2016

Supine blood pressure readings could spot heart problems missed by readings taken while seated, preliminary research suggests.

The application of antimicrobial textiles is rising rapidly because of their healthcare, comfort, and hygienic attributes. This work aimed to develop …

"Hit-and-run" treatment with senolytics, which in the case of D + Q have elimination half-lives

Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis-driven approach. SC accumulate with ageing and at causal sites of multiple chronic disorders, including diseases acco …

Ladies, you are looking at the power of carbon dioxide medicine. This is the same woman before, after one year and after two years of daily application of a carbon dioxide gel that is applied directly to the face. What this will do to the skin this will do to one’s internal tissues when... View Article

Clostridioides difficile , the leading cause of antibiotic-associated diarrhoea worldwide, is a genetically diverse species which can metabolise a number of nutrient sources upon colonising a dysbiotic gut environment. Trehalose, a disaccharide sugar consisting of two glucose molecules bonded by an α 1,1-glycosidic bond, has been hypothesised to be involved in the emergence of C. difficile hypervirulence due to its increased utilisation by the RT027 and RT078 strains. Here, growth in trehalose as the sole carbon source was shown to be non-uniform across representative C. difficile strains, even though the genes for its metabolism were induced. Growth in trehalose reduced the expression of genes associated with toxin production and sporulation in the C. difficile R20291 (RT027) and M120 (RT078) strains in vitro, suggesting an inhibitory effect on virulence factors. Interestingly, the R20291 TreR transcriptional regulatory protein appeared to possess an activator function as its DNA-binding ability was increased in the presence of its effector, trehalose-6-phosphate. Using RNA-sequencing analysis, we report the identification of a putative trehalose metabolism pathway which is induced during growth in trehalose: this has not been previously described within the C. difficile species. These data demonstrate the metabolic diversity exhibited by C. difficile which warrants further investigation to elucidate the molecular basis of trehalose metabolism within this important gut pathogen.

Should you take a creatine supplement? This is a frequent question I get asked when I lecture, as well as on various online forums. Ultimately, I think it makes a …

Salmonella typhimurium (ST) poses a serious threat to host health, and the adverse effects of antibiotic treatment necessitate the urgent search for i…

Dr. William Makis Discusses Turbo Cancers After the Shot.

Polymer nanoparticles deliver mRNA to the lung for mucosal vaccination Alexandra Suberi et al. Sci Transl Med. 2023. https://pubmed.ncbi.nlm.nih.gov/37585505/ . Injectable mRNA-based vaccines were ins

Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are caused by a combination of multiple events that damage neuronal function. A well-characterized biomarker of neurodegeneration is the accumulation of proteinaceous aggregates in the brain. However, the gradually worsening symptoms of neurodegenerative diseases are unlikely to be solely due to the result of a mutation in a single gene, but rather a multi-step process involving epigenetic changes. Recently, it has been suggested that a fraction of epigenetic alternations may be correlated to neurodegeneration in the brain. Unlike DNA mutations, epigenetic alterations are reversible, and therefore raise the possibilities for therapeutic intervention, including dietary modifications. Additionally, reactive oxygen species may contribute to the pathogenesis of Alzheimer’s disease and Parkinson’s disease through epigenetic alternation. Given that the antioxidant properties of plant-derived phytochemicals are likely to exhibit pleiotropic effects against ROS-mediated epigenetic alternation, dietary intervention may be promising for the management of neurodegeneration in these diseases. In this review, the state-of-the-art applications using single-cell multimodal omics approaches, including epigenetics, and dietary approaches for the identification of novel biomarkers and therapeutic approaches for the treatment of neurodegenerative diseases are discussed.

Get FREE Access to This Docuseries and Learn from 50 Top Medical Doctors the Secrets to Become AGELESS

(NaturalHealth365) A recent study revealed a connection between atopic dermatitis (eczema), and the development of IBD.

Papers Reviewed: Sep.22, 2023 - Blix et al. - Norwegian study of 20,000 women Sep. 2023 - Thabet et al. - Saudi Study of 500 women ages 18-45 Sep.2023 - Jensen et al. - Danish study of 13,600 women ages 16-65 Aug.2023 - Trogstad et al. - Norwegian study of 3972 women ages 18-30

Watch now (27 mins) | RUMBLE LINK: Sep.18, 2023 - Dr.William Makis’ NCI Testimony (Full - 3 hours)

(NaturalHealth365) Scientists believe delayed gut microbiota maturation is responsible for childhood allergies.

The overarching issue with the mRNA technology is the free floating spike protein created in the body. How long does it stay? What are the potential issues? We hit the latest science. POSTED: September 22, 2023

Oncologist and cancer researcher, Dr William Makis, is sounding the alarm on the sudden rise in “turbo cancers”, a recent term coined for the incredibly fast growing cancers found in COVID vaccinated individuals. Hear what the early data is showing in the causal relationship with the vaccine and the struggles doctors are having treating these […]

While virtually every US Health Advisor is recommending the new COVID-19 booster for everyone older than 6 months old this Fall, Florida Surgeon General, Dr. Joseph Ladapo, has taken a firm stance to urge healthy people under 65 to NOT get the booster. Hear about the lack of evidence of efficacy and the attacks he […]

Levetiracetam is a novel antiepileptic drug used to treat partial, myoclonic, and tonic-clonic seizures. In 2000, the FDA approved the use of the oral formulation as adjunctive therapy for the treatment of focal seizures, myoclonic seizures, and primary generalized seizures. In addition, the FDA approved intravenous levetiracetam in 2006 for use in patients older than 15 years as adjunctive anticonvulsant therapy when the oral formulation is not tolerated. This activity covers levetiracetam, including mechanism of action, pharmacology, adverse event profiles, eligible patient populations, and monitoring. In addition, it highlights the interprofessional team's role in managing conditions where levetiracetam therapy is helpful.

Quick easy-to-read overview of Keppra. Includes: how it works, upsides, downsides, bottom line, tips, response and effectiveness.

Nathan S. Bryan, Ph.D CEO/FOUNDER OF NO2U & NITRIC OXIDE LEADING EXPERT Dr. Bryan has made many seminal discoveries in the Nitric Oxide field that has resulted in over a dozen U.S. and International patents. He is also a successful entrepreneur who has been able to bring his Nitric Oxide technology to consumers. Dr. Bryan has published a number of highly-cited papers and authored or edited five books. His work has made him a recognized international leader in molecular medicine and Nitric Oxide biochemistry. If your body can't make Nitric Oxide, we are here to help!

There are some foods you can cut around the mold, while others may make you sick; here are some tips for how to reduce mold growth on your food.

Founded by a chronic UTI sufferer, Uqora makes UTI relief products and proactive urinary tract health supplements that work. Try Uqora risk-free today!

In 2016, The Corbett Report released the 9/11 Suspects series in individual installments. Now, as we approach the 19th anniversary of the 9/11 false flag, The Corbett Report is proud to re-release the documentary as a single upload. This release features updated visuals courtesy of video editor Broc West. Please spread the word about this important information.

Evidence suggests the Saudi government may have been involved in the 9/11 attacks, but the US government, FBI and CIA covered up the connection.

Not all sugars are created equal, which matters when it comes to your health. Here's the difference between sucrose, glucose and fructose.

2018 Interview Kai-Fu Lee, Ph.D., a leading expert on artificial intelligence (AI), a venture capitalist and author of “AI Superpowers: China, Silicon Valley, and the New World Order,” has spent decades working for tech giants such as Apple, Micros…