Parkinsons

(NaturalHealth365) As evidence of the weed killer’s toxicity continues to pour in, the EPA turns its head and supports the use of paraquat.

Microbiota-gut-brain axis, the bidirectional relationship between the gut microbiota and the brain, has been increasingly appreciated in the pathogene…

We have already reported that glucosamine (GlcN) distinctly abrogates the pigmentation of human epidermal equivalents stimulated by stem cell factor + endothelin-1 (SE). In this study, we characterized the molecular mechanism involved in the anti-melanogenic effects of GlcN using normal human melanocytes (NHMs) in culture. The SE-stimulated gene (12 h) and protein (24 h) expression levels of melanocyte-specific proteins (at the indicated times post-stimulation) were significantly abrogated by pretreatment with GlcN for 72 h. Western blotting analysis of the phosphorylation of intracellular signaling molecules in the MAPK pathway revealed that despite the significantly decreased level of total CREB protein at all times post-stimulation, the SE-stimulated phosphorylation of ERK, CREB and MITF is not attenuated at 15 min post-stimulation in GlcN-treated NHMs. However, the SE-stimulated protein expression level of total MITF at 2 and 6 h post-stimulation was significantly abrogated by 72 h pretreatment with GlcN. Consistently, pretreatment with GlcN for 72 h abrogated the stimulated gene and protein expression levels of MITF at 1 h and 2 h post-stimulation, respectively. Analysis of gene and protein expression levels also demonstrated that pretreatment with GlcN for 72 h significantly reduced the protein levels of CREB and MITF without affecting their gene expression levels prior to the SE stimulation. Silencing with a CREB siRNA distinctly abrogated the SE-stimulated expression of MITF (at 2 h post-stimulation) and melanocyte-specific proteins (at 24 h post-stimulation). Similarly, transfection of MITF siRNA markedly abrogated the SE-stimulated expression of MITF protein and melanocyte-specific proteins at 2 and 24 h post-stimulation, respectively. Finally, the decreased levels of CREB and MITF proteins induced by 72 h pretreatment with GlcN were abrogated by the co-addition of the proteosomal degradation inhibitor MG132. These findings suggest that the anti-melanogenic effect elicited by GlcN is mediated via the decreased expression of MITF which results from the attenuated transcriptional activity of CREB due to proteolytic degradation.

Parkinson's disease (PD) is one of the most common progressive neurodegenerative diseases. It is characterized neuropathologically by the presence of alpha-synuclein containing Lewy Bodies in the substantia nigra of the brain with loss of dopaminergic neurons in the pars compacta of the substantia n …

The search for therapeutic targets for Parkinson's disease (PD) is hindered by the incomplete understanding of the pathophysiology of the disease. Mitochondrial dysfunction is an area with high potential. The neurobiological signaling connections between the gut microbiome and the central nervous sy …

We now can convincingly demonstrate that a ketogenic diet is helpful in Parkinson’s, and we now have a better understanding of the underlying mechanisms.

Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothesis that the intestine might be an early site of PD disease in response to an environmental toxin or pathogen. One potential mechanism for environmental toxin(s) and proinflammatory luminal products to gain access to mucosal neuronal tissue and promote oxidative stress is compromised intestinal barrier integrity. However, the role of intestinal permeability in PD has never been tested. We hypothesized that PD subjects might exhibit increased intestinal permeability to proinflammatory bacterial products in the intestine. To test our hypothesis we evaluated intestinal permeability in subjects newly diagnosed with PD and compared their values to healthy subjects. In addition, we obtained intestinal biopsies from both groups and used immunohistochemistry to assess bacterial translocation, nitrotyrosine (oxidative stress), and alpha-synuclein. We also evaluated serum markers of endotoxin exposure including LPS binding protein (LBP). Our data show that our PD subjects exhibit significantly greater intestinal permeability (gut leakiness) than controls. In addition, this intestinal hyperpermeability significantly correlated with increased intestinal mucosa staining for E. coli bacteria, nitrotyrosine, and alpha-synuclein as well as serum LBP levels in PD subjects. These data represent not only the first demonstration of abnormal intestinal permeability in PD subjects but also the first correlation of increased intestinal permeability in PD with intestinal alpha–synuclein (the hallmark of PD), as well as staining for gram negative bacteria and tissue oxidative stress. Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects. Trial Registration Clinicaltrials.gov NCT01155492

Sarah King, PT, DPT shows people diagnosed with Parkinson's Disease how to create a personalized Parkinson’s action plan that improves their symptoms, so they can spend less time worrying and more time doing the things they love, with the people they love, for as long as possible.

Share This Sign up at: ParkinsonsDisease.blog About Jonathan Sackner-Bernstein, MD Dr. Sackner-Bernstein shares his pursuit of conquering Parkinson's, using expertise developed as Columbia University faculty, FDA senior official, DARPA insider and witness to the toll of PD. Dr. S-B’s Linkedin page RightBrainBio, Inc. was incorporated in 2022 to develop tranformative therapies for people with Parkinson's.

Exploring Ivermectin’s Neuromodulatory Role in Enhancing Parkinson’s Treatment

Can Ivermectin play a key role in treating Parkinson's Disease? Two peer-reviewed papers—one by Warnecke et al. (2020) and another by Wa...

Science says eating just one meal per day can improve your health. Learn more at https://highintensityhealth.com/OMAD ----- Connect with Bill Curtis: https://www.thefourthfoodgroup.com/ Related Video testing the KetoAid Ketone Ester: https://youtu.be/V-ILObXYsaQ This episode is brought to you by: ➢ Health IQ, an insurance company that helps health conscious people like weightlifters, cyclist, keto dieters and vegetarians get lower rates on their life insurance. ➢ Get a Free Quote: http://healthiq.com/HIH Somnifix.com, the world’s only hypoallergenic mouth tape, developed by Harvard Scientists. https://www.somnifix.com Key Timestamps: 01:55 Journalist Bill Curtis has had Parkinson's since 2000. As predicted, he was dramatically affected 10 years later with advanced Parkinson's. Now the only symptom he has is a slight tremor. 04:48 Within about 2 hours of eating carbs, Bill will begin to shake and feel rigid. He doesn't get the full on symptoms he had before. 07:38 Bill was in an exercise program. In an attempt to enhance the effects of the program, he fasted overnight and had nothing for breakfast before the workout. He found it alleviated his profound fatigue. 11:27 Fasting helped with the fatigue, but there were many more symptoms that were not reversed. Bill continued researching. 13:02 Bill exercised fasted every day for a year. He lost weight, but eventually, it stopped working. As you become fit, you make fewer ketones. 15:04 Dr. Veech suggested that Bill try Bulletproof Coffee after the night fast. Nearly all of his symptoms abated at the end of the first hour. 19:36 The military has been experimenting with Dr. Veech's ketone ester for radiation exposure. 22:26 A therapeutic ketogenic diet is one with 80 to 90% of your food as fat. Bill has devised 4 levels of ketosis. 30:33 Within the first 10 days of taking ketone ester, Bill no longer had urinary incontinence. 32:07 There is data that an elevation of uric acid it will delay the onset of Parkinson's. If you have Parkinson's, and your uric acid levels are higher, you decline more slowly. 36:14 BHB allows you to make more dopamine, serotonin, adrenaline, noradrenaline and nitric oxide. 38:00 In advanced Parkinson's neurotransmitters are negatively impacted. With ketosis, you are making serotonin, noradrenaline, adrenaline, dopamine and nitric oxide synthase. 38:52 Every antioxidant has to be recharged with an electron from NADPH, directly or indirectly. 39:50 Beta hydroxybutyrate raises NADPH levels using isocitrate dehydrogenase in the cytoplasm, outside of the mitochondria. 42:24 NADPH levels in the mitochondria does not correlate with NADPH levels in the cytosol. We should measure the cytosolic NADPH. 44:09 NADPH voltage is dependent upon the relative concentrations. More equals more resilience. 48:52 Dismutase does not get its electrons from the battery. It does this by taking 2 molecules of superoxide, oxidizing one and reducing the other. 52:59 You have the ability to use ketones to restore ischemia-reperfusion and turn off inflammation. 54:08 NADPH controls inflammation. 55:04 Dr. Veech found that treating Alzheimer's mouse models with beta hydroxybutyrate kept them from accumulating beta amyloid deposits. 58:03 Bill believes that TBI will respond very well to BHB, as evidenced by people close to him with head injuries. 01:02:41 Bill has created an online course to help people help each other. You need a cook, a coach, a nutritionist and a doctor. 01:04:36 Bill must still take his Parkinson's medications.

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Parkinson's disease (PD) is a neurodegenerative disorder and leading cause of death worldwide, whose pathogenesis has been linked to toxic environmental exposures. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (i) to compile, and group by exposure …

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This article originally appeared in the Fall 2016 issue of Health Science magazine, the member magazine of the National Health Association. Csilla Veress, N.D., L.Ac is a Naturopathic doctor and Licensed Acupuncturist at TrueNorth Health Center in Santa Rosa, California. She received her Master’s in Acupuncture and Oriental Medicine, and her Doctorate in aturopathic medicine from Bastyr University. While in medical school, Dr. Veress completed a two-year internship in cancer research at Bastyr Integrative Oncology Research Center. She has completed additional training in Classical Homeopathy at the New England School of Homeopathy and advanced comprehensive neurotransmitter training at/from Institute of Neurotransmitter Science. Dr. Veress is passionate about preventative care, and emphasizes nutrition-based medicine. She implements natural hygiene and a Naturopathic medical approach, supporting patients to heal their bodies through lifestyle, food, and water fasting. Parkinson’s disease is a progressive and debilitating neurological disorder that affects one million Americans and more than four million people worldwide. It is not known exactly what causes Parkinson’s disease (PD) and it is without a cure.  According to the National Institute of Neurological Disorders and Stroke, PD affects more men than women (by 50%), and is found more often in older people (60 years old on average, although “early onset” can occur before age 50). Total risk is 2 to 5% unless a family member has a known gene for the disease. Knowing exactly how many cases of PD exist is difficult (the estimate is about 50,000 a year in the U.S.) since in the early stages many people think that their symptoms reflect normal aging, so they don’t consult their doctors. Other health conditions may also present symptoms similar to PD (there is no definitive test to find out if someone has the disease). Tremors in the arms or legs are considered the hallmark of Parkinson’s, though the disease inevitably progresses. As motor control diminishes, simple tasks like writing and walking are typically the first to go. Patients eventually become wheelchair-bound and suffer from dementia. But perhaps most disturbing is that Parkinson’s disease responds poorly to conventional therapy. Click here to read the entire article as a PDF.

Mitochondrial dysfunction is a hallmark of Parkinson's disease (PD) pathogenesis, contributing to increased oxidative stress and impaired endo-lysosomal-proteasome system efficiency underlying neuronal injury. Genetic studies have identified 19 monogenic mutations-accounting for ~10% of PD cases-tha …

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Dr. Gilbert discusses the seven new medications that were approved to treat Parkinson’s disease motor symptoms since 2017

Parkinson's disease (PD) is a progressive neurodegenerative disease for which stem cell research has created hope in the last few years. Seven PD pati…

Parkinson's disease (PD) is a neurodegenerative disease affecting dopaminergic neurons in the nigrostriatal and gastrointestinal tracts, causing both motor and non-motor symptoms. This study examined the neuroprotective effects of trehalose. This sugar is confined in the gut due to the absence of tr …

(NaturalHealth365) Common environmental contaminant frequently present in tap water may increase your risk of Parkinson's disease.

(NaturalHealth365) Parkinson's disease affects over 10 million people worldwide. Find out why gut health matters.

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