For years I have been warning about the health threats associated with consuming ever-popular fast foods. Fast food consumption in America is a significant aspect of the country’s food culture, …
Amir Tsarfati: For Unto Us a Child is Born - YouTube
Often, Christians wonder if it's appropriate to celebrate Christmas. What is the real story of Christmas anyway? Can God have a son? If so, how? And where wo...
The Shocking Reason Governments FEAR Jesus and Oppose Christmas - the Mystery No One Talks About - YouTube
What is the SHOCKING REASON Governments fear Jesus and Christmas? Why do they oppose Him and His followers? The real reason is a MYSTERY that no one talks ab...
Secular museum docent (Reggie McGuire) presents his best case for evolution at the natural history museum, but little does he know that Christina (Hannah Bra...
Top Ten Historical References to Jesus Outside of the Bible: Digging for Truth Episode 222 - YouTube
ABR staff member Bryan Windle joins Henry Smith to countdown the top ten historical references to Jesus outside of the Bible. Despite ludicrous claims that J...
Efficacy and anti-inflammatory properties of low-molecular-weight fucoidan in patients with atopic dermatitis: a randomized double-blinded placebo-controlled trial
Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease. Fucoidans are reportedly effective in treating AD; however, their clinical efficacy requires further exploration. This study...
Fucoidan attenuates chronic colitis and behavioral deficits by reshaping gut microbiota-brain axis balance - ScienceDirect
Inflammatory bowel disease (IBD) often coexists with depression, posing considerable challenges for treatment. This study aimed to investigate the the…
Laminaria japonica polysaccharide alleviates type 2 diabetes by regulating the microbiota-gut-liver axis: A multi-omics mechanistic analysis - ScienceDirect
The hypoglycemic effects of low-molecular-weight Laminaria japonica polysaccharide (LJO) were investigated in type 2 diabetes mellitus (T2DM) mice, fo…
Peace in the Middle East. Is it Possible? - YouTube
This is an excerpt from a Prophecy Watchers podcast titled "The Biblical Plan for Mideast Peace" which previously aired here on 11/30/23.Thanks For Watching...
Nanogels with covalently bound and releasable trehalose for autophagy stimulation in atherosclerosis | Journal of Nanobiotechnology | Full Text
Atherosclerosis, cholesterol-driven plaque formation in arteries, is a complex multicellular disease which is a leading cause of vascular diseases. During the progression of atherosclerosis, the autophagic function is impaired, resulting in lipid accumulation-mediated foam cell formation. The stimulation of autophagy is crucial for the recovery of cellular recycling process. One of the potential autophagy inducers is trehalose, a naturally occurring non-reducing disaccharide. However, trehalose has poor bioavailability due to its hydrophilic nature which results in poor penetration through cell membranes. To enhance its bioavailability, we developed trehalose-releasing nanogels (TNG) for the treatment of atherosclerosis. The nanogels were fabricated through copolymerization of 6-O-acryloyl-trehalose with the selected acrylamide-type monomers affording a high trehalose conjugation (~ 58%, w/w). TNG showed a relatively small hydrodynamic diameter (dH, 67 nm) and a uniform spherical shape and were characterized by negative ζ potential (-18 mV). Thanks to the trehalose-rich content, TNG demonstrated excellent colloidal stability in biological media containing serum and were non-hemolytic to red blood cells. In vitro study confirmed that TNG could stimulate autophagy in foam cells and enhance lipid efflux and in vivo study in ApoE−/− mice indicated a significant reduction in atherosclerotic plaques, while increasing autophagic markers. In conclusion, TNG hold great promise as a trehalose delivery system to restore impaired autophagy-mediated lipid efflux in atherosclerosis and subsequently reduce atherosclerotic plaques. Graphical abstract
Strategies for the Development of Glycomimetic Drug Candidates - PMC
Carbohydrates are a structurally-diverse group of natural products which play an important role in numerous biological processes, including immune regulation, infection, and cancer metastasis. Many diseases have been correlated with changes in the composition ...
Agaricus bisporus-Derived Glucosamine Hydrochloride Regulates VEGF through BMP Signaling to Promote Zebrafish Vascular Development and Impairment Repair
Glucosamine hydrochloride (GAH) is a natural component of glycoproteins present in almost all human tissues and participates in the construction of human tissues and cell membranes. GAH has a wide range of biological activities, particularly in anti-inflammatory and osteogenic damage repair. At present, little is known about how GAH functions in angiogenesis. To determine the role of GAH on vascular development and impairment repair, we used the inhibitors VRI, DMH1, and dorsomorphin (DM) to construct vascular-impaired models in Tg(kdrl: mCherry) transgenic zebrafish. We then treated with GAH and measured its repair effects on vascular impairment through fluorescence intensity, mRNA, and protein expression levels of vascular-specific markers. Our results indicate that GAH promotes vascular development and repairs impairment by regulating the vascular endothelial growth factor (VEGF) signaling pathway through modulation of bone morphogenetic protein (BMP) signaling. This study provides an experimental basis for the development of GAH as a drug to repair vascular diseases.
Characterization of novel alginate-Aloe Vera raft systems for treatment of gastroesophageal reflux disease - ScienceDirect
Raft-forming systems are designed to relieve reflux symptoms by forming a physical barrier on top of the stomach. The present study aimed to evaluate …
How to Master Your Melatonin and Optimize Your Sleep - with Dr. Deanna Minich | EP168 - YouTube
Visit https://www.puritycoffee.com/empoweringneurologist for more information on Balance and use code PERLMUTTER for 30% off a one-time purchase of Balance. ...
Download top software such as Video Cutter - Video To MP3 Converter - Free File Unlocker - Simple Disable Key - MP3 Converter - MP3 Cutter - PDF Joiner
Using REAL Biblical Evidence to Challenge Sabbath Vs Sunday Worship - And HOW to "Keep" It - YouTube
Should Christians keep the Sabbath or Sunday? It is a very controversial question. Or should they keep both? And more important than observing it is HOW shou...