2016

9993 bookmarks
Newest
Effects of UV/H2O2 Degradation on the Physicochemical and Antibacterial Properties of Fucoidan
Effects of UV/H2O2 Degradation on the Physicochemical and Antibacterial Properties of Fucoidan
The applications of fucoidan in the food industry were limited due to its high molecular weight and low solubility. Moderate degradation was required to depolymerize fucoidan. A few studies have reported that fucoidan has potential antibacterial activity, but its antibacterial mechanism needs further investigation. In this study, the degraded fucoidans were obtained after ultraviolet/hydrogen peroxide treatment (UV/H2O2) at different times. Their physicochemical properties and antibacterial activities against Staphylococcus aureus and Escherichia coli were investigated. The results showed that the average molecular weights of degraded fucoidans were significantly decreased (up to 22.04 times). They were mainly composed of fucose, galactose, and some glucuronic acid. Fucoidan degraded for 90 min (DFuc-90) showed the strongest antibacterial activities against Staphylococcus aureus and Escherichia coli, with inhibition zones of 27.70 + 0.84 mm and 9.25 + 0.61 mm, respectively. The minimum inhibitory concentrations (MIC) were 8 mg/mL and 4 mg/mL, respectively. DFuc-90 could inhibit the bacteria by damaging the cell wall, accumulating intracellular reactive oxygen species, reducing adenosine triphosphate synthesis, and inhibiting bacterial metabolic activity. Therefore, UV/H2O2 treatment could effectively degrade fucoidan and enhance its antibacterial activity.
·mdpi.com·
Effects of UV/H2O2 Degradation on the Physicochemical and Antibacterial Properties of Fucoidan
Recent updates in the treatment of diabetic polyneuropathy - PMC
Recent updates in the treatment of diabetic polyneuropathy - PMC
Distal symmetric diabetic peripheral polyneuropathy (DPN) is the most common form of neuropathy in the world, affecting 30 to 50% of diabetic individuals and resulting in significant morbidity and socioeconomic costs. This review summarizes updates in ...
·ncbi.nlm.nih.gov·
Recent updates in the treatment of diabetic polyneuropathy - PMC
Nerve Damage and Celiac Disease - YouTube
Nerve Damage and Celiac Disease - YouTube
What is celiac disease and how does it cause nerve damage? Learn more: https://winsantor.com/nerve-damage-and-celiac-disease-the-hidden-connection/Visit our ...
·youtube.com·
Nerve Damage and Celiac Disease - YouTube
Fucoidan Improves Early Stage Diabetic Nephropathy via the Gut Microbiota–Mitochondria Axis in High-Fat Diet-Induced Diabetic Mice | Journal of Agricultural and Food Chemistry
Fucoidan Improves Early Stage Diabetic Nephropathy via the Gut Microbiota–Mitochondria Axis in High-Fat Diet-Induced Diabetic Mice | Journal of Agricultural and Food Chemistry
Diabetic nephropathy (DN) is a common microvascular complication of diabetes. Fucoidan, a polysaccharide containing fucose and sulfate group, ameliorates DN. However, the underlying mechanism has not been fully understood. This study aimed to explore the effects and mechanism of fucoidan on DN in high-fat diet-induced diabetic mice. A total of 90 C57BL/6J mice were randomly assigned to six groups (n = 15) as follows: normal control (NC), diabetes mellitus (DM), metformin (MTF), low-dose fucoidan (LFC), medium-dose fucoidan (MFC), and high-dose fucoidan (HFC). A technique based on fluorescein isothiocyanate (FITC-sinistin) elimination kinetics measured percutaneously was applied to determine the glomerular filtration rate (GFR). After 24 weeks, the mice were sacrificed and an early stage DN model was confirmed by GFR hyperfiltration, elevated urinary creatinine, normal urinary albumin, tubulointerstitial fibrosis, and glomerular hypertrophy. Fucoidan significantly improved the GFR hyperfiltration and renal fibrosis. An enriched SCFAs-producing bacteria and increased acetic concentration in cecum contents were found in fucoidan groups, as well as increased renal ATP levels and improved mitochondrial dysfunction. The renal inflammation and fibrosis were ameliorated through inhibiting the MAPKs pathway. In conclusion, fucoidan improved early stage DN targeting the microbiota–mitochondria axis by ameliorating mitochondrial oxidative stress and inhibiting the MAPKs pathway.
·pubs.acs.org·
Fucoidan Improves Early Stage Diabetic Nephropathy via the Gut Microbiota–Mitochondria Axis in High-Fat Diet-Induced Diabetic Mice | Journal of Agricultural and Food Chemistry
Taurine Powder - Pure Bulk Vitamins & Supplements - PureBulk, Inc.
Taurine Powder - Pure Bulk Vitamins & Supplements - PureBulk, Inc.
Supplement Facts & Directions Supplement Facts Serving Size: 800 milligrams Servings Per Container: Varies Amount Per Serving % Daily Value* Taurine 800 mg † * Percent Daily Values are based on a 2,000 calorie diet.† Daily Value Not Established ‡ These supplement facts may vary from the product you receive. Please call for exact numbers. Other Ingredients: None Contains: Free of: Sugar, Soy, Dairy, Yeast, Gluten, Corn & Additives. Directions: As a dietary supplement, take 800 mg (3/16 tsp) up to two times daily, or as directed by a physician. Accurate gram weight scale recommended. Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Keep out of reach of children. Store in a cool, dark & dry place. Product Details Did You Know? The word taurine comes from the Latin
·purebulk.com·
Taurine Powder - Pure Bulk Vitamins & Supplements - PureBulk, Inc.
Taurine Powder | Taurine Supplement
Taurine Powder | Taurine Supplement
Unleash the potential of your daily regimen with our pristine BulkSupplements.com Taurine powder. Pure, high-quality, fine powder for seamless mixing, it's the perfect addition to beverages or pre-workout shakes. Fuel your day with a serving of excellence – energizing your ambitions, one serving at a time. Get ready to power through!
·bulksupplements.com·
Taurine Powder | Taurine Supplement
Male Fertility and the Semen Microbiome - David Perlmutter M.D.
Male Fertility and the Semen Microbiome - David Perlmutter M.D.
It seems as if there is no limit to the various body systems that are now being characterized as having a unique association with bacteria and other resident living organisms. …
·drperlmutter.com·
Male Fertility and the Semen Microbiome - David Perlmutter M.D.