2016

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Fast Food is Contaminated - David Perlmutter M.D.
Fast Food is Contaminated - David Perlmutter M.D.
For years I have been warning about the health threats associated with consuming ever-popular fast foods. Fast food consumption in America is a significant aspect of the country’s food culture, …
·drperlmutter.com·
Fast Food is Contaminated - David Perlmutter M.D.
Genesis Impact (Full Movie) - YouTube
Genesis Impact (Full Movie) - YouTube
Secular museum docent (Reggie McGuire) presents his best case for evolution at the natural history museum, but little does he know that Christina (Hannah Bra...
·youtube.com·
Genesis Impact (Full Movie) - YouTube
Efficacy and anti-inflammatory properties of low-molecular-weight fucoidan in patients with atopic dermatitis: a randomized double-blinded placebo-controlled trial
Efficacy and anti-inflammatory properties of low-molecular-weight fucoidan in patients with atopic dermatitis: a randomized double-blinded placebo-controlled trial
Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease. Fucoidans are reportedly effective in treating AD; however, their clinical efficacy requires further exploration. This study...
·tandfonline.com·
Efficacy and anti-inflammatory properties of low-molecular-weight fucoidan in patients with atopic dermatitis: a randomized double-blinded placebo-controlled trial
Laminaria japonica polysaccharide alleviates type 2 diabetes by regulating the microbiota-gut-liver axis: A multi-omics mechanistic analysis - ScienceDirect
Laminaria japonica polysaccharide alleviates type 2 diabetes by regulating the microbiota-gut-liver axis: A multi-omics mechanistic analysis - ScienceDirect
The hypoglycemic effects of low-molecular-weight Laminaria japonica polysaccharide (LJO) were investigated in type 2 diabetes mellitus (T2DM) mice, fo…
·sciencedirect.com·
Laminaria japonica polysaccharide alleviates type 2 diabetes by regulating the microbiota-gut-liver axis: A multi-omics mechanistic analysis - ScienceDirect
Peace in the Middle East. Is it Possible? - YouTube
Peace in the Middle East. Is it Possible? - YouTube
This is an excerpt from a Prophecy Watchers podcast titled "The Biblical Plan for Mideast Peace" which previously aired here on 11/30/23.Thanks For Watching...
·youtube.com·
Peace in the Middle East. Is it Possible? - YouTube
Nanogels with covalently bound and releasable trehalose for autophagy stimulation in atherosclerosis | Journal of Nanobiotechnology | Full Text
Nanogels with covalently bound and releasable trehalose for autophagy stimulation in atherosclerosis | Journal of Nanobiotechnology | Full Text
Atherosclerosis, cholesterol-driven plaque formation in arteries, is a complex multicellular disease which is a leading cause of vascular diseases. During the progression of atherosclerosis, the autophagic function is impaired, resulting in lipid accumulation-mediated foam cell formation. The stimulation of autophagy is crucial for the recovery of cellular recycling process. One of the potential autophagy inducers is trehalose, a naturally occurring non-reducing disaccharide. However, trehalose has poor bioavailability due to its hydrophilic nature which results in poor penetration through cell membranes. To enhance its bioavailability, we developed trehalose-releasing nanogels (TNG) for the treatment of atherosclerosis. The nanogels were fabricated through copolymerization of 6-O-acryloyl-trehalose with the selected acrylamide-type monomers affording a high trehalose conjugation (~ 58%, w/w). TNG showed a relatively small hydrodynamic diameter (dH, 67 nm) and a uniform spherical shape and were characterized by negative ζ potential (-18 mV). Thanks to the trehalose-rich content, TNG demonstrated excellent colloidal stability in biological media containing serum and were non-hemolytic to red blood cells. In vitro study confirmed that TNG could stimulate autophagy in foam cells and enhance lipid efflux and in vivo study in ApoE−/− mice indicated a significant reduction in atherosclerotic plaques, while increasing autophagic markers. In conclusion, TNG hold great promise as a trehalose delivery system to restore impaired autophagy-mediated lipid efflux in atherosclerosis and subsequently reduce atherosclerotic plaques. Graphical abstract
·jnanobiotechnology.biomedcentral.com·
Nanogels with covalently bound and releasable trehalose for autophagy stimulation in atherosclerosis | Journal of Nanobiotechnology | Full Text
Strategies for the Development of Glycomimetic Drug Candidates - PMC
Strategies for the Development of Glycomimetic Drug Candidates - PMC
Carbohydrates are a structurally-diverse group of natural products which play an important role in numerous biological processes, including immune regulation, infection, and cancer metastasis. Many diseases have been correlated with changes in the composition ...
·ncbi.nlm.nih.gov·
Strategies for the Development of Glycomimetic Drug Candidates - PMC
Agaricus bisporus-Derived Glucosamine Hydrochloride Regulates VEGF through BMP Signaling to Promote Zebrafish Vascular Development and Impairment Repair
Agaricus bisporus-Derived Glucosamine Hydrochloride Regulates VEGF through BMP Signaling to Promote Zebrafish Vascular Development and Impairment Repair
Glucosamine hydrochloride (GAH) is a natural component of glycoproteins present in almost all human tissues and participates in the construction of human tissues and cell membranes. GAH has a wide range of biological activities, particularly in anti-inflammatory and osteogenic damage repair. At present, little is known about how GAH functions in angiogenesis. To determine the role of GAH on vascular development and impairment repair, we used the inhibitors VRI, DMH1, and dorsomorphin (DM) to construct vascular-impaired models in Tg(kdrl: mCherry) transgenic zebrafish. We then treated with GAH and measured its repair effects on vascular impairment through fluorescence intensity, mRNA, and protein expression levels of vascular-specific markers. Our results indicate that GAH promotes vascular development and repairs impairment by regulating the vascular endothelial growth factor (VEGF) signaling pathway through modulation of bone morphogenetic protein (BMP) signaling. This study provides an experimental basis for the development of GAH as a drug to repair vascular diseases.
·mdpi.com·
Agaricus bisporus-Derived Glucosamine Hydrochloride Regulates VEGF through BMP Signaling to Promote Zebrafish Vascular Development and Impairment Repair