2016

Molecular Neurobiology - There is no acquiesced remedy for the treatment of traumatic brain injury (TBI)-associated impairment, especially cognitive decline. The first 24 h after TBI is a...

Background/Objectives: Fucoidan, a sulfated polysaccharide derived from marine algae, is known for its antioxidant and immunomodulatory properties. Galectin-3 (Gal-3), a protein associated with cardiovascular fibrosis, has been identified as a potential therapeutic target in cardiac remodeling. This study aimed to evaluate whether fucoidan could inhibit Gal-3 activity and mitigate cardiac remodeling in a mouse model of pressure overload-induced cardiac hypertrophy. Methods: To test this hypothesis, we used transverse aortic constriction (TAC) surgery to induce pressure overload in normotensive mice, replicating the pathological features of cardiac hypertrophy. Mice were treated with fucoidan at a dose of 1.5 or 7.5 mg/kg/day. In vivo assessments of cardiac function, fibrosis, inflammation, and Gal-3 expression were performed. Results: Pressure overload led to significant upregulation of serum Gal-3 levels, increased cardiac collagen deposition, and elevated markers of fibrosis and inflammation. In mice treated with fucoidan, these effects were significantly attenuated. Fucoidan treatment prevented the upregulation of Gal-3, reduced collagen deposition, and decreased inflammatory cell infiltration, suggesting an inhibition of both fibrosis and inflammation. Conclusions: Fucoidan effectively mitigated the adverse effects of pressure overload in this mouse model, including reduced Gal-3 expression, fibrosis, and inflammation. These findings suggest that fucoidan holds promise as a therapeutic agent for preventing or delaying cardiac remodeling and associated complications, such as fibrosis and inflammation, in pressure overload-induced cardiac hypertrophy. Further research is needed to explore the underlying mechanisms and clinical applicability of fucoidan in cardiac disease.

The lipid-lowering activity of fucoidan has been widely reported, but the exploration of its mechanisms is relatively limited, and studies on its dire…

(NaturalHealth365) Rates of nonalcoholic fatty liver disease are surging worldwide. A review shows the potential of berberine against NAFLD.

Why isn’t Tony Fauci in prison? You’ll wonder after you watch “Thank You, Dr. Fauci,” now out on TCN. Jenner Furst made the documentary. Even if you think you know a lot, this is an amazing conversation. Watch the documentary here: https://tuckercarlson.com/fauci Follow Tucker on X: https://x.com/TuckerCarlson Paid partnerships with: PreBorn: Save babies and souls at https://PreBorn.com/Tucker Jase Medical: Use promo code “Tucker” for an extra discount at https://Jasemedical.com Eight Sleep: Get $350 off the Pod 4 Ultra at https://EightSleep.com/Tucker #TuckerCarlson #DrFauci #science #documentary #China #bioweapons #BillGates #DonaldTrump #DARPA #CDC #JoeBiden #Ukraine #news #politics Chapters: 0:00 Exposing Fauci and the COVID Cover-up 04:24 The Truth About COVID's Origins 09:53 Were the 2001 Anthrax Attacks a False Flag? 22:26 The Real Reason Fauci Pushed for mRNA Vaccines 30:34 The Pandemic Began Much Earlier Than You Were Told 39:02 Why COVID Is Different From Any Other Virus 45:16 The Relationship Between Food and COVID 48:27 Exposing DARPA's Shadowy “Project DEFUSE” 01:00:12 Who Got Rich From COVID? 01:19:24 Donald Trump's Historic Appointments 01:28:06 Bio Labs in Ukraine

— Matthew Rife (@RifeTechnology)

(NaturalHealth365) New study shows that a certain type of exercise can slow down tumor growth. Great news for cancer patients.

(NaturalHealth365) Discover how extra virgin olive oil can help reduce the risk of heart attack and stroke. Learn about its benefits.

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

Genesis 1 - In the beginning God created the heavens and the earth.

He Is Risen - Now after the Sabbath, as the first day of the week began to dawn, Mary Magdalene and the other Mary came to see the tomb. And behold, there was a great earthquake; for an angel of the Lord ...

Notes: https://docs.google.com/document/d/1n5hgThrV3MZtsO__96smugPJJ8OAmRIh/edit?usp=drivesdk&ouid=102430545303799711405&rtpof=true&sd=true C04-5-16

Roger Ver is facing life in prison for revealing how the US government worked secretly to subvert cryptocurrency and prevent economic freedom. More people should hear this story. Follow Tucker on X: h

As a sixth grader, Vogel participated in a hearing test. The only problem – she never heard the proverbial beeps. Vogel was hearing impaired and without the means or insurance to secure hearing aids. Fast forward to her mid-20s, and Vogel finally experienced the power of sound. Vogel shares her journey and the impact of the high costs of hearing aids on adolescent addiction and suicidal ideation. It’s time to listen. Christy Vogel is passionate about her mission to ignite joy in everyone she meets. She's been leaving her mark in the industry by providing her clients with expert marketing talent and results-oriented programs to help them reach their goals. With over 25 years of marketing experience, Christy understands how vital marketing leadership can be to the success of any corporation. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

DuckDuckGo. Privacy, Simplified.

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

(NaturalHealth365) VOCs are highly toxic substances that contaminate the air you breathe, especially at night if you're not careful.

Rheumatoid Arthritis is an auto-immune condition resulting in the formation of autoantibodies that cause joint and systemic inflammation. Different si…

Background: Aloe vera, often dubbed the "plant of immortality," has been cherished for its healing properties throughout history.

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

Comprehensive analysis of the lipid content in Cordyceps sinensis samples is essential for optimizing their effective use. Understanding the lipid profile can significantly enhance the application of this valuable fungus across various fields, including nutrition and medicine. However, to date, there is limited knowledge regarding the effects of different drying methods on the quality of lipids present in Cordyceps sinensis. In this study, we employed a broadly targeted lipidomic strategy to conduct a comprehensive analysis of the lipid composition in Cordyceps sinensis subjected to various drying methods. A comprehensive analysis identified a total of 765 distinct lipid species from fresh Cordyceps sinensis (FC), vacuum-freeze-dried Cordyceps sinensis (VG), oven-dried Cordyceps sinensis (OG), and air-dried Cordyceps sinensis (AG). Among these, glycerophospholipids (GP) were the most abundant, followed by glycerides (GL) and sphingolipids (SP). In this study, a total of 659 lipids demonstrated statistically significant differences, as indicated by a p-value (p) < 1. Among these lipids, triglycerides (TG) exhibited the highest concentration, followed by several others, including ceramide-ascorbic acid (Cer-AS), phosphatidylethanolamine (PE), lysophosphatidylcholine (LPC), and phosphatidylserine (PS). OG was the fastest drying method; however, PCA and OPLS-DA analyses indicated that the most significant changes in the lipids of Cordyceps sinensis were observed under the OG method. Specifically, 517 differentially accumulated lipids were significantly down-regulated, while only 10 lipids were significantly up-regulated. This disparity may be attributed to the degradation and oxidation of lipids. The metabolic pathways of glycerolipid, glycerophospholipid, and cholesterol are critical during the drying process of Cordyceps sinensis. This study provides valuable insights that can enhance quality control and offer guidelines for the appropriate storage of this medicinal fungus.

(NaturalHealth365) Green leafy vegetables can slow down cognitive decline by more than a decade. Learn which ones are the best.

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

7 Foods and Nutrients Proven to Cut Macular Degeneration Risk. As the baby-boomers age, blindness from age-related macular degeneration is on the rise. More than 3 million more people will become victims in the next five years. Eating right can lower your risk

11 Foods Proven to Lower Glaucoma Risk. Glaucoma leads to incurable blindness. There are no early warning signs. Half of people with the disease don't even know they have it. Changing your diet can cut your risk