The Crucial Role of NAD+ (Niacinamide) in Optimal Health- Interview with Nichola Conlon, Ph.D.,
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Niacinamide - Vitamin B3 Powder - PureBulk - PureBulk, Inc.
Supplement Facts & Directions Supplement Facts Serving Size: 450 milligrams Servings Per Container: Varies Amount Per Serving % Daily Value* Niacin (as Niacinamide) 450 mg 2250% * Percent Daily Values are based on a 2,000 calorie diet.† Daily Value Not Established ‡ These supplement facts may vary from the product you receive. Please call for exact numbers. Other Ingredients: None Contains: Free of: Sugar, Soy, Dairy, Yeast, Gluten, Corn & Additives. Directions: As a dietary supplement, take 450 mg daily, or as directed by a physician. Accurate gram weight scale recommended. Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Keep out of reach of children. Store in a cool, dark & dry place. Product Details What is Niacinamide? Niacinamide, also called nicotinamide, Vitamin B3, or nicotinic acid amide, is
This page contains all that I have written about the rapidly spreading COVID-19. My Public Health and clinical experience in Emergency Medicine and Internal Medicine have given me the tools to unde…
13 ways that the SARS-CoV-2 spike protein causes damage
The SARS-CoV-2 virus has four structural proteins. The spike, membrane, envelop, and nucleocapsid proteins. The spike protein protrudes from the middle of the coronavirus and attaches to the ACE2 r…
Correlation Analysis between Gut Microbiota Alterations and the Cytokine Response in Patients with Coronavirus Disease during Hospitalization - PubMed
The role of the intestinal microbiota in coronavirus disease 2019 (COVID-19) is being elucidated. Here, we analyzed the temporal changes in microbiota composition and the correlation between inflammation biomarkers/cytokines and microbiota in hospitalized COVID-19 patients. We obtained stool specime …
Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations - PubMed
Respiratory dysfunction after COVID-19 is associated with altered gut microbiota and persistently elevated LBP levels. Our results should be regarded as hypothesis generating, pointing to a potential gut-lung axis that should be further investigated in relation to long-term pulmonary dysfunction and …
COVID Long Hauler (Symptoms and Management) - YouTube
Please read and agree to the disclaimer before watching this video.
. COVID Long Hauler (Symptoms and Management)
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Possible causes
Is it because of the persistent virus or slow clearance of it?
Is it because of the immune cell mutation?
Is it because of autoimmune response due to molecular mimicry?
Is it because of other viruses reactivating e.g. EBV which in turn can cause fatigue.
Is it a blood flow issues to brain?
Is it an infection of the brain tissue?
Is it the damage to the endothelium of the blood vessels? (Difference in sex shows that the issue is more common in women which also aligns with more immune system issues in women, hence, it is possibly the immune system vs., endothelial damage.)
A registry for long haulers
https://youandmeregistry.com/about/
Leronlimab study
https://clinicaltrials.gov/ct2/show/NCT04678830
CCR5 receptor function is to help promote immune cell chemotaxis. It is also a receptor for the HIV virus.
https://en.wikipedia.org/wiki/CCR5
What is the problem (symptoms?)
More than 200 symptoms
Most common are the following
Fatigue
Body aches
Breathing issues
Brain fog/Cognitive impairment (similar to myalgic encephalomyelitis/chronic fatigue syndrome ME/CFS)
Cough
Chills
Sweat
Headache
GIT issues
References for symptoms
https://jamanetwork.com/journals/jama/fullarticle/2771111
https://greatist.com/health/covid-long-haulers-symptoms#what-a-day-feels-like
https://www.medrxiv.org/content/10.1101/2020.12.24.20248802v2
https://www.medrxiv.org/content/10.1101/2020.12.24.20248802v2.full.pdf
What is the tragedy?
Psychosomaticizing of the problem by physicians.
Outright ignoring it.
Not knowing how to approach it even when they empathize with the patient’s symptoms.
Harvard’s article
https://www.health.harvard.edu/blog/the-tragedy-of-the-post-covid-long-haulers-2020101521173
A good article to read
https://jamanetwork.com/journals/jama/fullarticle/2771111
How large is the problem?
More than 30% of the COVID patients.
Not necessarily only severe cases.
UK study says about 10%
Brain fog
Fluvoxamine, glymphatic massage, neck and spine pumping.
An important site to keep in mind for long haulers (long hauler science tracker)
https://www.c19recoveryawareness.com/research
Dr. Patterson and Dr. Yo paper
https://www.biorxiv.org/content/10.1101/2020.12.16.423122v1
Important points:
LH can result from mild infection as well. Hence, LH is not a consequence of the severe COVID only. That means labs for severe cases cannot represent accurately the LH consequence.
IL6, IL8, TNF-alpha are persistently high. They cycle.
Dr. Patterson
VEGF elevated in 79% of LH, burning sensation, neuropathy, numbness, tingling, weakness, brain fog.
Maraviroc decreases VEGF - helping with brain fog. Plus brings RANTES and IL6 down.
Triad: Ivermectin, Maraviroc, and low dose steroids are showing improvement (85%-90% are responding.)
Listen to Dr. Patterson and Dr. Yo for long hauler severity index
https://www.pscp.tv/w/1YqxoyWBjEBGv
CD8 cell count is very low - single digits. 2-7% normal is 30%. Almost as immunosuppressed as HIV.
Low CD8 count means detectable virus for 87 days
25% LHs have low CD8%.
CCR5 - allows cells to reach the area of inflammation. Maybe a delta 32 deletion causes protection against severe COVID. It is for the CCR5. It is possible that lower CCR5 receptors in heterozygous patients keeps the immune response to a lower level, while homozygous people for the CCR5 receptors have a higher number of CCR5 receptors responding more to RANTES, which in turn causes an overwhelming response to SARS-COV-2.
Maraviroc
https://en.wikipedia.org/wiki/Maraviroc
#drbeen #koolbeens #COVID ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
A central role for amyloid fibrin microclots in long COVIDPASC origins and therapeutic implications - PubMed
Post-acute sequelae of COVID (PASC), usually referred to as 'Long COVID' (a phenotype of COVID-19), is a relatively frequent consequence of SARS-CoV-2 infection, in which symptoms such as breathlessness, fatigue, 'brain fog', tissue damage, inflammation, and coagulopathies (dysfunctions of the blood …
Hyperbaric oxygen treatment for long coronavirus disease-19 a case report - PubMed
We report the first case of successfully treated long COVID symptoms with hyperbaric oxygen therapy with improvements in cognition and cardiopulmonary function. The beneficial effects of hyperbaric oxygen shed additional light on the pathophysiology of long COVID. As this is a single case report, fu …
Nutrients Free Full-Text The Role of Nutrients in Prevention, Treatment and Post-Coronavirus Disease-2019 (COVID-19)
SARS-CoV-2 virus, infecting human cells via its spike protein, causes Coronavirus disease 2019 (COVID-19). COVID-19 is characterized by shortness of breath, fever, and pneumonia and is sometimes fatal. Unfortunately, to date, there is still no definite therapy to treat COVID-19. Therefore, the World Health Organization (WHO) approved only supportive care. During the COVID-19 pandemic, the need to maintain a correct intake of nutrients to support very weakened patients in overcoming disease arose. The literature available on nutrient intake for COVID-19 is mainly focused on prevention. However, the safe intake of micro- and/or macro-nutrients can be useful either for preventing infection and supporting the immune response during COVID-19, as well as in the post-acute phase, i.e., “long COVID”, that is sometimes characterized by the onset of various long lasting and disabling symptoms. The aim of this review is to focus on the role of nutrient intake during all the different phases of the disease, including prevention, the acute phase, and finally long COVID.
The effect of statins on average survival in randomised trials, an analysis of end point postponement - PubMed
Statin treatment results in a surprisingly small average gain in overall survival within the trials' running time. For patients whose life expectancy is limited or who have adverse effects of treatment, withholding statin therapy should be considered.
Full article Serious adverse events and deaths in PCSK9 inhibitor trials reported on ClinicalTrials.gov a systematic review
(2020). Serious adverse events and deaths in PCSK9 inhibitor trials reported on ClinicalTrials.gov: a systematic review. Expert Review of Clinical Pharmacology: Vol. 13, No. 7, pp. 787-796.
PCSK9 Inhibitors and Neurocognitive Adverse Events Exploring the FDA Directive and a Proposal for N-of-1 Trials SpringerLink
Drug Safety - Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors are a novel class of medications that greatly lower low-density lipoprotein cholesterol (LDL-C) by upregulating LDL...
Full article LDL-C does not cause cardiovascular disease a comprehensive review of the current literature
(2018). LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature. Expert Review of Clinical Pharmacology: Vol. 11, No. 10, pp. 959-970.
First Effective Treatment for Long Covid Stunning Data from Huge New Study - YouTube
The long tail of Covid-19 has left hundreds of thousands suffering numerous and debilitating symptoms.
In this film I break down the results from my most recent study of 812 long haulers, on the efficacy of diet, supplements and medication in treating the condition and their effects on each of the symptoms.
Is there now a statistically proven regimen of treatment for the condition? Yes, I believe there is.
Huge thanks to Dr Tina Peers and Dr Ade Wentzel without whom none of this would have been possible.
IMPORTANT: It is ESSENTIAL to talk to your doctor before taking any supplements that you have not taken before, or begin taking them at a larger dose. This regimen is NOT appropriate for children so they should speak to their doctor before taking any of these.
Nicotinic acid / Niacin also has several strong counter-indications, they can be seen here:
https://www.nice.org.uk/donotdo/do-no...
https://en.wikipedia.org/wiki/Niacin
I have to be clear and say that I am not a doctor, nor am I personally advocating you take Niacin or any other supplement or medication mentioned in this film. This is a decision you must make yourself with the consultation of your GP if you have any concerns at all.
So, all that said - here is what I am currently taking.
Niacin: I started at a low dose (10-20mg)/ be careful of flushing
Selenium: 100mcg / day
Zinc: 15-30mg / day
Quercetin: 500mg 3x / day
Vitamin C: 500-1000mg 3x / day
Vitamin D: 3-5000iu / day
0:00 Introduction
0:49 The Treatment Plans
2:21 The Study
4:45 Treatment Efficacy
12:11 T and P Numbers
13:05 The Statistical Breakdown
16:36 Conclusion
Wondering who I am and why I'm making these films? I discuss it here:
https://www.youtube.com/watch?v=FULycGPmN18
REFERENCES:
MCAS and Long Covid - Dr Tina Peers:
https://static1.squarespace.com/static/5a4269f28c56a85fe95206ea/t/5fdbcd3932dbdf6e63fdace7/1608240486599/DrTinaPeers-LongCovid-17Dec2020.pdf
Miller, Wentzel & Richards - NAD+ deficiency and Covid 19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322475/
Nikita Alexandrov, NAD+ deficiency
https://nkalex.medium.com/the-team-of-front-line-doctors-and-biohackers-who-seem-to-have-solved-long-covid-5f9852f1101d
Original research: Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome
Long-term complications after COVID-19 are common, but the potential cause for persistent symptoms after viral clearance remains unclear.To investigate whether gut microbiome composition is linked to post-acute COVID-19 syndrome (PACS), defined as at ...
Original research Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome - PMC
Long-term complications after COVID-19 are common, but the potential cause for persistent symptoms after viral clearance remains unclear.To investigate whether gut microbiome composition is linked to post-acute COVID-19 syndrome (PACS), defined as at ...
Targeting the monocytic endothelial platelet axis with maraviroc and pravastatin as a therapeutic option to treat long covid post acute sequelae of covid
Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
There are limited proven therapies for COVID-19. Vitamin C’s antioxidant, anti-inflammatory and immunomodulating effects make it a potential therapeutic candidate, both for the prevention and amelioration of COVID-19 infection, and as an adjunctive therapy in the critical care of COVID-19. This literature review focuses on vitamin C deficiency in respiratory infections, including COVID-19, and the mechanisms of action in infectious disease, including support of the stress response, its role in preventing and treating colds and pneumonia, and its role in treating sepsis and COVID-19. The evidence to date indicates that oral vitamin C (2–8 g/day) may reduce the incidence and duration of respiratory infections and intravenous vitamin C (6–24 g/day) has been shown to reduce mortality, intensive care unit (ICU) and hospital stays, and time on mechanical ventilation for severe respiratory infections. Further trials are urgently warranted. Given the favourable safety profile and low cost of vitamin C, and the frequency of vitamin C deficiency in respiratory infections, it may be worthwhile testing patients’ vitamin C status and treating them accordingly with intravenous administration within ICUs and oral administration in hospitalised persons with COVID-19.