2016

To evaluate the efficacy and safety of chondroitin sulfate and/or glucosamine hydrochloride in alleviating symptoms and improving the dysfunction of Kashin-Beck disease (KBD) patients.

Purpose: SYSADOAs (symptomatic slow-acting drugs for osteoarthritis) are a heterogeneous group of drugs that have the ability to modify the symptoms of osteoarthritis (OA) slowly and independently of NSAIDs, analgesics or any other therapeutic option. The main drugs included in this group are glucosamine (sulphate or hydrochloride) (GS) and chondroitin sulphate (CS), widely prescribed for the treatment of OA in some countries. Although the efficacy of GS and CS for the treatment of OA remains controversial, several human, animal and laboratory studies have suggested that both drugs show anti-inflammatory properties that could reduce the risk of several diseases.

Background To investigate the ameliorative effects of glucosamine (GS), chondroitin sulphate (CS) and glucosamine plus chondroitin sulphate (GC) on rheumatoid arthritis (RA) in rats, and to explore the mechanism of GS, CS and GC in improving RA based on the gut microbiota. Methods RA rat models were effectively developed 14 days after CFA injection, and then garaged with GS, CS and GC. Body weight and paw volume of rats were monitored at multiple time points at the beginning of CFA injection. Until D36, serum and ankle tissue specimens were used to measure levels of circulating inflammatory factors (TNF-α, IL-1β, MMP-3, NO and PGE2) and local inflammatory indicators (TLR-4 and NF-κB). On D18, D25, and D36, intergroup gut microbiota was compared using 16S rRNA gene sequencing and bioinformatics analysis. We also performed the correlation analysis of gut bacteria, joint swelling and inflammatory indicators. Results GC, rather than GS and CS, could reduce right paw volumes, levels of TLR-4 and NF-κB in synovial tissues. In addition, enriched genera in RA model rats screened out by LEfSe analysis could be inhibited by GC intervention, including potential LPS-producing bacteria (Enterobacter, Bacteroides, Erysipelotrichaceae_unclassified and Erysipelotrichaceae_uncultured) and some other opportunistic pathogens (Esherichia_Shigella, Nosocomiicoccus, NK4A214_group, Odoribacter, Corynebacterium and Candidatus_Saccharimonas.etc.) that positively correlated with pro-inflammatory cytokines, right paw volume, and pathology scores. Furthermore, the gut microbiota dysbiosis was observed to recover before alleviating joint swelling after interventions. Conclusions GC could inhibit potential LPS-producing bacteria and the activation of TLR-4/NF-κB pathway in RA rats, thus alleviating RA-induced joint injury.

Bioactivities of fucoidan, a class of marine algal polysaccharides, vary depending on the original algal species. The aim of this study was toexplore …

This study aimed to investigate the potential benefits Gum Arabic/Acacia Senegal (GA) in mitigating the harmful effects of cisplatin (CP) on spermatog…

What underlies the war on fat? It’s big business, wanting us all to eat more refined carbs and sugar to replace the fat calories that we’ve been instructed to reduce. And I can think of no one who has done more to open our eyes to this ongoing travesty than Nina Teicholz. Here’s more about her from her website: Nina Teicholz is an investigative science journalist and leader in nutrition reporting who is challenging the conventional wisdom on dietary fat–particularly, whether saturated fat causes heart disease and whether fat really makes you fat. The New York Times bestselling author of The Big Fat Surprise. Teicholz also serves as Executive Director of The Nutrition Coalition, an independent non-profit group that promotes evidence-based nutrition policy. She is one of a new generation of researchers arguing that diets lower in carbohydrates are a scientifically sound approach for reversing nutrition-related diseases. For more than half a century, we’ve been told to eat a diet high in grains, low in fat, saturated fat (and cholesterol), but the last two decades of research have led a growing number of scientists to conclude that this diet, despite being rigorously tested, could never be shown to prevent any kind of disease. Teicholz’s work also explains why this diet has remained official policy for so long: the roles played by crusading scientists, the food industry, and more. The story is as much about politics as it is about science, and Nina Teicholz’s research ultimately confirms that the traditional foods we were told to abandon (meat, cheese, eggs, butter) are safe, and even good for health. Nina Teicholz has been called “The Rachel Carson of the nutrition movement.” Her book has been called a “must read” by some of the most prestigious medical journals in the world, including The Lancet, The BMJ, and the American Journal of Clinical Nutrition. In speaking about Nina, the immediate past-president of the World Heart Federation, said at the Davos Cardiology Update Davos (2017) “She shook up the nutrition world, but she was right.” Please enjoy this compelling interview with one of my personal heroes. ==== TIMESTAMPS: 0:00 Intro 3:30 Contradictions in the Plant-based movement 10:02 Who funds the Food Pyramid 15:59 The Carbs & Fats Debate 22:36 Debunking Keto Myths 27:07 Debating Dr. David Katz 33:37 Answering Keto Questions 40:03 White House Conference on Nutrition 48:08 Conclusion ==== Nina Teicholz is a science journalist and author of the New York Times bestseller, The Big Fat Surprise, which upended the conventional wisdom on dietary fat–especially saturated fat and seed oils. Teicholz is also the founder of the Nutrition Coalition, a nonprofit working to ensure that nutrition policy reflects the best and most current science. Teicholz has appeared on most major TV networks, and her work has been published in the New York Times, Wall Street Journal, the Economist, as well as in academic journals including The BMJ and the journal of the National Academy of Sciences. She is a graduate of Stanford and Oxford Universities and is now author of the “Unsettled Science” column hosted on Substack. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

By now, you've heard low-fat diets aren’t all they're cracked up to be. But did you know that monounsaturated fat in particular has powerful health benefits?

Do you find yourself squinting and straining to read the daily news and wondering why the writing on menus has become so small? Are you interested in keeping your vision sharp no matter what your age? If so, these five best foods for eye health are a natural way to give your vision a boost from the inside out!

The symptoms and amount of medication needed by a diabetic can be greatly reduced by utilizing these 20 natural healing techniques. Dozens of scientific references are provided.

Is it the casein or the cow insulin that explains the link between milk consumption and the development of type I diabetes? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ If you missed the prequel to this video, check out Does Casein in Milk Exposure Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-casein-in-milk-exposure-trigger-type-1-diabetes) More on the concerns with cow’s milk exposure in infancy and childhood in: • Childhood Constipation and Cow’s Milk (http://nutritionfacts.org/video/childhood-constipation-and-cows-milk/) • Formula for Childhood Obesity (http://nutritionfacts.org/video/Formula-for-Childhood-Obesity) • Cow’s Milk Casomorphin and Crib Death (http://nutritionfacts.org/video/cows-milk-casomorphin-and-crib-death/) • Cow’s Milk Casomorphin and Autism (http://nutritionfacts.org/video/cows-milk-casomorphin-and-autism/) So what’s The Best Baby Formula? (http://nutritionfacts.org/video/the-best-baby-formula/) Breast milk! Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/does-bovine-insulin-in-milk-trigger-type-1-diabetes and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/does-bovine-insulin-in-milk-trigger-type-1-diabetes. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credits: Bradley Johnson via flickr and Jean-Alein via pixabay. Images have been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

“Fear of consumer reaction” led the U.S. dairy industry to suppress the discovery in retail milk of live paraTB bacteria, a pathogen linked to type 1 diabetes. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ For an exploration of other possibilities as to why cow’s milk consumption is linked to this autoimmune destruction of insulin production see Does Casein in Milk Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-casein-in-milk-trigger-type-1-diabetes/) and Does Bovine Insulin in Milk Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-bovine-insulin-in-milk-trigger-type-1-diabetes/). If it’s in the milk, what about the meat? That’s the subject of my next two videos in this 3-part series, Meat Consumption and the Development of Type 1 Diabetes (http://nutritionfacts.org/video/meat-consumption-and-the-development-of-type-1-diabetes) and Does Paratuberculosis in Meat Trigger Type 1 Diabetes? (http://nutritionfacts.org/video/does-paratuberculosis-in-meat-trigger-type-1-diabetes). But if we don’t drink milk, what about our bone health? See my video Is Milk Good for Our Bones? (http://nutritionfacts.org/video/is-milk-good-for-our-bones). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/does-paratuberculosis-in-milk-trigger-type-1-diabetes and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/does-paratuberculosis-in-milk-trigger-type-1-diabetes. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: ponce_photography via pixabay. Image has been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

http://www.drcousens.com Dr. Cousens' Reversing Diabetes Naturally Protocol is a medically-supervised nutritional therapy program for type 1 and type 2 diabetics, as well as pre-diabetics who do not want to live their lives codependent to Insulin and other medication drugs. During the program participants reverse the negative genetic expression of diabetes to a physiology of health and well-being. A series of workshops empower the participant to become proficient at integrating plant-source only live foods into their daily lives, therewith continuing to reducing the metabolic inflammation naturally. Supported by scientific research, Dr. Cousens' clinical results make this protocol the most comprehensive and successful diabetes reversing programs in the world. For more information, contact: Tree of Life Rejuvenation Center www.drcousens.com www.treeoflife.nu USA: 866 394 2520 International: 520 233 7010

People who increase their consumption of sugary beverages -- whether they contain added or naturally occurring sugar -- may face moderately higher risk of type 2 diabetes.

Women who began having menstrual cycles at age 11 had a 39 percent higher risk of developing gestational diabetes, new research has demonstrated. The study followed more than 27,000 women and observed that when menarche began at age 11 compared to age 14, women had a 39 percent higher risk of developing gestational diabetes. An increased risk, although lower, also occurred when menarche began at 12 and 13.

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People with diabetes often suffer from wounds that are slow to heal and can lead to ulcers, gangrene and amputation. New research from an international group shows that, in mouse models of diabetes, slow healing is associated with weaker electrical currents in wounds. The results could ultimately open up new approaches for managing diabetic patients.

Dr. Hallberg has just completed a study in which she demonstrated profound success in actually treating diabetes using a closely monitored ketogenic diet.

Metformin is the most commonly used drug to treat type 2 diabetes (T2D), though not all patients respond to it, and still, others do not tolerate it. García-Calzón et al . analyzed genome-wide DNA methylation in the blood of drug-naïve patients who were recently diagnosed with T2D. They found that DNA methylation at specific loci associated with future metformin response or tolerance, respectively, across multiple cohorts. These epigenetic markers may have theranostic potential regarding which patients should receive metformin. Metformin is the first-line pharmacotherapy for managing type 2 diabetes (T2D). However, many patients with T2D do not respond to or tolerate metformin well. Currently, there are no phenotypes that successfully predict glycemic response to, or tolerance of, metformin. We explored whether blood-based epigenetic markers could discriminate metformin response and tolerance by analyzing genome-wide DNA methylation in drug-naïve patients with T2D at the time of their diagnosis. DNA methylation of 11 and 4 sites differed between glycemic responders/nonresponders and metformin-tolerant/intolerant patients, respectively, in discovery and replication cohorts. Greater methylation at these sites associated with a higher risk of not responding to or not tolerating metformin with odds ratios between 1.43 and 3.09 per 1-SD methylation increase. Methylation risk scores (MRSs) of the 11 identified sites differed between glycemic responders and nonresponders with areas under the curve (AUCs) of 0.80 to 0.98. MRSs of the 4 sites associated with future metformin intolerance generated AUCs of 0.85 to 0.93. Some of these blood-based methylation markers mirrored the epigenetic pattern in adipose tissue, a key tissue in diabetes pathogenesis, and genes to which these markers were annotated to had biological functions in hepatocytes that altered metformin-related phenotypes. Overall, we could discriminate between glycemic responders/nonresponders and participants tolerant/intolerant to metformin at diagnosis by measuring blood-based epigenetic markers in drug-naïve patients with T2D. This epigenetics-based tool may be further developed to help patients with T2D receive optimal therapy.

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Healing kidneys naturally with Sodium Bicarbonate.Sodium Bicarbonate for kidney treatment can dramatically slow the progress of chronic kidney disease.

Two decades ago, I was on the path to a lifetime of type-2 diabetes. Living on processed foods and lacking exercise, I suffered from hypoglycemia, high cholesterol and numerous other health [...]

Consuming a plant-based diet -- especially one rich in high-quality plant foods such as whole grains, fruits, vegetables, nuts, and legumes -- is linked with substantially lower risk of developing type 2 diabetes, according to a new study.

Type 2 diabetes can be prevented, arrested, and even reversed with a healthy enough diet. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ You can imagine how overwhelming NutritionFacts.org might be for someone new to the site. With videos on more than 2,000 health topics, where do you even begin? Imagine someone stumbling onto the site when the new video-of-the-day is about how some spice can be effective in treating a particular form of arthritis. It would be easy to miss the forest for the trees. That’s why I created this new series of overview videos, which are basically taken straight from my hour-long live 2016 presentation How Not to Die: Preventing, Arresting, and Reversing Our Top 15 Killers (http://nutritionfacts.org/video/how-not-to-die). If you missed How Not to Die from Heart Disease (http://nutritionfacts.org/video/how-not-to-die-from-heart-disease/) or How Not to Die from Cancer (http://nutritionfacts.org/video/how-not-to-die-from-cancer/), check them out and stay tuned for How Not to Die from Kidney Disease (http://nutritionfacts.org/video/how-not-to-die-from-kidney-disease/) and How Not to Die from High Blood Pressure (http://nutritionfacts.org/video/how-not-to-die-from-high-blood-pressure). If this video inspired you to learn more about the role diet may play in preventing and treating diabetes, check out some of these other popular videos on the topic: • Plant-Based Diets and Diabetes (http://nutritionfacts.org/video/Plant-Based-Diets-and-Diabetes) • Can Diabetic Retinopathy Be Reversed? (http://nutritionfacts.org/video/can-diabetic-retinopathy-be-reversed) • What Causes Insulin Resistance? (http://nutritionfacts.org/what-causes-insulin-resistance) • Diabetes as a Disease of Fat Toxicity (http://nutritionfacts.org/video/Diabetes-as-a-Disease-of-Fat-Toxicity) • What Causes Diabetes? (http://nutritionfacts.org/video/what-causes-diabetes) • Why is Meat a Risk Factor for Diabetes? (http://nutritionfacts.org/video/why-is-meat-a-risk-factor-for-diabetes) • How May Plants Protect Against Diabetes? (http://nutritionfacts.org/video/how-may-plants-protect-against-diabetes/) • Plant-Based Diets for Diabetes (http://nutritionfacts.org/video/plant-based-diets-for-diabetes) • Turmeric Curcumin for Prediabetes (http://nutritionfacts.org/video/turmeric-curcumin-for-prediabetes) • Eggs and Diabetes (http://nutritionfacts.org/video/eggs-and-diabetes/) • Fish and Diabetes (http://nutritionfacts.org/video/fish-and-diabetes/) • Diabetics Should Take Their Pulses (http://www.nutritionfacts.org/video/diabetics-should-take-their-pulses/) • How to Prevent Prediabetes from Turning into Diabetes (http://nutritionfacts.org/video/How-to-Prevent-Prediabetes-from-Turning-into-Diabetes) • Curing Painful Diabetic Neuropathy (http://nutritionfacts.org/video/curing-painful-diabetic-neuropathy) • Can Vinegar Help with Blood Sugar Control? (http://nutritionfacts.org/video/can-vinegar-help-with-blood-sugar-control) • When Drugs & Diets Don't Lower Diabetes Deaths (http://nutritionfacts.org/video/when-drugs-and-diets-dont-lower-diabetes-deaths) • Reversing Diabetes with Food (http://nutritionfacts.org/video/reversing-diabetes-with-food) • Diabetes Reversal: Is it the Calories or the Food? (http://nutritionfacts.org/video/13.diabetes-reversal-is-it-the-calories-or-the-food) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/how-not-to-die-from-diabetes and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/how-not-to-die-from-diabetes. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Videography courtesy of Grant Peacock. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Abnormal denaturation and aggregation of human amylin or islet amyloid polypeptide (IAPP) into amyloid fibrils has been implicated in the pathogenesis of type 2 diabetic mellitus. Trehalose, a super-hydrophilic molecule, has been shown to prevent denaturation of biomolecules when they are under environmental stress

It's clear the lifestyle factors that impact metabolic disease play a key role in influencing the health of the brain and long-term cognitive capacity.