Parkinson’s and dairy may not just be explained by the pesticides and lactose. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ Dairy and Parkinson’s? See Preventing Parkinson’s Disease With Diet (http://nutritionfacts.org/video/preventing-parkinsons-disease-with-diet) Lactose and Parkinson’s? See Could Lactose Explain the Milk - Parkinson’s Disease Link? (http://nutritionfacts.org/video/could-lactose-explain-milk-parkinsons-disease-link) Uric acid as an antioxidant? I’ve touched on that before in Miocene Meteorites and Uric Acid (http://nutritionfacts.org/video/miocene-meteorites-and-uric-acid/). If levels are too high consider cutting down on Flesh and Fructose (http://nutritionfacts.org/video/flesh-and-fructose/) and eating cherries (see Gout Treatment with a Cherry on Top (http://nutritionfacts.org/video/gout-treatment-with-a-cherry-on-top/) and Treating Gout with Cherry Juice (http://nutritionfacts.org/video/treating-gout-with-cherry-juice/)). Check out Preventing Gout Attacks with Diet (http://nutritionfacts.org/video/preventing-gout-attacks-with-diet/). Can a plant-based diet be used to treat Parkinson’s? See Treating Parkinson’s Disease With Diet (http://nutritionfacts.org/video/treating-parkinsons-disease-with-diet/). Any plant foods in particular that may help? Try nightshade veggies: • Is Something in Tobacco Protective Against Parkinson’s Disease? (http://nutritionfacts.org/topics/Is-something-in-tobacco-protective-against-parkinsons-disease) • Peppers and Parkinson’s: The Benefits of Smoking Without the Risks? (http://nutritionfacts.org/video/peppers-and-parkinsons-the-benefits-of-smoking-without-the-risks) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/parkinsons-disease-and-the-uric-acid-sweet-spot and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/parkinsons-disease-and-the-uric-acid-sweet-spot. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image Credit: Meditations via Pixabay. Image has been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

There is an ever-increasing body of evidence that clearly shows the incredible threat posed by dietary fructose in multiple areas of human health. A diet higher in fructose is associated with increased risk for weight gain and type 2 diabetes, and just considering these two processes alone, the stage becomes set for all kinds of other downstream maladies. We are now seeing robust data that relates fructose consumption to increased risk of brain degeneration and even compromised brain function. In this video, I explore one recent publication that was quite extensive and related fructose consumption in the form of beverages to a rapid increase in brain shrinkage as well as a significant decline in cognitive function. We then explore the mechanisms whereby this occurs including how fructose is metabolized into uric acid, compounding the threat to the brain. In my new book, Drop Acid (https://amzn.to/309RuqN), we go much deeper into the science that reveals how elevated uric acid, a product of fructose metabolism, poses such a significant threat to the brain. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

This work aims to explore the amelioration of fucoidan on adenine-induced hyperuricemia and hepatorental damage. Adenine-induced hyperuricemic mice were administered with fucoidan, allopurinol and vehicle control respectively to compare the effects of the drugs. Serum uric acid, urea nitrogen, hepatorenal functions, activities of hepatic adenosine deaminase (ADA), xanthine oxidase (XOD), renal urate transporter 1 (URAT1) and NF-κB p65 were assessed. As the serum uric acid, urea nitrogen, creatinine, glutamic oxalacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) data demonstrated, the adenine not only mediated hepatorenal function disorders, but also induced hyperuricemia in mice. Meanwhile, activities of hepatic ADA and XOD were markedly augmented by adenine, and the expression of URAT1 was promoted, which was conducive to the reabsorption of urate. However, exposure to fucoidan completely reversed those adenine-induced negative alternations in mice, and the activities of hepatic ADA and XOD were recovered to the normal level. It was obvious that hepatic and renal functions were protected by fucoidan treatment. The expression of URAT1 was returned to normal, resulting in an increase of renal urate excretion and consequent healing of adenine-induced hyperuricemia in mice. Expression and activation of NF-κB p65 was promoted in kidneys of adenine treated mice, but suppressed in kidneys of mice exposed to fucoidan from Laminaria japonica or allopurinol. In conclusion, the fucoidan is a potential therapeutic agent for the treatment of hyperuricemia through dual regulatory roles on inhibition of hepatic metabolism and promotion of renal excretion of urate.

Cherry consumption has been shown to successfully prevent gout arthritis attacks, but what about cherry juice concentrate? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ Here are the other videos I’ve done on the power of cherries to control inflammation: • Anti-inflammatory Life is a Bowl of Cherries (https://nutritionfacts.org/video/anti-inflammatory-life-is-a-bowl-of-cherries/) • Gout Treatment with a Cherry on Top (https://nutritionfacts.org/video/gout-treatment-with-a-cherry-on-top/) • Reducing Muscle Soreness With Berries (https://nutritionfacts.org/video/reducing-muscle-soreness-with-berries/) Tart cherries (the kind people make pies out of, not the sweet kind) may also help with sleep (Tart Cherries for Insomnia: https://nutritionfacts.org/video/tart-cherries-for-insomnia). What do you do with frozen cherries? I just eat them straight—suck on them like popsicles, but they’re also an integral part of my Healthy Chocolate Milkshakes (https://nutritionfacts.org/video/healthy-chocolate-milkshakes/). Another way to help treat gout is to drink lots of water and keep one’s urine alkaline by eating lots of dark green leafy vegetables (see Testing Your Diet with Pee & Purple Cabbage: https://nutritionfacts.org/video/testing-your-diet-with-pee-purple-cabbage/). Since this video came out, I have a newer one on gout: Preventing Gout Attacks with Diet (https://nutritionfacts.org/video/preventing-gout-attacks-with-diet/). And what role does uric acid play in Parkinson’s disease? See Parkinson’s Disease and the Uric Acid Sweet Spot (https://nutritionfacts.org/video/parkinsons-disease-and-the-uric-acid-sweet-spot/). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/flashback-friday-treating-gout-with-cherry-juice and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/flashback-friday-treating-gout-with-cherry-juice. You’ll also find a transcript and acknowledgments for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new Image Credit: cnick via Pixabay. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

This study aimed to explore the mechanism of fucoidan in chronic kidney disease (CKD)-triggered cognitive dysfunction. The adenine-induced ICR strain CKD mice model was applied, and RNA-Seq was performed for differential gene analysis between aged-CKD and normal mice. As a result, fucoidan (100 and 200 mg kg−1) significantly reversed adenine-induced high expression of urea, uric acid in urine, and creatinine in serum, as well as the novel object recognition memory and spatial memory deficits. RNA sequencing analysis indicated that oxidative and inflammatory signaling were involved in adenine-induced kidney injury and cognitive dysfunction; furthermore, fucoidan inhibited oxidative stress via GSK3β-Nrf2-HO-1 signaling and ameliorated inflammatory response through regulation of microglia/macrophage polarization in the kidney and hippocampus of CKD mice. Additionally, we clarified six hallmarks in the hippocampus and four in the kidney, which were correlated with CKD-triggered cognitive dysfunction. This study provides a theoretical basis for the application of fucoidan in the treatment of CKD-triggered memory deficits.

The NLRP3 inflammasome promotes the pathogenesis of metabolic, neurodegenerative and infectious diseases. Increasing evidences show that the NLRP3 inflammasome is a promising therapeutic target in inflammatory diseases. Glucosamine is widely used as a dietary supplement to promote the health of cartilage tissue and is expected to exert anti-inflammatory activity in joint inflammation, which is a nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome-associated complication. Here, we investigated whether GlcN inhibits the NLRP3 inflammasome and dissected the underlying molecular mechanisms. We found that GlcN suppressed the NLRP3 inflammasome in mouse and human macrophages. A mechanistic study revealed that GlcN inhibited the expression of NLRP3 and IL-1β precursor by reducing reactive oxygen species generation and NF-κB activation in lipopolysaccharide-activated macrophages. GlcN also suppressed mitochondrial reactive oxygen species generation and mitochondrial integrity loss in NLRP3-activated macrophages. Additionally, GlcN disrupted NLRP3 inflammasome assembly by inhibiting NLRP3 binding to PKR, NEK7 and ASC. Furthermore, oral administration of GlcN reduced peritoneal neutrophils influx and lavage fluids concentrations of IL-1β, IL-6 MCP-1 and TNF-α in uric acid crystal-injected mice. These results indicated that GlcN might be a novel dietary supplement for the amelioration of NLRP3 inflammasome-associated complications.