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Vaccine effectiveness against SARS-CoV-2 infection with the Omicron or Delta variants following a two-dose or booster BNT162b2 or mRNA-1273 vaccination series
Vaccine effectiveness against SARS-CoV-2 infection with the Omicron or Delta variants following a two-dose or booster BNT162b2 or mRNA-1273 vaccination series
In this brief communication we are showing original research results with early estimates from Danish nationwide databases of vaccine effectiveness (VE) against the novel SARS-CoV-2 Omicron variant (B.1.1.529) up to five months after a primary vaccination series with the BNT162b2 or mRNA-1273 vaccines. Our study provides evidence of protection against infection with the Omicron variant after completion of a primary vaccination series with the BNT162b2 or mRNA-1273 vaccines; in particular, we found a VE against the Omicron variant of 55.2% (95% confidence interval (CI): 23.5 to 73.7%) and 36.7% (95% CI: 69.9 to 76.4%) for the BNT162b2 and mRNA-1273 vaccines, respectively, in the first month after primary vaccination. However, the VE is significantly lower than that against Delta infection and declines rapidly over just a few months. The VE is re-established upon revaccination with the BNT162b2 vaccine (54.6%, 95% CI: 30.4 to 70.4%). ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study did not receive any funding ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: We used only administrative register data for the study. According to Danish law, ethics approval is exempt for such research, and the Danish Data Protection Agency, which is a dedicated ethics and legal oversight body, thus waives ethical approval for our study of administrative register data, when no individual contact of participants is necessary and only aggregate results are included as findings. The study is therefore fully compliant with all legal and ethical requirements and there are no further processes available regarding such studies. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes De-identified data are available for access to members of the scientific and medical community for non-commercial use only upon reasonable request to the authors
·medrxiv.org·
Vaccine effectiveness against SARS-CoV-2 infection with the Omicron or Delta variants following a two-dose or booster BNT162b2 or mRNA-1273 vaccination series
More Good News on Ivermectin
More Good News on Ivermectin
When it comes to the treatment of COVID-19, many Western nations have been hobbled by the politicization of ...
·theepochtimes.com·
More Good News on Ivermectin
Blood Clotting Symptoms, Causes, and Support Strategies - YouTube
Blood Clotting Symptoms, Causes, and Support Strategies - YouTube
In this video, I will go over what blood viscosity and blood clotting are. I will explain the major symptoms of poor blood viscosity. I will go over the risk factors for blood clotting. You will learn about diagnosis and conventional treatment options for blood clotting. You will understand the major functional root causes of blood clotting. I will share my top natural support strategies for blood clotting. For more info go here: https://drjockers.com/blood-clotting/ Inflam Defense: https://store.drjockers.com/products/inflam-defense Use coupon code Jockers10 at checkout to save orders on https://store.drjockers.com/
·youtube.com·
Blood Clotting Symptoms, Causes, and Support Strategies - YouTube
Relative Incidence of Office Visits and Cumulative Rates of Billed Diagnoses Along the Axis of Vaccination - PubMed
Relative Incidence of Office Visits and Cumulative Rates of Billed Diagnoses Along the Axis of Vaccination - PubMed
We performed a retrospective analysis spanning ten years of pediatric practice focused on patients with variable vaccination born into a practice, presenting a unique opportunity to study the effects of variable vaccination on outcomes. The average total incidence of billed office visits per outcome …
·pubmed.ncbi.nlm.nih.gov·
Relative Incidence of Office Visits and Cumulative Rates of Billed Diagnoses Along the Axis of Vaccination - PubMed
Episodes 1 Live
Episodes 1 Live
Watch Episode 1: Vaccine Truth: Dispelling the Myths This first episode is packed with the TRUTH about the vaccine. We’ve gathered a group of top vaccine experts who have tried to get the information to you but, instead, have been censored and suppressed. PLUS, we have a special BRAND NEW BONUS EPISODE tonight, featuring Dr. Peter McCullough and Dr. Bryan Ardis. You’ll discover the alarming answers to questions about the vaccine that the “experts” don’t want you to know. What Dr. Peter McCullough, an internist and cardiologist in Dallas, Texas, had to say about the deadly spike protein will leave you speechless. Even U.S. federal agencies are trying to cover up the research coming out about the harmful vaxx (unsuccessfully, as Dr. McCullough reveals). He goes into detail about the hundreds and hundreds of cases all around the world of top athletes dropping dead on the playing field. This is extremely alarming to hear. And the rest of what he covers includes even more disturbing studies, revealing data about vaxxed victim’s autopsies and shocking news you won't hear anywhere else. Dr. Bryan Ardis dives into numerous disturbing facts that will leave your brain spinning. For example, why are male teenagers showing 20x the heart problems after the jab than the CDC expected (surely they told the FDA about this, right?) And you have to hear what he had to say about the shocking statement he found in the American Heart Association’s Circulation Journal regarding what they’ve seen happening to patients’ hearts after receiving the jab… Turns out it has been a MASSIVE coverup. Who would have guessed that? Dr. Ardis also discusses the one disease happening after the jab that’s worrying doctors all over the world (once diagnosed, 20% will die in 2 years, 50% will die in 5 years). You need to hear this directly from Dr. Ardis himself, for your own safety.
·vsecretscc.com·
Episodes 1 Live
Scientists identify gut-derived metabolites that play a role in neurodegeneration -- ScienceDaily
Scientists identify gut-derived metabolites that play a role in neurodegeneration -- ScienceDaily
A New York-based, multi-institutional research team has found high levels of three toxic metabolites produced by gut bacteria in the cerebrospinal fluid and plasma samples of multiple sclerosis (MS) patients. The important findings further scientists' understanding of how gut bacteria can impact the course of neurological diseases by producing compounds that are toxic to nerve cells.
·sciencedaily.com·
Scientists identify gut-derived metabolites that play a role in neurodegeneration -- ScienceDaily
Antioxidants Free Full-Text Antioxidants into Nopal (Opuntia ficus-indica), Important Inhibitors of Free Radicals’ Formation HTML
Antioxidants Free Full-Text Antioxidants into Nopal (Opuntia ficus-indica), Important Inhibitors of Free Radicals’ Formation HTML
Nopal (Opuntia ficus indica) belonging to the Cactacea family has many nutritional benefits attributed to a wide variety of phenolic and flavonoid compounds. Coumaric acid (COA), ferulic acid (FLA), protocatechuic acid (PRA), and gallic acid (GAA) are the phenolic acids (PhAs) present in nopal. In this study, the role of these PhAs in copper-induced oxidative stress was investigated using the density functional theory (DFT). The PhAs form 5 thermodynamically favorable complexes with Cu(II), their conditional Gibbs free energies of reaction (ΔG’, at pH = 7.4, in kcal/mol) are from −23 kcal/mol to −18 kcal/mol. All of them are bi-dentate complexes. The complexes of PRA and GAA are capable of inhibiting the Cu(II) reduction by both O2•− and Asc−, their reactions with the chelated metal are endergonic having rate constants about ~10−5–102 M−1 s−1, PhAs can prevent the formation of hydroxyl free radicals by chelating the copper ions. Once the hydroxyl radicals are formed by Fenton reactions, the complexes of PhAs with Cu(II) can immediately react with them, thus inhibiting the damage that they can cause to molecules of biological interest. The reactions between PhAs-Cu(II) complexes and hydroxyl free radical were estimated to be diffusion-limited (~108 M−1s−1). Thus, these chelates can reduce the harmful effects caused by the most reactive free radical existent immediately after it is formed by Fenton reactions.
·mdpi.com·
Antioxidants Free Full-Text Antioxidants into Nopal (Opuntia ficus-indica), Important Inhibitors of Free Radicals’ Formation HTML