Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol - ISOM
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Introduction
Many theories exist regarding the origin of cancer, namely the metabolic theory (Seyfried & Chinopoulos, 2021), the somatic mutation theory (SMT) (Hanahan & Weinberg, 2000), the cancer stem cell theory (Capp, 2019), and the tissue organization theory (Soto & Sonnenschein, 2011). In a recently published study, a new concept was introduced the
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About Jonathan Sackner-Bernstein, MD
Dr. Sackner-Bernstein shares his pursuit of conquering Parkinson's, using expertise developed as Columbia University faculty, FDA senior official, DARPA insider and witness to the toll of PD.
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RightBrainBio, Inc. was incorporated in 2022 to develop tranformative therapies for people with Parkinson's.
Anti-lung cancer activities of polysaccharides from Laminaria japonica: Network pharmacology and structural insights - ScienceDirect
This study investigates the anti-lung cancer activities of polysaccharides extracted from Laminaria japonica, focusing on their bioactive components a…
Frontiers | Fucoidan as a Therapeutic Agent for Ulcerative Colitis: Mechanisms of Action and Modulation of the Gut Microbiota
Ulcerative colitis (UC), a chronic inflammatory bowel disease driven by gut dysbiosis, immune dysregulation, and oxidative stress, lacks universally effectiv...
Undaria pinnatifida Fucoidan Enhances Gut Microbiome, Butyrate Production, and Exerts Anti-Inflammatory Effects in an In Vitro Short-Term SHIME® Coupled to a Caco-2/THP-1 Co-Culture Model
Fucoidans have demonstrated a wide range of bioactivities including immune modulation and benefits in gut health. To gain a deeper understanding on the effects of fucoidan from Undaria pinnatifida (UPF) on the colonic microbiome, the short-term Simulator of the Human Intestinal Microbial Ecosystem®, a validated in vitro gut model, was applied. Following a three-week intervention period on adult faecal samples from three healthy donors, microbial community activity of the colonic microbiota was assessed by quantifying short-chain fatty acids while composition was analysed utilising 16S-targeted Illumina sequencing. Metagenomic data were used to describe changes in community structure. To assess the secretion of cytokines, co-culture experiments using Caco-2 and THP1-Blue™ cells were performed. UPF supplementation over a three-week period had a profound butyrogenic effect while also enriching colonic microbial diversity, consistently stimulating saccharolytic genera, and reducing genera linked with potentially negative health effects in both regions of the colon. Mild immune modulatory effects of UPF were also observed. Colonic fermentation of UPF showed anti-inflammatory properties by inducing the secretion of the anti-inflammatory cytokines IL-6 and IL-10 in two out of three donors in the proximal and distal colon. In conclusion, UPF supplementation may provide significant gut health benefits.
Yes, I’m Excited about Allulose - David Perlmutter M.D.
Allulose, a rare sugar, has gained significant attention in recent years due to its numerous health benefits, primarily concerning metabolic health. To be sure, it seems like it is everywhere …
Dose-dependent therapeutic effects of gum acacia on kidney and metabolic dysfunction in adenine-induced chronic kidney disease in rats: involvement of antioxidant pathways | The Journal of Basic and Applied Zoology | Full Text
Background Chronic kidney disease (CKD) poses significant health challenges worldwide, with limited effective natural therapies targeting its progression through antioxidant mechanisms. Although gum acacia (GA) has shown general metabolic benefits, its dose-dependent therapeutic efficacy in CKD and its effects on key antioxidant pathways remain unclear. This study aimed to evaluate the therapeutic potential of gum acacia (GA) in an adenine (AD)-induced CKD rat model. Methods Rats were randomly assigned to five groups (n = 7 per group): Group I (control), Group II (GA at 600 mg/kg for 14 days), Group III (AD at 600 mg/kg for 10 days), and Groups IV and V (AD for 10 days followed by GA at 300 mg/kg or 600 mg/kg for 14 days). All treatments were administered daily by oral gavage. Results AD treatment led to significant reductions in body weight, increased relative kidney weight, and disrupted kidney and liver function markers, including elevated urea, creatinine, ALT, GGT, and glucose levels. AD also increased oxidative stress, altered blood parameters, and caused downregulation of APRT mRNA expression and upregulation of FGF-23 expression. GA treatment at both doses (300 and 600 mg/kg) mitigated these abnormalities, significantly improving kidney and liver function, enhancing antioxidant status, and ameliorating hematological and metabolic disturbances. The most pronounced effects were observed with the 600 mg/kg dose. Conclusions Building on prior indications of GA’s benefits, our findings offer new and comprehensive evidence of its dose-dependent therapeutic effects in adenine-induced CKD, particularly through the modulation of oxidative stress pathways and regulation of APRT and FGF-23 expression. These insights lay the groundwork for future clinical translation.
BREAKING: mRNA Shots Induce Cancer-Linked Bone Marrow Reprogramming Within Weeks
New study analyzed leukemia patients who developed cancer within weeks of mRNA injection—their bone marrow showed distinct cancer-associated metabolic alterations.
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Enzymatic Hydrolysis Altered the Physicochemical and Immunogenic Profile of Protein-based Ingredients Derived from Industrial Hempseed (Cannabis sativa L.) - ScienceDirect
From creatine to magnesium, specific nutrients appear to influence inflammation, synaptic plasticity, and even structural integrity of brain tissue, and may ...
Plant-based diets in general and certain plant foods in particular may be used to successfully treat Parkinson's disease in part by boosting L-DOPA levels. W...
Treating Parkinson’s with diet NutritionFacts.org - YouTube
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This Food Reversed My Immune Age by 47% in 90 Days - YouTube
What if you could reverse your immune system’s age by nearly 50%—in just 90 days? In this powerful follow-up conversation, I’m joined again by Dr. Jeff Bland...
Yes, I’m Excited about Allulose - David Perlmutter M.D.
Allulose, a rare sugar, has gained significant attention in recent years due to its numerous health benefits, primarily concerning metabolic health. To be sure, it seems like it is everywhere …
