2016

Cardiovascular disease (CVD) is the leading cause of death worldwide. The human body is populated by a diverse community of microbes, dominated by bacteria, but also including viruses and fungi. The largest and most complex of these communities is located in the gastrointestinal system and, with its associated genome, is known as the gut microbiome. Gut microbiome perturbations and related dysbiosis have been implicated in the progression and pathogenesis of CVD, including atherosclerosis, hypertension, and heart failure. Although there have been advances in the characterization and analysis of the gut microbiota and associated bacterial metabolites, the exact mechanisms through which they exert their action are not well understood. This review will focus on the role of the gut microbiome and associated functional components in the development and progression of atherosclerosis. Potential treatments to alter the gut microbiome to prevent or treat atherosclerosis and CVD are also discussed.

For years, the medical community has viewed Parkinson’s Disease (PD) primarily as a neurological disorder, defined by its hallmark motor symptoms such as tremors, rigidity, and postural instability. However, recent …

(NaturalHealth365) Research reveals that chemotherapy damages the brain. Find out how to regain cognitive function.

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Holistic practitioner, Barry Smeltzer, MPAS, PA-C, FAAEM, discusses his journey from conventional medicine after healing his son from autism with the help of his wife using alternative treatments. Hear about his Holistic Medical Clinic, Healing Provisions, and the upcoming annual conference with the American Academy of Environmental Medicine in San Antonio. POSTED: October 6, 2023

A new study has detected heart inflammation in all mRNA vaccinated patients who were undergoing routine medical checkups for other reasons. If replicated, the findings could upend the idea of rare myocarditis after COVID vaccination.

Japanese researcher, Dr. Takayuki Miyazawa, took to the streets of Japan in an historic effort to convey information about research showing the Omicron variant may have been artificially synthesized. Learn how The HighWire has been leading the worldwide media coverage of this important issue. POSTED: October 9, 2023

(NaturalHealth365) Recent study found that developing type 2 diabetes before the age of 30 is especially dangerous.

(NaturalHealth365) Find out how common forms of seaweed may offer a natural way to suppress tumor growth and prevent cancer.

European Journal of Epidemiology - Light-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk factor. We applied...

Supplement Facts & Directions Supplement Facts Serving Size: 500 milligrams Servings Per Container: Varies Amount Per Serving % Daily Value* Lion's Mane Extract (Hericium erinaceus) (sporocarp) 500 mg       (Standardized to ≥30% Polysaccharide) † * Percent Daily Values are based on a 2,000 calorie diet.† Daily Value Not Established ‡ These supplement facts may vary from the product you receive. Please call for exact numbers. Supplement Facts Serving Size: 1 Capsule Servings Per Container: Varies Amount Per Serving % Daily Value* Lion's Mane Extract (Hericium erinaceus) (sporocarp) 500 mg (Standardized to ≥30% Polysaccharide) † * Percent Daily Values are based on a 2,000 calorie diet.† Daily Value Not Established ‡ These supplement facts may vary from the product you receive. Please call for exact numbers. Supplement Facts Serving Size: 1 Capsule Servings Per Container: Varies Amount Per Serving % Daily

Hericium erinaceus a culinary and medicinal mushroom is a well established candidate for brain and nerve health. Ganoderma lucidum, Grifola frondosa and Sarcodon scabrosus have been reported to have neurite outgrowth and neuronal health benefits. The ...

Epilepsy is a common neurological disorder of which seizures are a core symptom. Approximately one third of epileptic patients are resistant to antiepileptic drugs and therefore require alternative therapeutic options. Dietary and nutritional supplements ...

Supine blood pressure readings could spot heart problems missed by readings taken while seated, preliminary research suggests.

The application of antimicrobial textiles is rising rapidly because of their healthcare, comfort, and hygienic attributes. This work aimed to develop …

"Hit-and-run" treatment with senolytics, which in the case of D + Q have elimination half-lives

Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis-driven approach. SC accumulate with ageing and at causal sites of multiple chronic disorders, including diseases acco …

Ladies, you are looking at the power of carbon dioxide medicine. This is the same woman before, after one year and after two years of daily application of a carbon dioxide gel that is applied directly to the face. What this will do to the skin this will do to one’s internal tissues when... View Article

Clostridioides difficile , the leading cause of antibiotic-associated diarrhoea worldwide, is a genetically diverse species which can metabolise a number of nutrient sources upon colonising a dysbiotic gut environment. Trehalose, a disaccharide sugar consisting of two glucose molecules bonded by an α 1,1-glycosidic bond, has been hypothesised to be involved in the emergence of C. difficile hypervirulence due to its increased utilisation by the RT027 and RT078 strains. Here, growth in trehalose as the sole carbon source was shown to be non-uniform across representative C. difficile strains, even though the genes for its metabolism were induced. Growth in trehalose reduced the expression of genes associated with toxin production and sporulation in the C. difficile R20291 (RT027) and M120 (RT078) strains in vitro, suggesting an inhibitory effect on virulence factors. Interestingly, the R20291 TreR transcriptional regulatory protein appeared to possess an activator function as its DNA-binding ability was increased in the presence of its effector, trehalose-6-phosphate. Using RNA-sequencing analysis, we report the identification of a putative trehalose metabolism pathway which is induced during growth in trehalose: this has not been previously described within the C. difficile species. These data demonstrate the metabolic diversity exhibited by C. difficile which warrants further investigation to elucidate the molecular basis of trehalose metabolism within this important gut pathogen.

Should you take a creatine supplement? This is a frequent question I get asked when I lecture, as well as on various online forums. Ultimately, I think it makes a …

Salmonella typhimurium (ST) poses a serious threat to host health, and the adverse effects of antibiotic treatment necessitate the urgent search for i…

Dr. William Makis Discusses Turbo Cancers After the Shot.

Polymer nanoparticles deliver mRNA to the lung for mucosal vaccination Alexandra Suberi et al. Sci Transl Med. 2023. https://pubmed.ncbi.nlm.nih.gov/37585505/ . Injectable mRNA-based vaccines were ins

Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are caused by a combination of multiple events that damage neuronal function. A well-characterized biomarker of neurodegeneration is the accumulation of proteinaceous aggregates in the brain. However, the gradually worsening symptoms of neurodegenerative diseases are unlikely to be solely due to the result of a mutation in a single gene, but rather a multi-step process involving epigenetic changes. Recently, it has been suggested that a fraction of epigenetic alternations may be correlated to neurodegeneration in the brain. Unlike DNA mutations, epigenetic alterations are reversible, and therefore raise the possibilities for therapeutic intervention, including dietary modifications. Additionally, reactive oxygen species may contribute to the pathogenesis of Alzheimer’s disease and Parkinson’s disease through epigenetic alternation. Given that the antioxidant properties of plant-derived phytochemicals are likely to exhibit pleiotropic effects against ROS-mediated epigenetic alternation, dietary intervention may be promising for the management of neurodegeneration in these diseases. In this review, the state-of-the-art applications using single-cell multimodal omics approaches, including epigenetics, and dietary approaches for the identification of novel biomarkers and therapeutic approaches for the treatment of neurodegenerative diseases are discussed.

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(NaturalHealth365) A recent study revealed a connection between atopic dermatitis (eczema), and the development of IBD.

Papers Reviewed: Sep.22, 2023 - Blix et al. - Norwegian study of 20,000 women Sep. 2023 - Thabet et al. - Saudi Study of 500 women ages 18-45 Sep.2023 - Jensen et al. - Danish study of 13,600 women ages 16-65 Aug.2023 - Trogstad et al. - Norwegian study of 3972 women ages 18-30