2016

Dimethyl sulfoxide (DMSO) is an effective solvent and cytoprotectant agent that can induce diverse actions in experimental settings, ranging from meta…

Type 1 diabetes mellitus (T1D) is caused by the destruction of insulin-producing β cells in pancreatic islets by autoimmune T cells. Islet transplanta…

(Dimethyl Sulfoxide[Title/Abstract]) AND (liver[Title/Abstract]) - Search Results - PubMed

(Dimethyl Sulfoxide) AND (diabetes) - Search Results - PubMed

(Dimethyl Sulfoxide[Title]) AND (diabetes[Title/Abstract]) - Search Results - PubMed

Fucoidan is a fucose-rich sulfated polysaccharide that has gained attention owing to its various biological activities. In this study, fucoidan was isolated from Saccharina japonica using an enzyme-assisted method, and its antioxidant and anti-hepatocarcinoma effects were evaluated. The fucoidan was a 112.8 kDa polysaccharide comprising seven monosaccharides: fucose, xylose, glucuronic acid, rhamnose, glucose, mannose, and galactose. The main chain residues were (1 → 3)-α-L-Fucp and (1 → 4)-α-L-Fucp units with sulfate groups at the C-2/C-4 positions of the (1 → 3)-α-L-Fucp residues. S. japonica fucoidans showed excellent antioxidant potency with values of 1.02 mg TE/g and 5.39 mg TE/g for the ABTS and FRAP assays, respectively. Additionally, they exerted antitumor efficacy and low systemic toxicity in H22 tumor-bearing mice, with a tumor inhibition rate of 42.93%. Furthermore, it significantly inhibited tumor angiogenesis and reduced pro-inflammatory cytokines levels (IL-1β, IL-6, and TNF-α). Our results suggest that fucoidan isolated from S. japonica possesses potent antioxidant and anticancer properties and may be used as a potential agent for hepatocellular carcinoma treatment.

Jesus warned His disciples that deceptions about Him and in His name would be the first thing they needed to be on guard about in the Last Days in Matthew 24...

(NaturalHealth365) Scientists have discovered that fructose can threaten memory areas of the brain and overall well-being.

Exploring the forgotten but critically important science of zeta potential

Bryan Windle joins Henry to count down the top ten discoveries related to the book of Jeremiah.

Biology Dictionary provides definition, examples and quiz for common biology terms, including molecular biology, cell biology, genetics, ecology and more!

(NaturalHealth365) Lawsuits reveal how Big Pharma ignores the health dangers of antidepressants and continues to poison the population.

The global incidence of hyperuricemia (HUA) is gradually increasing, and HUA poses a severe threat to human health. Between 25% and 50% of HUA patients are not effectively treated with current clinical medications due to drug contraindications or severe adverse reactions. Therefore, novel safe and effective uric acid-lowering products are needed. Fucoidan is a naturally derived polysaccharide containing sulfate groups exclusively found in brown algae. Although there are reports on the anti-HUA effects of fucoidan, the simultaneous regulation of gut microbiota by anti-HUA still needs to be fully understood. In this study, potassium oxonate (PO) and hypoxanthine-induced HUA model mice were treated with 100, 200 and 400 mg/kg fucoidan (from Laminaria japonica) for 14 days. The levels associated with HUA were quantified using assay kits to assess fucoidan intervention. 16S rRNA gene sequencing was used to analyze the effects of fucoidan in mice with HUA. The results showed that fucoidan reduced serum uric acid and urea nitrogen levels in a dose-dependent manner, and serum creatinine levels in the 200 and 400 mg/kg fucoidan groups were similar to those in the control group. It decreased the expression of uric acid metabolic protein levels of xanthine oxidase (XOD), adenosine deaminase (ADA), and glucose transporter (GLUT9) and increased ATP binding cassette subfamily G member 2 (ABCG2) protein expression. 16S rRNA gene sequencing revealed that the richness (Chao and Ace indices) and diversity (Shannon and Simpson indices) of the gut microbiota in model mice decreased, whereas supplementation with fucoidan alleviated gut microbiota dysbiosis in HUA model mice, leading to a gradual approach of α-diversity and β-diversity towards the control mice. Additionally, fucoidan supplementation significantly increased the abundance of beneficial bacteria, which are negatively correlated with the HUA-associated phenotypes, reassuring the positive effects of fucoidan on gut health. This study proposed that fucoidan can be considered a potential candidate for preventing and treating HUA.

A remarkable cancer treatment has been hiding in plain sight for decades

From the creators of the record-setting films, Plandemic and Indoctornation, The Great Awakening reveals the big picture of what’s really going on in the world.

Filmmaker, Matthew Guthrie, discusses his groundbreaking documentary, “Follow the Silenced”, chronicling the biggest cover-up of a generation of the devastating injuries from the experimental COVID-19 vaccines. Four years in the making, the film follows not only the heartbreaking stories of the injured, but the diabolical concealment traced all the way to the head of the […]

With the NIH showing little concern to study long COVID despite pouring $1 billion into research, a new bombshell study on patients with a debilitating post-vaccination syndrome is showing elevated spike protein levels over 2 years (the time of study) after vaccination. AIR DATE: March 6, 2025

(NaturalHealth365) Discover the powerful health benefits of avocados from fighting cancer to supporting heart health.

What no one tells you about having a healthy pregnancy

Cutting Edge Fitness Advice

Years ago, X-ray was the diagnostic procedure of choice in pregnancy but today we understand more about the harmful effects of radiation so ultrasound is used

Introduction: While perceived as safe, diagnostic ultrasound has the potential to cause biological effects on the body tissues. The aim of this study was to eva...

Your source for nebulizers, jet nebulizers, ultrasonic nebulizers, spacers, oximeters, nebulizer parts, nebulizer cups, and tubing.

The Forgotten Lessons in Lung Health

What they don't tell you about having a healthy baby