Cancer

Lung cancer is one of the most common cancer in cancer-related deaths worldwide, which is characterized by its strong metastatic potential. The melatonin hormone secreted by the pineal grand has an a...

Melatonin, which is synthesized by the pineal gland and released into the blood, exhibits antitumor properties. However, the mechanisms underlying these effects, particularly in stomach cancer, remain unknown. In the present study, the effect of melatonin on the nuclear factor (NF)‑κB signaling pathway and the mitogen‑activated protein kinase signaling pathway, involving p38 and c‑Jun‑N‑terminal kinase (JNK), were investigated in SGC7901 gastric cancer cells. In addition, the effect of melatonin on the survival, migration and apoptosis of these cells was investigated in vitro in order to evaluate the use of melatonin for the treatment of gastric cancer. The results of the present study revealed that melatonin decreased the viability and migration of SGC7901 cells. Furthermore, melatonin induced apoptosis. Melatonin was identified to elevate the expression levels of phosphorylated (p)‑p38 and p‑JNK protein, and decrease the expression level of nucleic p‑p65. These results suggest that the protein levels of p65, p38 and JNK are associated with the survival of SGC7901 cells following treatment with melatonin. The optimal concentration of melatonin was demonstrated to be 2 mM, which significantly induced apoptosis following a 24 h treatment period. These findings suggest that conflicting growth signals in cells may inhibit the efficacy of melatonin in the treatment of gastric cancer. Therefore, adjunct therapy would be required to improve the efficacy of melatonin in the treatment of cancer.

There is highly credible evidence that melatonin mitigates cancer at the initiation, progression and metastasis phases. In many cases, the molecular mechanisms underpinning these inhibitory actions have been proposed. What is rather perplexing, however, is the large number of processes by which mela …

The long-recognized fact that oxidative stress within mitochondria is a hallmark of mitochondrial dysfunction has stimulated the development of mitochondria-targeted antioxidant therapies. Melatonin should be included among the pharmacological agents able to modulate mitochondrial functions in cancer, given that a number of relevant melatonin-dependent effects are triggered by targeting mitochondrial functions. Indeed, melatonin may modulate the mitochondrial respiratory chain, thus antagonizing the cancer highly glycolytic bioenergetic pathway of cancer cells. Modulation of the mitochondrial respiratory chain, together with Ca2+ release and mitochondrial apoptotic effectors, may enhance the spontaneous or drug-induced apoptotic processes. Given that melatonin may efficiently counteract the Warburg effect while stimulating mitochondrial differentiation and mitochondrial-based apoptosis, it is argued that the pineal neurohormone could represent a promising new perspective in cancer treatment strategy.

ReferenceEl-Haggar SM, El-Shitany NA, Mostafa MF, El-Bassiouny NA. Metformin may protect nondiabetic breast cancer women from metastasis. Clin Exp Metastasis. 2016;33(4):339-357. ObjectiveTo investigate the impact of adding metformin to breast cancer adjuvant therapy in nondiabetic womenStudy Design and ParticipantsParticipants included women aged 40 to 65 from Damanhour Oncology Center (Damanhour, Egypt) with newly diagnosed breast cancer.

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Epithelia are protected from adverse conditions by a mucous barrier. The secreted and transmembrane mucins that constitute the mucous barrier are largely unrecognized as effectors of carcinogenesis. However, both types of mucins are intimately involved ...

Objectives We aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis. Design We performed 16S rRNA gene analysis of gastric mucosal samples from 81 cases including superficial gastritis (SG), atrophic gastritis (AG), intestinal metaplasia (IM) and gastric cancer (GC) from Xi’an, China, to determine mucosal microbiome dysbiosis across stages of GC. We validated the results in mucosal samples of 126 cases from Inner Mongolia, China. Results We observed significant mucosa microbial dysbiosis in IM and GC subjects, with significant enrichment of 21 and depletion of 10 bacterial taxa in GC compared with SG (q

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Study of colorectal, lung cancer cells treated with low-dose naltrexone (LDN) and chemotherapy. LDN had anticancer activity during treatment schedules.

An experimental nanoparticle therapy that combines low-density lipoproteins (LDL) and fish oil preferentially kills primary liver cancer cells without harming healthy cells, researchers report.

Conventional medicine offers little hope in the fight against deadly malignant melanoma, but there are multiple foods, botanicals, and vitamins with proven anti-melanoma activity within nature’s pharmacopeia

This Naturopathic Oncology course contains a turnkey cancer treatment program that can be set up by any practitioner, clinic, spa, or hospital and even by patients and their families at home. If you need more information: https://drsircus.com/conquering-cancer-course/

Every cell in our body contains the complete DNA library. So-called methyl groups regulate that in body tissues only the genetic information is expressed that is indeed needed in this tissue. Now, for the first time, researchers verified that a lack of methyl groups in the gene body leads to an incorrect gene activation and, as a consequence, may lead to the emergence of cancer.

A simple change in diet could boost vitamin D levels for millions of Americans suffering from Type 2 diabetes, according to new research.

The lack of oxygen in tumor cells changes the cells' gene expression, thereby contributing to the growth of cancer, suggest researchers. The findings are far-reaching, as the study also proved that maintaining a proper oxygen supply in tumors inhibits these so-called 'epigenetic aberrations.'

What do cancer cells and a runny nose have in common? Researchers say the answer may hold the key to making cancer treatment better. They have discovered a new gene target -- a chink in pancreatic cancer's defensive armor. Their discovery may point to new targeted therapies and a way to help make current treatments for this deadly cancer more effective.

The greedy metabolism of cancer cells to target kidney cell carcinomas, which kill more than 100,000 Americans each year, has been exploited by researchers. The team showed that the majority of renal cell cancers rewire their metabolism in a way that leaves them addicted to the nutrient cystine. By depriving the cancer cells of cystine, the researchers were able to trigger a form of cell death called necrosis in tumor cells.

Providing Advanced Nutritional Support for Cancer Patients and Survivors

Oxygenating the Body Series “But nobody today can say that one does not know what cancer and its prime cause be. On the contrary, there is no disease whose prime cause is better known, so that today ignorance is no longer an excuse,” said Nobel Prize Winner Otto Warburg in a meeting of Nobel Laureates... View Article

The presence of certain bacteria in the mouth may reveal increased risk for pancreatic cancer and enable earlier, more precise treatment, report investigators. Pancreatic cancer patients are known to be susceptible to gum disease, cavities, and poor oral health in general, say the study authors. That vulnerability led the research team to search for direct links between the makeup of bacteria driving oral disease and subsequent development of pancreatic cancer, a disease that often escapes early diagnosis and causes 40,000 US deaths annually.

Drinking piping hot coffee, tea and the caffeine-infused beverage yerba mate probably causes cancer, the World Health Organization has announced.

A natural extract derived from India's neem tree could potentially be used to treat pancreatic cancer, according to a new study. Researchers tested nimbolide, a compound found in neem leaves, against pancreatic cancer in cell lines and mice. The results revealed that nimbolide can stop pancreatic cancer's growth and metastasis without harming normal, healthy cells.

Should the active ingredient in aspirin be considered an essential vitamin? Note: around minute 3:40, Dr. Greger says "What happened to the other 799?" He meant "792." Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ If you missed the first two videos in this series, I discuss the pros and cons in Should We All Take Aspirin to Prevent Heart Disease? (http://nutritionfacts.org/video/should-we-all-take-aspirin-to-prevent-heart-disease) and Should We All Take Aspirin to Prevent Cancer? (http://nutritionfacts.org/video/should-we-all-take-aspirin-to-prevent-cancer). The drug-like anti-inflammatory power of certain plant foods may make them a risky proposition during pregnancy. See Caution: Anti-inflammatory Foods in the Third Trimester (http://nutritionfacts.org/video/caution-anti-inflammatory-foods-in-the-third-trimester/). Herbs and spices don’t just have some of the most anti-inflammatory properties, but also the most antioxidant power. See Antioxidants in a Pinch (http://nutritionfacts.org/video/antioxidants-in-a-pinch/). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/plants-with-aspirin-aspirations and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/plants-with-aspirin-aspirations. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image Credit: Food & Function https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Point 4 for Cancer Success - Dr Conners explains that an understanding of circulating tumor cells is essential for every cancer patient

Ever since chemotherapy and radiation became the 'standard of care,' oncology has been in the Dark Ages. Could the scientific community finally be waking up to the incomparable power of foods to cure what conventional treatment only makes worse?