2016
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease
Thioredoxin-interacting protein (TXNIP) is an important regulatory protein for thioredoxin (TRX) that elicits the generation of reactive oxygen species (ROS) by inhibiting the redox function of TRX...
! 1 THE APPROACHING ‘TIDAL WAVE’ OF CANCER - The HighWire
Many have abandoned the media’s desperate attempt to ignore why cancer rates are spiking. Now, the American Cancer Society is sounding the alarm, predicting an 80% increase in tumors by 2050. Meanwhile, independent researchers have stepped up and honed in on credible sources pointing to the mass COVID vaccine rollout in 2021 as the prime […]
THE ANTIDOTE | The Explosive Truth, Origin, and Antidote for Covid-19 | SHARE EVERYWHERE.
Watch this explosive interview with Dr. Bryan Ardis and Jason Shurka exposing the truth, origin, and unexpected antidote for C19 that ravaged the world. Dr. Bryan Ardis is a renowned doctor and resear
Glucosamine Enhancement of Learning and Memory Functions by Promoting Fibroblast Growth Factor 21 Production
Fibroblast growth factor 21 (FGF21) plays a crucial role in metabolism and brain function. Glucosamine (GLN) has been recognized for its diverse beneficial effects. This study aimed to elucidate the modulation of FGF21 production by GLN and its impact on learning and memory functions. Using both in vivo and in vitro models, we investigated the effects of GLN on mice fed with a normal diet or high-fat diet and on mouse HT22 hippocampal cells, STHdhQ7/Q7 striatal cells, and rat primary cortical neurons challenged with GLN. Our results indicated that GLN promotes learning and memory functions in mice and upregulates FGF21 expression in the hippocampus, cortex, and striatum, as well as in HT22 cells, STHdhQ7/Q7 cells, and cortical neurons. In animals receiving GLN together with an FGF21 receptor FGFR1 inhibitor (PD173074), the GLN-enhanced learning and memory functions and induction of FGF21 production in the hippocampus were significantly attenuated. While exploring the underlying molecular mechanisms, the potential involvement of NF-κB, Akt, p38, JNK, PKA, and PPARα in HT22 and NF-κB, Akt, p38, and PPARα in STHdhQ7/Q7 were noted; GLN was able to mediate the activation of p65, Akt, p38, and CREB in HT22 and p65, Akt, and p38 in STHdhQ7/Q7 cells. Our accumulated findings suggest that GLN may increase learning and memory functions by inducing FGF21 production in the brain. This induction appears to be mediated, at least in part, through GLN’s activation of the NF-κB, Akt, p38, and PKA/CREB pathways.
Sean Hashmi MD - YouTube
Hello, dear friends! I'm Dr. Sean Hashmi, founder of SELF Principle, a community focused on the latest research in nutrition, longevity, health, wellness, and kidney disease. As a father, husband, and kidney disease specialist, my journey in medicine began with personal loss and my family's health struggles. These experiences ignited my passion to explore the healing power of nutrition and wellness. Here, we'll delve into scientific insights, engaging expert interviews, and real stories. More than just learning, this channel is about connecting, growing, and supporting one another on the path to better health. Your thoughts, challenges, and triumphs matter to me, so please SUBSCRIBE and join our VIP list by hitting the bell. Together, we'll embark on a journey toward understanding, compassion, and wellness. With heartfelt gratitude, Sean Hashmi, MD, MS, FASN
Plant Based Kidney Health - YouTube
Learn about your kidneys, how to protect them, and what to eat when you have kidney disease! Dr. Sean Hashmi is a Board Certified Nephrologist and Michele Crosmer is a Registered Dietitian and Certified Specialist in Renal Nutrition. We hope to educate and empower you to take control of your health and make proactive lifestyle choices to protect kidney health! Thanks so much for subscribing to our channel! Sean Hashmi, MD, MS, FASN and Michele Crosmer, RD, CSR
Allulose Reduces Hypertrophy and Endoplasmic Reticulum Stress Induced by Palmitic Acid in Murine 3T3-L1 Adipocytes
Natural rare sugars are an alternative category of sweeteners with positive physiologic and metabolic effects both in in vitro and animal models. D-allulose is a D-fructose epimer that combines 70% sucrose sweetness with the advantage of an extremely low energy content. However, there are no data about the effect of D-allulose against adipose dysfunction; thus, it remains to be confirmed whether D-allulose is useful in the prevention and in treatment of adipose tissue alterations. With this aim, we evaluated D-allulose’s preventive effects on lipid accumulation in 3T3-L1 murine adipocytes exposed to palmitic acid (PA), a trigger for hypertrophic adipocytes. D-allulose in place of glucose prevented adipocyte hypertrophy and the activation of adipogenic markers C/EBP-β and PPARγ induced by high PA concentrations. Additionally, D-allulose pretreatment inhibited the NF-κB pathway and endoplasmic reticulum stress caused by PA, through activation of the Nrf2 pathway. Interestingly, these effects were also observed as D-allulose post PA treatment. Although our data need to be confirmed through in vivo models, our findings suggest that incorporating D-allulose as a glucose substitute in the diet might have a protective role in adipocyte function and support a unique mechanism of action in this sugar as a preventive or therapeutic compound against PA lipotoxicity through the modulation of pathways connected to lipid transport and metabolism.
Is the April 8 Eclipse a Symbol of Divine Judgment or Not - The Ultimate Analysis - YouTube
Is the April 8 Eclipse a Symbol of God's Judgment or not? It IS the most anticipated eclipse in history with the National Guard already called out to control the crowds. But how can we decide if it's a sign from God or that judgment is coming? Click here to watch this Nelson Walters video to discover how to decide if it's a warning of God's judgment on the USA and when that might happen.
This video contains AI images from our AI Artist team including Christian Vichi, Robert Forsbach, Jonathan Merrill, Jason Lawrence, and FreethroughChrist
Testifying to the Resurrection - with Dr. Fred Baltz - YouTube
AUDIO ONLY: Timothy Mahoney concludes his discussion with Dr. Fred Baltz about the Sudarium of Oviedo, believed by many to be the burial face cloth of Jesus referenced in the Gospel of John, Chapter 20.
What kind of scientific analysis was used to study the Sudarium and what did the team conducting the analysis find? What additional connections have been made between the Sudarium and the Shroud of Turin? What does it mean for us today if these cloths are authentic?
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Two Main MTHFR Variants Explained: MTHFR C677T and MTHFR A1298C - YouTube
Discussing the two main MTHFR variations and our personal experiences with them in my recent podcast with Karalynne Call @just.ingredients.podcast
The two main MTHFR variants are MTHFR C677T and A1298C.
These MTHFR variants are also called MTHFR mutations, MTHFR polymorphisms, MTHFR SNPs.
Want to learn more about the MTHFR gene and 7 other really important ones? Read Dr. Lynch's book, Dirty Genes:
https://amzn.to/3TQh1yI
StrateGene Report:
Interpret over 100 genetic variations over 9 different pathways using your 23andme, Ancestry or SelfDecode raw data
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