Mitigation of inflammation and oxidative stress in FCA-induced arthritic rat model through gum acacia intervention: a comprehensive in‑vivo study | Inflammopharmacology
Rheumatoid arthritis is a persistent immune-mediated inflammatory disorder that primarily affects joint bones, impacting approximately 0.5–1.0% of the global population. People with RA are 1.5 times more likely to develop cardiovascular conditions, including atherosclerosis. This study explored the therapeutic potential of GAc in a rat model of RA induced by CFA, focusing on its impact on biomarkers associated with atherosclerosis. Molecular docking studies indicated strong binding affinities of GAc with key inflammatory cytokines, including TNF-α, IL-6, IL-1β, NF-κB and PRMT-1. The experimental model of 23 days involved the induction of arthritis by injecting 0.15 mL of CFA into the sub-plantar region of the rats’ left hind paws. GAc was dissolved in distilled water and administered to rats via oral gavage. Our results revealed that the administration of GAc, particularly in combination with MtxSt (GAc 10 g/kg + MtxSt), significantly (p < 0.001) reduced arthritic scores, joint stiffness scores, paw thickness, levels of lipids (LDL, VLDL, TG, and TC), asymmetric dimethylarginine (ADMA), homocysteine, oxidative stress, and pro-inflammatory cytokines. In addition, GAc markedly (p < 0.001) improved body weight, hematological parameters (RBC, %HCT and Hb), HDL, dimethylarginine dimethylaminohydrolase-1(DDAH-1), and CST levels. Histopathological assessments showed that GAc 10 g/kg + MtxSt significantly alleviated bone and cartilage erosion (p < 0.001), pannus formation (p < 0.001), synovial hyperplasia (p < 0.01), vascular congestion (p < 0.001) and inflammatory cell infiltration (p < 0.001). The therapeutic efficacy of GAc is ascribed to its anti-inflammatory, antioxidant, and anti-atherosclerotic properties. This study suggested that combining GAc with MtxSt exerts a synergistic effect in mitigating inflammation and reducing the risk of atherosclerosis associated with RA.
The Dr. Ardis Show | Dr Ardis Answers to Parkinsons | Episode 08.13.2025
In this weeks episode of the Dr Ardis Show, Dr. Ardis Answers to Parkinson’s , Dr. Ardis reveals natural strategies and science-backed solutions to help combat Parkinson’s disease and other neurologic
Emergence of taurine as a therapeutic agent for neurological disorders - PMC
Taurine is a sulfur-containing, semi-essential amino acid that occurs naturally in the body. It alternates between inflammation and oxidative stress-mediated injury in various disease models. As part of its limiting functions, taurine also modulates ...
N-acetyl-cysteine in the treatment of Parkinson’s disease. What are we waiting for? - ScienceDirect
Parkinson’s disease is an age-related neurodegenerative disorder that is ameliorated with levodopa. However, long-term use of this drug is limited by …
Mechanisms of Laminaria japonica Polysaccharide Digestion and Absorption: Structure, In Vivo Fluorescence Imaging, and Gut Microbiota | Journal of Agricultural and Food Chemistry
This study clarified the structure and digestive properties of the Laminaria japonica polysaccharide (LJP). It was demonstrated that LJP belongs to a heteropolysaccharide composed of mannuronic acid, fucose, galactose, glucuronic acid, mannose, xylose, glucose, and guluronic acid in the proportion of 34.56%: 30.55%: 10.63%: 7.52%: 6.66%: 3.74%: 3.62%: 2.72%, with a backbone chain composed of →4)-β-d-ManA-(1→, →3)-α-l-Fucp-(1→, →4)-α-GulA-(1→, →3,4)-α-GlcA-(1→, and →4)-β-d-GlcA-(1→. In vivo fluorescence imaging indicated that LJP was mainly distributed in the stomach and intestinal segments of mice, and the fluorescence signal gradually disappeared after 12 h of digestion. In addition, LJP had no effect on the phenotype and general health of mice while promoting the proliferation of the beneficial bacteria Rikenella, Rikenellaceae_RC9_gut_group. Notably, 100 mg/kg LJP significantly increased the levels of acetic and butyric acid in the mice feces, which were 1.51 and 2.65 folds higher than the controls, respectively. Our study illuminated the absorption and distribution mechanism of LJP, providing a scientific reference for revealing LJP as a potential prebiotic.
BEWARE: They’re Trying to Fool You With This SHADY Practice - YouTube
Scientific fraud is on the rise. In this episode of Answers News, our hosts Bryan Osborne, Avery Foley, and Dr. Brian Thomas share their perspectives on this...
I Got ChatGPT To Admit Its Antichrist Purpose... - YouTube
ChatGPT Just Admitted Its Antichrist Purpose...They said it was just a tool… but what if it’s part of something much darker? In this video, I confront ChatGP...
Healthy water creates the structure, solidity and circulation throughout the body and plays a critical role in preventing many common "inexplicable" diseases.
JUST RELEASED: The NOW Prophecies Are Coming To Pass - YouTube
This is a vintage conference message by Bill Salus delivered in 2018, but has just now been released on YouTube by the host ministry called, Here the Watchme...
Stevia Kills Lyme Disease Pathogen Better Than Antibiotics
Lyme disease is exceedingly difficult to treat, due to its well-known shape-shifting (pleomorphic) abilities, with conventional antibiotics often failing to produce a long-term cure. Could the commonly used natural plant stevia provide a safer, and more effective means to combat this increasingly prevalent infection?
Charting a Path Toward New Treatments for Lyme Infection-Associated Chronic Illnesses - PubMed
Around 10-20% of people who contract Lyme disease, the most common tickborne disease in the U.S., develop persistent, often debilitating symptoms such as chronic pain, fatigue, and cognitive dysfunction. Lyme infection-associated chronic illnesses (IACI) share symptoms common to other IACI such as L …
Lyme disease and the pursuit of a clinical cure - PMC
Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-borne illness in the United States. Many aspects of the disease are still topics of controversy within the scientific and medical communities. One particular ...
PhosChol PPC is the #1 healthcare professional brand of pharmaceutical grade polyenyl-phosphatidylcholine (PPC). Over 200 million doses have been administered by doctors in the United States alone. PhosChol is the highest concentrated source of active ingredient and is the Gold Standard PC for purity, and results.
WHISTLEBLOWER: July "Practice" Red Heifer Ceremony was ACTUALLY REAL!! - YouTube
A whistleblower reports that July's Red Heifer "Trial Run" was actually REAL! And that the Red Heifer was 100% perfect. Click here to watch this explosive Ne...
Jonathan Cahn Answers Candace Owens & Varied Anti-Semites | Jonathan Cahn Prophetic - YouTube
What happened to Candace Owens? Something dark. Jonathan Cahn addresses it, the charges she’s levelled against the Jewish people, and even the rise of antis...
Repurposed Drugs in Oncology: Current State Of The Evidence And A Case Series In Metastatic Lung Cancer
A review of the existing evidence base for repurposing drugs to treat cancer, followed by a case series of five consecutive patients treated with combination repurposed drug protocols.
Progress in the Study of Fucoidan Degradation - ScienceDirect
Fucoidan, a sulfated polysaccharide, demonstrates many biological activities. It has found extensive applications across medicine, food, cosmetics, an…