2016

(NaturalHealth365) PFAS chemicals are destroying your immune system at the cellular level. Discover proven strategies to reduce exposure.

Purpose of Review The discovery of per- and polyfluoroalkyl substances (PFAS) in the environment and humans worldwide has ignited scientific research, government inquiry, and public concern over numerous adverse health effects associated with PFAS exposure. In this review, we discuss the use of PFAS immunotoxicity data in regulatory and clinical decision-making contexts and question whether recent efforts adequately account for PFAS immunotoxicity in public health decision-making. Recent Findings Government and academic reviews confirm the strongest human evidence for PFAS immunotoxicity is reduced antibody production in response to vaccinations, particularly for tetanus and diphtheria. However, recent events, such as the economic analysis supporting the proposed national primary drinking water regulations and clinical monitoring recommendations, indicate a failure to adequately incorporate these data into regulatory and clinical decisions. Summary To be more protective of public health, we recommend using all relevant immunotoxicity data to inform current and future PFAS-related chemical risk assessment and regulation. Biological measures of immune system effects, such as reduced antibody levels in response to vaccination, should be used as valid and informative markers of health outcomes and risks associated with PFAS exposure. Routine toxicity testing should be expanded to include immunotoxicity evaluations in adult and developing organisms. In addition, clinical recommendations for PFAS-exposed individuals and communities should be revisited and strengthened to provide guidance on incorporating immune system monitoring and other actions that can be taken to protect against adverse health outcomes.

Our objective was to evaluate the effectiveness of a hempseed-enriched diet to improve health outcomes for the Apc min/+ mouse, a commonly used animal model for colorectal cancer. Numerous adenomas located in the epithelial wall of the small intestine cause nutrient malabsorption and disruption of gut barrier function that enables infiltration of endotoxins into the bloodstream. Systemic inflammation and marked losses of lean and adipose tissue result in a body-wasting condition called cachexia. We hypothesized that a hempseed-enriched diet would reduce the severity of tumor burden and cachexia in Apc min/+ mice fed the diet beginning at age 7 weeks up to 25 weeks. To test this hypothesis, three diet groups (n =8 each) of female Apc min/+ mice were studied in a longitudinal design using a base diet (AIN-93G) supplemented with ground whole hempseeds (w : w ) at either 0% (Control), 5%, or 15%. Food intake and body weight were recorded daily to assess energy balance and determine the onset of cachexia, as indicated by weight loss and decreased food intake. DXA scanning was performed throughout the study every four weeks during pre-cachexia and a final time after onset of cachexia at end point, when individual mice had lost approximately 15-20% of their maximum body weight. Mice in all three diet groups grew and gained weight characteristic of young growing mice during pre-cachexia between ages 5 and 12 weeks. The age of cachexia onset occurred after 12 weeks but varied between individual mice and did not appear to be influenced by diet. Decreases in body weight during cachexia were associated with decreased food intake. For all three diet groups, body compositional changes revealed losses of lean and adipose tissue, while bone mineral density was preserved. Visual inspection revealed that the intestinal tumors developed in all mice, including those fed the hempseed-enriched diet. Work is in progress to quantitatively determine intestinal tumor burden (tumor location, number, size, total area) in the fixed tissues. In conclusion, a hempseed-enriched diet alone, as an intervention, does not appear to have a remarkable impact on the prevention of intestinal tumors or cachexia in female Apc min/+ mice. (Sex differences were not evaluated.) Colorado State University Pueblo SEED Grant This abstract was presented at the American Physiology Summit 2025 and is only available in HTML format. There is no downloadable file or PDF version. The Physiology editorial board was not involved in the peer review process.

In this fascinating interview, Del Tackett talks with geologist Dr. Andrew Snelling about helium retention in zircon crystals from New Mexico granite. While ...

(NaturalHealth365) A brand new study confirms that toxic heavy metals like lead and mercury attack your heart in 7 devastating ways.

Earlier laboratory-based evidence has suggested that polyphenol-rich, decaffeinated whole coffee cherry extract (CCE) supports improvements in acute and long-term cognitive performance. To better understand CCE's potential to promote cognitive processing, we conducted a first-of-its-kind remote clin …

Objectives: Brain-derived neurotrophic factor (BDNF) plays an essential role in brain and metabolic health. The fact that higher concentrations are associated with improved cognitive performance has resulted in numerous intervention trials that aim at elevating BDNF levels. This systematic re …

There is an urgent need to identify interventions that broadly target aging-related cognitive decline and progression to Alzheimer’s disease (AD). Bottlenose dolphins (Tursiops truncatus) have histologic changes similar to AD in humans, and they also develop shared age-associated co-morbidities identified as risk factors for AD in humans, including type 2 diabetes, ferroptosis, and iron overload, which can be driven by nutritional C15:0 deficiency. We hypothesized that (1) dolphins would have amyloid beta (Aβ) plaques and neuroinflammation that paralleled that of humans in relation to age-related progression, quantitative concentration, and brain region; and (2) C15:0 would have dose-dependent activities relevant to protecting cognitive health. Quantitative immunohistochemistry staining was used to assess 68 tissues from archived brains of 19 Navy dolphins to evaluate associations among amyloid beta (Aβ) plaques and neuroinflammation by brain region, sex, and age group. Further, dose-dependent C15:0 activities, using a third-party panel intended to screen for potential AD therapeutics, were evaluated. Similar to humans, dolphins had the highest Aβ plaque density variation in the hippocampus (90th percentile of 4.95 plaques/mm2), where plaque density increased with age (p = 0.05). All measured markers of neuroinflammation were detected, including the highest concentrations of activated microglia (CD68+) in the hippocampus (0.46 ± 0.38 cells/mm2). C15:0 was a dose-dependent inhibitor of two targets, fatty acid amide hydrolase (FAAH) (IC50 2.5 µM, 89% maximum inhibition at 50 µM relative to URB597) and monoamine oxidase B (MAO-B) (IC50 19.4 µM, 70% maximum inhibition at 50 µM relative to R(-)-Deprenyl). These activities have demonstrated efficacy against Aβ formation and neuroinflammation, including protection of cognitive function in the hippocampus. These findings suggest that, in addition to protecting against AD co-morbidities, C15:0 may play a distinct role in supporting cognitive health, especially at higher concentrations.

This case-control of older US adults examines risk of Parkinson Disease by proximity of residence to a golf course.

There are many different forms of dementia. Learn how to identify symptoms and causes, while protecting yourself from cognitive impairment.

Intermittent and extended fasting has extraordinary health benefits. Discover how to put together a fasting lifestyle and improve your health!

Parkinson's disease is progressive neurological degenerative state. Discover natural solutions and 17 action steps to improve brain health.

Stanford Parkinson's Community Outreach has created a list of the best resources available on the topic of symptom trackers for PD.

A New & Improved App to Help Track Your Symptoms Each person’s Parkinson’s disease symptoms are different. The more you and your care team know, the more personalized your care can be. The user-friendly APDA Symptom Tracker app helps you capture the details of your symptoms, with new and enhanced features including a medication tracker, notes section, […]

Crippling brain injuries used to be a well recognized complication of vaccination. What changed?

(NaturalHealth365) New research reveals up to 13% of dementia cases may actually be treatable liver conditions.

The University of Rochester Medical Center (URMC) is one of the nation’s leading academic medical centers. It forms the centerpiece of the University of Rochester’s health research, teaching and patient care missions. The University of Rochester Medical Center is a private, coeducational, nonsectarian, and nonprofit research university.

Dr. Ray Dorsey is a medical doctor and Professor of Neurology at the University of Rochester. He is working to identify and eliminate the root causes of Park...

Jonathan Cahn opens up of the Book of Revelation, we’re going to see (& use!) one of the most amazing, important, and overlooked decoders that God has given ...

Jesus quoted the Old Testament to show WHEN Christians escape in the Rapture. What is that prophecy, when will it take place. Quoting the same passage, Paul ...

Unpacking what's inside real milk and the incredible health benefits it provides

Discover the transformative potential of L-Serine powder, a powerhouse in the world of wellness support. A favored choice among those who prioritize their health regimen, L-Serine stands out in the vast landscape of nutritional supplements. Experience a choice that discerning wellness enthusiasts trust—an addition to your daily routine that signifies dedication to optimal well-being.