2016

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Direct hybridization and bioinformatics analysis of circulating microRNAs in patients with Alzheimer’s disease under intravenous trehalose treatment - ScienceDirect
Direct hybridization and bioinformatics analysis of circulating microRNAs in patients with Alzheimer’s disease under intravenous trehalose treatment - ScienceDirect
Trehalose has been proposed as a possible therapeutic option for attenuating the neuropathological changes associated with neurodegeneration, includin…
·sciencedirect.com·
Direct hybridization and bioinformatics analysis of circulating microRNAs in patients with Alzheimer’s disease under intravenous trehalose treatment - ScienceDirect
! ! Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study | Annals of the Rheumatic Diseases
! ! Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study | Annals of the Rheumatic Diseases
Objectives To evaluate the associations of regular glucosamine use with all-cause and cause-specific mortality in a large prospective cohort. Methods This population-based prospective cohort study included 495 077 women and men (mean (SD) age, 56.6 (8.1) years) from the UK Biobank study. Participants were recruited from 2006 to 2010 and were followed up through 2018. We evaluated all-cause mortality and mortality due to cardiovascular disease (CVD), cancer, respiratory and digestive disease. HRs and 95% CIs for all-cause and cause-specific mortality were calculated using Cox proportional hazards models with adjustment for potential confounding variables. Results At baseline, 19.1% of the participants reported regular use of glucosamine supplements. During a median follow-up of 8.9 years (IQR 8.3–9.7 years), 19 882 all-cause deaths were recorded, including 3802 CVD deaths, 8090 cancer deaths, 3380 respiratory disease deaths and 1061 digestive disease deaths. In multivariable adjusted analyses, the HRs associated with glucosamine use were 0.85 (95% CI 0.82 to 0.89) for all-cause mortality, 0.82 (95% CI 0.74 to 0.90) for CVD mortality, 0.94 (95% CI 0.88 to 0.99) for cancer mortality, 0.73 (95% CI 0.66 to 0.81) for respiratory mortality and 0.74 (95% CI 0.62 to 0.90) for digestive mortality. The inverse associations of glucosamine use with all-cause mortality seemed to be somewhat stronger among current than non-current smokers (p for interaction=0.00080). Conclusions Regular glucosamine supplementation was associated with lower mortality due to all causes, cancer, CVD, respiratory and digestive diseases.
·ard.bmj.com·
! ! Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study | Annals of the Rheumatic Diseases
Association of habitual glucosamine use with risk of microvascular complications among individuals with type 2 diabetes: a prospective cohort study in UK biobank | Nutrition & Diabetes
Association of habitual glucosamine use with risk of microvascular complications among individuals with type 2 diabetes: a prospective cohort study in UK biobank | Nutrition & Diabetes
Nutrition & Diabetes - Association of habitual glucosamine use with risk of microvascular complications among individuals with type 2 diabetes: a prospective cohort study in UK biobank
·nature.com·
Association of habitual glucosamine use with risk of microvascular complications among individuals with type 2 diabetes: a prospective cohort study in UK biobank | Nutrition & Diabetes
Cellular Fragility Syndrome & C15:0 Deficiency – fatty15
Cellular Fragility Syndrome & C15:0 Deficiency – fatty15
A big paper was just published on a newly discovered nutritional C15:0 deficiency syndrome, called Cellular Fragility Syndrome. This is a big deal because nutritional deficiency syndromes (like vitamin C deficiency and scurvy, or vitamin D deficiency and rickets) are rarely discovered. This latest paper describes how d
·fatty15.com·
Cellular Fragility Syndrome & C15:0 Deficiency – fatty15
Pentadecanoylcarnitine is a newly discovered endocannabinoid with pleiotropic activities relevant to supporting physical and mental health | Scientific Reports
Pentadecanoylcarnitine is a newly discovered endocannabinoid with pleiotropic activities relevant to supporting physical and mental health | Scientific Reports
Scientific Reports - Pentadecanoylcarnitine is a newly discovered endocannabinoid with pleiotropic activities relevant to supporting physical and mental health
·nature.com·
Pentadecanoylcarnitine is a newly discovered endocannabinoid with pleiotropic activities relevant to supporting physical and mental health | Scientific Reports
Dimethyl Sulfoxide (DMSO) - Dr. Stanley Jacob
Dimethyl Sulfoxide (DMSO) - Dr. Stanley Jacob
Dr. Stanley Jacob, the father of DMSO offers information on DMSO & MSM. DMSO (dimethyl sulfoxide), a potent scavenger of free radicals, was first introduced to the scientific community in 1963 by a research team headed by Stanley W. Jacob, MD.
·dmso.org·
Dimethyl Sulfoxide (DMSO) - Dr. Stanley Jacob
DR. SUZANNE HUMPHRIES ON MEASLES MYTHS AND MANIPULATED DATA - The HighWire
DR. SUZANNE HUMPHRIES ON MEASLES MYTHS AND MANIPULATED DATA - The HighWire
Internist and Co-Author of “Dissolving Illusions”, Suzanne Humphries, MD discusses her awakening to the catastrophic dangers of vaccination and walks Del through the data of how severe illness and death from disease declined rapidly across the board years before the introduction of vaccines. Hear how data continues to be manipulated and cherry picked even today […]
·thehighwire.com·
DR. SUZANNE HUMPHRIES ON MEASLES MYTHS AND MANIPULATED DATA - The HighWire