Glyconutrients

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Essential Sugars - Innvista
Essential Sugars - Innvista
Pages Introduction Dictionary Economic Alternatives Fucose Galactose Glucosamine Glucose Mannose N-Acetylneuraminic Acid Nacetylgalactosamine Sugar
·innvista.com·
Essential Sugars - Innvista
! One size does not fit all – Trehalose metabolism by Clostridioides difficile is variable across the five phylogenetic lineages | Microbiology Society
! One size does not fit all – Trehalose metabolism by Clostridioides difficile is variable across the five phylogenetic lineages | Microbiology Society
Clostridioides difficile , the leading cause of antibiotic-associated diarrhoea worldwide, is a genetically diverse species which can metabolise a number of nutrient sources upon colonising a dysbiotic gut environment. Trehalose, a disaccharide sugar consisting of two glucose molecules bonded by an α 1,1-glycosidic bond, has been hypothesised to be involved in the emergence of C. difficile hypervirulence due to its increased utilisation by the RT027 and RT078 strains. Here, growth in trehalose as the sole carbon source was shown to be non-uniform across representative C. difficile strains, even though the genes for its metabolism were induced. Growth in trehalose reduced the expression of genes associated with toxin production and sporulation in the C. difficile R20291 (RT027) and M120 (RT078) strains in vitro, suggesting an inhibitory effect on virulence factors. Interestingly, the R20291 TreR transcriptional regulatory protein appeared to possess an activator function as its DNA-binding ability was increased in the presence of its effector, trehalose-6-phosphate. Using RNA-sequencing analysis, we report the identification of a putative trehalose metabolism pathway which is induced during growth in trehalose: this has not been previously described within the C. difficile species. These data demonstrate the metabolic diversity exhibited by C. difficile which warrants further investigation to elucidate the molecular basis of trehalose metabolism within this important gut pathogen.
·microbiologyresearch.org·
! One size does not fit all – Trehalose metabolism by Clostridioides difficile is variable across the five phylogenetic lineages | Microbiology Society
Fucoidan alleviates Salmonella-induced inflammation and mortality by modulating gut microbiota and metabolites, protecting intestinal barrier, and inhibiting NF-κB pathway - ScienceDirect
Fucoidan alleviates Salmonella-induced inflammation and mortality by modulating gut microbiota and metabolites, protecting intestinal barrier, and inhibiting NF-κB pathway - ScienceDirect
Salmonella typhimurium (ST) poses a serious threat to host health, and the adverse effects of antibiotic treatment necessitate the urgent search for i…
·sciencedirect.com·
Fucoidan alleviates Salmonella-induced inflammation and mortality by modulating gut microbiota and metabolites, protecting intestinal barrier, and inhibiting NF-κB pathway - ScienceDirect
Sucrose vs Glucose vs Fructose: What's the Difference?
Sucrose vs Glucose vs Fructose: What's the Difference?
Not all sugars are created equal, which matters when it comes to your health. Here's the difference between sucrose, glucose and fructose.
·healthline.com·
Sucrose vs Glucose vs Fructose: What's the Difference?
Frontiers | Identification of Acacia Gum Fermenting Bacteria from Pooled Human Feces using Anaerobic Enrichment Culture
Frontiers | Identification of Acacia Gum Fermenting Bacteria from Pooled Human Feces using Anaerobic Enrichment Culture
Commercial acacia gum (AG) used in this study is a premium-grade free-flowing powder. It is a gummy exudate composed of arabinogalactan branched polysaccharide, a biopolymer of arabinose and galactose. Also known as food additive, acacia gum (E414), which is presently marketed as a functional dietary fiber to improve overall human gut health. The health effects may be related to the luminal pH regulation from the short-chain fatty acids (SCFA) production. Studies suggested that amylolytic and butyrogenic pathways are the major factors determining the SCFA outcome of AG in the lower gut. However, the primary bacteria involved in the fermentation have not been studied. This study aimed to investigate the putative primary degraders of acacia gum in the gut ecosystem. Isolation and identification of gum-fermenting bacteria were performed through enrichment culture fermentation. The experiment was conducted in an anaerobic chamber for 144 h in three stages. The study was conducted in triplicate using an anaerobic chamber system. This culture system allows specific responses to support only bacteria that are responsible for gum fermentation among the gut microbiota. Five bacterial strains were isolated and found to be gum-fermenting bacteria. Based on the 16s RNA sequence, the isolates matched to butyrate-producing Escherichia fergusonii, ATCC 35469.
·frontiersin.org·
Frontiers | Identification of Acacia Gum Fermenting Bacteria from Pooled Human Feces using Anaerobic Enrichment Culture
Habitual glucosamine use, APOE genotypes, and risk of incident cause-specific dementia in the older population | Alzheimer's Research & Therapy | Full Text
Habitual glucosamine use, APOE genotypes, and risk of incident cause-specific dementia in the older population | Alzheimer's Research & Therapy | Full Text
Background The relationship of glucosamine use with incident dementia in the older population remains uncertain. We aimed to evaluate the longitudinal association between habitual glucosamine supplement and the risk of cause-specific dementia and examine the possible effect modifiers on this association. Methods The study included 214,945 participants over the age of 60 who had available information on glucosamine use and did not have dementia at baseline in the UK Biobank. The APOE genotypes were determined by a combination variant of rs429358 and rs7412. The primary outcome was incident vascular dementia, incident Alzheimer’s disease, and incident frontotemporal dementia, respectively. Results Over a median follow-up duration of 12 years, 1039, 1774, and 122 participants developed vascular dementia, Alzheimer’s disease, and frontotemporal dementia, respectively. Overall, habitual glucosamine use was significantly associated with a lower risk of incident vascular dementia (adjusted HR, 0.82; 95%CI, 0.70–0.96), but not significantly associated with incident Alzheimer’s disease (adjusted HR, 1.02; 95%CI, 0.92–1.14) and incident frontotemporal dementia (adjusted HR, 0.95; 95%CI, 0.63–1.43). Moreover, the inverse association between habitual glucosamine use and incident vascular dementia was more pronounced in participants with concomitant supplement of calcium (P-interaction = 0.011), and those without concomitant supplement of zinc (P-interaction = 0.018). However, APOE ε4 dosage and baseline cognitive function did not significantly modify the relationships of glucosamine use with incident vascular dementia or Alzheimer’s disease (All P-interactions > 0.05). Conclusions Regardless of APOE genotypes and baseline cognitive function, habitual glucosamine use was significantly inversely associated with incident vascular dementia in the older population.
·alzres.biomedcentral.com·
Habitual glucosamine use, APOE genotypes, and risk of incident cause-specific dementia in the older population | Alzheimer's Research & Therapy | Full Text
Crystals | Free Full-Text | Solubility and Crystallization of Glucosamine Hydrochloride in Water with the Presence of Additives
Crystals | Free Full-Text | Solubility and Crystallization of Glucosamine Hydrochloride in Water with the Presence of Additives
Glucosamine hydrochloride (GAH) is a kind of natural hexose, which is used to promote the synthesis of mucopolysaccharides and improve the metabolism of articular cartilage. In this paper, the solubility of GAH in pure water and aqueous system with the presence of three kinds of additives (HCl, NaCl, KCl) at temperatures ranging from 278.15 K to 323.15 K was determined by gravimetric method. When there are additives in water, the solubility of GAH increases with the increase of temperature and decreases with the increase of concentration of the three kinds of additives. When the additives were at similar mole fractions, HCl led to the lowest solubility of GAH. The modified Apelblat model and van’t Hoff model were used to correlate the solubility data. The average relative deviation (ARD) data of Apelblat and van’t Hoff models were less than 5%, indicating good fitting results. Based on the thermodynamic data, the cooling crystallization process of GAH was performed. It was found that the additives could affect the crystal morphology, particle size, and yield of GAH products. This study supplemented the thermodynamic data of GAH and studied the cooling crystallization process in the presence of GAH additives, which provided important guidance for the optimization of the crystallization process.
·mdpi.com·
Crystals | Free Full-Text | Solubility and Crystallization of Glucosamine Hydrochloride in Water with the Presence of Additives
Aloe Vera for Diabetes: Research, Pros, Cons, and More
Aloe Vera for Diabetes: Research, Pros, Cons, and More
Aloe vera still needs to be researched more for its use in treating diabetes, but preliminary results show that it could help lower both fasting glucose and A1C.
·healthline.com·
Aloe Vera for Diabetes: Research, Pros, Cons, and More
Marine Drugs | Free Full-Text | Bioactivity of Fucoidan-Rich Extracts from Fucus vesiculosus against Rotavirus and Foodborne Pathogens
Marine Drugs | Free Full-Text | Bioactivity of Fucoidan-Rich Extracts from Fucus vesiculosus against Rotavirus and Foodborne Pathogens
Marine algae are sources of bioactive components with defensive properties of great value against microbial infections. This study investigated the bioactivity of extracts from brown algae Fucus vesiculosus against rotavirus, the worldwide leading cause of acute gastroenteritis in infants and young children. Moreover, one of the extracts was tested against four foodborne bacteria: Campylobacter jejuni, Escherichia coli, Salmonella Typhimurium, and Listeria monocytogenes, and the non-pathogenic: E. coli K12. In vitro tests using MA104 cells revealed that both whole algae extracts and crude fucoidan precipitates neutralized rotavirus in a dose-responsive manner. The maximum neutralization activity was observed when the rotavirus was incubated with 100 μg mL−1 of the hydrochloric acid-obtained crude fucoidan (91.8%), although crude fucoidan extracted using citric acid also demonstrated high values (89.5%) at the same concentration. Furthermore, molecular weight fractionation of extracts decreased their antirotaviral activity and high molecular weight fractions exhibited higher activity compared to those of lower molecular weight. A seaweed extract with high antirotaviral activity was also found to inhibit the growth of C. jejuni, S. Typhimurium, and L. monocytogenes at a concentration of 0.2 mg mL−1. Overall, this study expands the current knowledge regarding the antimicrobial mechanisms of action of extracts from F. vesiculosus.
·mdpi.com·
Marine Drugs | Free Full-Text | Bioactivity of Fucoidan-Rich Extracts from Fucus vesiculosus against Rotavirus and Foodborne Pathogens
Aloe vera Gel Ameliorates Fat-Rich and High Fructose (FRHF) Diet-Induced Pancreatic and Splenic Damage in Mice | Borneo Journal of Pharmacy
Aloe vera Gel Ameliorates Fat-Rich and High Fructose (FRHF) Diet-Induced Pancreatic and Splenic Damage in Mice | Borneo Journal of Pharmacy
High-fat diet alone or in combination with high fructose has been known to induce diabetes, obesity, hypertension, and immune dysfunction. The study evaluates the role of Aloe vera in fat-rich and high fructose diet-induced (FRHFD) hyperglycemias in addition to testicular and splenic morphology in mice. Twenty BALB/c Mice were randomly distributed into four groups (n=5). The groups were fed on a normal diet, FRHFD, FRHFD + 10 g Aloe vera , and FRHFD + 20 g Aloe vera for 10 weeks. All the mice were sacrificed a day after the 10 weeks of treatment. The result showed that mice fed on FRHFD plus Aloe vera had a significantly lower (p
·journal.umpr.ac.id·
Aloe vera Gel Ameliorates Fat-Rich and High Fructose (FRHF) Diet-Induced Pancreatic and Splenic Damage in Mice | Borneo Journal of Pharmacy
Maternal dietary fiber intake during pregnancy and child development: the Japan Environment and Children's Study
Maternal dietary fiber intake during pregnancy and child development: the Japan Environment and Children's Study
BackgroundAnimal studies have shown that maternal low-fiber diets during pregnancy may impair brain development and function in offspring, but this has not been validated by epidemiological studies. The aim of this study was to investigate the link between maternal dietary fiber intake during pregnancy and neurodevelopmental delay in offspring using a large birth cohort.MethodsA total of 76,207 mother-infant pairs were analyzed using data from the Japan Environment and Children's Study, a nationwide prospective cohort study. Maternal dietary fiber intake was estimated using the food frequency questionnaire in mid-pregnancy. Maternal dietary fiber intake was adjusted for energy and classified into quintiles. Developmental delay was assessed in five domains using the Japanese version of the Ages and Stages Questionnaire, Third Edition at the age of 3 years. The logistic regression analysis was performed to estimate the odds ratio (OR) and 95% confidence interval (CI) for the link between dietary fiber intake during pregnancy and developmental delay at the age of 3 years.ResultsThe lowest intake group of total dietary fiber had a higher risk of delayed communication [adjusted OR (aOR), 1.51; 95% CI, 1.32–1.74], fine motor (aOR, 1.45; 95% CI, 1.32–1.61), problem-solving (aOR, 1.46; 95% CI, 1.32–1.61), and personal-social skills (aOR, 1.30; 95% CI, 1.12–1.50) than did the highest intake group. An analysis that excluded the effects of insufficient folic acid intake during pregna...
·frontiersin.org·
Maternal dietary fiber intake during pregnancy and child development: the Japan Environment and Children's Study
Polymers | Free Full-Text | Novel Fucoidan Pharmaceutical Formulations and Their Potential Application in Oncology—A Review
Polymers | Free Full-Text | Novel Fucoidan Pharmaceutical Formulations and Their Potential Application in Oncology—A Review
Fucoidan belongs to the family of marine sulfated, L-fucose-rich polysaccharides found in the cell wall matrix of various brown algae species. In the last few years, sulfated polysaccharides have attracted the attention of researchers due to their broad biological activities such as anticoagulant, antithrombotic, antidiabetic, immunomodulatory, anticancer and antiproliferative effects. Recently the application of fucoidan in the field of pharmaceutical technology has been widely investigated. Due to its low toxicity, biocompatibility and biodegradability, fucoidan plays an important role as a drug carrier for the formulation of various drug delivery systems, especially as a biopolymer with anticancer activity, used for targeted delivery of chemotherapeutics in oncology. Furthermore, the presence of sulfate residues with negative charge in its structure enables fucoidan to form ionic complexes with oppositely charged molecules, providing relatively easy structure-forming properties in combination with other polymers. The aim of the present study was to overview essential fucoidan characteristics, related to its application in the development of pharmaceutical formulations as a single drug carrier or in combinations with other polymers. Special focus was placed on micro- and nanosized drug delivery systems with polysaccharides and their application in the field of oncology.
·mdpi.com·
Polymers | Free Full-Text | Novel Fucoidan Pharmaceutical Formulations and Their Potential Application in Oncology—A Review
Pharmacokinetics of fucoidan and low molecular weight fucoidan from Saccharina japonica after oral administration to mice | SpringerLink
Pharmacokinetics of fucoidan and low molecular weight fucoidan from Saccharina japonica after oral administration to mice | SpringerLink
Journal of Oceanology and Limnology - The brown seaweed, Sacchairna japonica, has been used in traditional Chinese medicine for over one thousand years. Oral administration of fucoidan or low...
·link.springer.com·
Pharmacokinetics of fucoidan and low molecular weight fucoidan from Saccharina japonica after oral administration to mice | SpringerLink
Allulose Sweetener, a Low Calorie Sugar
Allulose Sweetener, a Low Calorie Sugar
Allulose is a low calorie sugar with the same clean, sweet taste you expect from sugar. Learn how you can incorporate it into a healthy diet and lifestyle.
·allulose.org·
Allulose Sweetener, a Low Calorie Sugar
Allulose Sugar - David Perlmutter M.D.
Allulose Sugar - David Perlmutter M.D.
Allulose, a rare sugar, has gained significant attention in recent years due to its numerous health benefits, primarily concerning metabolic health. To be sure, it seems like it is everywhere …
·drperlmutter.com·
Allulose Sugar - David Perlmutter M.D.
Bulk Glyconutrients: Coffee Fruit Powder
Bulk Glyconutrients: Coffee Fruit Powder
Coffee Fruit Powder from VDF FutureCeuticals.   Each level teaspoon is approximately 3 grams with 75 servings per 1/2 pound.  Caffeine 0.8%  The recommended serving serving size is 1/4...
·glycop.com·
Bulk Glyconutrients: Coffee Fruit Powder
Undaria pinnatifida fucoidan ameliorates dietary fiber deficiency-induced inflammation and lipid abnormality by modulating mucosal microbiota and protecting intestinal barrier integrity - ScienceDirect
Undaria pinnatifida fucoidan ameliorates dietary fiber deficiency-induced inflammation and lipid abnormality by modulating mucosal microbiota and protecting intestinal barrier integrity - ScienceDirect
Dietary fiber deficiency (FD) is a new public health concern, with limited understanding of its impact on host energy requirements and health. In this…
·sciencedirect.com·
Undaria pinnatifida fucoidan ameliorates dietary fiber deficiency-induced inflammation and lipid abnormality by modulating mucosal microbiota and protecting intestinal barrier integrity - ScienceDirect
Association Between Glucosamine Use and the Risk of Incident Heart Failure: The UK Biobank Cohort Study and Mendelian Randomization Analysis - ScienceDirect
Association Between Glucosamine Use and the Risk of Incident Heart Failure: The UK Biobank Cohort Study and Mendelian Randomization Analysis - ScienceDirect
To evaluate the association between regular glucosamine intake and heart failure (HF) and to explore whether the association is mediated by relevant c…
·sciencedirect.com·
Association Between Glucosamine Use and the Risk of Incident Heart Failure: The UK Biobank Cohort Study and Mendelian Randomization Analysis - ScienceDirect
A neuroprotective dose of trehalose is harmless to metabolic organs: comprehensive histopathological analysis of liver, pancreas, and kidney | SpringerLink
A neuroprotective dose of trehalose is harmless to metabolic organs: comprehensive histopathological analysis of liver, pancreas, and kidney | SpringerLink
DARU Journal of Pharmaceutical Sciences - Trehalose is a non-reducing disaccharide synthesized by lower organisms. It has recently received special attention because of its neuroprotective...
·link.springer.com·
A neuroprotective dose of trehalose is harmless to metabolic organs: comprehensive histopathological analysis of liver, pancreas, and kidney | SpringerLink