2016

Anti-Inflammatory Properties of Glucosamine Used in Combination with Plants Extracts on Adjuvant Arthritis Rat. PubMed, SCI, Scopus, ESCI, PMC indexed

Atherosclerosis, cholesterol-driven plaque formation in arteries, is a complex multicellular disease which is a leading cause of vascular diseases. During the progression of atherosclerosis, the autophagic function is impaired, resulting in lipid accumulation-mediated foam cell formation. The stimulation of autophagy is crucial for the recovery of cellular recycling process. One of the potential autophagy inducers is trehalose, a naturally occurring non-reducing disaccharide. However, trehalose has poor bioavailability due to its hydrophilic nature which results in poor penetration through cell membranes. To enhance its bioavailability, we developed trehalose-releasing nanogels (TNG) for the treatment of atherosclerosis. The nanogels were fabricated through copolymerization of 6-O-acryloyl-trehalose with the selected acrylamide-type monomers affording a high trehalose conjugation (~ 58%, w/w). TNG showed a relatively small hydrodynamic diameter (dH, 67 nm) and a uniform spherical shape and were characterized by negative ζ potential (-18 mV). Thanks to the trehalose-rich content, TNG demonstrated excellent colloidal stability in biological media containing serum and were non-hemolytic to red blood cells. In vitro study confirmed that TNG could stimulate autophagy in foam cells and enhance lipid efflux and in vivo study in ApoE−/− mice indicated a significant reduction in atherosclerotic plaques, while increasing autophagic markers. In conclusion, TNG hold great promise as a trehalose delivery system to restore impaired autophagy-mediated lipid efflux in atherosclerosis and subsequently reduce atherosclerotic plaques. Graphical abstract

Carbohydrates are a structurally-diverse group of natural products which play an important role in numerous biological processes, including immune regulation, infection, and cancer metastasis. Many diseases have been correlated with changes in the composition ...

This is an excerpt from a Prophecy Watchers podcast titled "The Biblical Plan for Mideast Peace" which previously aired here on 11/30/23.Thanks For Watching...

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Non-GMO Project Verified, Keto Certified, Grain-Free/Gluten-Free Certified, FODMAP Friendly Certified, Kosher, Halal, Plant-Based and Naturally Vegan. RxSugar®. There Is No Substitute™. RxSugar® is Sugar Reimagined®! Live Swealthy™ - Sweet & Healthy!

Micro Ingredients Pure Allulose Sweetener, 3 Pounds (48 Ounces), Plant Based Brown Sugar Alternative, No After Taste, Keto Diet and Vegan Friendly. Fine Granules, Keto Friendly, Sugar Alternative, Zero Calorie Sweetener. Great for Tea, Coffee, Drinks, Baking, Cooking and More. Scoop included to get the measurement ever

BulkSupplements Allulose is a natural sweetener perfect for baking and adding sweetness to food and drinks without all of the excess sugar. It can also replace other sweeteners in recipes, allowing you to eat the same treats but with fewer calories and carbohydrates! This allulose is gluten free and filler free, making it safe for people with dietary restrictions. It's also incredibly easy to use - just substitute one cup of your usual sweetener with two-thirds of a cup of BulkSupplements Allulose and enjoy the same flavor without all of the unhealthy sugar content. If you're looking for a sugar substitute or want to cut down on your daily calorie intake, then try BulkSupplements Allulose today! You won't regret it!

D-allulose, a rare sugar, has been proposed to have potential benefits in addressing metabolic disorders such as obesity and type 2 diabetes (T2D). However, the precise mechanisms underlying these effects remain poorly understood. We aimed to elucidate the mechanisms by which D-allulose influences obesity-induced insulin resistance. We conducted gene set enrichment analysis on the liver and white adipose tissue of mice exposed to a high-fat diet (HFD) along with the white adipose tissue of individuals with obesity. Our study revealed that D-allulose effectively suppressed IFN-γ, restored chemokine signaling, and enhanced macrophage function in the livers of HFD-fed mice. This implies that D-allulose curtails liver inflammation, alleviating insulin resistance and subsequently impacting adipose tissue. Furthermore, D-allulose supplementation improved mitochondrial NADH homeostasis and translation in both the liver and white adipose tissue of HFD-fed mice. Notably, we observed decreased NADH homeostasis and mitochondrial translation in the omental tissue of insulin-resistant obese subjects compared to their insulin-sensitive counterparts. Taken together, these results suggest that supplementation with allulose improves obesity-induced insulin resistance by mitigating the disruptions in macrophage and mitochondrial function. Furthermore, our data reinforce the crucial role that mitochondrial energy expenditure plays in the development of insulin resistance triggered by obesity.

Allulose in human diet: the knowns and the unknowns - Volume 128 Issue 2

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We tried all six flavors of the "adult cereal" to see how it compares to its sugary counterparts.

Magic Spoon is high-protein, keto-friendly, gluten-free cereal with 0g of sugar. Available in Cocoa, Frosted, Blueberry, Peanut Butter and Cinnamon.

Get up to 53% off the P600 cookware and a FREE set of silicone utensils: https://chefsfoundry.com/DrPerlmutter🧠 Stay ahead with the latest in science, nutri...

In this enlightening video, renowned scientist Dr. Nathan S. Bryan delves into the fascinating world of Nitric Oxide (NO), unraveling its crucial role in our...

Have the writings of the Watchers or Fallen Angels been discovered in a PREFLOOD CITY in Turkey? Do these ruins warn about both the Flood and the final destr...

Scientist Paul Garner joins us again to discuss his book “Fossils and the Flood.” Informed by the latest creationist scholarship and richly illustrated—this ...

Jeffrey Dach MD, TrueMedMD

Should Christians keep the Sabbath or Sunday? It is a very controversial question. Or should they keep both? And more important than observing it is HOW shou...

Become a certified functional health coach with our online training programs! TRULY HEAL offers top health coach certification for natural cancer treatment, and more.

Understand the connection between sugar and nitric oxide production

(NaturalHealth365) Recent research indicates plastic chemicals are harmful to human health, may even damage your heart.

Background and Purpose Diabetic vascular complication is a leading cause of disability and mortality in diabetes patients. Low molecular weight fucoidan (LMWF) is a promising drug candidate for diab...

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(NaturalHealth365) Cooking potatoes and other foods at high temperatures can increase your risk of getting cancer. Find out more.