2016

Decades of neglect in understanding the actual causes of dementia have transformed it into one of the most costly diseases in existence.

Background: Aging is associated with chronic diseases and increased oxidative stress, particularly affecting liver function. Aging is linked to chronic diseases and heightened oxidative stress, particularly impacting liver function. Recent research has demonstrated that oral administration of trehalose offers multiple benefits for various tissues and organs.Methods: This study investigated the effects of oral trehalose (2% in water) on the gene expression of key markers linked to liver oxidative stress and inflammation in 4-month-old adult and 24-month-old Wistar rats. Thirty-two male Wistar rats (n = 8) were randomly assigned into four groups: adult control, aged control, adult trehalose (2% in water), and aged trehalose, over a treatment period of one month. Following treatment, liver tissues were analyzed using real-time PCR for genes related to oxidative stress (PGC-1α, NRF2, and SOD) and inflammation (NF-κB, IL-1β, TNF-α, and TGF-β).Results: Our findings revealed a significant up-regulation of PGC-1α, NRF2, and SOD in aged trehalose group compared to the aged control (P < 0.001); however, SOD expression increased by trehalose administration in aged rats compared to other 3 groups. Inflammatory markers (NF-κB, IL-1β, TNF-α) were significantly reduced by trehalose, and TGF-β expression, involved in fibrosis, was attenuated exclusively in aged rats compared with controls (P < 0.05).Conclusion: These results suggest that trehalose has a protective effect on hepatic function, particularly in the aging population, and highlight its potential therapeutic role in age-associated liver dysfunction.

This review explores the pharmacological potential of chondroitin sulfate and fucoidan as immunomodulatory agents targeting N-acetylgalactosaminidase (nagalase) to normalize immune responses. Nagalase, an enzyme produced by tumor and virus-infected cells, contributes to immune suppression by deactivating macrophage-activating factor. Both chondroitin sulfate and fucoidan, as representatives of glycosaminoglycans and heteropolysaccharides, exhibit significant potential in inhibiting nagalase activity, thereby restoring immune functionality. Chondroitin sulfate, a key component of the extracellular matrix, demonstrates anti-inflammatory and tissue-regenerative properties by modulating nuclear factor (NF)-κB pathways and cytokine expression. Fucoidan, a sulfated polysaccharide derived from brown seaweed, enhances immune responses through macrophage and natural killer cell activation, while also exhibiting antiviral and anticancer activities. This dual action positions these compounds as promising agents for therapeutic interventions in chronic inflammatory conditions, cancer, and infectious diseases. The synergistic effects of chondroitin sulfate and fucoidan highlight their potential to address the root causes of immune dysregulation. This review aims to elucidate the underlying mechanisms of action and explore the clinical applications of these compounds within the framework of innovative immunotherapeutic strategies. However, current evidence is limited by the predominance of preclinical studies and variability in experimental models. Well-designed clinical trials are needed to validate their efficacy for therapeutic use.

This review explores the pharmacological potential of chondroitin sulfate and fucoidan as immunomodulatory agents targeting N-acetylgalactosaminidase (nagalase) to normalize immune responses. Nagalase, an enzyme produced by tumor and virus-infected cells, contributes to immune suppression by deactivating macrophage-activating factor. Both chondroitin sulfate and fucoidan, as representatives of glycosaminoglycans and heteropolysaccharides, exhibit significant potential in inhibiting nagalase activity, thereby restoring immune functionality. Chondroitin sulfate, a key component of the extracellular matrix, demonstrates anti-inflammatory and tissue-regenerative properties by modulating nuclear factor (NF)-κB pathways and cytokine expression. Fucoidan, a sulfated polysaccharide derived from brown seaweed, enhances immune responses through macrophage and natural killer cell activation, while also exhibiting antiviral and anticancer activities. This dual action positions these compounds as promising agents for therapeutic interventions in chronic inflammatory conditions, cancer, and infectious diseases. The synergistic effects of chondroitin sulfate and fucoidan highlight their potential to address the root causes of immune dysregulation. This review aims to elucidate the underlying mechanisms of action and explore the clinical applications of these compounds within the framework of innovative immunotherapeutic strategies. However, current evidence is limited by the predominance of preclinical studies and variability in experimental models. Well-designed clinical trials are needed to validate their efficacy for therapeutic use.

This study investigated the anti-obesity and anti-inflammatory effects of D-Allulose compared to erythritol in high-fat diet (HFD)-fed mice, focusing …

The origins of Christianity have been debated amongst scholars and experts over the centuries. A team of graphic experts use cutting-edge software to bring t...

Isaiah has been called the “fifth evangelist” and his book the “fifth gospel.” Within its 66 chapters, Isaiah presents the Messiah’s birth, character, life, ...

A powerful essay on the Yazidi genocide, global silence, and the clash of civilizations exposing selective outrage and moral hypocrisy.

President Donald Trump addresses the United Nations General Assembly in New York City. #foxnews #news #us #foxSubscribe to Fox News: https://bit.ly/2vBUvASWa...

Shalom ${contact.name.first}, Over the years many people have contacted us with questions regarding the Greek Septuagint (LXX) versus the Hebrew Masoretic Text (MT). There is a heated debate about the reliability and accuracy of the Hebrew Masoretic Text, and a growing number of Bible believers are now relying on the second-hand Greek LXX translation rather than on the original Hebrew text. In this video, we investigate the claims of Dr. Henry B. Smith, who maintains that the Greek LXX has preserved the correct and original chronology, while the chronology of the Hebrew MT has allegedly been corrupted by over 1,000 years! Thankfully, this debate can be settled with clear evidence from the Biblical narrative itself! By calculating Methuselah's age with regards to the flood, we can show very clearly which version is correct and which version is corrupt. We also respond to a well-known counter argument on this topic. Watch this video if you would like to know which version of the Tanach (Old Testament) has been corrupted and which version can be trusted: Hebrew Bible vs. Greek Bible - Numbers (Amounts) in the Greek Septuagint

Archaeologist Dr. Titus Kennedy joins us as we explore the city of Zoar and its relationship to the sin cities of Sodom and Gomorrah. We will survey the arch...

Recent dramatic discoveries in genetics have rolled back the curtain on one of the most epic periods in all of pre-European North American history. Join Dr. ...

In this exciting series, Dr. Nathaniel Jeanson takes viewers on a deep dive into the genetics, indigenous histories, linguistics, and archaeology of North Am...

Silicon Valley Elites are holding secret sessions on the Antichrist this week. There will be no filming or recording. Are they planning to help him rise and ...

Jonathan Cahn reveals the dark and shocking secret behind the Charlie Kirk assassination – the realm of witches and demonic agents, the ancient queen Jezebel...

The Charlie Kirk Assassination - Why did it happen? What does it all mean? What does it have to do with the future? And what do we need to know and do? Jona...

NEW PROOF of the year and day of Jesus return - and biblical proof of why we CAN know the day IF we watch for signs. This proof demonstrates that 70 7's from...

A former FBI agent who was embedded in the CIA’s Bin Laden unit, Mark Rossini, claims the CIA was fully aware that the 9/11 hijackers were in the United Stat...

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Evidence of Extreme Explosive Energy resulting from the Nuclear demolition of the World Trade Center.

A concise, credible and complete documentation on the Nuclear demolition of the World Trade Center.

Infant rats exposed to “safe” cell phone radiation levels suffered impaired neuronal development and disrupted brain chemistry, while parallel in-vitro tests showed DNA damage in neural stem cells.

With cell phones in our pockets, Wi-Fi routers in nearly every home, and smart devices all around us, concern over electromagnetic fields (EMFs) is growing. Dr. Carlos Ritter joins Del to break down what the science really shows about EMF exposure and its potential impact on human health. Ritter doesn’t stop at raising an alarm; […]

Vaccine DNA plasmid-derived Spike gene sequence integrated into chromosome 19 with perfect 20/20 bp identity — accompanied by widespread genomic dysfunction.

CDC/FDA safety thresholds breached as COVID shots disrupt the blood–brain barrier, unleashing meningitis, encephalitis, prion disease, brain abscesses, herpes reactivations, and more.

International evidence converges: mRNA shots are unsafe, ineffective, contaminated, and in violation of international law.

Sentinel case of a young stage IV bladder cancer patient reveals a vaccine-derived Spike gene sequence embedded in chromosome 19 with a perfect 20/20 bp match.

Unlock the truth about mRNA vaccines with Christie Grace MSc, and discover what’s really inside — information that could take down the entire platform. This ...

Dr Gina Loudon Asks Dr McCullough to Explain on American Sunrise