2016

Can Ivermectin play a key role in treating Parkinson's Disease? Two peer-reviewed papers—one by Warnecke et al. (2020) and another by Wa...

Parkinson's disease (PD) is a neurodegenerative disorder and leading cause of death worldwide, whose pathogenesis has been linked to toxic environmental exposures. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (i) to compile, and group by exposure …

Mitochondrial dysfunction is a hallmark of Parkinson's disease (PD) pathogenesis, contributing to increased oxidative stress and impaired endo-lysosomal-proteasome system efficiency underlying neuronal injury. Genetic studies have identified 19 monogenic mutations-accounting for ~10% of PD cases-tha …

Dr. Gilbert discusses the seven new medications that were approved to treat Parkinson’s disease motor symptoms since 2017

Parkinson's disease (PD) is a neurodegenerative disease affecting dopaminergic neurons in the nigrostriatal and gastrointestinal tracts, causing both motor and non-motor symptoms. This study examined the neuroprotective effects of trehalose. This sugar is confined in the gut due to the absence of tr …

Transcranial magnetic stimulation (TMS) is an effective method used to diagnose and treat many neurological disorders. Although repetitive TMS (rTMS) has been used to treat a variety of serious pathological conditions including stroke, depression, ...

This case-control of older US adults examines risk of Parkinson Disease by proximity of residence to a golf course.

Chlorine dioxide was discovered over 200 years ago. It's use has steadily expanded into many industries and therapeutic applications despite a near global regulatory blockade on clinical research.

Peptides are attracting a growing interest for therapeutic applications in biomedicine. In Parkinson's disease (PD), different human endogenous peptides have been associated with beneficial effects, including protein aggregation inhibition, reduced inflammation, or the protection of dopaminergic neu …

Parkinson's disease (PD) is a progressive movement disorder resulting primarily from loss of nigrostriatal dopaminergic neurons. PD is characterized by the accumulation of protein aggregates, and evidence suggests that aberrant protein deposition in ...

Because the data say RB-190 should work.

There are many different forms of dementia. Learn how to identify symptoms and causes, while protecting yourself from cognitive impairment.

Cerebral glucose and insulin metabolism is impaired in Alzheimer's disease (AD). Ketones provide alternative energy. Will medium chain triglyceride (MCT) oil, a nutritional source of ketones, impact cognition in AD? This was a 6‐month randomized, ...

There is an urgent need to identify interventions that broadly target aging-related cognitive decline and progression to Alzheimer’s disease (AD). Bottlenose dolphins (Tursiops truncatus) have histologic changes similar to AD in humans, and they also develop shared age-associated co-morbidities identified as risk factors for AD in humans, including type 2 diabetes, ferroptosis, and iron overload, which can be driven by nutritional C15:0 deficiency. We hypothesized that (1) dolphins would have amyloid beta (Aβ) plaques and neuroinflammation that paralleled that of humans in relation to age-related progression, quantitative concentration, and brain region; and (2) C15:0 would have dose-dependent activities relevant to protecting cognitive health. Quantitative immunohistochemistry staining was used to assess 68 tissues from archived brains of 19 Navy dolphins to evaluate associations among amyloid beta (Aβ) plaques and neuroinflammation by brain region, sex, and age group. Further, dose-dependent C15:0 activities, using a third-party panel intended to screen for potential AD therapeutics, were evaluated. Similar to humans, dolphins had the highest Aβ plaque density variation in the hippocampus (90th percentile of 4.95 plaques/mm2), where plaque density increased with age (p = 0.05). All measured markers of neuroinflammation were detected, including the highest concentrations of activated microglia (CD68+) in the hippocampus (0.46 ± 0.38 cells/mm2). C15:0 was a dose-dependent inhibitor of two targets, fatty acid amide hydrolase (FAAH) (IC50 2.5 µM, 89% maximum inhibition at 50 µM relative to URB597) and monoamine oxidase B (MAO-B) (IC50 19.4 µM, 70% maximum inhibition at 50 µM relative to R(-)-Deprenyl). These activities have demonstrated efficacy against Aβ formation and neuroinflammation, including protection of cognitive function in the hippocampus. These findings suggest that, in addition to protecting against AD co-morbidities, C15:0 may play a distinct role in supporting cognitive health, especially at higher concentrations.

Jesus quoted the Old Testament to show WHEN Christians escape in the Rapture. What is that prophecy, when will it take place. Quoting the same passage, Paul ...

Dr. Ray Dorsey is a medical doctor and Professor of Neurology at the University of Rochester. He is working to identify and eliminate the root causes of Park...

Jonathan Cahn opens up of the Book of Revelation, we’re going to see (& use!) one of the most amazing, important, and overlooked decoders that God has given ...

Crippling brain injuries used to be a well recognized complication of vaccination. What changed?

A New & Improved App to Help Track Your Symptoms Each person’s Parkinson’s disease symptoms are different. The more you and your care team know, the more personalized your care can be. The user-friendly APDA Symptom Tracker app helps you capture the details of your symptoms, with new and enhanced features including a medication tracker, notes section, […]

The University of Rochester Medical Center (URMC) is one of the nation’s leading academic medical centers. It forms the centerpiece of the University of Rochester’s health research, teaching and patient care missions. The University of Rochester Medical Center is a private, coeducational, nonsectarian, and nonprofit research university.

Parkinson's disease is progressive neurological degenerative state. Discover natural solutions and 17 action steps to improve brain health.

Stanford Parkinson's Community Outreach has created a list of the best resources available on the topic of symptom trackers for PD.

(NaturalHealth365) New research reveals up to 13% of dementia cases may actually be treatable liver conditions.

Bayer recently warned of completely halting production of glyphosate due to billions of dollars in court ruling due to links to deadly cancers. Jefferey reports on the extent the manufacturers are going to keep this harmful product on shelves and what chemicals advocacy groups are targeting next to keep Americans safe. AIR DATE: April 24, […]

Who in the world would try to lower their cholesterol by eating an entire sleeve of Oreos every day for a month? Meet Nick Norwitz, PhD, an Oxford graduate a...

DOGE leader Elon Musk, alongside his team, joins 'Jesse Watters Primetime' to discuss efforts to slash government waste. #foxnews #jessewattersprimetime #usn...

(NaturalHealth365) New study reveals how chemotherapy releases toxic particles that damage DNA in healthy cells long after treatment ends.

President Trump hits China with massive tariffs in an economic counterattack. Gordon Chang joins us to expose shocking Chinese influence in America’s militar...

Over the past years, countless American journalists have embedded with Zelensky’s military. On the Russian side, there’s only one: Patrick Lancaster.Paid par...