Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab707/6353927
Background
Post-vaccination myocarditis and pericarditis reported after coronavirus mRNA vaccines.
The effect of accidental intravenous injection of this vaccine on the heart is unknown
Methods in mice
Compared difference between i.m. and i.v. injection of vaccine
Clinical manifestations
Histopathological changes
Tissue mRNA expression
Serum levels of cytokines and troponins
With normal saline (NS) control
Results
Intravenous SARS-CoV-2 mRNA Vaccine Administration Induced Grossly Visible Pathology in Heart
Only IV group developed histopathological changes of myopericarditis
Evidenced by cardiomyocyte degeneration
Apoptosis
Necrosis with adjacent inflammatory cell infiltration
Calcific deposits on visceral pericardium
But
Evidence of coronary artery or other cardiac pathologies was absent
Spike antigen (immunostaining) occasionally found in infiltrating immune cells of the heart
And in cardiomyocytes and intracardiac vascular endothelial cells
The histological changes of myopericarditis after the first IV-priming dose persisted for 2 weeks
and were markedly aggravated by a second IM- or IV-booster dose
Numerous inflammatory cytokines found in cardiac tissue
(interleukin (IL)-1β, interferon (IFN)-β, IL-6, and tumor necrosis factor (TNF)-α)
in the IV group but not the IM group
compatible with presence of myopericarditis in the IV group
Ballooning degeneration of hepatocytes was consistently found in the IV group.
All other organs appeared normal.
Conclusions
In vivo evidence that inadvertent intravenous injection of COVID-19 mRNA vaccines may induce myopericarditis.
Brief withdrawal of syringe plunger to exclude blood aspiration may be one possible way to reduce such risk.
Both Pfizer/BioNTech and Moderna have clearly stated that their vaccines should only be given via IM route
Current CDC and WHO guidelines no longer recommend precautionary measures during IM vaccine administration
The CDC Pink Book 2020 and WHO
2015 position paper have recommended against aspiration prior to vaccine injection so as to minimize pain
Deltoid to the vastus lateralis?
Our study indicates that IV injection of vaccines might partially contribute to this clinical phenotype,
thus warranting a reconsideration of the practice of IM injection without aspiration,
which carries the risk of inadvertent IV injection.
Thrombocytopenia in mice reported in 2006
Blood, (2006)
https://ashpublications.org/blood/article/109/7/2832/125650/Adenovirus-induced-thrombocytopenia-the-role-of
All mice received virus through a single tail vein injection
Thrombocytopenia has been consistently reported following the administration of adenoviral gene transfer vectors.
Keto Diet Proven Effective in Alzheimer's - with Dr. Matthew Phillips
In our discussions in recent years about Alzheimer's disease, certainly one dietary recommendation seems to gain the spotlight and that is a ketogenic diet.
Use the tag #Vaccine to bring up important documents related to Vaccine Exemptions, Prevention and Treatment. I am really impressed with the ! 1 Free Rapid Virus Recovery Book.
The sequel to the historic Judy Mikovitz interview lays bare the corrupt and dangerous machinations behind Covid and the mandatory vaccine through the expert eyes of Dr. David Martin.
Link to featured video
https://www.youtube.com/watch?v=ctwX1cz_-dw&t=323s
Link to Wefwafwa’s channel
https://www.youtube.com/channel/UCzsLklGgOttU3Se-WGLp7ow
(he needs more subscribers)
Link to support Wefwafwa’s work in Africa
patreon:https://www.patreon.com/awmedicalvideos
Drugs Shown to Inhibit SARS-CoV-2 in COVID-19 Disease: Comparative Basic and Clinical Pharmacology of Molnupiravir and Ivermectin
https://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v9-id1149.pdf
https://www.linkedin.com/in/leslie-adesuyi-ajayi-md-phd-fbpharmacols-fwacp-69154a38/
There are still many nations where vaccines are not yet widely available,
There is a gradual shift in focus, to antiviral drugs,
Adjunctive chemoprophylaxis
Active treatment of new SARS-CoV-2 infections
Post -vaccination breakthrough COVID-19 cases
The two ways to get new drugs
Develop novel antiviral drugs for SARS-CoV-2
Repurpose existing FDA -approved drugs to treat COVID-19
Ivermectin is the most studied “repurposed” medication globally,
in randomized clinical trials, retrospective studies and meta- analyses.
Molnupiravir and Ivermectin Anti-SARS- CoV-2 Mechanisms, Pharmacokinetics and Pharmacodynamics
Molnupiravir is a broad spectrum antiviral agent against SARS- CoV-2, SARS-CoV,
seasonal or pandemic influenza and MERS corona virus
Ivermectin is an FDA-approved, WHO essential drug used as broad spectrum antiparasitic, antibiotic
and which has demonstrated broad spectrum antiviral activity against RNA viruses, including HIV, Zika, MERS corona virus
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
https://www.sciencedirect.com/science/article/pii/S0166354220302011
5000-fold inhibition of SARS-CoV-2, (99.98% at 48 hours
The inhibitory concentration IC50 of Molnupiravir shows it to be a more potent anti-SARS-CoV-2 agent, compared to Ivermectin in vitro.
Both molnupiravir and ivermectin are well absorbed after oral dosing
Tmax of molnupiravir being 1-1.75 hours,
With a half life of 7 hours
Tmax of ivermectin is 4-6 hours
Very long half life of 81-91 hours
Ivermectin, being lipophilic has a large volume of distribution
Ivermectin has the ability to accumulate in the lungs
The anti-SARS-CoV-2 actions, both of molnupiravir and ivermectin, are dose and concentration dependent
Molnupiravir active metabolite (NHC-5’ Triphosphate), acts as a competitive alternative substrate for viral RNA
causing viral mutagenesis or mutations, which leads to viral error catastrophe and extinction of replication
There is some concern about the safety of NHC -nucleoside triphosphate, which is also mutagenic to mammalian cells
Ivermectin, multifarious actions,
Binding to SARS-CoV-2 spike protein S
Reducing cell entry via human ACE2 receptors
Reducing viral transcription
Inhibition of cytokine production and inflammation
(not yet been shown for molnupiravir)
Complimentary pharmacokinetics and pharmacodynamics of the drugs
May be additive or synergistic
This should be further investigated in anti-SARS- CoV-2 antiviral combination therapy.
A combination of molnupiravir with Ivermectin putatively, in effects on RdRP or cytokine release.
Cost
https://www.who.int/selection_medicines/committees/expert/21/reviews/Ivermectin_Review1.pdf
The cost for a package of 100 tablets of 3 mg ivermectin is $2.96.
Say, 12mg per day for 5 days = $0.53
Safety
http://www.vigiaccess.org
https://www.who-umc.org/vigibase/vigibase/
Efficacy
Ivermectin
https://pubmed.ncbi.nlm.nih.gov/34145166/
For deaths, average risk ratio 0.38, (62% benefit) (moderate-certainty evidence
https://ivmmeta.com
Early treatment
Late treatment
Prophylaxis
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015017.pub2/epdf/full
Main results, Treating people in hospital with COVID-19
We don't know whether ivermectin compared with placebo or usual care, 28 days after treatment:–
leads to more or fewer deaths
worsens or improves patients' condition assessed by need for ventilation or oxygen
increases or reduces unwanted events
Preventing COVID-19
We don't know whether ivermectin leads to more or fewer deaths compared with no drug
The FDA has been assuming that nearly all of the adverse events reported in VAERS have been due to "over-reporting" of "background events." In short, there is nothing to see here: it's all noise. This
Fully Vaccinated Are COVID 'Super-Spreaders,' Says Inventor of mRNA
On the latest episode of "The Hidden Gateway" podcast, Dr. Robert Malone, recognized for his role in inventing mRNA vaccine technology, said, "The idea that if you have a workplace where everybody's vaccinated, you're not going to have virus spread is totally false. A total lie."
The Effect of Trehalose in Inhibiting Liver Damage via The Il-6 Pathway in Old Mice International Journal Papier Advance and Scientific Review
Trehalose is a non-reducing disaccharide consisting of two glucose molecules linked by a 1–1 glycosidic bond. Trehalose can play a role in organ detoxification, antioxidant enzyme activity, reducing lipid peroxidation and reducing the secretion of inflammatory factors TNF-, IL-1β, Il-6, thereby inhibiting liver damage. Because of its role, this study aims to determine the effect of trehalose administration on liver damage through the IL-6 expression pathway with experimental post-test design with control group design. This research was conducted using samples of old rats, namely Wistar rats (Rattus novergicus). The old rats used were 21 male species which were then divided into 3 groups, namely the old control group, the old rat group that was given sucrose, and the old rat group that was given trehalose. Then observed for 8 weeks, namely in March - May 2021 at the Faculty of Medicine, Hasanuddin University Makassar. The results obtained from the 3 groups showed a significant value that the administration of trehalose sugar in elderly mice had an effect on reducing the inflammatory factor IL-6 because it activated autophagy in macrophages thereby reducing cytokine production and vascular inflammation so as to be able to restore all aging mice to a level like observed in young mice. It is also known that aged rat liver, which is characterized by ER UPR activation and inflammatory signaling, decreases nicotinamide and UDP-N-acetyl-hexosamines, and reduces proteasome activity. Therefore, trehalose can be an effective therapeutic strategy against age-related disorders of proteostasis in the liver.
It’s Mandate Mayhem! Southwest Airlines in Disarray; Is Biden’s Vaccine Order Legal?; The Pushback Against Tyranny Goes Viral!; Tech CEO’s New Mandate-Free Job Site Guests: Tammy Clark, Kristen Meghan, Andrew Crapuchettes
How Israeli Ministry of Health, deleted thousands of testimonies
I re-posted this from YouTube (where it will surely be censored) to Rumble where it will live on. Original video from Avi Barak Media. This video details on how Israel citizens weren't given a place t
Think you might be gluten sensitive? Take the quiz:
https://www.glutenfreesociety.org/gluten-sensitivity-intolerance-self-test/
Can gluten cause muscle and joint pain? For genetically susceptible individuals, the intestinal damage caused by gluten in combination with an overactive immune system and chronic state of inflammation leads to celiac disease.
Celiac disease is an autoimmune condition that causes your immune system to attack your intestines, which creates even more damage and inflammation. But as I mentioned, the inflammatory effects aren’t limited to your gut. Which is why celiac disease is associated with many other autoimmune conditions. And several of them cause your immune system to attack your muscles and joints, which causes pain.
To connect with Dr. Osborne visit:
On the web: https://drpeterosborne.com/
Facebook: https://www.facebook.com/DoctorPeterOsborne/
Pinterest: https://www.pinterest.com/docosborne/
Instagram: https://www.instagram.com/drosborne
Twitter: https://twitter.com/glutenology
*These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Peter Osborne is one of the most sought after alternative and nutritional experts in the world. A Diplomate with the American Clinical Board of Nutrition, a graduate of Texas Chiropractic College, and a doctor of pastoral science, Dr. Osborne is one of the world’s leading authorities on gluten, nutrition, and natural health. He is the founder GlutenFreeSociety.org, one of the world's largest informational sites on gluten sensitivity. In addition, he is the author of the best selling book, No Grain No Pain, published by Touchstone (Simon & Schuster). His work has been featured by PBS, Netflix, Amazon, Fox, and many other nationally recognized outlets. For more information, visit us at https://www.glutenfreesociety.org/ or call 281-903-7527
Think you might be gluten sensitive? Take the quiz:
https://www.glutenfreesociety.org/gluten-sensitivity-intolerance-self-test/
Let's talk about some of the mechanisms of how gluten actually causes damage. Unfortunately, we're not going to get into all of them but I want to go over some of the major ones in this video.
- GI Damage and Leaky Gut - can lead to development of additional allergies and autoimmune disease.
- Malabsorption of Vitamins - leads to immune system deficits and inability to heal and repair.
- Altered Gut Bacteria - can lead to increased risk of infections and immune system dysregulation.
In each case, the pain is there because most likely you're doing something detrimental to your health - whether that's eating grain or other things that can cause chronic inflammatory pain or chemically induced pain. Grain represents more than 50 percent of the caloric intake of Americans and it's one of the top causes of chronic pain. If we could make this change, you would see pain clinics going out of business, and you would see hospitals with empty waiting rooms because so many people would be so much less inflamed and have so fewer problems as a result of this process driving their health into the hole into the ground.
To connect with Dr. Osborne visit:
On the web: https://drpeterosborne.com/
Facebook: https://www.facebook.com/DoctorPeterOsborne/
Pinterest: https://www.pinterest.com/docosborne/
Instagram: https://www.instagram.com/drosborne
Twitter: https://twitter.com/glutenology
*These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Peter Osborne is one of the most sought after alternative and nutritional experts in the world. A Diplomate with the American Clinical Board of Nutrition, a graduate of Texas Chiropractic College, and a doctor of pastoral science, Dr. Osborne is one of the world’s leading authorities on gluten, nutrition, and natural health. He is the founder GlutenFreeSociety.org, one of the world's largest informational sites on gluten sensitivity. In addition, he is the author of the best selling book, No Grain No Pain, published by Touchstone (Simon & Schuster). His work has been featured by PBS, Netflix, Amazon, Fox, and many other nationally recognized outlets. For more information, visit us at https://www.glutenfreesociety.org/ or call 281-903-7527
Is there a causal relationship between trehalose consumption and Clostridioides difficile infection - PubMed
Currently, there is no proven causal association between the incidence or severity of human CDI and the presence of trehalose metabolism variants. Furthermore, microbial metabolism reduces trehalose bioavailability, potentially removing this competitive advantage for C. difficile trehalose metabolis …
Effects of adding L-arginine orally to standard therapy in patients with COVID-19 A randomized, double-blind, placebo-controlled, parallel-group trial
In this interim analysis, adding oral L-arginine to standard therapy in patients with severe COVID-19 significantly decreases the length of hospitalization and reduces the respiratory support at 10 but not at 20 days after starting the treatment.
Hydrogen Peroxide as an Adjuvant Therapy for COVID-19 A Case Series of Patients and Caregivers in the Mexico City Metropolitan Area
Knowledge of the antiseptic effects of hydrogen peroxide (H2O2) dates back to the late 19th century, and its mechanisms of action has been amply described. Globally, many physicians have reported using H2O2 successfully, in different modalities, against COVID-19. Given its anti-infective and oxygenating properties, hydrogen peroxide may offer prophylactic and therapeutic applications for responding to the COVID-19 pandemic. We report a consecutive case series of twenty-three COVID-19 patients (of 36 initially enrolled) who had been diagnosed by their primary care physician (mean age: 39, range: 8 months–70 years; 74% male) and twenty-eight caregivers in the Mexico City Metropolitan Area who received a complementary and alternative medicine (CAM) telemedicine treatment with H2O2 taken by mouth (PO, at a concentration of 0.06%), oral rinse (mouthwash, 1.5%), and/or nebulization (0.2%). We describe the treatment program and report the response of the COVID-19 patients and their caregivers. The patients mainly recovered well, reporting feeling “completely better” at 9.5 days on average. Two (9%) were hospitalized prior to joining the study, and one did not fully recover. Patients frequently reported nausea and sometimes dizziness or vomiting related to the oral treatment. None of the twenty-eight caregivers in close contact with the patients reported contracting COVID-19. Given its low cost and medical potential and considering its relative safety if used properly, we suggest that randomized controlled trials should be conducted. These should include both SARS-CoV-2-positive and SARS-CoV-2-negative participants, with single or combined modes of administration of H2O2, to study the benefits of this simple molecule and offer safe guidance regarding its use by health professionals.
Click here to subscribe - https://www.glutenfreesociety.org/wxrn
Diabetes is a chronic health condition that affects how the body turns food into energy.
In simplified terms, carbohydrate-containing food that we eat gets broken down into sugar (or glucose) by the body and released into your bloodstream. When your blood sugar rises, it signals your pancreas to release insulin. Insulin helps to get the sugar from the blood into your body’s cells to be used as energy.
In a healthy person with properly-functioning insulin, this process works efficiently. However, if a person has diabetes, the body either doesn’t make enough insulin or can’t use the insulin it makes as well as it should. When there isn’t enough insulin, or if our cells stop responding to insulin, the amount of sugar rises in your bloodstream.
So how might gluten influence this process of food intake, blood sugar, and insulin function?
I'll answer this question and more in this Ultimate Crash Course on Diabetes!
(1:00) How prevalent is Type II Diabetes in the US?
(2:20) Lookout for these diabetes symptoms in children
(3:10) Comparison of different types of diabetes - Which came first?
(4:50) Type 3 Diabetes
(9:40) What is Gestational Diabetes?
(13:00) The impact of gluten in relation to diabetes
(15:15) Possible prevention of diabetes with a gluten free diet
(17:15) Leaky Gut - inflammation that contributes to diabetes
(19:20) Is a gluten free diet always a preventative?
(21:45) The BIGGEST keys to reversing diabetes
(35:00) Answering your questions, live.
Looking for the recommended supplements? Check out these gluten and grain free formulas:
Vitamin D - glutenfreesociety.org/GlutenFreeD
Zinc - glutenfreesociety.org/UltraZinc
COQ10 - glutenfreesociety.org/CoQ10Max
Magnesium - glutenfreesociety.org/UltraMg
B-Vitamins - glutenfreesociety.org/BComplete
Multivitamin - glutenfreesociety.org/UltraNutrients
To connect with Dr. Osborne visit:
On the web: https://drpeterosborne.com/
Facebook: https://www.facebook.com/DoctorPeterOsborne/
Pinterest: https://www.pinterest.com/docosborne/
Instagram: https://www.instagram.com/drosborne
Twitter: https://twitter.com/glutenology
*These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
Dr. Ealy's Fearless, Love-Driven Activism at It's Finest! EXPOSING Data Manipulation at the CDC : In this powerful interview, you will meet Dr. Henry Ealy, one of the most courageous, principled, and productive humanitarians of our time, who has gathered together some of the world's finest researchers to expose the CDC's COVID data manipulation and overinflation, which translated into the government's draconian COVID policies.Don't forget to check out the following links mentioned in this important interview (which we encourage you to share widely):1) Breaking News: Oregon legislators file for a Federal Grand Jury Investigation2) COVID-19 Data Collection, Comorbidity & Federal Law: A Historical Retrospective 3) The Problems With PCR Testing Why Public Officials Shouldn’t Base Restrictions On PCR Tests4) COVID-19: Restoring Public Trust During A Global Health Crisis5) Register for COVID CON 2021Don't forget to register for COVID CONFERENCE 2021, STARTING OCTOBER 14TH HERE. Get free access for the kick off day! You are invited to attend an exciting in-person and online event, the COVID CON ‘21 SOLUTION SUMMIT, kicking off October 14th, 15th & 16th from the Church of Glad Tidings in Live Oak, California!⠀✅ Claim Your Free Special Guest Pass at the LINK below for the first day of the conference & get 10% off for the rest of the weekend, using Promo Code: GMI.⠀What’s also fantastic about this community-building, solution-centered gathering is that all proceeds go directly towards funding unbiased science, public education and expert legal action coordinated to fight for and protect your freedom!⠀The good news is that the COVID CON ‘21 team has also created a growing list of FREE and amazingly useful resources to support you and your family available at the link HERE.
Senator Rand Paul, MD, laid into Xavier Becerra, the Secretary of the Department of Health and Human Services, last week for publicly insulting the intelligence of anyone who has questioned natural immunity over immunity from the #Covid vaccine. #RandPaul #XavierBecerra #FlatEarthers #HHS #NaturalImmunity #VaccineEfficacy #VaccineSafety #VaccineMandate #TheHighwire #DelBigtree #HW236 POSTED: October 8, 2021