2016

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Mitigation of inflammation and oxidative stress in FCA-induced arthritic rat model through gum acacia intervention: a comprehensive in‑vivo study | Inflammopharmacology
Mitigation of inflammation and oxidative stress in FCA-induced arthritic rat model through gum acacia intervention: a comprehensive in‑vivo study | Inflammopharmacology
Rheumatoid arthritis is a persistent immune-mediated inflammatory disorder that primarily affects joint bones, impacting approximately 0.5–1.0% of the global population. People with RA are 1.5 times more likely to develop cardiovascular conditions, including atherosclerosis. This study explored the therapeutic potential of GAc in a rat model of RA induced by CFA, focusing on its impact on biomarkers associated with atherosclerosis. Molecular docking studies indicated strong binding affinities of GAc with key inflammatory cytokines, including TNF-α, IL-6, IL-1β, NF-κB and PRMT-1. The experimental model of 23 days involved the induction of arthritis by injecting 0.15 mL of CFA into the sub-plantar region of the rats’ left hind paws. GAc was dissolved in distilled water and administered to rats via oral gavage. Our results revealed that the administration of GAc, particularly in combination with MtxSt (GAc 10 g/kg + MtxSt), significantly (p < 0.001) reduced arthritic scores, joint stiffness scores, paw thickness, levels of lipids (LDL, VLDL, TG, and TC), asymmetric dimethylarginine (ADMA), homocysteine, oxidative stress, and pro-inflammatory cytokines. In addition, GAc markedly (p < 0.001) improved body weight, hematological parameters (RBC, %HCT and Hb), HDL, dimethylarginine dimethylaminohydrolase-1(DDAH-1), and CST levels. Histopathological assessments showed that GAc 10 g/kg + MtxSt significantly alleviated bone and cartilage erosion (p < 0.001), pannus formation (p < 0.001), synovial hyperplasia (p < 0.01), vascular congestion (p < 0.001) and inflammatory cell infiltration (p < 0.001). The therapeutic efficacy of GAc is ascribed to its anti-inflammatory, antioxidant, and anti-atherosclerotic properties. This study suggested that combining GAc with MtxSt exerts a synergistic effect in mitigating inflammation and reducing the risk of atherosclerosis associated with RA.
·link.springer.com·
Mitigation of inflammation and oxidative stress in FCA-induced arthritic rat model through gum acacia intervention: a comprehensive in‑vivo study | Inflammopharmacology
Mechanisms of Laminaria japonica Polysaccharide Digestion and Absorption: Structure, In Vivo Fluorescence Imaging, and Gut Microbiota | Journal of Agricultural and Food Chemistry
Mechanisms of Laminaria japonica Polysaccharide Digestion and Absorption: Structure, In Vivo Fluorescence Imaging, and Gut Microbiota | Journal of Agricultural and Food Chemistry
This study clarified the structure and digestive properties of the Laminaria japonica polysaccharide (LJP). It was demonstrated that LJP belongs to a heteropolysaccharide composed of mannuronic acid, fucose, galactose, glucuronic acid, mannose, xylose, glucose, and guluronic acid in the proportion of 34.56%: 30.55%: 10.63%: 7.52%: 6.66%: 3.74%: 3.62%: 2.72%, with a backbone chain composed of →4)-β-d-ManA-(1→, →3)-α-l-Fucp-(1→, →4)-α-GulA-(1→, →3,4)-α-GlcA-(1→, and →4)-β-d-GlcA-(1→. In vivo fluorescence imaging indicated that LJP was mainly distributed in the stomach and intestinal segments of mice, and the fluorescence signal gradually disappeared after 12 h of digestion. In addition, LJP had no effect on the phenotype and general health of mice while promoting the proliferation of the beneficial bacteria Rikenella, Rikenellaceae_RC9_gut_group. Notably, 100 mg/kg LJP significantly increased the levels of acetic and butyric acid in the mice feces, which were 1.51 and 2.65 folds higher than the controls, respectively. Our study illuminated the absorption and distribution mechanism of LJP, providing a scientific reference for revealing LJP as a potential prebiotic.
·pubs.acs.org·
Mechanisms of Laminaria japonica Polysaccharide Digestion and Absorption: Structure, In Vivo Fluorescence Imaging, and Gut Microbiota | Journal of Agricultural and Food Chemistry
I Got ChatGPT To Admit Its Antichrist Purpose... - YouTube
I Got ChatGPT To Admit Its Antichrist Purpose... - YouTube
ChatGPT Just Admitted Its Antichrist Purpose...They said it was just a tool… but what if it’s part of something much darker? In this video, I confront ChatGP...
·youtube.com·
I Got ChatGPT To Admit Its Antichrist Purpose... - YouTube
The Hidden Powers of Water That Shape Our Health
The Hidden Powers of Water That Shape Our Health
Healthy water creates the structure, solidity and circulation throughout the body and plays a critical role in preventing many common "inexplicable" diseases.
·midwesterndoctor.com·
The Hidden Powers of Water That Shape Our Health
Stevia Kills Lyme Disease Pathogen Better Than Antibiotics
Stevia Kills Lyme Disease Pathogen Better Than Antibiotics
Lyme disease is exceedingly difficult to treat, due to its well-known shape-shifting (pleomorphic) abilities, with conventional antibiotics often failing to produce a long-term cure. Could the commonly used natural plant stevia provide a safer, and more effective means to combat this increasingly prevalent infection?
·greenmedinfo.com·
Stevia Kills Lyme Disease Pathogen Better Than Antibiotics
Charting a Path Toward New Treatments for Lyme Infection-Associated Chronic Illnesses - PubMed
Charting a Path Toward New Treatments for Lyme Infection-Associated Chronic Illnesses - PubMed
Around 10-20% of people who contract Lyme disease, the most common tickborne disease in the U.S., develop persistent, often debilitating symptoms such as chronic pain, fatigue, and cognitive dysfunction. Lyme infection-associated chronic illnesses (IACI) share symptoms common to other IACI such as L …
·pubmed.ncbi.nlm.nih.gov·
Charting a Path Toward New Treatments for Lyme Infection-Associated Chronic Illnesses - PubMed
Lyme disease and the pursuit of a clinical cure - PMC
Lyme disease and the pursuit of a clinical cure - PMC
Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-borne illness in the United States. Many aspects of the disease are still topics of controversy within the scientific and medical communities. One particular ...
·pmc.ncbi.nlm.nih.gov·
Lyme disease and the pursuit of a clinical cure - PMC
PhosChol PPC
PhosChol PPC
PhosChol PPC is the #1 healthcare professional brand of pharmaceutical grade polyenyl-phosphatidylcholine (PPC). Over 200 million doses have been administered by doctors in the United States alone. PhosChol is the highest concentrated source of active ingredient and is the Gold Standard PC for purity, and results.
·nutrasal.com·
PhosChol PPC