2016

Trehalose is a disaccharide of two D-glucose molecules linked by a glycosidic linkage, which plays both structural and functional roles in bacteria. Trehalose can be synthesized and degraded by several pathways, and induction of trehalose biosynthesis ...

Spinal cord injury (SCI) is a major cause of irreversible nerve injury and leads to serious tissue loss and neurological dysfunction. Thorough investigation of cellular mechanisms, such as autophagy, is crucial for developing novel and effective therapeutics. We administered trehalose, an mTOR-independent autophagy agonist, in SCI rats suffering from moderate compression injury to elucidate the relationship between autophagy and SCI and evaluate trehalose’s therapeutic potential. 60 rats were divided into 4 groups and were treated with either control vehicle, trehalose, chloroquine, or trehalose + chloroquine 2 weeks prior to administration of moderate spinal cord crush injury. 20 additional sham rats were treated with control vehicle. H&E staining, Nissl staining, western blot, and immunofluorescence studies were conducted to examine nerve morphology and quantify autophagy and mitochondrial-dependent apoptosis at various time points after surgery. Functional recovery was assessed over a period of 4 weeks after surgery. Trehalose promotes autophagosome recruitment via an mTOR-independent pathway, enhances autophagy flux in neurons, inhibits apoptosis via the intrinsic mitochondria-dependent pathway, reduces lesion cavity expansion, decreases neuron loss, and ultimately improves functional recovery following SCI (all ). Furthermore, these effects were diminished upon administration of chloroquine, an autophagy flux inhibitor, indicating that trehalose’s beneficial effects were due largely to activation of autophagy. This study presents new evidence that autophagy plays a critical neuroprotective and neuroregenerative role in SCI, and that mTOR-independent activation of autophagy with trehalose leads to improved outcomes. Thus, trehalose has great translational potential as a novel therapeutic agent after SCI.

Aloe vera (L.) Burm. f. is a typical traditional Chinese medicine (TCM) collected in the Pharmacopoeia of the People's Republic of China (version 2015…

Do you know your vitamin D level? If not, getting your blood tested—and optimizing your levels—is one of ...

The $1 Billion Whistleblower Search; International Vaccine Mandates Start; W.H.O. Insider Exposes Pandemic Response; The Ultimate Proof Masks Don’t Work! Guest: Astrid Stuckelberger, PhD #TheCovidCartel #WHO #Tedros #UnMaskUs #CovidVaccineWhistleblower ORIGINAL AIR-DATE: July 15, 2021

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ICAN wrote to the Chief of California’s OSHA to request that, to the extent that CAL OSHA’S recommendations will allow less stringent mask rules for fully vaccinated individuals, those less […]

Compared with a usual diet supplemented with low-fat healthy-eating guidelines, patients on the ketogenic diet improved in daily function and quality of...

A new theory for the causes of dementia and other neurodegenerative diseases has been developed, involving an out-of-control immune system.

Contrary to mainstream medical belief, safe, natural, and nontoxic treatments can alleviate the symptoms of senile dementia. Research has demonstrated how these remedies can aid in preventing the onset of senile dementia.

More than 40% of dementia diagnoses have been shown to be wrong. Here's what may really be going on.

Dementia and Alzheimer's a big problem in industrialized countries. With the aging population at greater and greater risk for these conditions, it is imperative to understand that there are a variety of natural ways to stop dementia in its tracks. In this video, Dr. Osborne breaks down 6 natural ways you can overcome brain inflammation (brainflammation) including: 1. Avoid gluten 2. Eat lots of healthy fats 3. Avoid eating excessive carbohydrates 4. Take exercise more seriously 5. Maintain a healthy blood sugar 6. Do a medication review with your doctor. Remember, natural help is all about your diet and your lifestyle. There are no magic cures. You have to put in the work. To connect with Dr. Osborne visit: Facebook: https://www.facebook.com/DoctorPeterO... Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.

A new theory for the causes of dementia and other neurodegenerative diseases has been developed, involving an out-of-control immune system.

Drs. Ayesha and Dean Sherzai are the authors of The 30-Day Alzheimer’s Solution. It is most user-friendly book dedicated to brain health.

Drugs being used to treat Alzheimer’s disease are actually associated with a more aggressive decline in cognitive function.