2016

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What’s your gut telling you? How researchers are investigating the link between myocarditis and intestinal microbiota | European Heart Journal | Oxford Academic
What’s your gut telling you? How researchers are investigating the link between myocarditis and intestinal microbiota | European Heart Journal | Oxford Academic
Burkhard Ludewig DVM is Head of the Medical Research Centre of the Kantonsspital St Gallen, Switzerland (Figure 1). His investigative work in cardio immuno
Heart
·academic.oup.com·
What’s your gut telling you? How researchers are investigating the link between myocarditis and intestinal microbiota | European Heart Journal | Oxford Academic
Gut microbiome in ADHD and its relation to neural reward anticipation
Gut microbiome in ADHD and its relation to neural reward anticipation
Background Microorganisms in the human intestine (i.e. the gut microbiome) have an increasingly recognized impact on human health, including brain functioning. Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder associated with abnormalities in dopamine neurotransmission and deficits in reward processing and its underlying neuro-circuitry including the ventral striatum. The microbiome might contribute to ADHD etiology via the gut-brain axis. In this pilot study, we investigated potential differences in the microbiome between ADHD cases and undiagnosed controls, as well as its relation to neural reward processing. Methods We used 16S rRNA marker gene sequencing (16S) to identify bacterial taxa and their predicted gene functions in 19 ADHD and 77 control participants. Using functional magnetic resonance imaging (fMRI), we interrogated the effect of observed microbiome differences in neural reward responses in a subset of 28 participants, independent of diagnosis. Results For the first time, we describe gut microbial makeup of adolescents and adults diagnosed with ADHD. We found that the relative abundance of several bacterial taxa differed between cases and controls, albeit marginally significant. A nominal increase in the Bifidobacterium genus was observed in ADHD cases. In a hypothesis-driven approach, we found that the observed increase was linked to significantly enhanced 16S-based predicted bacterial gene functionality encoding cyclohexadienyl dehydratase in cases relative to controls. This enzyme is involved in the synthesis of phenylalanine, a precursor of dopamine. Increased relative abundance of this functionality was significantly associated with decreased ventral striatal fMRI responses during reward anticipation, independent of ADHD diagnosis and age. Conclusions Our results show increases in gut microbiome predicted function of dopamine precursor synthesis between ADHD cases and controls. This increase in microbiome function relates to decreased neural responses to reward anticipation. Decreased neural reward anticipation constitutes one of the hallmarks of ADHD.
Biome
·journals.plos.org·
Gut microbiome in ADHD and its relation to neural reward anticipation
Infant Gut Microbiome Associated with Cognitive Development - Biologic (...)
Infant Gut Microbiome Associated with Cognitive Development - Biologic (...)
Studies in rodents provide compelling evidence that microorganisms inhabiting the gut influence neurodevelopment. In particular, experimental manipulations that alter intestinal microbiota impact exploratory and communicative behaviors and cognitive performance. In humans, the first years of life are a dynamic time in gut colonization and brain development, but little is known about the relationship between these two processes.
Biome
·biologicalpsychiatryjournal.com·
Infant Gut Microbiome Associated with Cognitive Development - Biologic (...)
Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease
Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothesis that the intestine might be an early site of PD disease in response to an environmental toxin or pathogen. One potential mechanism for environmental toxin(s) and proinflammatory luminal products to gain access to mucosal neuronal tissue and promote oxidative stress is compromised intestinal barrier integrity. However, the role of intestinal permeability in PD has never been tested. We hypothesized that PD subjects might exhibit increased intestinal permeability to proinflammatory bacterial products in the intestine. To test our hypothesis we evaluated intestinal permeability in subjects newly diagnosed with PD and compared their values to healthy subjects. In addition, we obtained intestinal biopsies from both groups and used immunohistochemistry to assess bacterial translocation, nitrotyrosine (oxidative stress), and alpha-synuclein. We also evaluated serum markers of endotoxin exposure including LPS binding protein (LBP). Our data show that our PD subjects exhibit significantly greater intestinal permeability (gut leakiness) than controls. In addition, this intestinal hyperpermeability significantly correlated with increased intestinal mucosa staining for E. coli bacteria, nitrotyrosine, and alpha-synuclein as well as serum LBP levels in PD subjects. These data represent not only the first demonstration of abnormal intestinal permeability in PD subjects but also the first correlation of increased intestinal permeability in PD with intestinal alpha–synuclein (the hallmark of PD), as well as staining for gram negative bacteria and tissue oxidative stress. Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects. Trial Registration Clinicaltrials.gov NCT01155492
Parkinsons
·journals.plos.org·
Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease
The Power Of Our Activating Serum - YouTube
The Power Of Our Activating Serum - YouTube
The Nitric Oxide Activating Serum stimulates collagen production and restores the youthful oxygen, hydration, and nutrient-rich blood flow to your skin cells. It works on a cellular level DEEP within the skin, to get at the root cause of your wrinkles and improve the appearance of aging skin. #skincare #wellness #antiaging Supercharge Your Health with Clinically Proven Nitric Oxide Solutions – Visit Now https://n1o1.com 🔔 Boost Your Health with Nitric Oxide: Unlock Its Secrets for Peak Performance & Wellbeing. Subscribe Now! https://www.youtube.com/@DrNathanSBryanNitricOxide/?sub_confirmation=1 ✅Important Links to Follow 🔗Linktree https://linktr.ee/n1o1 🔗 N101 www.n1o1.com ✅ Stay Connected With Us. 👉Facebook: https://www.facebook.com/pneumanitricoxide/ 👉Instagram: https://www.instagram.com/n1o1.by.pneuma.nitric.oxide/ 👉Website: https://drnathansbryan.com/ ============================= ✅ Recommended Playlists 👉 Redefining Medicine - Dr. Nathan Bryan https://www.youtube.com/watch?v=iK9JzHpNdHM&list=PLZm8V0VIi2Y43P1qewE4uZv8mkpW_xm_Y&pp=iAQB 👉 Shorts https://www.youtube.com/watch?v=ztMZuUVyuHk&list=PLZm8V0VIi2Y6JJMHY7CeVvlOGVVAiQqhf&pp=iAQB ✅ Other Videos You Might Be Interested In Watching: 👉 Unlocking the Power of Nitric Oxide: Transforming Modern Medicine & Patient Care https://www.youtube.com/watch?v=tmj9FZqIV2g 👉 Disclosures and transparency on companies and products in which I am and am not involved. https://www.youtube.com/watch?v=o5kr_IeWnVk&t=18s 👉 Regenacast Podcast interview with Sean Berman of Cell Surgical Network. https://www.youtube.com/watch?v=9cwx4nIM9Mw&t=29s 👉 Sugar Crush Podcast with Dr. Rick Jacoby and Dr. Nathan S Bryan https://www.youtube.com/watch?v=cwo71eKe_Ic 👉 There is only one way to deliver nitric oxide to the human body. https://www.youtube.com/watch?v=nN2275k89ic ============================= ✅ About Dr Nathan Bryan Nitric Oxide. Nathan S. Bryan, Ph.D CEO/FOUNDER OF NO2U & NITRIC OXIDE LEADING EXPERT Dr. Bryan has made many seminal discoveries in the Nitric Oxide field, resulting in over a dozen U.S. and International patents. He is also a successful entrepreneur who has brought his Nitric Oxide technology to consumers. Dr. Bryan has published many highly cited papers and authored or edited five books. His work has made him a recognized international leader in molecular medicine and Nitric Oxide biochemistry. If your body can't make Nitric Oxide, we are here to help! 🔔 Nitric oxide: Your secret weapon for health, performance & longevity. Subscribe & unlock the knowledge! https://www.youtube.com/@DrNathanSBryanNitricOxide/?sub_confirmation=1 ================================= ⚠️DISCLAIMER: We do not accept any liability for any loss or damage incurred from you acting or not acting as a result of watching any of our publications. You acknowledge that you use the information we provide at your own risk. Do your research. Copyright Notice: This video and our YouTube channel contain dialogue, music, and images that are the property of Dr Nathan Bryan Nitric Oxide. You are authorized to share the video link and channel and embed this video in your website or others as long as a link back to our YouTube channel is provided. © Dr Nathan Bryan Nitric Oxide
1 Nitric oxide
·youtube.com·
The Power Of Our Activating Serum - YouTube
Author Tim Cohen - YouTube
Author Tim Cohen - YouTube
Author of must-read, peerless works on prophecy, theology, Christology, "aliens" and related history. SUPPORT TIM COHEN (via Prophecy House): https://paypal.me/AuthorTimCohen For more of Tim's current social media links, or to join his email list(s), visit: https://www.prophecyhouse.com "Your financial gifts are welcome and very much needed, and will be used to bear fruit for God’s Kingdom." — Timothy Cohen Timothy (Tim) Cohen is an internationally-known author, teacher, speaker, researcher, analyst and computer technologist. Called by God in 1987 to be “him who has understanding” (Rev 13:18), Cohen has researched and written what many are now coming to view as Christendom’s foremost prophetic and theological works (Rev 19:10). Additionally, he is now offering the world actual disclosure on complex life elsewhere in Earth’s solar system.
Tribulation
·youtube.com·
Author Tim Cohen - YouTube