(trehalose[Title]) AND (parkinson[Title]) - Search Results - PubMed
Parkinsons
(trehalose[Title/Abstract]) AND (parkinson[Title/Abstract]) - Search Results - PubMed
A neuroprotective dose of trehalose is harmless to metabolic organs: comprehensive histopathological analysis of liver, pancreas, and kidney - PubMed
Our study demonstrates that systemic trehalose administration preserved the typical histological architecture of the organs involved in its metabolism, supporting its safety as a potential neuroprotective agent.
Association between increased and decreased gut microbiota abundance and Parkinson's disease: A systematic review and subgroup meta-analysis - PubMed
Patients in the PD cohort exhibited distinctive microbiota compositions compared to healthy individuals, with unique differential patterns in gut microbiome abundance at the phylum, family, and genus levels that may be associated wtih PD pathogenesis.
Can Ivermectin play a key role in treating Parkinson's Disease? at DuckDuckGo
Gut brain axis: an insight into microbiota role in Parkinson's disease - PubMed
Parkinson's disease (PD) is one of the most common progressive neurodegenerative diseases. It is characterized neuropathologically by the presence of alpha-synuclein containing Lewy Bodies in the substantia nigra of the brain with loss of dopaminergic neurons in the pars compacta of the substantia n …
Gut Microbial Metabolites in Parkinson's Disease: Implications of Mitochondrial Dysfunction in the Pathogenesis and Treatment - PubMed
The search for therapeutic targets for Parkinson's disease (PD) is hindered by the incomplete understanding of the pathophysiology of the disease. Mitochondrial dysfunction is an area with high potential. The neurobiological signaling connections between the gut microbiome and the central nervous sy …
Ivermectin as Adjunct Therapy for Parkinson’s Disease: Dopaminergic Modulation Insights (2025 Review)
Exploring Ivermectin’s Neuromodulatory Role in Enhancing Parkinson’s Treatment
Ivermectin for Parkinson’s & Dementia: Exploring Its Potential as an Adjunct Neuroprotective Therapy (2025)
Can Ivermectin play a key role in treating Parkinson's Disease? Two peer-reviewed papers—one by Warnecke et al. (2020) and another by Wa...
Literature review and meta-analysis of environmental toxins associated with increased risk of Parkinson's disease - PubMed
Parkinson's disease (PD) is a neurodegenerative disorder and leading cause of death worldwide, whose pathogenesis has been linked to toxic environmental exposures. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (i) to compile, and group by exposure …
Mitochondrial Dysfunction in Genetic and Non-Genetic Parkinson's Disease - PubMed
Mitochondrial dysfunction is a hallmark of Parkinson's disease (PD) pathogenesis, contributing to increased oxidative stress and impaired endo-lysosomal-proteasome system efficiency underlying neuronal injury. Genetic studies have identified 19 monogenic mutations-accounting for ~10% of PD cases-tha …
New Treatments for Parkinson’s Disease | APDA
Dr. Gilbert discusses the seven new medications that were approved to treat Parkinson’s disease motor symptoms since 2017
Oral Trehalose Intake Modulates the Microbiota-Gut-Brain Axis and Is Neuroprotective in a Synucleinopathy Mouse Model - PubMed
Parkinson's disease (PD) is a neurodegenerative disease affecting dopaminergic neurons in the nigrostriatal and gastrointestinal tracts, causing both motor and non-motor symptoms. This study examined the neuroprotective effects of trehalose. This sugar is confined in the gut due to the absence of tr …
Possible Mechanisms Underlying the Therapeutic Effects of Transcranial Magnetic Stimulation - PMC
Transcranial magnetic stimulation (TMS) is an effective method used to diagnose and treat many neurological disorders. Although repetitive TMS (rTMS) has been used to treat a variety of serious pathological conditions including stroke, depression, ...
Proximity to Golf Courses and Risk of Parkinson Disease | Neurology | JAMA Network Open | JAMA Network
This case-control of older US adults examines risk of Parkinson Disease by proximity of residence to a golf course.
The History Of Chlorine Dioxide - by Pierre Kory, MD, MPA
Chlorine dioxide was discovered over 200 years ago. It's use has steadily expanded into many industries and therapeutic applications despite a near global regulatory blockade on clinical research.
The role of amphipathic and cationic helical peptides in Parkinson's disease - PubMed
Peptides are attracting a growing interest for therapeutic applications in biomedicine. In Parkinson's disease (PD), different human endogenous peptides have been associated with beneficial effects, including protein aggregation inhibition, reduced inflammation, or the protection of dopaminergic neu …
Trehalose as a promising therapeutic candidate for the treatment of Parkinson's disease - PMC
Parkinson's disease (PD) is a progressive movement disorder resulting primarily from loss of nigrostriatal dopaminergic neurons. PD is characterized by the accumulation of protein aggregates, and evidence suggests that aberrant protein deposition in ...
Why should dopamine reduction work for Parkinson's?
Because the data say RB-190 should work.
APDA Symptom Tracker App | American Parkinson Disease Association
A New & Improved App to Help Track Your Symptoms Each person’s Parkinson’s disease symptoms are different. The more you and your care team know, the more personalized your care can be. The user-friendly APDA Symptom Tracker app helps you capture the details of your symptoms, with new and enhanced features including a medication tracker, notes section, […]
Earl R. Dorsey, M.D. | UR Medicine
The University of Rochester Medical Center (URMC) is one of the nation’s leading academic medical centers. It forms the centerpiece of the University of Rochester’s health research, teaching and patient care missions.
The University of Rochester Medical Center is a private, coeducational, nonsectarian, and nonprofit research university.
! ! Parkinson's Disease: Symptoms, Causes and Support Strategies
Parkinson's disease is progressive neurological degenerative state. Discover natural solutions and 17 action steps to improve brain health.
Symptom Trackers | Stanford Parkinson's Community Outreach | Stanford Medicine
Stanford Parkinson's Community Outreach has created a list of the best resources available on the topic of symptom trackers for PD.
l-serine parkinson's at DuckDuckGo
L-Serine Powder Supplement - Memory Booster
Discover the transformative potential of L-Serine powder, a powerhouse in the world of wellness support. A favored choice among those who prioritize their health regimen, L-Serine stands out in the vast landscape of nutritional supplements. Experience a choice that discerning wellness enthusiasts trust—an addition to your daily routine that signifies dedication to optimal well-being.
Parkinson's Disease Natural Treatment and Remedies in 5 Steps - Dr. Axe
Parkinson’s is a degenerative illness that results in loss of intentional movement. Try these recommendations for Parkinson’s disease natural treatment.
Parkinson's Symptoms, Causes & Risk Factors - Dr. Axe
Parkinson's symptoms can make everyday tasks difficult, so if you have these Parkinson's symptoms, it's time to take steps to prevent its progression.
Phosphatidylserine, inflammation, and central nervous system diseases - PMC
Fucoidan ameliorates rotenone-induced Parkinsonism in mice by regulating the microbiota-gut-brain axis - ScienceDirect
Microbiota-gut-brain axis, the bidirectional relationship between the gut microbiota and the brain, has been increasingly appreciated in the pathogene…
Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothesis that the intestine might be an early site of PD disease in response to an environmental toxin or pathogen. One potential mechanism for environmental toxin(s) and proinflammatory luminal products to gain access to mucosal neuronal tissue and promote oxidative stress is compromised intestinal barrier integrity. However, the role of intestinal permeability in PD has never been tested. We hypothesized that PD subjects might exhibit increased intestinal permeability to proinflammatory bacterial products in the intestine. To test our hypothesis we evaluated intestinal permeability in subjects newly diagnosed with PD and compared their values to healthy subjects. In addition, we obtained intestinal biopsies from both groups and used immunohistochemistry to assess bacterial translocation, nitrotyrosine (oxidative stress), and alpha-synuclein. We also evaluated serum markers of endotoxin exposure including LPS binding protein (LBP). Our data show that our PD subjects exhibit significantly greater intestinal permeability (gut leakiness) than controls. In addition, this intestinal hyperpermeability significantly correlated with increased intestinal mucosa staining for E. coli bacteria, nitrotyrosine, and alpha-synuclein as well as serum LBP levels in PD subjects. These data represent not only the first demonstration of abnormal intestinal permeability in PD subjects but also the first correlation of increased intestinal permeability in PD with intestinal alpha–synuclein (the hallmark of PD), as well as staining for gram negative bacteria and tissue oxidative stress. Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects. Trial Registration Clinicaltrials.gov NCT01155492