IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein - PubMed
Less than a year after the global emergence of the coronavirus SARS-CoV-2, a novel vaccine platform based on mRNA technology was introduced to the market. Globally, around 13.38 billion COVID-19 vaccine doses of diverse platforms have been administered. To date, 72.3% of the total population has bee …
Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent? - PMC
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown diverse life-threatening effects, most of which are considered short-term. In addition to its short-term effects, which has claimed many millions of lives since 2019, the long-term ...
Cureus | A Case of Pure Pericarditis Associated With COVID-19: Application of Classical Clinical Evaluation for Differential Diagnosis | Article
Pericarditis of varying severity is being recognized as a rare complication of the COVID-19 infection. We present a patient with an electrocardiogram (EKG) and physical exam findings that initia...
Cureus | Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching | Article
Background: Ivermectin has demonstrated different mechanisms of action that potentially protect from both coronavirus disease 2019 (COVID-19) infection and COVID-19-related comorbidities. Based ...
Cureus | Estimation of Excess Mortality in Germany During 2020-2022 | Article
Background This study estimates the burden of COVID-19 on mortality in Germany. It is expected that many people have died because of the new COVID-19 virus who otherwise would not have died. ...
Dr David Martin at International Covid Summit III - European Parliament: It is Genocide!
SAVE IT FOR POSTERITY https://9xbuddy.in/ THEN SHARE IT EVERYWHERE, LIKE THERE IS NO TOMORROW .. International Covid Summit III - Part 1 - European Parliament, Brussels, Full - Time Stamps plus Super Links in the Description https://rumble.com/v2…
Fucoidan Ameliorates Ferroptosis in Ischemia-reperfusion-induced Liver Injury through Nrf2/HO-1/GPX4 Activation
Liver ischemia-reperfusion (IR) injury is a common pathological process in liver surgery. Ferroptosis, which is closely related to lipid peroxidation, has recently been confirmed to be involved in the pathogenesis of IR injury. However, the development of drugs that regulate ferroptosis has been slow, and a complete understanding of the mechanisms underlying ferroptosis has not yet been achieved. Fucoidan (Fu) is a sulfated polysaccharide that has attracted research interest due to its advantages of easy access and wide biological activity.
The Action and Mechanism of Trehalose on GATA4 Autophagy Degradation and Ventricular Remodeling - PubMed
Trehalose significantly abates myocardial hypertrophy and pressure overload-induced cardiomyocyte apoptosis in mice. The cardioprotective effect of trehalose on enhanced autophagy is attributed, at least in part, to the promotion of autophagic degradation of GATA4.
Boswellia with MSM Beats Glucosamine for Knee Osteoarthritis - Journal of Plant Medicines
New research finds that MSM and Boswellia reduce pain and increase mobility for osteoarthritis patients - beating glucosamine sulfate for effectiveness.
Talking S%!T with Sabine Hazan, MD - Disease, Digestion and Fecal Transplants - YouTube
Dr. Sabine Hazan, MD, a gastroenterologist and world leading expert in the microbiome discusses her research on the relationship between {ov!d and the GI tra...
The Unholy Meaning of the Name "BLACK ROCK" - Who Controls 25% of the Earth's Money - YouTube
The company Black Rock controls 25% of the money on earth. But who controls Black Rock? Its name carries an unholy meaning that discloses the power behind all that money. Watch this Nelson Walters video to discover who they are and what they are planning.
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Debunking Deep Time with C-14 Dating: Digging for Truth Episode 204 - YouTube
Dr. Brian Thomas joins us to discuss his research on radiocarbon dating. He’ll explain the method, its inherent assumptions, and how it actually supports a r...
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Keto and Low-Carb Living for Ultimate Health & Well-Being | KETO-MOJO
Kickstart your Keto journey now; learn the steps to Keto success, test and track your glucose & ketones to measure ketosis, and get fantastic Keto recipes.
The Ketone and Blood Glucose Monitoring System- Interview with Dorian Greenow
2018 Interview Dorian Greenow, also known as Mister Mojo, is the cofounder of Keto-Mojo, viewed by many experts as the best strategy to measure your ketone levels. While ketones can be measured by blood, breath or urine testing, blood testing is th…
Toxics | Free Full-Text | Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by Aloe vera in Wistar Rats
Pesticide exposure can pose a serious risk to nontarget animals. Cartap is being broadly used in agricultural fields. The toxic effects of cartap on the levels of hepatotoxicity and neurotoxicity have not been properly studied in mammalian systems. Therefore, the present work focused on the effect of cartap on the liver and brain of Wistar rats and made an assessment of the ameliorating potential of A. vera. The experimental animals were divided into 4 groups, comprising six rats in each: Group 1—Control; Group 2—A. vera; Group 3—Cartap; and Group 4—A. vera + Cartap. The animals orally given cartap and A. vera were sacrificed after 24 h of the final treatment and histological and biochemical investigations were conducted in liver and brain of Wistar rats. Cartap at sublethal concentrations caused substantial decreases in CAT, SOD, and GST levels in the experimental rats. The activity levels of transaminases and phosphatases in cartap group were also found to be substantially altered. The AChE activity was recorded as decreasing in RBC membrane and brain of the cartap-treated animals. The TNF-α and IL-6 level in serum were increased expressively in the cartap challenged groups. Histological investigation of liver showed disorganized hepatic cords and severely congested central veins due to cartap. However, the A. vera extract was observed to significantly protect against the effects of cartap toxicity. The protective impact of A. vera against cartap toxicity may be due to the existence of antioxidants in it. These findings suggest that A. vera may be developed as a potential supplement to the appropriate medication in the treatment of cartap toxicity.
Frontiers | Fucoidan inhibits apoptosis and improves cardiac remodeling by inhibiting p53 transcriptional activation through USP22/Sirt 1
Background: Humans with hypertensive heart disease are more likely to experience heart failure, arrhythmia, myocardial infarction, and sudden death, and it is crucial to treat this condition. Fucoidan (FO) is a natural substance derived from marine algae that has antioxidant and immunomodulatory activities. FO has also been shown to regulate apoptosis. However, whether FO can protect against cardiac hypertrophy is unknown.Methods: We investigated the effect of FO in hypertrophic models in vivo and in vitro. C57BL/6 mice were given an oral gavage of FO (300 mg/kg/day) or PBS (internal control) the day before surgery, followed by a 14-day infusion of Ang II or saline. AC-16 cells were treated with si-USP22 for 4 h and then treated with Ang II (100 nM) for 24 h. Systolic blood pressure (SBP) was recorded, echocardiography was used to assess cardiac function, and pathological changes in heart tissues were assessed by histological staining. Apoptosis levels were detected by TUNEL assays. The mRNA level of genes was assessed by qPCR. Protein expression was detected by immunoblotting.Results: Our data showed that USP22 expression was lowered in Ang II-infused animals and cells, which could promote cardiac dysfunction and remodeling. However, treatment with FO significantly upregulated the expression of USP22 and reduced the incidence of cardiac hypertrophy, fibrosis, inflammation, and oxidative responses. Additionally, FO treatment lowered p53 expression and apoptosis while incre...