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Nutrients Free Full-Text The Role of Nutrients in Prevention, Treatment and Post-Coronavirus Disease-2019 (COVID-19)
Nutrients Free Full-Text The Role of Nutrients in Prevention, Treatment and Post-Coronavirus Disease-2019 (COVID-19)
SARS-CoV-2 virus, infecting human cells via its spike protein, causes Coronavirus disease 2019 (COVID-19). COVID-19 is characterized by shortness of breath, fever, and pneumonia and is sometimes fatal. Unfortunately, to date, there is still no definite therapy to treat COVID-19. Therefore, the World Health Organization (WHO) approved only supportive care. During the COVID-19 pandemic, the need to maintain a correct intake of nutrients to support very weakened patients in overcoming disease arose. The literature available on nutrient intake for COVID-19 is mainly focused on prevention. However, the safe intake of micro- and/or macro-nutrients can be useful either for preventing infection and supporting the immune response during COVID-19, as well as in the post-acute phase, i.e., “long COVID”, that is sometimes characterized by the onset of various long lasting and disabling symptoms. The aim of this review is to focus on the role of nutrient intake during all the different phases of the disease, including prevention, the acute phase, and finally long COVID.
·mdpi.com·
Nutrients Free Full-Text The Role of Nutrients in Prevention, Treatment and Post-Coronavirus Disease-2019 (COVID-19)
The effect of statins on average survival in randomised trials, an analysis of end point postponement - PubMed
The effect of statins on average survival in randomised trials, an analysis of end point postponement - PubMed
Statin treatment results in a surprisingly small average gain in overall survival within the trials' running time. For patients whose life expectancy is limited or who have adverse effects of treatment, withholding statin therapy should be considered.
·pubmed.ncbi.nlm.nih.gov·
The effect of statins on average survival in randomised trials, an analysis of end point postponement - PubMed
First Effective Treatment for Long Covid Stunning Data from Huge New Study - YouTube
First Effective Treatment for Long Covid Stunning Data from Huge New Study - YouTube
The long tail of Covid-19 has left hundreds of thousands suffering numerous and debilitating symptoms. In this film I break down the results from my most recent study of 812 long haulers, on the efficacy of diet, supplements and medication in treating the condition and their effects on each of the symptoms. Is there now a statistically proven regimen of treatment for the condition? Yes, I believe there is. Huge thanks to Dr Tina Peers and Dr Ade Wentzel without whom none of this would have been possible. IMPORTANT: It is ESSENTIAL to talk to your doctor before taking any supplements that you have not taken before, or begin taking them at a larger dose. This regimen is NOT appropriate for children so they should speak to their doctor before taking any of these. Nicotinic acid / Niacin also has several strong counter-indications, they can be seen here: https://www.nice.org.uk/donotdo/do-no... https://en.wikipedia.org/wiki/Niacin I have to be clear and say that I am not a doctor, nor am I personally advocating you take Niacin or any other supplement or medication mentioned in this film. This is a decision you must make yourself with the consultation of your GP if you have any concerns at all. So, all that said - here is what I am currently taking. Niacin: I started at a low dose (10-20mg)/ be careful of flushing Selenium: 100mcg / day Zinc: 15-30mg / day Quercetin: 500mg 3x / day Vitamin C: 500-1000mg 3x / day Vitamin D: 3-5000iu / day 0:00 Introduction 0:49 The Treatment Plans 2:21 The Study 4:45 Treatment Efficacy 12:11 T and P Numbers 13:05 The Statistical Breakdown 16:36 Conclusion Wondering who I am and why I'm making these films? I discuss it here: https://www.youtube.com/watch?v=FULycGPmN18 REFERENCES: MCAS and Long Covid - Dr Tina Peers: https://static1.squarespace.com/static/5a4269f28c56a85fe95206ea/t/5fdbcd3932dbdf6e63fdace7/1608240486599/DrTinaPeers-LongCovid-17Dec2020.pdf Miller, Wentzel & Richards - NAD+ deficiency and Covid 19 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322475/ Nikita Alexandrov, NAD+ deficiency https://nkalex.medium.com/the-team-of-front-line-doctors-and-biohackers-who-seem-to-have-solved-long-covid-5f9852f1101d
·youtube.com·
First Effective Treatment for Long Covid Stunning Data from Huge New Study - YouTube
Original research: Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome
Original research: Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome
Long-term complications after COVID-19 are common, but the potential cause for persistent symptoms after viral clearance remains unclear.To investigate whether gut microbiome composition is linked to post-acute COVID-19 syndrome (PACS), defined as at ...
·ncbi.nlm.nih.gov·
Original research: Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome
Original research Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome - PMC
Original research Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome - PMC
Long-term complications after COVID-19 are common, but the potential cause for persistent symptoms after viral clearance remains unclear.To investigate whether gut microbiome composition is linked to post-acute COVID-19 syndrome (PACS), defined as at ...
·ncbi.nlm.nih.gov·
Original research Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome - PMC
Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
There are limited proven therapies for COVID-19. Vitamin C’s antioxidant, anti-inflammatory and immunomodulating effects make it a potential therapeutic candidate, both for the prevention and amelioration of COVID-19 infection, and as an adjunctive therapy in the critical care of COVID-19. This literature review focuses on vitamin C deficiency in respiratory infections, including COVID-19, and the mechanisms of action in infectious disease, including support of the stress response, its role in preventing and treating colds and pneumonia, and its role in treating sepsis and COVID-19. The evidence to date indicates that oral vitamin C (2–8 g/day) may reduce the incidence and duration of respiratory infections and intravenous vitamin C (6–24 g/day) has been shown to reduce mortality, intensive care unit (ICU) and hospital stays, and time on mechanical ventilation for severe respiratory infections. Further trials are urgently warranted. Given the favourable safety profile and low cost of vitamin C, and the frequency of vitamin C deficiency in respiratory infections, it may be worthwhile testing patients’ vitamin C status and treating them accordingly with intravenous administration within ICUs and oral administration in hospitalised persons with COVID-19.
·mdpi.com·
Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
Long-term persistence of the SARS-CoV-2 spike protein: evidence and implications
Long-term persistence of the SARS-CoV-2 spike protein: evidence and implications
This paper discusses the recent study by Bansal et al. on the detection of spike protein in persons vaccinated with the Pfizer mRNA vaccine. The most significant finding is that spike protein is found on exosomes, that is, cell-derived vesicles, for at least four months after the second injection. This surprisingly long persistence raises the prospect of sustained inflammation within and damage to organs which
·doctors4covidethics.org·
Long-term persistence of the SARS-CoV-2 spike protein: evidence and implications
Long Term Covid - What You Need to Know Today
Long Term Covid - What You Need to Know Today
Dr. Carlos del Rio joins us today to discuss these long-term health consequences of COVID-19 in terms of frequency, mechanisms, and possible therapeutics.
·drperlmutter.com·
Long Term Covid - What You Need to Know Today
Spike Proteins In Immune Cells - Dr. Bruce Patterson Discusses COVID Long Haul
Spike Proteins In Immune Cells - Dr. Bruce Patterson Discusses COVID Long Haul
Spike Proteins In Immune Cells - Dr. Bruce Patterson Discusses COVID Long Haul Dr. Bruce Patterson’s team has discovered that the S1 pieces of the spike proteins persist in the monocytes resulting in immune dysregulation and long-haul syndrome. Let’s discuss these findings with him. Dr. Patterson’s site: https://covidlonghaulers.com/ Disclosure: Dr. Mobeen Syed, or DrBeen have no commercial interest with Dr. Bruce Patterson’s organization. Want to support this work to get a balanced take on the medical sciences? Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US Join us on Discord: https://discord.gg/bkmg3rk3sQ Claim your #koolbeen title here: https://www.drbeen.com/koolbeen-title-registry/ #drbeen #koolbeens #COVID
·facebook.com·
Spike Proteins In Immune Cells - Dr. Bruce Patterson Discusses COVID Long Haul
DR. PAUL THOMAS MD - DrPaulApproved
DR. PAUL THOMAS MD - DrPaulApproved
DrPaulApproved.com & Dr. Paul Thomas MD, brings you the best, and most important research, information, products, blogs and videos, vitamins and nutritional supplements, and provide links to information we feel you should not go without.
·paulthomasmd.com·
DR. PAUL THOMAS MD - DrPaulApproved
Life Free Full-Text Trehalose Activates Hepatic and Myocardial Autophagy and Has Anti-Inflammatory Effects in dbdb Diabetic Mice
Life Free Full-Text Trehalose Activates Hepatic and Myocardial Autophagy and Has Anti-Inflammatory Effects in dbdb Diabetic Mice
Db/db mice (carrying a mutation in the gene encoding leptin receptor) show autophagy suppression. Our aim was to evaluate the effect of autophagy inducer trehalose on liver and heart autophagy in db/db mice and to study inflammation dysregulation and the suitability of chitinases’ expression levels as diabetes markers. Thirty-eight male db/db mice and C57/BL mice (control) were used. The db/db model manifested inflammation symptoms: overexpression of TNF-α in the spleen and underexpression of IL-10 in the liver and spleen (cytokine imbalance). Simultaneously, we revealed decreased expression of chitotriosidase (CHIT1) and acid mammalian chitinase (CHIA) in the liver of db/db mice. CHIA expression in db/db mice is significantly lower only in the spleen. Trehalose treatment significantly reduced blood glucose concentration and glycated hemoglobin. Treatment of db/db mice by trehalose was followed by increased autophagy induction in the heart and liver (increased autolysosomes volume density studied by morphometric electron-microscopic method). Trehalose exerted beneficial cardiac effects possibly via increased lipophagy (uptake of lipid droplets). The autophagy activation by trehalose had several positive effects on the heart and liver of db/db mice; therefore, lipophagy activation seems to be a promising therapy for diabetes.
·mdpi.com·
Life Free Full-Text Trehalose Activates Hepatic and Myocardial Autophagy and Has Anti-Inflammatory Effects in dbdb Diabetic Mice
Predicting & Preventing Long-Haul Covid - with Dr. Heath & Dr. Su The Empowering Neurologist EP146 - YouTube
Predicting & Preventing Long-Haul Covid - with Dr. Heath & Dr. Su The Empowering Neurologist EP146 - YouTube
As it relates to COVID-19, there seems to be an incredible amount of interest in the death rate which happens to be exceedingly, exceedingly low. Why I find this challenging is because there is another problem associated with this infection that isn't getting the type of attention that it deserves. This goes by the common name, long-haul Covid. This simply means that after "recovering" from the initial infection, a fairly significant percentage of individuals continue to experience symptoms that at times may be debilitating. Research just published has demonstrated an ability to actually predict who is at the greatest risk for developing long-term symptoms after COVID-19 infection. We will be interviewing today Dr. James Heath and Dr. Yapeng Su from the Institute for Systems Biology at the University of Washington. They have identified four characteristics that are clearly and strongly associated with persistent symptoms of Covid-19 and as such, this is important information for all of us. They include: The presence of particular autoantibodies A high viral (RNA) load Type 2 diabetes Reactivation of the Epstein-Barr virus, which sits latent in the blood of most people following a childhood infection I’ll tell you more about these dedicated researchers in the intro to the video. ==== TIMESTAMPS: 0:00 Intro 3:40 Important Study on Longterm Effects 7:11 Predicting Severity of Disease 15:00 4 Ways to Predict 21:30 Chronic EBV 26:00 Preventing Long-Haul Covid 39:08 Conclusion ==== James R. Heath, PhD President and Professor, Institute for Systems Biology Professor of Bioengineering, Univ of Washington James Heath serves as the President of the Institute for Systems Biology in Seattle WA. Until early 2018 he was the Elizabeth W. Gilloon Professor of Chemistry at Caltech. For 15 years he directed the National Cancer Institute funded NSB Cancer Center program. Dr. Heath received a BSc in 1984 from Baylor University and a PhD in chemistry in 1988 from Rice University, where he was the principal student involved in the Nobel Prize–winning discovery of C60 and the fullerenes. He was a Miller Fellow at UC Berkeley from 1988 to 1991 and served on the technical staff at IBM Watson Labs from 1991 to 1993. In 1994 he joined the faculty at UCLA. He founded the California NanoSystems Institute in 2000 and served as its director until moving to Caltech. Dr. Heath’s lab works on fundamental problems at the interface of the chemical, physical, biological, and biomedical sciences, with focus areas of molecular biotechnologies and oncology. Dr. Heath has published around 400 refereed scientific publications with an h-index of 122. He has received numerous awards, including a Public Service Commendation from California Governor Grey Davis, the Director’s Service Award from the NCI, the Sackler Prize, Irving Weinstein Award from the AACR, and he was named by Forbes in 2011 as one of the 7 most powerful innovators in the world.. He has founded several companies, including Integrated Diagnostics (sold to Biodesix in 2018), Indi Molecular, PACT Pharma, Sofie Biosciences, ISB BioAnalytica, and Isoplexis (now a public company). _______ Dr. Yapeng Su received his Ph.D. degree at Caltech, co-advised by Prof. James R. Heath and Prof. David Baltimore. Yapeng’s Ph.D. research resided at the intersection of physical science, biotechnology, and systems biology with a particular focus on cancer. His research utilized systems biology approaches and various single-cell technologies to tackle one of the biggest problems in cancer: drug resistance. His Ph.D. thesis was awarded the highest honor of the Division of Chemistry and Chemical Engineering at Caltech. After obtaining his Ph.D., Yapeng conducted a brief postdoc research scientist in Prof. Leroy Hood's lab at the Institute for Systems Biology. In close collaboration with a group of world-leading immunologists (Prof. Mark M. Davis, Prof. Phil Greenberg, Prof. Raphael Gottardo, Prof. James R Heath, Prof. Jeff Bluestone, Prof. Lewis Lanier, Prof. Alan Aderem), Yapeng’s research in the Hood lab utilizes data science, multi-omic bulk, and single-cell analysis to investigate the systems immunology of COVID-19. Currently, Yapeng is a Mahan Fellow at the Fred Hutch Cancer Research Center. His research utilized systems-level big data and machine learning to provide rationales on how to better engineer live immune cells as an effective therapy for treating cancer. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1
·youtube.com·
Predicting & Preventing Long-Haul Covid - with Dr. Heath & Dr. Su The Empowering Neurologist EP146 - YouTube