2016

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1 Trehalose-Induced Remodelling of the Human Microbiota Affects Clostridioides difficile Infection Outcome in an In Vitro Colonic Model A Pilot Study
1 Trehalose-Induced Remodelling of the Human Microbiota Affects Clostridioides difficile Infection Outcome in an In Vitro Colonic Model A Pilot Study
Within the human intestinal tract, dietary, microbial- and host-derived compounds are used as signals by many pathogenic organisms, including Clostridioides difficile. Trehalose has been reported to enhance virulence of certain C. difficile ribotypes; ...
·ncbi.nlm.nih.gov·
1 Trehalose-Induced Remodelling of the Human Microbiota Affects Clostridioides difficile Infection Outcome in an In Vitro Colonic Model A Pilot Study
Mucopolysaccharidosis and Autophagy Controversies on the Contribution of the Process to the Pathogenesis and Possible Therapeutic Applications
Mucopolysaccharidosis and Autophagy Controversies on the Contribution of the Process to the Pathogenesis and Possible Therapeutic Applications
Mucopolysaccharidosis (MPS) consists of a group of 11 enzymatic defects which result in accumulation of undegraded glycosaminoglycans (GAG) in lysosomes. MPS is a severe metabolic disease for which only bone marrow/hematopoietic stem cell transplantation ...
·ncbi.nlm.nih.gov·
Mucopolysaccharidosis and Autophagy Controversies on the Contribution of the Process to the Pathogenesis and Possible Therapeutic Applications
1 Rand Paul Vs. Dr. Fauci Their Three Most Recent Senate Hearing Clashes - YouTube
1 Rand Paul Vs. Dr. Fauci Their Three Most Recent Senate Hearing Clashes - YouTube
Today was not the first time Sen. Rand Paul (R-KY) and Dr. Anthony Fauci clashed in a Senate hearing. READ MORE: https://www.forbes.com/sites/joewalsh/2021/07/20/fauci-and-rand-paul-accuse-each-other-of-lying-in-tense-testimony-over-covid-origins/?sh=623da6e64c73 Stay Connected Forbes on Facebook: http://fb.com/forbes Forbes Video on Twitter: http://www.twitter.com/forbes Forbes Video on Instagram: http://instagram.com/forbes More From Forbes: http://forbes.com
·youtube.com·
1 Rand Paul Vs. Dr. Fauci Their Three Most Recent Senate Hearing Clashes - YouTube
Lab Testing for Copper - don't be misled! - YouTube
Lab Testing for Copper - don't be misled! - YouTube
Work with Dr. Osborne: https://bit.ly/2njbynb Serum Copper can be very misleading for copper adequacy in the diet, typically a reflection of your last meal and not of long term storage. *Best Way to Test* Lymphocyte Proliferation – Measures long term storage Ceruloplasmin Red Blood Cell Levels To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
·youtube.com·
Lab Testing for Copper - don't be misled! - YouTube
! Episode 224 THE COVID CARTEL - The Highwire
! Episode 224 THE COVID CARTEL - The Highwire
The $1 Billion Whistleblower Search; International Vaccine Mandates Start; W.H.O. Insider Exposes Pandemic Response; The Ultimate Proof Masks Don’t Work! Guest: Astrid Stuckelberger, PhD #TheCovidCartel #WHO #Tedros #UnMaskUs #CovidVaccineWhistleblower ORIGINAL AIR-DATE: July 15, 2021
·thehighwire.com·
! Episode 224 THE COVID CARTEL - The Highwire
Trehalose and bacterial virulence
Trehalose and bacterial virulence
Trehalose is a disaccharide of two D-glucose molecules linked by a glycosidic linkage, which plays both structural and functional roles in bacteria. Trehalose can be synthesized and degraded by several pathways, and induction of trehalose biosynthesis ...
·ncbi.nlm.nih.gov·
Trehalose and bacterial virulence
Aloe vera gel extract Safety evaluation for acute and chronic oral administration in Sprague-Dawley rats and anticancer activity in breast and lung cancer cells - ScienceDirect
Aloe vera gel extract Safety evaluation for acute and chronic oral administration in Sprague-Dawley rats and anticancer activity in breast and lung cancer cells - ScienceDirect
Aloe vera (L.) Burm. f. is a typical traditional Chinese medicine (TCM) collected in the Pharmacopoeia of the People's Republic of China (version 2015…
·sciencedirect.com·
Aloe vera gel extract Safety evaluation for acute and chronic oral administration in Sprague-Dawley rats and anticancer activity in breast and lung cancer cells - ScienceDirect
Trehalose Augments Neuron Survival and Improves Recovery from Spinal Cord Injury via mTOR-Independent Activation of Autophagy
Trehalose Augments Neuron Survival and Improves Recovery from Spinal Cord Injury via mTOR-Independent Activation of Autophagy
Spinal cord injury (SCI) is a major cause of irreversible nerve injury and leads to serious tissue loss and neurological dysfunction. Thorough investigation of cellular mechanisms, such as autophagy, is crucial for developing novel and effective therapeutics. We administered trehalose, an mTOR-independent autophagy agonist, in SCI rats suffering from moderate compression injury to elucidate the relationship between autophagy and SCI and evaluate trehalose’s therapeutic potential. 60 rats were divided into 4 groups and were treated with either control vehicle, trehalose, chloroquine, or trehalose + chloroquine 2 weeks prior to administration of moderate spinal cord crush injury. 20 additional sham rats were treated with control vehicle. H&E staining, Nissl staining, western blot, and immunofluorescence studies were conducted to examine nerve morphology and quantify autophagy and mitochondrial-dependent apoptosis at various time points after surgery. Functional recovery was assessed over a period of 4 weeks after surgery. Trehalose promotes autophagosome recruitment via an mTOR-independent pathway, enhances autophagy flux in neurons, inhibits apoptosis via the intrinsic mitochondria-dependent pathway, reduces lesion cavity expansion, decreases neuron loss, and ultimately improves functional recovery following SCI (all ). Furthermore, these effects were diminished upon administration of chloroquine, an autophagy flux inhibitor, indicating that trehalose’s beneficial effects were due largely to activation of autophagy. This study presents new evidence that autophagy plays a critical neuroprotective and neuroregenerative role in SCI, and that mTOR-independent activation of autophagy with trehalose leads to improved outcomes. Thus, trehalose has great translational potential as a novel therapeutic agent after SCI.
·hindawi.com·
Trehalose Augments Neuron Survival and Improves Recovery from Spinal Cord Injury via mTOR-Independent Activation of Autophagy
Trehalose in Machado-Joseph Disease Safety, Tolerability, and Efficacy - PubMed
Trehalose in Machado-Joseph Disease Safety, Tolerability, and Efficacy - PubMed
Machado-Joseph disease (MJD) is relatively prevalent among the Yemenite Jewish subpopulation living in Israel. Currently, there is no treatment able to modify the disease progression. Trehalose is a disaccharide with protein-stabilizing and autophagy-enhancing properties. In animal models of MJD, tr …
·pubmed.ncbi.nlm.nih.gov·
Trehalose in Machado-Joseph Disease Safety, Tolerability, and Efficacy - PubMed
Brain-derived neurotrophic factor (BDNF) variation to aerobic exercise and aloe vera intake in women with type 2 diabetes
Brain-derived neurotrophic factor (BDNF) variation to aerobic exercise and aloe vera intake in women with type 2 diabetes
This study aimed to investigate the interactive effect of aloe vera intake and eight weeks’ aerobic exercise on serum BDNF, glucose, and insulin levels in women with type 2 diabetes. In this experimental study, 32 women with type 2 diabetes were selected and randomly divided into four groups of control, supplement, exercise, exercise + supplement. The exercise program was performed 3 sessions per week for 8 weeks (40 min of exercise with 50-60% of heart rate reserve in the first four weeks and 60 min of exercise with 60-80% of heart rate reserve in the second four weeks). The supplement taking groups received 400 mg/kg of oral aloe Vera 3 days per week for 8 weeks. The data were analyzed using analysis of covariance (ANCOVA). A significant increase was observed in BDNF levels, insulin sensitivity of patients in the supplement, exercise, and exercise + supplement groups (p=0.001). The glucose and insulin levels, insulin resistance, BMI, and body fat percentage significantly decreased in the supplement, exercise, and exercise + supplement groups (p=0.001). It seems aloe Vera intake and aerobic exercise to have protective effects against development of type 2 diabetes complications in women.
·jeoct.com·
Brain-derived neurotrophic factor (BDNF) variation to aerobic exercise and aloe vera intake in women with type 2 diabetes
Is there a link with gluten and OCD Would shingles be related to gluten exposure + more answers! - YouTube
Is there a link with gluten and OCD Would shingles be related to gluten exposure + more answers! - YouTube
Click here to subscribe - https://www.glutenfreesociety.org/wxrn 00:00 - I think my tell for gluten exposure is “brain fog”. 00:57 - is there a link with gluten and OCD? 01:10 - can gluten cause multiple chemical sensitivities? 01:46 - how long does it take for your brain or spinal cord to develop a lesion after being exposed to gluten? 03:51 - I have Celiac and ataxia. How much Vitamin C should I take? 04:40 - I have had microscopic colitis for 25 years 05:30 - can LPS form a biofilm? 05:56 - is IGG deficiency possible to repair? 07:58 - can fatty liver and diabetes cause the same leaky brain symptoms? 08:30 - migraines, depression, seizures 09:33 - how is it that centenarians in Italy eat grains and pasta yet still live for so long? 11:16 - would shingles be related to gluten exposure? 12:49 - I was diagnosed with MS and was told to avoid gluten. 14:09 - is it possible to heal nerve damage with a grain free diet? 15:42 - GI doctor told me not to take vitamin D unless test shows that it is low. 16:10 - is there a connection between gluten and Parkinson’s? 17:07 - My 12 year olds hands are shaking. Could that be a symptom? 19:45 - when you inadvertently consume gluten, what should you do? 20:34 - lemon seed consumption? 21:21 - blurry or double vision? 21:35 - root causes of degenerative disc disease 22:00 - is L-glutamine good to use for leaky gut? 22:40 - can celiac disease kill you in the long run? 23:10 - what is the one best food to fight inflammation? 24:30 - collagen for a leaky gut? 25:30 - can you eat too much meat? 26:53 - what do you think about alpha lipoic acid as a chelator of heavy metals? 27:35 - would tinnitus be considered a neurological problem if it was not due to noise? 28:37 - supplements being pulled from the market 29:25 - do probiotics make inflammation worse? 31:07 - best testing to see if you are gluten sensitive? 31:40 - my doctor told me: “don’t eat gluten, and see what happens” 33:34 - is white willow complex okay for people with tinnitus? 33:45 - is it okay to eat sorghum? 34:24 - Supplements to pull radiation out? 35:10 - more thoughts on the va((ine. To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
·youtube.com·
Is there a link with gluten and OCD Would shingles be related to gluten exposure + more answers! - YouTube
Neuroprotective and Preventative Effects of Molecular Hydrogen causes the release of ghrelin - PubMed
Neuroprotective and Preventative Effects of Molecular Hydrogen causes the release of ghrelin - PubMed
One of the beneficial effects of molecular hydrogen (H2, hydrogen gas) is neuroprotection and prevention of neurological disorders. It is important and useful if taking H2 every day can prevent or ameliorate the progression of neurodegenerative disorders, such as Parkinson's di …
·pubmed.ncbi.nlm.nih.gov·
Neuroprotective and Preventative Effects of Molecular Hydrogen causes the release of ghrelin - PubMed
How much water should I drink Is the 8 glasses rule valid - YouTube
How much water should I drink Is the 8 glasses rule valid - YouTube
Click here to subscribe - https://www.glutenfreesociety.org/wxrn Ultra Electrolytes - https://www.glutenfreesociety.org/shop/supplements/general-health/ultra-electrolytes/ AquaTru - https://www.aquatruwater.com/?oid=2&affid=25&c=POsborne The general guideline for water consumption from the National Academies of Sciences, Engineering, and Medicine is 15.5 cups per day for men and 11.5 cups per day for women. This recommendation refers to all fluids which can come from water, other unsweetened beverages like herbal tea, coconut water, and bone broth, and whole foods with high water content, like fruits and vegetables. However, these are general guidelines that group all men and women into one category. Clearly, needs are higher for some populations than others. This may include those who are physically active, live in warm or dry climates or at high altitude, and pregnant women. You can also gauge your intake and needs by tuning into your own thirst cues. We often misread thirst for hunger, so try water first before reaching for a snack next time. You can also pay attention to the color of your urine to get personalized feedback on how hydrated you are. If the color of your urine is very pale yellow to light yellow, you’re well hydrated. Darker yellow urine is a sign of dehydration. To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.
·youtube.com·
How much water should I drink Is the 8 glasses rule valid - YouTube