2016

Think your cholesterol test tells the whole story? Think again. In this episode, Dr. Nathan Bryan reveals three overlooked but essential blood tests that can...

As the fourth-largest global food crop, the quality and functional characteristics of processed potato products are closely linked to endogenous sugar metabolism in tubers, with the trehalose–sucrose metabolism playing a key role in processing adaptability. This study analyzed 333 accessions from a tetraploid potato natural population. The trehalose and sucrose content of potato tubers at harvest was quantified using the high-performance liquid chromatography (HPLC) method. Combined with whole-genome resequencing, a genome-wide association study (GWAS) was conducted to map regulatory loci and identify candidate genes. The results showed that relative trehalose content in tubers was 20.38–24.78, while relative sucrose content was 10.32–19.50. Frequency histograms for both sugars exhibited normal distributions characteristic of quantitative traits, and a positive correlation was observed between them. GWAS for trehalose identified 111 significant SNP loci, mainly on chromosomes 10 and 12, leading to the identification of 88 candidate genes. Kyoto encyclopedia of genes and genomes analysis (KEGG) revealed that trehalose-related genes were primarily involved in pathways such as ABC transporters, tricarboxylic acid (TCA) cycle, and cysteine and methionine metabolism. Candidate genes potentially regulating tuber trehalose content included GH10, GH28, GH127, UXS, UGT, PMEI, and MYB108. For sucrose, GWAS identified 279 significant SNP loci, mainly on chromosomes 5, 6, and 12, resulting in 111 candidate genes. KEGG enrichment analysis showed that sucrose-related genes were enriched in pathways including starch and sucrose metabolism, cyanoamino acid metabolism, and phenylpropanoid biosynthesis. Candidate genes potentially regulating tuber sucrose content included GH17, GH31,GH47, GH9A4, SPP1, BGLU12, GSA1, TPS8, cwINV4, HXK, UST, MYB5, MYB14, and WRKY11. Therefore, this study provides marker loci for trehalose and sucrose metabolism research, aiming to clarify their regulatory mechanisms and support potato variety improvement and superior germplasm development.

Regular use of glucosamine was associated with a reduced risk of several age-related chronic diseases. Further studies are needed to confirm these findings and to clarify its potential role in supporting healthy aging.

This study aimed to elucidate the anticancer mechanism of Fucoidan (FCD) in Benzo(a)pyrene (B(a)P)-induced lung cancer, especially its effect on club …

Unveiling Jay's Bhattacharya's extraordinary initiative to rebuild American Science

In what is yet another great investigative report by Lorie Johnson of CBN, we hear how coconut oil is helping people with Alzheimer's, Parkinson's, and ALS.

L-arginine is a semi-essential amino acid that serves as a precursor to nitric oxide (NO), which supports blood flow, cardiovascular health, and other physiological processes.

The Multi-Billion Dollar Deception That Turned Our Most Vital Molecule Into Public Enemy #1

More evidence that international health care organizations (and all governmental health care and regulatory agencies) are fully captured by Big Pharma.

Has a hidden secret discovery on the Temple Mount completely reversed Israel's plans for how to build the Third Temple? Was this discovery made by King David...

(NaturalHealth365) Russian study of 86 women reveals chemotherapy makes lasting impact on brain structure.

(NaturalHealth365) 8-year study of 5.7 million Americans reveals men with dementia face 24% higher mortality than women.

A long-term high-fat diet (HFD) causes obesity, disrupting gut microbiota and body metabolite balance, increasing the risk of Alzheimer's disease (AD). Fermented hempseed may restore microbiota balance, improve metabolism, and reduce neuroinflammation, potentially protecting against cognitive decline. This s

Beets became a health craze in 2012 after Olympic athletes revealed their secret weapon: beetroot’s ability to enhance performance through increased nitric o...

(NaturalHealth365) Groundbreaking analysis of 42 studies reveals how glyphosate fuels global fatty liver epidemic.

(NaturalHealth365) Nitrates in drinking water increase premature birth and low birth weight risk even at 1% of EPA safety levels.

How Scalar Wave Physics Validates Ancient Crystal Wisdom

Scientific fraud is on the rise. In this episode of Answers News, our hosts Bryan Osborne, Avery Foley, and Dr. Brian Thomas share their perspectives on this...

Watch now (48 mins) | My 2014 Interview on The Truth About Cancer

Parkinson’s disease is an age-related neurodegenerative disorder that is ameliorated with levodopa. However, long-term use of this drug is limited by …

In this weeks episode of the Dr Ardis Show, Dr. Ardis Answers to Parkinson’s , Dr. Ardis reveals natural strategies and science-backed solutions to help combat Parkinson’s disease and other neurologic

Taurine is a sulfur-containing, semi-essential amino acid that occurs naturally in the body. It alternates between inflammation and oxidative stress-mediated injury in various disease models. As part of its limiting functions, taurine also modulates ...

ChatGPT Just Admitted Its Antichrist Purpose...They said it was just a tool… but what if it’s part of something much darker? In this video, I confront ChatGP...

Why the same mushroom that expands your mind also extends your cellular lifespan

This study clarified the structure and digestive properties of the Laminaria japonica polysaccharide (LJP). It was demonstrated that LJP belongs to a heteropolysaccharide composed of mannuronic acid, fucose, galactose, glucuronic acid, mannose, xylose, glucose, and guluronic acid in the proportion of 34.56%: 30.55%: 10.63%: 7.52%: 6.66%: 3.74%: 3.62%: 2.72%, with a backbone chain composed of →4)-β-d-ManA-(1→, →3)-α-l-Fucp-(1→, →4)-α-GulA-(1→, →3,4)-α-GlcA-(1→, and →4)-β-d-GlcA-(1→. In vivo fluorescence imaging indicated that LJP was mainly distributed in the stomach and intestinal segments of mice, and the fluorescence signal gradually disappeared after 12 h of digestion. In addition, LJP had no effect on the phenotype and general health of mice while promoting the proliferation of the beneficial bacteria Rikenella, Rikenellaceae_RC9_gut_group. Notably, 100 mg/kg LJP significantly increased the levels of acetic and butyric acid in the mice feces, which were 1.51 and 2.65 folds higher than the controls, respectively. Our study illuminated the absorption and distribution mechanism of LJP, providing a scientific reference for revealing LJP as a potential prebiotic.

Rheumatoid arthritis is a persistent immune-mediated inflammatory disorder that primarily affects joint bones, impacting approximately 0.5–1.0% of the global population. People with RA are 1.5 times more likely to develop cardiovascular conditions, including atherosclerosis. This study explored the therapeutic potential of GAc in a rat model of RA induced by CFA, focusing on its impact on biomarkers associated with atherosclerosis. Molecular docking studies indicated strong binding affinities of GAc with key inflammatory cytokines, including TNF-α, IL-6, IL-1β, NF-κB and PRMT-1. The experimental model of 23 days involved the induction of arthritis by injecting 0.15 mL of CFA into the sub-plantar region of the rats’ left hind paws. GAc was dissolved in distilled water and administered to rats via oral gavage. Our results revealed that the administration of GAc, particularly in combination with MtxSt (GAc 10 g/kg + MtxSt), significantly (p < 0.001) reduced arthritic scores, joint stiffness scores, paw thickness, levels of lipids (LDL, VLDL, TG, and TC), asymmetric dimethylarginine (ADMA), homocysteine, oxidative stress, and pro-inflammatory cytokines. In addition, GAc markedly (p < 0.001) improved body weight, hematological parameters (RBC, %HCT and Hb), HDL, dimethylarginine dimethylaminohydrolase-1(DDAH-1), and CST levels. Histopathological assessments showed that GAc 10 g/kg + MtxSt significantly alleviated bone and cartilage erosion (p < 0.001), pannus formation (p < 0.001), synovial hyperplasia (p < 0.01), vascular congestion (p < 0.001) and inflammatory cell infiltration (p < 0.001). The therapeutic efficacy of GAc is ascribed to its anti-inflammatory, antioxidant, and anti-atherosclerotic properties. This study suggested that combining GAc with MtxSt exerts a synergistic effect in mitigating inflammation and reducing the risk of atherosclerosis associated with RA.

17 years after "The Dark Side of Wheat," the science is stronger and the stakes are higher