2016

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Want better sleep, faster recovery, and peak performance? In this powerful episode of The Dr. Hyman Show, Dr. Mark Hyman sits down with human performance exp...

This natural compound relieves pain, heals tissue, and treats countless “untreatable” conditions.

How DMSO being mixed with numerous common medications creates a myriad of remarkable therapeutic possibilities

Link to the notes:  https://docs.google.com/document/d/1G0JYEOi1HyTzyT3RxAX8AbIZejyZyl_s/edit?usp=drivesdk&ouid=102430545303799711405&rtpof=true&sd=true C04-5-18

(NaturalHealth365) New research reveals women with heart disease have 10% higher odds of aggressive breast cancer.

The data that shows the less appreciated and forgotten consequences of vaccination.

(NaturalHealth365) University of Maryland study finds HPV shots increase autonomic dysfunction risk by 23%, and that's not all.

#Parkinsons #TheParkinsonsPlan #EnvironmentalHealth #Neuroscience #PreventParkinsonsParkinson’s disease is rising faster than ever before — with 90,000 new U...

An interesting new article suggests value of creatine supplementation in Alzheimer's disease

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱I’m thrilled to...

Find light in the darkness of Alzheimer's and Dementia. Feel better in 5 weeks or get fully reimbursed. See how EVY LIGHT® could help you!

Low molecular weight fucoidan (LMWF), a depolymerized form, is known to possess superior bioactivities compared to its high molecular weight counterpa…

What they don't tell us about salt and how to select the healthiest options

Clean, speed up, and protect your PC with Spyzooka. Remove spyware, fix errors, and optimize performance—fast, easy, and effective!

Ron Wyatt's discovery of Sodom and Gomorrah is miraculous- the evidence was hidden until just the right time! the remains are spectacular to view and the mes...

This culture that came BEFORE the Native Americans is ASTONISHING. In this video, Dr. Nathaniel Jeanson uncovers some surprising archaeological discoveries h...

Henry B. Smith Jr. of Associates for Biblical Research is the guest on Let Us Reason and discusses the numerical divergences between the Masoretic Text, Sama...

In this video, Dr. Bill Salus discusses the following with host Nino Rodriguez;*Trump’s relationship with Israel and his potential place in prophecy,*The rol...

Ezekiel 38 is a marquee prophetic event of the end times. Many of today's top experts think it could be the next prophecy to find fulfillment. But are they c...

Israel is at the center of the End Times. So Jewish End Time beliefs influence what happens NEXT. And they are NOT what you EXPECT. They will impact how Jew...

It happened before our eyes. It shocked the world. But what if there was an ancient mystery lying behind it all, playing out before the world? Jonathan Cahn ...

About 2600 years ago, the prophet Jeremiah predicted that in the latter days a disaster would happen in ELAM, which is in modern day SW IRAN. The details of ...

In this video, Dr. Nathan Bryan explains a detoxification protocol designed to target chronic diseases driven by nutrient deficiencies and toxin exposure. Th...

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱In our modern w...

Dwayne “The Rock” Johnson discusses his health journey —and the test results that pushed him to take more control of his health.In this powerful episode of T...

The Immense Dangers of the GLP-1 drugs and the Scandalous Corruption That Led the FDA to Push Them Upon America

Ozempic works… until it doesn’t. Then your real problems begin.

Glioblastoma presents significant challenges in neuro-oncology due to its aggressive nature, drug resistance, and restrictions imposed by the blood–brain barrier. Ivermectin (IVM), known for its antiparasitic properties, has been highlighted as a promising treatment for tumors and an alternative therapy for glioma, although it exhibits low oral bioavailability. Therefore, we investigated the in vivo effect of IVM encapsulation in organic and inorganic nanosystems, first screened in vitro against different tumor cells and subsequently evaluated in vitro and in vivo glioma models. We produced IVM-loaded poly(ε-caprolactone) nanocapsules (IVM-NC) using the interfacial deposition method, and IVM-loaded nanostructured silica particles (IVM-MCM) by loading IVM into commercial MCM-41 silica using the incipient wetness method. IVM-NC had a nanometric size (190 nm), a unimodal size distribution (span <2), and a high encapsulation efficiency (100% at 1 mg/mL). IVM-MCM exhibited a well-organized hexagonal mesoporous structure and high drug loading (0.12 mg/mg). Nanoencapsulated IVM significantly reduced the viability of various cancer cell lines, particularly glioma cell lines, which led us to evaluate them in a preclinical glioma model. We implanted adult male Wistar rats with C6 cells. Intranasal delivery of IVM-NC (60 μg/rat/day for 10 days) resulted in a larger decrease in tumor size compared with the group treated with free IVM, along with histopathological improvements. Treatment with IVM-MCM did not decrease the tumor size. However, both treatments were well-tolerated, with no adverse effects on weight, biochemical, or hematological parameters, or lung histology. Furthermore, the effective equivalent dose of IVM (26 μg/kg) in the rat glioma model was lower than the approved human dose for parasitic infections. This study marks the first exploration of IVM delivery to the brain. In summary, nasal administration of nanoencapsulated IVM via nanocapsules presents a promising avenue for targeted therapy against glioblastoma, with potential implications for clinical translation.