2016

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Combined treatment with glucosamine and chondroitin sulfate improves rheumatoid arthritis in rats by regulating the gut microbiota | Nutrition & Metabolism | Full Text
Combined treatment with glucosamine and chondroitin sulfate improves rheumatoid arthritis in rats by regulating the gut microbiota | Nutrition & Metabolism | Full Text
Background To investigate the ameliorative effects of glucosamine (GS), chondroitin sulphate (CS) and glucosamine plus chondroitin sulphate (GC) on rheumatoid arthritis (RA) in rats, and to explore the mechanism of GS, CS and GC in improving RA based on the gut microbiota. Methods RA rat models were effectively developed 14 days after CFA injection, and then garaged with GS, CS and GC. Body weight and paw volume of rats were monitored at multiple time points at the beginning of CFA injection. Until D36, serum and ankle tissue specimens were used to measure levels of circulating inflammatory factors (TNF-α, IL-1β, MMP-3, NO and PGE2) and local inflammatory indicators (TLR-4 and NF-κB). On D18, D25, and D36, intergroup gut microbiota was compared using 16S rRNA gene sequencing and bioinformatics analysis. We also performed the correlation analysis of gut bacteria, joint swelling and inflammatory indicators. Results GC, rather than GS and CS, could reduce right paw volumes, levels of TLR-4 and NF-κB in synovial tissues. In addition, enriched genera in RA model rats screened out by LEfSe analysis could be inhibited by GC intervention, including potential LPS-producing bacteria (Enterobacter, Bacteroides, Erysipelotrichaceae_unclassified and Erysipelotrichaceae_uncultured) and some other opportunistic pathogens (Esherichia_Shigella, Nosocomiicoccus, NK4A214_group, Odoribacter, Corynebacterium and Candidatus_Saccharimonas.etc.) that positively correlated with pro-inflammatory cytokines, right paw volume, and pathology scores. Furthermore, the gut microbiota dysbiosis was observed to recover before alleviating joint swelling after interventions. Conclusions GC could inhibit potential LPS-producing bacteria and the activation of TLR-4/NF-κB pathway in RA rats, thus alleviating RA-induced joint injury.
·nutritionandmetabolism.biomedcentral.com·
Combined treatment with glucosamine and chondroitin sulfate improves rheumatoid arthritis in rats by regulating the gut microbiota | Nutrition & Metabolism | Full Text
How to Fix Your Leaky Brain - David Perlmutter M.D.
How to Fix Your Leaky Brain - David Perlmutter M.D.
A relatively new player in the discussion of factors leading to Alzheimer’s is the breakdown of the so-called blood-brain barrier (BBB). The blood-brain barrier is essentially a checkpoint within the …
·drperlmutter.com·
How to Fix Your Leaky Brain - David Perlmutter M.D.
5 Top Foods for Eye Health | GreenMedInfo | Blog Entry
5 Top Foods for Eye Health | GreenMedInfo | Blog Entry
Do you find yourself squinting and straining to read the daily news and wondering why the writing on menus has become so small? Are you interested in keeping your vision sharp no matter what your age? If so, these five best foods for eye health are a natural way to give your vision a boost from the inside out!
·greenmedinfo.com·
5 Top Foods for Eye Health | GreenMedInfo | Blog Entry
"JESUS THE NAZARENE" found hidden in Image of Shroud of Turin - How Did it Get There? - YouTube
"JESUS THE NAZARENE" found hidden in Image of Shroud of Turin - How Did it Get There? - YouTube
The words "Yeshua (Jesus) the Nazarene" were found hidden in the image of the Shroud of Turin, the infamous cloth that supposedly holds the image of Jesus at the moment of His resurrection. These words were only found when the image was examined by a visualization program on a computer. Only then were they visible. How did those words get on the image? Are they related to an ancient Roman practice of the day? What other evidence is there that the Shroud is authentic? Watch this Nelson Walters Holy Week video for incredible answers. LAST DAYS OVERCOMERS https://lastdaysovercomer.org
·youtube.com·
"JESUS THE NAZARENE" found hidden in Image of Shroud of Turin - How Did it Get There? - YouTube
Top Ten Evidences for Noah's Flood - Genesis Apologetics 2023 - YouTube
Top Ten Evidences for Noah's Flood - Genesis Apologetics 2023 - YouTube
President Dan Biddle of Genesis Apologetics presents on Noah's Flood at the 2023 Alpha Omega Conference. Topics covered include: Pangea, Catastrophic Plate Tectonics, Subduction, Volcanism, Tsunamis, Sloss Megasequences, Buried Dinosaurs, and the Morrison Formation. See here for our main Noah's Flood video: https://youtu.be/zd5-dHxOQhg
·youtube.com·
Top Ten Evidences for Noah's Flood - Genesis Apologetics 2023 - YouTube
The Big Fat Surprise - Why Dietary Guidelines are Making us Fat | The Empowering Neurologist EP 161 - YouTube
The Big Fat Surprise - Why Dietary Guidelines are Making us Fat | The Empowering Neurologist EP 161 - YouTube
What underlies the war on fat? It’s big business, wanting us all to eat more refined carbs and sugar to replace the fat calories that we’ve been instructed to reduce. And I can think of no one who has done more to open our eyes to this ongoing travesty than Nina Teicholz. Here’s more about her from her website: Nina Teicholz is an investigative science journalist and leader in nutrition reporting who is challenging the conventional wisdom on dietary fat–particularly, whether saturated fat causes heart disease and whether fat really makes you fat. The New York Times bestselling author of The Big Fat Surprise. Teicholz also serves as Executive Director of The Nutrition Coalition, an independent non-profit group that promotes evidence-based nutrition policy. She is one of a new generation of researchers arguing that diets lower in carbohydrates are a scientifically sound approach for reversing nutrition-related diseases. For more than half a century, we’ve been told to eat a diet high in grains, low in fat, saturated fat (and cholesterol), but the last two decades of research have led a growing number of scientists to conclude that this diet, despite being rigorously tested, could never be shown to prevent any kind of disease. Teicholz’s work also explains why this diet has remained official policy for so long: the roles played by crusading scientists, the food industry, and more. The story is as much about politics as it is about science, and Nina Teicholz’s research ultimately confirms that the traditional foods we were told to abandon (meat, cheese, eggs, butter) are safe, and even good for health. Nina Teicholz has been called “The Rachel Carson of the nutrition movement.” Her book has been called a “must read” by some of the most prestigious medical journals in the world, including The Lancet, The BMJ, and the American Journal of Clinical Nutrition. In speaking about Nina, the immediate past-president of the World Heart Federation, said at the Davos Cardiology Update Davos (2017) “She shook up the nutrition world, but she was right.” Please enjoy this compelling interview with one of my personal heroes. ==== TIMESTAMPS: 0:00 Intro 3:30 Contradictions in the Plant-based movement 10:02 Who funds the Food Pyramid 15:59 The Carbs & Fats Debate 22:36 Debunking Keto Myths 27:07 Debating Dr. David Katz 33:37 Answering Keto Questions 40:03 White House Conference on Nutrition 48:08 Conclusion ==== Nina Teicholz is a science journalist and author of the New York Times bestseller, The Big Fat Surprise, which upended the conventional wisdom on dietary fat–especially saturated fat and seed oils. Teicholz is also the founder of the Nutrition Coalition, a nonprofit working to ensure that nutrition policy reflects the best and most current science. Teicholz has appeared on most major TV networks, and her work has been published in the New York Times, Wall Street Journal, the Economist, as well as in academic journals including The BMJ and the journal of the National Academy of Sciences. She is a graduate of Stanford and Oxford Universities and is now author of the “Unsettled Science” column hosted on Substack. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1
·youtube.com·
The Big Fat Surprise - Why Dietary Guidelines are Making us Fat | The Empowering Neurologist EP 161 - YouTube
Dietary Trehalose as a Bioactive Nutrient - PubMed
Dietary Trehalose as a Bioactive Nutrient - PubMed
Trehalose is a naturally occurring, non-reducing disaccharide comprising two covalently-linked glucose molecules. It possesses unique physiochemical properties, which account for multiple biological roles in a variety of prokaryotic and eukaryotic organisms. In the past few decades, intensive resear …
·pubmed.ncbi.nlm.nih.gov·
Dietary Trehalose as a Bioactive Nutrient - PubMed
The Hope That Was (Session 1) | Speaker: Dr. David Reagan - YouTube
The Hope That Was (Session 1) | Speaker: Dr. David Reagan - YouTube
Join Dr. David Reagan as he describes the hope that was! Lamb & Lion Ministries held its 2023 Hope Springs Eternal Regional Bible Prophecy Conference at Hikes Point Christian Church in Louisville, KY on Saturday, March 11th. SALVATION What Must I Do to Be Saved? - https://christinprophecy.org/articles/what-must-i-do-to-be-saved/ CONNECT Website: https://christinprophecy.org Blog: https://christinprophecyblog.org Resources: https://lamblionresources.com Podcasts: https://christinprophecy.org/podcasts/ App: https://www.lamblion.mobi FOLLOW US Facebook: https://www.facebook.com/lamblionministries/ Twitter: https://twitter.com/christnprophecy Instagram: https://www.instagram.com/christinprophecy/ Pinterest: https://www.pinterest.com/proclaimJesus SUMMARY Join Dr. David Reagan as he describes the hope that was! For more episodes of "Christ in Prophecy" subscribe to this channel, and please visit us at https://christinprophecy.org/. #DavidRReagan #AmericaInProphecy #HopeSpringsEternalConference
·youtube.com·
The Hope That Was (Session 1) | Speaker: Dr. David Reagan - YouTube
A Combination of Deep-Sea Water and Fucoidan Alleviates T2DM through Modulation of Gut Microbiota and Metabolic Pathways
A Combination of Deep-Sea Water and Fucoidan Alleviates T2DM through Modulation of Gut Microbiota and Metabolic Pathways
Fucoidan and deep-sea water (DSW) are attractive marine resources for treating type 2 diabetes (T2DM). In this study, the regulation and mechanism associated with the co-administration of the two were first studied using T2DM rats, induced by a high fat diet (HFD) and streptozocin (STZ) injection. Results demonstrate that, compared to those with DSW or FPS alone, the orally administered combination of DSW and FPS (CDF), especially the high dose (H-CDF), could preferably inhibit weight loss, decrease levels of fasting blood glucose (FBG) and lipids, and improve hepatopancreatic pathology and the abnormal Akt/GSK-3β signaling pathway. The fecal metabolomics data show that H-CDF could regulate the abnormal levels of metabolites mainly through the regulation of linoleic acid (LA) metabolism, bile acid (BA) metabolism, and other related pathways. Moreover, H-CDF could adjust the diversity and richness of bacterial flora and enrich bacterial groups, such as Lactobacillaceae and Ruminococcaceae UCG-014. In addition, Spearman correlation analysis illustrated that the interaction between the gut microbiota and BAs plays an essential role in the action of H-CDF. In the ileum, H-CDF was verified to inhibit activation of the farnesoid X receptor (FXR)–fibroblast growth factor 15 (FGF15) pathway, which is regulated by the microbiota–BA–axis. In conclusion, H-CDF enriched Lactobacillaceae and Ruminococcaceae UCG-014, thereby changing BA metabolism, linoleic acid metabolism, and other related pathways, as well as enhancing insulin sensitivity and improving glucose and lipid metabolism.
·mdpi.com·
A Combination of Deep-Sea Water and Fucoidan Alleviates T2DM through Modulation of Gut Microbiota and Metabolic Pathways
#1 Sign That You Overdosed on Vitamin D - YouTube
#1 Sign That You Overdosed on Vitamin D - YouTube
Learn more about vitamin D toxicity and the top signs of vitamin D overdose. DATA: https://www.bmj.com/content/366/bmj.l4673.long https://www.frontiersin.org/articles/10.3389/fimmu.2022.790444/full https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971338/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535888/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535888/ https://iopscience.iop.org/article/10.1088/1742-6596/1073/4/042034/pdf https://vitamindwiki.com/Overview+Toxicity+of+vitamin+D https://vitamindwiki.com/tiki-index.php?page_id=2489 Watch my Other Videos on Vitamin D: How Much Vitamin D Do I Need? ▶️ https://youtu.be/NFxQJmvgXOQ Is it Safe to Take 10,000 IUs of Vitamin D3? ▶️ https://youtu.be/gjJdzHIwDDU The 7 Warning Signs of a Vitamin D Deficiency ▶️ https://youtu.be/nk4DAjtcviI 0:00 Introduction: Vitamin D overdose 0:10 Vitamin D toxicity 3:40 The #1 sign of vitamin D overdose 4:02 Other signs of too much vitamin D 4:40 Vitamin D2 vs. vitamin D3 6:25 Learn more about calcification! Today we’re going to talk about vitamin D toxicity and the signs you’re taking too much vitamin D. It’s important to keep in mind that the dangers of vitamin D deficiency outweigh the dangers of getting too much vitamin D. It’s also very difficult to overdose on vitamin D. Vitamin D works with other factors that support its function and absorption. Certain amounts of vitamin D can potentially have side effects but can be made safe by adjusting the cofactors. Magnesium and vitamin K2 are the main cofactors that help keep higher levels of vitamin D from becoming toxic. It’s also important to drink plenty of water. The side effects of vitamin D toxicity typically start to occur when a person is consuming hundreds of thousands of international units (IU) of vitamin D for many weeks. The #1 sign of vitamin D overdose: • Calcification Other signs of vitamin D overdose: • Kidney stones • Nerve symptoms (numbness, pain, or tingling) • Excessive thirst • Excessive urination In my opinion, it seems that many cases of vitamin D toxicity occur because of a person consuming too much vitamin D2—not vitamin D3. There are some big differences between vitamin D2 and vitamin D3. I also don’t think people will see the same benefits after taking vitamin D2 that they would if they took vitamin D3. A few things you need to know about vitamin D2: • It’s not as effective as D3 • It’s not as bioavailable as D3 • It’s not as studied as D3 • It doesn’t help prevent fractures like D3 can • It does help reverse rickets (in infants) • It has a different effect on depression than D3 • It doesn’t affect the immune system like D3 can Dr. Eric Berg DC Bio: Dr. Berg, age 57, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media. Follow Me On Social Media: Facebook: https://bit.ly/FB-DrBerg Instagram: https://bit.ly/IG-DrBerg Anchor: https://bit.ly/Anchor-DrBerg TikTok: https://bit.ly/TikTok-DrBerg Send a Message to his team: https://m.me/DrEricBerg Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients so he can focus on educating people as a full time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. #keto #ketodiet #weightloss #ketolifestyle Thanks for watching! I hope this helps explain the signs of vitamin D overdose. I’ll see you in the next video.
·youtube.com·
#1 Sign That You Overdosed on Vitamin D - YouTube