2016

Leading exosome biotechnology laboratory. Specializes in the production of perinatal MSC-derived exosome products for cosmetic treatment. Request a lab tour.

In this week’s episode of The Dr. Ardis Show, Dr. Bryan Ardis dives deep into the topic of Heart Failure, discussing its causes, risk factors, and most importantly, what you can do proactively to prev

DuckDuckGo. Privacy, Simplified.

DuckDuckGo. Privacy, Simplified.

Explore leucovorin's potential benefits for autism, its scientific background, research findings, and importance of personalized treatment approaches.

Protein, exercises, and key mechanisms to boost your brain with muscle. Get the E-book!

(NaturalHealth365) Discover how to support brain health naturally with key nutrients, lifestyle changes, and powerful antioxidants.

UAsure is an easy and quick way (just three steps with results in thirty seconds!) to measure the level of uric acid in your blood at any given time.

Leading exosome biotechnology laboratory. Specializes in the production of perinatal MSC-derived exosome products for cosmetic treatment. Request a lab tour.

(NaturalHealth365) Harsh hair dye chemicals have been shown to increase the risk of cancer. Discover a non-toxic way to eliminate grey hair.

Mucopolysaccharidosis type II (MPS II) is caused by a deficiency in iduronate-2-sulfatase (Ids), an enzyme that catabolizes glycosaminoglycan (GAG). Ids insufficiency results in the accumulation of GAG in various organs, ultimately resulting in multisystemic disease. Trehalose, a non-reducing disaccharide, has shown protective effects against various diseases. However, its potential utility through oral administration in MPS II has not yet been explored. In the present study, to investigate the efficacy of oral trehalose in Ids-knock-out (KO) mice, Ids-KO and wild type (WT) mice were treated with 2% trehalose dissolved in distilled water ad libitum for 24 weeks. Histological analysis revealed that almost all tissues from Ids-KO mice exhibited abnormal changes, including large vacuolization, inflammatory cell infiltration, and GAG deposition. However, oral administration of trehalose significantly suppressed GAG levels, vacuolization, inflammation and apoptosis in the spleen and brain. Additionally, oral trehalose considerably improved cognitive functions, such as short-term spatial learning and working memory, alongside limited improvements in walking capacity in Ids-KO mice. These results suggest that oral trehalose can reduce GAG accumulation, vacuolization and the number of apoptotic and inflammatory cells in pathological tissues including the brain, ultimately considerably improving spontaneous alteration behavior and could be a promising treatment option for MPS II.